Method of detecting at least one mechanism of resistance to cephalosporins by mass spectrometry

ABSTRACT

The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a cephalosporin, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.

This application is a divisional application of U.S. patent applicationSer. No. 14/111,118, filed Dec. 23, 2013, which is in turn a U.S.National Stage of International Application No. PCT/EP2012/057322, filedApr. 20, 2012, which claims priority from U.S. Provisional ApplicationNo. 61/477,907, filed Apr. 21, 2011. The disclosure of the priorapplications is hereby incorporated by reference herein in theirentirety.

The present invention relates to the field of microbiology. Moreprecisely, the invention relates to the detection of at least onemechanism of resistance to cephalosporins of at least one microorganismfrom a sample by using mass spectrometry.

Since Pasteur's discovery of microbes, microorganisms have been studiedby microscopy and biochemical analyses. These conventional methods areoften long and tedious, and analytical alternatives were sought veryearly on. This is why the analysis of bacteria by mass spectrometry wasinitiated from 1975 by J. Anhalt and C. Fenselau [1].

This preliminary work was followed by the study of fatty acids from thewall of the microorganisms using gas chromatography combined with massspectrometry (GC-MS) [2]. This method was popularised under the Englishterm FAME, standing for Fatty Acid Methyl Ester. It currentlyconstitutes a reference method for taxonomic studies. However, its useremains limited to certain specialised laboratories dealing with thetreatment of the sample by saponification, hydrolysis and derivation. In1996, the works by M. Claydon et al. [3] as well as by T. Krishnamurthyand P.

Ross [4] demonstrated the possibility of identifying different bacterialspecies with a MALDI-TOF mass spectrometer (English acronym for MatrixAssisted Laser Desorption Ionization—Time Of Flight). The analysiscombines the acquisition of a mass spectrum and the interpretation ofexpert software. It is extremely simple and can be carried out in a fewminutes. However it has only been making it into medical analysislaboratories fairly recently [5]. Its clinical use is currently limitedto the identification of bacteria and yeast species. It is not routinelyused to identify resistances to antimicrobials.

Yet the identification of resistances to antimicrobials such asantibiotics is an essential element in ensuring optimal patient care.

Other mass spectrometry methods, particularly in tandem, have beenproposed to meet these needs. By way of example, it is possible to citethe work of C. Fenselau et al. for identifying β-Lactamase with aquadripole-TOF (Q-TOF) [6].

However these research results are not applicable to routine clinicaluse. They were obtained with research instruments requiring highlyqualified personnel. The analysis times, often greater than one hour persample, are incompatible with the workload of a microbiological analysislaboratory.

More recently, S. Hofstadler et al. [7] proposed a method combining amicrobial genome amplification by PCR to a detection of the PCR productsby electrospray-TOF (ESI-TOF). This method is now fully automated [8].However, it requires a PCR amplification with the flaws inherent inmolecular biology, namely extraction yield, cost of the probes, etc.

In this context, the objective of the present invention is to propose amethod of detecting mechanisms of resistance to cephalosporins whichmakes it possible to overcome the disadvantages of the prior artmethods, namely providing an inexpensive method, without reagentsspecific to each species, particularly compared to molecular biologymethods, which gives a result in a short amount of time, less than onehour, and which can be used in routine clinical work, without requiringhighly qualified personnel.

To this end, the invention proposes a new method of detecting, by massspectrometry, at least one mechanism of resistance to at least oneantimicrobial of at least one microorganism from a sample, characterisedin that the antimicrobial is a cephalosporin and in that proteins and/orpeptides are detected as markers of said mechanism of resistance to atleast one cephalosporin-class antibiotic.

Advantageously, markers of resistance to several differentantimicrobials can be detected simultaneously.

As indicated in application PCT/FR2010/052181, markers of type and/orvirulence of said microorganisms can be detected in the same way by massspectrometry prior to or at the same time as the detection of theresistance mechanism markers.

Markers of resistance to at least one cephalosporin-class antimicrobialis understood to mean molecules of protein origin which arecharacteristic of said properties.

Cephalosporins are antibiotics belonging to the beta-lactam family. Theyare usually classified in several subclasses:

-   -   first-generation cephalosporins, such as cefazolin, cephalothin,        cefaclor, cephalexin, which are broken down by the        beta-lactamases of groups 1 and 2b, 2br, 2be, 2ber    -   second-generation cephalosporins, such as cefamandole,        cefpodoxime, cefuroxime, which are broken down by the        beta-lactamases of groups 1, 2be, 2ber    -   third-generation cephalosporins, such as cefotaxime,        ceftazidime, ceftriaxone, cefixime, which are broken down by the        beta-lactamases of groups 1, 2be, 2ber, even though they are        more stable than the first-generation and second-generation        cephalosporins    -   fourth-generation cephalosporins, such as cefepime and        cefpirome, which are broken down by the beta-lactamases of        groups 2be and 2ber    -   cephalosporins exhibiting anti-MRSA activity such as ceftaroline        and ceftobiprole, which are broken down by the beta-lactamases        of groups 2be and 2ber    -   cephamycins, such as cefoxitin, cefotetan, cefmetazole, which        are broken down by the beta-lactamases of group 1

Determination of the resistance to at least one antimicrobial isunderstood to mean determining the susceptibility of a microorganism tobeing destroyed by an antimicrobial. The proteins involved in theresistance mechanisms will differ depending on the family and thespecies.

The nomenclature of the beta-lactamases, beta-lactam-resistant bacterialenzymes, is not standardised. They are either classified in fourmolecular classes (A to D) on the basis of their primary structure, orin functional groups on the basis of the target substrates and theirresistance to inhibitors (for an overview, see [9] Bush and Jacoby,Antimicrobial Agents and Chemotherapy, 2010; 54 (3): 969-976). Formolecular classification, sequencing techniques have made more preciseclassification possible: for example, 183 variants of the TEM proteinhave been described (labelled TEM-i, with i being between 1 and 183).For the functional classification, Bush and Jacoby (supra) have proposednew functional subgroups:

-   -   the group 1 enzymes are cephalosporinases belonging to the        molecular class C. ACC, ACT, MIR, MOX, DHA, CMY and FOX are        plasmid-borne enzymes, belonging to this subgroup.    -   the group 2 enzymes belong to molecular classes A and D. This        group is itself subdivided into subgroups: 2a, 2b, 2be, 2br,        2ber, 2c, 2ce, 2d, 2de, 2df, 2f, etc. CTX-M (2be), SHV (2b, 2be        or 2br), PER (2be), VEB (2be) and TEM (2b, 2be, 2br or 2ber) are        enzymes belonging to this group.        -   The subgroup 2a corresponds to beta-lactamases which            hydrolyse benzylpenicillin and penicillin derivatives, but            which do not hydrolyse cephalosporins, carbapenems or            monobactams.        -   The subgroup 2b corresponds to broad-spectrum            beta-lactamases which hydrolyse first-generation penicillins            and cephalosporins such as cephaloridine and cephalothin,            and which are inhibited by clavulanic acid, sulfobactam, or            tazobactam. The variants TEM-1, TEM-2 and SHV-1 belong to            this subgroup.            -   The subgroup 2b corresponds to extended-spectrum                beta-lactamases (ESBL) which are also inhibited by                clavulanic acid, sulfobactam, or tazobactam. These                enzymes, in addition to the properties of subgroup 2b,                hydrolyse at least one oxyimino-beta-lactam such as                cefotaxime or ceftazidime, and monobactams such as                aztreonam. This subgroup contains numerous variants of                TEM and SHV, variants of PER and VEB, as well as CTX-M,                BEL-1, BES-1, SFO-1, TAL-1 and TAL-2.            -   The subgroup 2br corresponds to beta-lactamases from the                subgroup 2b which are insensitive to inhibition by                clavulanic acid, sulfobactam or tazobactam. This                subgroup contains variants of the enzymes TEM and SHV.            -   The subgroup 2ber corresponds to beta-lactamases from                the subgroup 2be which are insensitive to inhibition by                clavulanic acid, sulfobactam or tazobactam. This                subgroup contains TEM variants.        -   The subgroup 2ce is characterised by its ability to            hydrolyse carbenicillin or ticarcillin, as well as cefepime            and cefpirome. CARB-10 is part of this subgroup.        -   The subgroup 2d includes the OXA beta-lactamases capable of            hydrolysing cloxacillin or oxacillin. The OXAs (or            oxacillinases) correspond to class-D beta-lactamases,            according to their primary sequence, and they can confer            resistances to cephalosporins or to cephalosporins and to            carbapenems (Poirel et al., 2010, Antimicrobio. Agents            Chemother., 54:24-38).            -   The subgroup 2de includes OXAs having an extended                spectrum extended to oxy-imino-beta-lactams, but not to                carbapenems.            -   The subgroup 2df includes OXAs having a spectrum                extended to carbapenems.        -   The subgroup 2e corresponds to extended-spectrum            cephalosporinases, which are inhibited by clavulanic acid or            tazobactam.        -   The subgroup 2f corresponds to carbapenemases such as SME,            KPC or certain variants of GES. The first GES beta-lactamase            was isolated in 1998 in French Guiana (Poirel et al., 2000,            Antimicrobio. Agents Chemother., 43:622-632). This enzyme            (GES-1) conferred an ESBL resistance (subgroup 2be). The            second isolate from a bacterium bearing a GES beta-lactamase            was achieved in 2000 in South Africa (Poirel et al., 2001,            Antimicrobio. Agents Chemother., 45: 2598-2603). This enzyme            (GES-2) conferred a resistance to cephalosporins and to            carbapenems such as imipenem (subgroup 2f).    -   The group 3 enzymes are metallo-beta-lactamases known for        hydrolysing carbapenem-class antibiotics. The enzymes IMP, VIM,        CAU, GOB or FEZ are part of this group.

The method of the invention can be employed to detect mechanisms ofresistance to cephalosporins in bacteria. Thus, for example, as bacteriain which it is possible to seek a mechanism of resistance tocephalosporins according to the method of the invention, non-exhaustivemention may be made of:

-   -   the Enterobacteriaceae, using group 1 and group 2 proteins and        peptides as a resistance marker;    -   non-fermenting bacteria (Pseudomonas aeruginosa, Acinetobacter        baumannii)    -   etc.

It should further be noted that the strains known to be resistant tocarbapenems are also resistant to cephalosporins and to penicillins.Therefore, a method of detecting a mechanism of resistance tocarbapenems also makes it possible to detect a mechanism of resistanceto cephalosporins and to penicillins.

The sample on which the method of the invention can be employed is anysample susceptible of containing a target microorganism. The sample canbe of biological origin, either animal, vegetable or human. In this caseit may correspond to a specimen of biological fluid (whole blood, serum,plasma, urine, cerebrospinal fluid, organic secretion, for example), atissue specimen or isolated cells. This specimen can be used such as itis insofar as the markers of mechanisms of bacterial resistance tobeta-lactams are available in the sample tested, or it can, prior to theanalysis, undergo preparation by enrichment, extraction, concentration,purification, culturing, in accordance with methods known to the personskilled in the art.

The sample can be of industrial origin, or, according to anon-exhaustive list, can be an air specimen, a water specimen, a surfacespecimen, a part or a manufactured product, or a food product. Amongstthe food samples, non-exhaustive mention can be made of a sample of adairy product (yogurts, cheeses), of meat, of fish, of egg, of fruit, ofvegetable, of water, of a beverage (milk, fruit juice, soda, etc.).These food samples can also come from sauces or ready meals. Finally, afood sample can come from an animal feed, such as animal meals.

Upstream of the detection by mass spectrometry, the sample to beanalysed is preferably pre-treated to produce peptides from the entiretyof the proteins present in the sample to fragment these proteins intopeptides, for example by digestion with a proteolytic enzyme (protease),or by the action of a chemical reagent. In fact, the cleaving of theprotein can be performed by a physico-chemical treatment, by abiological treatment or by a combination of the two treatments. Amongstthe useable treatments, mention can be made of treatment by hydroxylradicals, in particular with H₂O₂. Treatment by hydroxyl radicalsresults in a cutting of the peptide bonds which takes place randomly onany of the protein's peptide bonds. The hydroxyl radical concentrationdetermines the number of cleavages performed, and therefore the lengthof the peptide fragments obtained. Other chemical treatments can also beused such as, for example, cyanogen bromide (CNBr) treatment whichspecifically splits the peptide bonds at the carboxyl group of themethionyl residues. It is also possible to perform partial acid cleavingat the aspartyl residues by heating a solution of proteins intrifluoroacetic acid to 1000° C.

Treatment of the proteins by enzymatic digestion is neverthelesspreferred over physico-chemical treatment because it preserves more ofthe structure of the protein, and is easier to control. “Enzymaticdigestion” is understood to mean the single or combined action of one ormore enzymes under appropriate reaction conditions. The enzymes carryingout the proteolysis, which are called proteases, cut the proteins atspecific locations. Each protease generally recognises a sequence ofamino acids within which it always makes the same cut. Certain proteasesrecognise a single amino acid or a sequence of two amino acids betweenwhich they perform a cleavage, whereas other proteases only recogniselonger sequences. These proteases can be endoproteases or exoproteases.Amongst the known proteases, mention may be made of the following asdescribed in WO2005/098071:

-   -   specific enzymes such as trypsin which splits the peptide bond        at the carboxyl group of the Arg and Lys residues, endolysin        which cleaves the peptide bond of the —CO group of the lysines,        chymotrypsin which hydrolyses the peptide bond at the carboxylic        group of the aromatic residues (Phe, Tyr and Trp), pepsin which        makes a cut at the NH₂ group of the aromatic residues (Phe, Tyr        and Trp), the protease V8 from the V8 strain of Staphylococcus        aureus which cleaves the peptide bond at the carboxylic group of        the Glu residue;    -   the non-specific enzymes such as thermolysin from the bacteria        Bacillus thermoproteolyticus which hydrolyses the peptide bond        of the NH₂ group of hydrophobic amino acids (Xaa-The, Xaa-Ile,        Xaa-Phe), subtilisin and pronase which are bacterial proteases        which hydrolyse practically all the bonds and can transform the        proteins into oligopeptides under controlled reaction conditions        (enzyme concentration and duration of reaction).

Several proteases may be used simultaneously, if their modes of actionare compatible, or they may be used successively. Within the frameworkof the invention, the digestion of the sample is preferably performed bythe action of a protease enzyme, for example trypsin.

The generation of peptides using a chemical reagent or a protease can beobtained by means of a simple reaction in solution. It can also beperformed with a microwave oven [10], or under pressure [11], or evenwith an ultrasound device [12]. In these three latter cases, theprotocol will be much faster.

Amongst the peptides thus obtained, the peptides specific to the proteinare referred to as proteotypic peptides. It is these which will beassayed by mass spectrometry. According to the invention, the markers ofthe mechanisms of bacterial resistance to cephalosporins are proteinsfrom the bacterium in which the mechanisms of resistance tocephalosporins are to be sought. In particular, said proteins aredigested into peptides, preferably by an enzyme, and more preferably bytrypsin. Similarly, the sample containing protein markers characterisingmechanisms of bacterial resistance to cephalosporins can also bepre-treated for the purposes of purification. This purificationpretreatment can be employed before or after the peptide production stepas described above.

The sample purification pretreatment is widely known to the personskilled in the art and may in particular employ the techniques ofcentrifugation, filtration, electrophoresis or chromatography. Theseseparating techniques can be used alone or in combination with oneanother to obtain a multidimensional separation. For example,multidimensional chromatography can be used by combining separation byion exchange chromatography with reversed-phase chromatography, asdescribed by T. Fortin et al. [13], or H. Keshishian et al. [14]. Inthese publications, the chromatography medium can be in a column or in acartridge (solid-phase extraction).

The electrophoretic or chromatographic fraction (or the retention timein monodimensional or multidimensional chromatography) of theproteotypic peptides is characteristic of each peptide, and employingthese techniques therefore makes it possible to select the proteotypicpeptide or peptides to be assayed. Such a fractionation of the producedpeptides makes it possible to increase the specificity of the subsequentassay by mass spectrometry.

An alternative to the electrophoresis or chromatography techniques forthe fractionation of the peptides consists in specifically purifying theN-glycopeptides ([15] and patent application WO 2008/066629). However,such a purification only makes it possible to quantify the peptideswhich have undergone an N-glycosylation post-translational modification.Not all proteins are glycosylated though, which therefore limits itsuse.

The mass spectrometry to be employed in the method of the invention iswidely known to the person skilled in the art as a powerful tool foranalysing and detecting different types of molecules. Generally, anytype of molecule able to be ionised can be detected according to itsmolecular mass with the aid of a mass spectrometer. According to thenature of the molecule to be detected, whether of protein or metabolicorigin, certain mass spectrometry technologies can be more suitable.Nevertheless, whatever mass spectrometry method is used for thedetection, this latter includes a step of ionising the target moleculeinto so-called molecular ions, in the present case a step of ionisingthe characterising markers, and a step of separating the molecular ionsobtained according to their mass.

All mass spectrometers therefore comprise:

-   -   an ionising source intended to ionise the markers present in the        sample to be analysed, i.e. to confer a positive or negative        charge upon these markers;    -   a mass analyser intended to separate the ionised markers, or        molecular ions, according to their mass-to-charge ratio (m/z);    -   a detector intended to measure the signal produced either        directly by the molecular ions, or by ions produced from        molecular ions as detailed hereafter.

The ionisation step necessary for employing mass spectrometry can beperformed via any method known to the person skilled in the art. Theionising source makes it possible to transform the molecules to beassayed into a gaseous and ionised state. An ionising source can be usedeither in positive mode to study the positive ions, or in negative modeto study the negative ions. Several types of sources exist and will beused depending on the result sought and the molecules analysed. Inparticular, mention may be made of:

-   -   electron ionisation (EI), chemical ionisation (CI) and        desorption chemical ionisation (DCI)    -   fast atom bombardment (FAB), metastable atom bombardment (MAB)        or ion bombardment (SIMS, LSIMS)    -   inductively coupled plasma (ICP)    -   atmospheric-pressure chemical ionisation (APCI) and        atmospheric-pressure photoionisation (APPI)    -   electronebulisation or electrospray (ESI)    -   matrix-assisted laser desorption/ionisation (MALDI),        surface-activated laser desorption/ionisation (SELDI) or        desorption/ionisation on silicon (DIOS)    -   ionisation/desorption by interaction with metastable species        (DART)

In particular, ionisation can be employed as follows: the samplecontaining the target molecules is introduced into an ionisation source,where the molecules are ionised in gaseous state and thus transformedinto molecular ions which correspond to the initial molecules. Anelectrospray ionisation (ESI) source makes it possible to ionise amolecule by making it pass from a liquid state into a gaseous state. Themolecular ions obtained therefore correspond to the molecules present inliquid state, with, in positive mode, one, two, or even three or moreadditional protons and therefore carry one, two, or even three or morecharges. For example, when the target molecule is a protein, anionisation of the proteotypic peptides obtained after fractionation ofthe target protein, by means of an electrospray source functioning inpositive mode, leads to polypeptide ions in gaseous state, with one,two, or even three or more additional protons and which therefore carryone, two, or even three or more charges, and makes it possible to movefrom a liquid state to a gaseous state [16]. This type of source isparticularly well suited when the target molecules or proteotypicpeptides obtained are separated beforehand by reversed-phase liquidchromatography. Nevertheless, the ionisation yield of the moleculespresent in the sample may vary depending on the concentration and thenature of the different species present. This phenomenon leads to amatrix effect well known to the person skilled in the art.

A MALDI ionisation source will allow ionisation of the molecules from asolid-state sample.

The mass analyser in which the step of separating the ionised markersaccording to their mass-to-charge ratio (m/z) is performed is any massanalyser known to the person skilled in the art. Mention can be made oflow-resolution analysers, quadripole or quadrupole (Q), 3D ion trap (IT)or linear ion trap (LIT), also called ion trap, and high-resolutionanalysers which make it possible to measure the exact mass of theanalytes and which in particular use the magnetic sector linked to anelectric sector, the time of flight (TOF), Fourier transform ioncyclotron resonance (FT-ICR), orbitrap.

The separation of the molecular ions depending upon their m/z ratio canbe employed just once (single mass spectrometry or MS), or severalsuccessive MS separations can be conducted. When two successive MSseparations are carried out, the analysis is called MS/MS or MS². Whenthree successive MS separations are carried out, the analysis is calledMS/MS/MS or MS³, and more generally, when n successive MS separationsare carried out, the analysis is called MS.

Amongst the techniques which employ several successive separations, SRM(Selected Reaction Monitoring) mode when detecting or assaying a singletarget molecule, or MRM (Multiple Reaction Monitoring) mode whendetecting or assaying several target molecules are particular uses ofMS² separation. Similarly the MRM³ mode is a particular use of MS/MS/MSseparation. This is referred to as targeted mass spectrometry.

In the case of a detection in single MS mode, it is the mass-to-chargeratio of the molecular ions obtained which is correlated to the targetmolecule to be detected.

In the case of detection in MS/MS mode, essentially two steps are added,compared to an MS assay, which are:

-   -   a fragmentation of the molecular ions, then called precursor        ions, to give ions called 1^(st) generation fragment ions, and    -   a separation of the ions called 1^(st) generation fragment ions        according to their mass (m/z)₂, the ratio (m/z)₁ corresponding        to the ratio (m/z) of the precursor ions.

It is therefore the mass-to-charge ratio of the 1^(st) generationfragment ions thus obtained which is correlated to the target moleculeto be detected. First-generation fragment ion is understood to be an ionderived from the precursor ion, following a fragmentation step and ofwhich the mass-to-charge ratio m/z is different from the precursor ion.

The (m/z)₁ and (m/z)₂ pairs are called transitions and arerepresentative of the characteristic ions to be detected.

The choice of the characteristic ions which are detected to becorrelated to the target molecule is made by the person skilled in theart in accordance with the standard methods. Their selection willadvantageously lead to the most sensitive, specific and robust assayspossible, in terms of reproducibility and reliability. In the methodsdeveloped for the selection of proteotypic peptides (m/z)₁, and of thefirst-generation fragment (m/z)₂, the choice is essentially based on theintensity of the response. For more details, it is possible to refer toV. Fusaro et al. [17]. Commercially available software, such as theMIDAS and MRM Pilot software from Applied Biosystems or MRMaid [18] canbe used by the person skilled in the art to allow him to predict all thepossible transition pairs. He can also make use of a database calledPeptideAtlas constructed by F Desiere et al. [19] to compile all of theMRM transitions of peptides described by the scientific community. Thisdatabase PeptideAtlas is freely available on the internet. Fornon-protein molecules, it is also possible to use databases, such as,for example, the one accessible through the Cliquid software from thecompany Applied Biosystems (United States of America).

An alternative approach to selecting the proteotypic peptides (m/z)₁ and(m/z)₂ consists in using MS/MS fragmentation spectra obtained duringother work. This work can be, for example, the phases of biomarkerdiscovery and identification by proteomic analysis. This approach wasproposed by Thermo Scientific during user conferences [18]. It makes itpossible to generate a list of candidate transitions from the peptidesidentified through testing by the SIEVE (Thermo Scientific) software.Certain criteria were detailed by J. Mead et al. [18] for the choice ofthe ions (m/z)₁ and (m/z)₂ and are detailed hereafter:

-   -   peptides with internal cleavage sites, i.e. with internal Lysine        or Arginine, must be avoided, unless the Lysine or Arginine is        followed by Proline,    -   peptides with Aspargine or Glutamine must be avoided because        they may deaminate,    -   peptides with Glutamine or Glutamic Acid at the N-terminal must        be avoided because they may cyclise spontaneously,    -   peptides with Methionine must be avoided because they may be        oxidised,    -   peptides with Cysteine must be avoided because they may be        non-reproducibly modified during a potential step of        denaturation, reduction and blocking of the thiol functions,    -   peptides with Proline may be considered to be favourable because        they generally produce intense fragments in MS/MS with a very        strong single peak. However, a very strong single fragment does        not make it possible to validate the identity of the transition        in a complex mixture. Indeed, only the simultaneous presence of        several characteristic fragments makes it possible to verify        that the precursor ion sought has actually been detected,    -   the peptides having a Proline adjacent to the C-terminal        (Position n−1) or in second position relative to the C-terminal        (position n−2) should be avoided because, in this case, the size        of the first-generation peptide fragment is generally considered        to be too small to be sufficiently specific,    -   the selection of fragments having a mass greater than the        precursor should be given preference in order to promote        specificity. To this end, it is necessary to select a dicharged        precursor ion and select the most intense first-generation ion        fragment having a mass greater than the precursor, i.e. a        monocharged first-generation fragment ion.

The fragmentation of the selected precursor ions is performed in afragmentation cell such as the triple quadripole model [20], ion trapmodel [21], or time-of-flight (TOF) model [22], which also make itpossible to separate ions. The fragmentation or fragmentations will beconventionally performed by collision with an inert gas such as argon ornitrogen, within an electrical field, by photo-excitation orphoto-dissociation using an intense light source, collision withelectrons or radical species, by applying a potential difference, forexample in a time-of-flight tube, or by any other activation mode. Thecharacteristics of the electrical field determine the intensity andnature of the fragmentation. Thus, the electrical field applied in thepresence of an inert gas, for example in a quadripole, determines thecollision energy provided to the ions. This collision energy will beoptimised, by the person skilled in the art, to increase the sensitivityof the transition to be assayed. By way of example, it is possible tovary the collision energy between 5 and 180 e⁻V in q2 in an AB SCIEXQTRAP® 5500 mass spectrometer from the company Applied Biosystems(Foster City, United States of America). Similarly, the duration of thecollision step and the excitation energy within, for example, an iontrap will be optimised by the person skilled in the art to lead to themost sensitive assay. By way of example, it is possible to vary thisduration, called excitation time, between 0.010 and 50 ms and theexcitation energy between 0 and 1 (arbitrary unit) in Q3 in an AB SCIEXQTRAP® 5500 mass spectrometer by the company Applied Biosystems.

Finally, the detection of the selected characteristic ions takes placein the conventional manner, particularly by means of a detector and aprocessing system. The detector collects the ions and produces anelectrical signal whose intensity depends on the amount of ionscollected. The signal obtained is then amplified such that it can beprocessed by computer. A computer data processing assembly makes itpossible to transform the information received by the mass spectrumdetector.

The principle of the SRM mode, or even of the MRM mode, is tospecifically select a precursor ion, fragment it, and then specificallyselect one of its fragment ions. For such applications, triplequadripole or hybrid triple quadripole/ion trap devices are generallyused.

In the case of a triple quadripole device (Q1q2Q3) used in MS² mode,with a view to assaying or detecting a target protein, the firstquadripole (Q1) makes it possible to filter the molecular ionscorresponding to the proteotypic peptides characteristic of the proteinto be assayed and obtained during an earlier digestion step, dependingon their mass-to-charge ratio (m/z). Only the peptides having themass-to-charge ratio of the proteotypic peptide sought, which ratio iscalled (m/z)₁, are transmitted into the second quadripole (q2) and actas precursor ions for the subsequent fragmentation. The analyser q2 canfragment the peptides of mass-to-charge ratio (m/z)₁ intofirst-generation fragment ions. Fragmentation is generally obtainedthrough collision of the precursor peptides with an inert gas, such asnitrogen or argon in q2. The first-generation fragment ions aretransmitted into a third quadripole (Q3) which filters thefirst-generation fragment ions depending on a specific mass-to-chargeratio, called (m/z)₂. Only the first-generation fragment ions having themass-to-charge ratio of a fragment characteristic of the soughtproteotypic peptide (m/z)₂ are transmitted into the detector in order tobe detected, or even quantified.

This mode of operation exhibits a double selectivity, with regard to theselection of the precursor ion on the one hand, and the selection of thefirst-generation fragment ion on the other hand. Mass spectrometry inSRM or MRM mode is therefore advantageous for quantification.

When the mass spectrometry employed in the method according to inventionis tandem mass spectrometry (MS², MS³, MS⁴ or MS⁵), several massanalysers can be linked to one another. For example, a first analyserseparates the ions, a collision cell makes it possible to fragment theions, and a second analyser separates the fragment ions. Certainanalysers, such as the ion traps or the FT-ICR, constitute severalanalysers in one and make it possible to fragment the ions and analysethe fragments directly.

According to preferred embodiments of the invention, the method of theinvention comprises one or more of the following characteristics:

-   -   the mass spectrometry employed for the properties of potential        resistance to at least one antimicrobial is MS/MS spectrometry,        which has the advantage of producing a fragment which is        specific to the molecule to be detected or quantified, and thus        of providing great specificity to the assaying method;    -   the MS/MS spectrometry is MRM which has the advantage of using        an analysis cycle time in the mass spectrometer of several tens        of milliseconds, which makes it possible to detect or quantify,        with a high degree of sensitivity, a large number of different        molecules in a multiplexed manner;    -   where applicable, the determination of the type properties and        of the virulence factor is performed in the same mass        spectrometry apparatus as the determination of the markers of        resistance to at least one antimicrobial, preferably        simultaneously, which has the advantage of reducing the analysis        time and the cost of the instrument, which also facilitates the        processing and the yielding of the results.

In addition to determining the resistance to an antibiotic, it isnecessary to identify the microorganism or microorganisms present in thesample to be tested.

The methods of identifying microorganisms are widely known to the personskilled in the art, as described for example by Murray P. R. et al. inManual of Clinical Microbiology, 2007, 9^(th) edition, and especially inVol. I, Section III, chapters 15 and 16 for bacteria and yeasts, Vol.II, Section VI, chapter 82 for viruses, and Vol. II, Section X, chapter135 for protozoa. As an example of conventional identification methods,mention can be made of the determination of the biological profile, byusing the Vitek 2 (bioMérieux) identification cards, for example, oreven by using molecular biology techniques with identification criteriabased on the study of the presence of certain genes, and on the study oftheir sequence.

Identification can be performed directly from the sample in which theidentification is made, or the microorganisms contained in the samplecan be cultured using methods well known to the person skilled in theart with optimal culture media and culturing conditions tailored to thespecies of microorganisms to be sought, as described by Murray P. R. etal. in Manual of Clinical Microbiology, 2007, 9^(th) edition, Vol. I,Section III, chapter 14, and in particular in Vol. I, Section IV,chapter 21 for bacteria, and Vol. II, Section VI, chapter 81 forviruses, Vol. II, Section VIII, chapter 117 for yeasts, and Vol. II,Section X, chapter 134 for protozoa.

Thus, generally, in the case of an identification using a biochemicalmethod of a bacterium in a specimen, it is first necessary to obtain itin a pure culture, for example after seeding on agar. Molecular biology(PCR) can in certain cases be applied directly to the sample to beanalysed.

Instead of cultivating the microorganisms, they can be concentrated bycapture directly in the sample by means of active surfaces. Such amethod was described by W.-J. Chen et al. [11] who captured differentbacterial species with the aid of magnetic beads with anFe₃O₄/TiO₂-activated surface. Capture by other means is also possible,such as a capture by lectins [23], or by antibodies [24], or byVancomycin [25]. The capture makes it possible to concentrate themicroorganisms and thus to reduce or even eliminate the culture step.This results in a considerable timesaving.

The identification may also be performed by mass spectrometry, inaccordance with the techniques described previously, preferably by MS,by MS/MS, or even by MS followed by MS/MS spectrometry, whichconstitutes one embodiment of the invention. In this case too, thesample can be subjected to a culture step beforehand, such as seeding onagar.

The use of an MS identification method is advantageous in that it may becarried out in a few minutes, and in that it requires a massspectrometer with a single analyser, i.e. a less complex instrument thana tandem mass spectrometer used in MS/MS.

The use of a method of identification by MS followed by MS/MSspectrometry is also advantageous. It makes it possible to check theidentity of the ions observed by MS, which increases the specificity ofthe analysis.

The use of an MRM-type MS/MS identification method has the advantage ofbeing more sensitive and simpler than the conventional MS followed byMS/MS approaches. This method requires neither a high-performancesoftware to process the information between the acquisition of the MSspectrum and of the MS/MS spectrum, nor a change in the setting of themachine parameters for linking up MS then MS/MS spectra.

The method of identification by MS may be employed with an electrospraysource on a raw sample, as described by S. Vaidyanathan et al. [26] orby R. Everley et al. [27] after chromatographic separation. Differentm/z ranges thus make it possible to identify the microorganisms. S.Vaidyanathan et al. used a window of between 200 and 2000 Th, and R.Everley et al. used a window of between 620 and 2450 Th. The massspectra may also be deconvoluted to access the mass of the proteinsindependently of their charge state. R. Everley et al. therefore usedmasses of between about 5,000 and 50,000 Da. Alternatively, the methodof identification by MS can also be employed with the aid of aMALDI-TOF, as described by Claydon et al. [3] and T. Krishnamurthy andP. Ross [4]. The analysis combines acquisition of a mass spectrum andinterpretation of expert software. It is extremely simple and can becarried out in a few minutes. This method of identification is currentlybecoming more widespread in medical analysis laboratories [28].

The identification of bacteria by MS followed by MS/MS via theirproteins present in the sample has been applied widely by a number ofteams. By way of example, mention can be made of the recent work ofManes N. et al. [29], who studied the peptidome of Salmonella enterica,or the work of R. Nandakumar et al. [30] or of L. Hernychova et al. [31]who have studied the proteome of bacteria after digestion of theproteins with trypsin. The conventional approach consists in i)acquiring an MS spectrum, ii) successively selecting each precursor ionobserved on the MS spectrum with an intense signal, iii) successivelyfragmenting each precursor ion and acquiring its MS/MS spectrum, iv)interrogating protein databases such as SWISS-PROT or NCBI, throughsoftware such as Mascot (Matrix Science, London, United Kingdom) orSEQUEST (Thermo Scientific, Waltham, United States of America), toidentify the peptide which has a strong probability of matching theMS/MS spectrum observed. This method may lead to the identification of amicroorganism if a protein or a peptide characteristic of the species isidentified.

One of the advantages of the use of the mass spectrometry lies in thatit is particularly useful for quantifying molecules, in the present casethe markers of the mechanisms of bacterial resistance to beta-lactams.To this end, the current intensity detected is used, which isproportional to the quantity of target molecule. The current intensitythus measured may serve as a quantitative measurement making it possibleto determine the quantity of target molecule present, which ischaracterised by its expression in International System (SI) mol/m³ orkg/m³ units, or by multiples or sub-multiples of these units, or by theusual derivatives of the SI units, including multiples or sub-multiplesthereof. As a non-limiting example, the units such as ng/ml or fmol/lare units characterising a quantitative measurement.

A calibration is nevertheless necessary in order to be able to correlatethe measured area of the peak, which corresponds to the currentintensity induced by the detected ions, to the quantity of targetmolecule to be assayed. For this purpose, the calibrationsconventionally used in mass spectrometry may be employed, within theframework of the invention. MRM assays are conventionally calibratedwith the aid of external standards or, preferably, with the aid ofinternal standards such as described by T. Fortin et al. [13]. If thetarget molecule is a proteotypic peptide which permits the assaying of aprotein of interest, the correlation between the quantitativemeasurement and the quantity of target proteotypic peptide, andsubsequently of protein of interest, is obtained by calibrating themeasured signal relative to a standard signal for which the quantity tobe assayed is known. The calibration may be performed using acalibration curve, for example obtained by successive injections ofstandard proteotypic peptide at different concentrations (externalcalibration), or preferably by internal calibration using a heavypeptide as an internal standard, for example in accordance with theAQUA, QconCAT or PSAQ methods detailed below. “Heavy peptide” isunderstood to mean a peptide corresponding to the proteotypic peptide,but in which one or more atoms of carbon 12 (¹²C) is (are) replaced bycarbon 13 (¹³C), and/or one or more atoms of nitrogen 14 (¹⁴N) is (are)replaced by nitrogen 15 (¹⁵N).

The use of heavy peptides as internal standards (AQUA) was also proposedin US patent application 2004/0229283. The principle is to artificiallysynthesise proteotypic peptides with amino acids containing isotopeswhich are heavier than the usual natural isotopes. Such amino acids areobtained, for example, by replacing some of the atoms of carbon 12 (¹²C)with carbon 13 (¹³C), or by replacing some of the atoms of nitrogen 14(¹⁴N) with nitrogen 15 (¹⁵N). The artificial peptide (AQUA) thussynthesised has strictly the same physicochemical properties as thenatural peptide (with the exception of a higher mass). It is generallyadded, at a given concentration, to the sample, upstream of assaying bymass spectroscopy, for example between the treatment entailing thecleaving of the proteins in the sample of interest and the fractionationof the peptides obtained after the treatment step. Thus, the AQUApeptide is co-purified with the natural peptide to be assayed, duringfractionation of the peptides. The two peptides are therefore injectedsimultaneously into the mass spectrometer, for assaying. They thenundergo the same ionisation yield in the source. The comparison of thepeak areas of the natural and AQUA peptides, whose concentration isknown, makes it possible to calculate the concentration of the naturalpeptide and thus trace back the concentration of the protein to beassayed. A variation of the AQUA technique was proposed by J.-M. Prattet al. [32] under the name QconCat. This variant is also described inpatent application WO 2006/128492. It consists in concatenating variousAQUA peptides and producing the artificial polypeptide in the form of aheavy recombinant protein. The recombinant protein is synthesised withamino acids comprising heavy isotopes. In this way, it is possible toobtain a standard to calibrate the simultaneous assay of severalproteins at lower cost. The QconCAT standard is added from the start,upstream of the treatment entailing the cleaving of the proteins andprior to the steps of protein fractionation, denaturation, reduction andblocking of the protein thiol functions, if these are present. TheQconCAT standard therefore undergoes the same treatment cycle entailingthe cleaving of the proteins as the natural protein, which makes itpossible to take account of the yield from the treatment step whichentails the cleaving of the proteins. In fact, the treatment,particularly by digestion, of the natural protein may not be complete.In this case, the use of an AQUA standard would lead to underestimatingthe quantity of natural protein. For full assaying, it may therefore beimportant to take into account the yields from treatment which entailsthe cleaving of the proteins. However, V. Brun et al. [33] have shownthat the QconQAT standards sometimes do not exactly reproduce thetreatment yield, particularly by digestion of the natural protein,undoubtedly due to a three-dimensional conformation different from theQconCAT protein.

V. Brun et al. [33] then proposed the use of a method dubbed PSAQ, anddescribed in patent application WO 2008/145763. In this case, theinternal standard is a recombinant protein having the same sequence asthe natural protein but synthesised with heavy amino acids. Thesynthesis is performed ex-vivo with heavy amino acids. This standard hasstrictly the same physicochemical properties as the natural protein(with the exception of a higher mass). It is added from the start,before the protein fractionation step, when the latter is present. It istherefore co-purified with the native protein, during the proteinfractionation step. It exhibits the same treatment yield, particularlyby digestion, as the native protein. The heavy peptide obtained aftercleaving is also co-purified with the natural peptide, if a peptidefractionation step is performed. The two peptides are therefore injectedsimultaneously into the mass spectrometer, to be quantitatively assayed.They then undergo the same ionisation yield in the source. Comparison ofthe peak areas of the natural and the reference peptides in the PSAQmethod make it possible to calculate the concentration of the protein tobe assayed taking into account all of the steps of the assay method.

All of these techniques, namely AQUA, QconCAT or PSAQ or any othercalibration technique, used in the mass spectrometry assays and inparticular in MRM or MS assays, may be employed to carry outcalibration, within the framework of the invention.

Preferably, the mass spectrometry used in the detection method accordingto the invention is MS/MS. More preferably, the mass spectrometry isMRM.

The method of the invention makes it possible to detect resistances tocephalosporin, characterised by the detection of at least one peptide asa resistance marker. Said resistance marker peptide preferably belongsto the proteins TEM, CMY, CTX-M, SHV, FOX, ACC, ACT, CARB, DHA, MIR,MOX, PER, VEB, OXA or GES.

In particular, the detection of a mechanism of resistance tocephalosporins induced by the expression of the TEM protein ischaracterised by the detection of at least one peptide belonging to theTEM protein and its different sequence variants SEQ ID No. 1 to SEQ IDNo. 165 and SEQ ID No. 1836 to SEQ ID No. 1843.

SEQ ID No. 1: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.2: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.3: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.4: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.5: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.6: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.7: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.8: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.9: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.10: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.11: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.12: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.13: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.14: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.15: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.16: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.17: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.18: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.19: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.20: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.21: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGGSERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKH SEQ ID No.22: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.23: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.24: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.25: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.26: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.27: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.28: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWHADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.29: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.30: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.31: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.32: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.33: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.34: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.35: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.36: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDELNRQIAEIGASLIKHW SEQ ID No.37: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRREPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.38: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.39: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSTGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.40: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGVRVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.41: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.42: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.43: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW SEQ ID No.44: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.45: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.46: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.47: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGGQATMDERNRQIAEIGASLIKHW SEQ ID No.48: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.49: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.50: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.51: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.52: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSLGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.53: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAEPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.54: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.55: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLDRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.56: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVIIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.57: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.58: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDPNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.59: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.60: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.61: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.62: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLDRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.63: MSIQHFRVALIPFFAAFCIPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.64: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDELNRQIAEIGASLIKHW SEQ ID No.65: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASQQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.66: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.67: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.68: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSCGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.69: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRAIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.70: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.71: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.72: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.73: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRREPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.74: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSGGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.75: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAVTMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.76: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAVTMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.77: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW SEQ ID No.78: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRCEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW SEQ ID No.79: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.80: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.81: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.82: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLHCWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.83: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTDELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.84: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMGDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.85: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTGGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK HW SEQ ID No.86: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.87: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.88: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.89: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.90: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGAKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.91: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLGRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.92: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIVEIGASLIKHW SEQ ID No.93: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.94: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDELNRQIAEIGASLIKHW SEQ ID No.95: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIVEIGASLIKHW SEQ ID No.96: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCNAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.97: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.98: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.99: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAELSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTSELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERSRQIAEIGASLIKHW SEQ ID No.100: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.101: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.102: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGADERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.103: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLRNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.104: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.105: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.106: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.107: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.108: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.109: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.110: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.111: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.112: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKHW SEQ ID No.113: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.114: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.115: MSIQHFRVALIPFLAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSREPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.116: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERETTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.117: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDNVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.118: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGEHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.119: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.120: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKPAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.121: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.122: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAVPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.123: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.124: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.125: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.126: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGGQATMDERNRQIAEIGASLIKHW SEQ ID No.127: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGRRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.128: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPIDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.129: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIEMDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.130: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVEDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.131: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGANERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.132: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.133: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDCWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.134: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLMRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK HW SEQ ID No.135: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLPDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSHGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIK HW SEQ ID No.136: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.137: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATKLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.138: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGVRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.139: MSIQHFRVALIPFFAAFCLPVFAHPDTLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.140: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGGSLIKHW SEQ ID No.141: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.142: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.143: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.144: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNIGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.145: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQSDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.146: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERDRQIAEIGASLIKHW SEQ ID No.147: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMISTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.148: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMVSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.149: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.150: MSIQHFRVALIPFFAAFCLPVFAHPKTLVKVKDAENQLGARVGYIELDLNSGKILESFRPEKRFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQSDVVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.151: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDEQNRQIAEIGASLIKLW SEQ ID No.152: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQVGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQTAEIGASLIKHW SEQ ID No.153: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.154: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVGELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.155: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGWFIADKSGASERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.156: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.157: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRGEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.158: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEICASLIKHW SEQ ID No.159: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.160: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVIIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.161: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERKRQIAEIGASLIKHW SEQ ID No.162: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEVDKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.163: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSVLPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.164: MSIKHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVKYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDSWEPELNEAIPNDERDTTTPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGTGKRGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.165: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGSTSGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGSQELTAFLHNMGDHVTRLDRWEPELNEAIPNDEADTTMPAAMATTLRKLLTGELLTLASRQQLIDWMADKVAGPLLRSALPAGWFIADKSGARERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1836: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1837: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMLSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1838: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1839: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1840: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1841: MSIQHFRVALIPFFAAFCFPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGASKRGSRGIIAALGPDGKPSRIVVIYMTGGQATMDERNRQIAEIGASLIKHW SEQ ID No.1842: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDHWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW SEQ ID No.1843: MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSSGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 166 to SEQ ID 261 and SEQ ID No. 1923 to SEQ ID 1928 asdefined hereafter:

Peptide SEQ ID Position of the peptide in the TEM Clinical No. Aminoacid sequence protein(s) interest SEQ ID CEPELNEAIPNDER 163-176 for theprotein of SEQ No. 78 2br No. 166 SEQ ID DAEDQLGAR 33-41 for theproteins of SEQ No. 1, 4, TEM No. 167 5, 6, 9, 10, 12, 14, 16, 18, 19,23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41,43, 45, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56, 60, 64, 65, 66, 68, 69,70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 85, 86, 87, 88,89, 90, 91, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 106, 107,108, 109, 110, 112, 113, 114, 115, 116, 117, 118, 121, 122, 123, 125,126, 127, 128, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140,141, 142, 144, 145, 146, 147, 149, 151, 153, 154, 155, 156, 157, 158,159, 160, 161, 162, 163, 1837, 1838, 1840, 1841, 1842, 1843, 1844 SEQ IDDAEDQLGSTSGYIELDLNSGK 33-53 for the protein of SEQ No. 165 2be No. 168SEQ ID DAEDQVGAR 33-41 for the protein of SEQ No. 152 2be No. 169 SEQ IDDAENQLGAR 33-41 for the protein of SEQ No. 150 TEM No. 170 SEQ IDDTTMPAAMATK 177-187 for the protein of SEQ No. 137 TEM No. 171 SEQ IDDTTMPAAMATTLR 177-189 for the proteins of SEQ No. 1, TEM No. 172 2, 3,4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21, 22, 23,24, 25, 26, 27, 28, 29, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 42, 43,44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 58, 59, 61, 62, 63,64, 65, 66, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 84,85, 90, 91, 92, 93, 94, 95, 96, 99, 100, 101, 102, 103, 105, 106, 108,109, 110, 111, 112, 113, 115, 117, 118, 119, 120, 122, 123, 124, 126,127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 139, 140, 141, 142,143, 144, 146, 148, 151, 152, 154, 155, 156, 157, 158, 159, 160, 161,162, 163, 165, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ IDDTTMPVAMATTLR 177-189 for the proteins of SEQ No. TEM No. 173 107, 145,150 SEQ ID DTTTPAAMATTLR 177-189 for the proteins of SEQ No. 19, TEM No.174 30, 41, 50, 60, 67, 82, 83, 86, 87, 88, 89, 97, 98, 104, 114, 121,125, 138, 147, 149, 153, 164 SEQ ID ELTAFLHNIGDHVTR 145-159 for theprotein of SEQ No. 144 TEM No. 175 SEQ ID ELTAFLHNMGDHVTR 145-159 forthe proteins of SEQ No. 1, TEM No. 176 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49, 50, 51, 52, 53, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85,86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102,104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 119,120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133,134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 145, 146, 147, 148,149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162,163, 164, 165, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ IDELTAFLHNMGDNVTR 145-159 for the protein of SEQ No. 117 2b No. 177 SEQ IDELTAFLHNMGEHVTR 145-159 for the protein of SEQ No. 118 2b No. 178 SEQ IDELTAFLR 145-151 for the proteins of SEQ No. 20, 2be No. 179 54, 103 SEQID EPELNEAIPNDER 164-176 for the proteins of SEQ No. 1, TEM No. 180 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40,41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58,59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76,77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109,110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 123, 124,125, 126, 127, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139,140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153,154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 1837, 1838, 1839,1840, 1841, 1842, 1843, 1844 SEQ ID ETTTPAAMATTLR 177-189 for theprotein of SEQ No. 116 2be No. 181 SEQ ID FPMISTFK 64-71 for theproteins of SEQ No. 30, 2br No. 182 35, 38, 147 SEQ ID FPMLSTFK 64-71for the proteins of SEQ No. 31, TEM No. 183 33, 37, 43, 48, 72, 76, 78,100, 115, 142, 146, 157, 1838 SEQ ID FPMMSTFK 64-71 for the proteins ofSEQ No. 1, 2, TEM No. 184 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 39, 40, 41, 42,44, 45, 46, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62,63, 64, 65, 66, 67, 68, 69, 70, 71, 74, 79, 80, 81, 82, 83, 84, 85, 86,87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 101, 102, 103, 104,105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 116, 117, 118, 119,120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133,134, 135, 136, 137, 138, 139, 143, 144, 145, 149, 150, 151, 152, 153,154, 155, 156, 158, 159, 160, 161, 162, 163, 164, 165, 1837, 1839, 1840,1841, 1842, 1843, 1844 SEQ ID FPMVSTFK 64-71 for the proteins of SEQ No.32, TEM No. 185 34, 36, 73, 77, 140, 141, 148 SEQ ID GEPELNEAIPNDER163-176 for the protein of SEQ No. 157 2be No. 186 SEQ ID GIIAALGPDGKPSR242-255 for the proteins of SEQ No. 1, TEM No. 187 2, 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44,45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62,63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98,99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112,113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126,127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140,141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154,155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 1837, 1838, 1839,1840, 1841, 1842, 1843, 1844; 241-254 for the protein of sequence SEQ IDNo. 165 SEQ ID GSCGIIAALGPDGKPSR 239-255 for the proteins of SEQ No. 29,2br No. 188 61, 63, 68 SEQ ID GSGGIIAALGPDGKPSR 239-255 for the proteinof SEQ No. 74 2br No. 189 SEQ ID GSHGIIAALGPDGKPSR 239-255 for theproteins of SEQ No. 49, 2br No. 190 134, 135 SEQ ID GSLGIIAALGPDGKPSR239-255 for the protein of SEQ No. 52 2br No. 191 SEQ IDGSSGIIAALGPDGKPSR 239-255 for the proteins of SEQ No. 28, TEM No. 19242, 56, 69, 72, 111, 160, 161, 1844 SEQ ID GSTGIIAALGPDGKPSR 239-255 forthe protein of SEQ No. 39 TEM No. 193 SEQ ID HLPDGMTVR 110-118 for theprotein of SEQ No. 135 TEM No. 194 SEQ ID HLTDGMTVR 110-118 for theproteins of SEQ No. 1, TEM No. 195 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66,67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84,86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102,103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116,117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130,131, 132, 133, 134, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145,146, 147, 148, 149, 150, 151, 152, 153, 155, 156, 157, 158, 159, 160,161, 162, 163, 164, 165, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844SEQ ID HLTGGMTVR 110-118 for the protein of SEQ No. 85 2b No. 196 SEQ IDIDAGQEQLGR 82-91 for the proteins of SEQ No. 107, TEM No. 197 145, 150,159 SEQ ID IHYSQNDLVEYSPVTEK 93-109 for the proteins of SEQ No. 1, 2,TEM No. 198 5, 7, 10, 11, 12, 13, 18, 19, 23, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 42, 43, 45, 46, 47, 49, 51, 52,53, 55, 56, 57, 59, 61, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74,75, 76, 77, 78, 79, 80, 81, 85, 86, 88, 90, 91, 92, 93, 94, 95, 96, 99,101, 103, 105, 106, 107, 108, 109, 110, 112, 115, 116, 117, 118, 122,125, 126, 127, 130, 132, 133, 134, 135, 136, 137, 139, 140, 141, 142,143, 144, 146, 147, 148, 151, 152, 153, 154, 156, 157, 158, 159, 160,161, 162, 163, 165, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQID IHYSQNDLVK 93-102 for the proteins of SEQ No. 3, 4, 2be No. 199 6, 8,9, 14, 15, 16, 17, 20, 21, 22, 24, 41, 44, 48, 50, 54, 58, 60, 62, 82,83, 84, 87, 89, 97, 98, 100, 102, 104, 111, 113, 114, 119, 120, 121,123, 124, 128, 129, 131, 138, 149, 155, 164 SEQ ID IHYSQSDLVEYSPVTEK93-109 for the protein of SEQ No. 145 2be No. 200 SEQ IDIHYSQSDVVEYSPVTEK 93-109 for the protein of SEQ No. 150 TEM No. 201 SEQID ILESFRPEER 54-63 for the proteins of SEQ No. 1, 2, TEM No. 202 3, 4,5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23,24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77,78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95,96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110,111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124,125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138,139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 151, 152, 153,154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 1837, 1838,1839, 1840, 1841, 1842, 1843, 1844 SEQ ID ILESFRPEK 54-62 for theprotein of SEQ No. 150 TEM No. 203 SEQ ID IVIIYTTGSQATMDER 256-271 forthe proteins of SEQ No. 56, 2br No. 204 160 SEQ ID IVVIYMTGGQATMDER256-271 for the proteins of SEQ No. 47, 2be No. 205 1842 SEQ IDIVVIYMTGSQATMDELNR 256-273 for the protein of SEQ No. 64 2be No. 206 SEQID IVVIYMTGSQATMDER 256-271 for the proteins of SEQ No. 4, TEM No. 2079, 13, 23, 25, 40, 45, 46, 68, 69, 70, 80, 81, 89, 93, 101, 102, 109,131, 155, 156, 1840, 1841 SEQ ID IVVIYTTGGQATMDER 256-271 for theprotein of SEQ No. 126 2be No. 208 SEQ ID IVVIYTTGSQATMDELNR 256-273 forthe proteins of SEQ No. 36, 2br No. 209 94 SEQ ID IVVIYTTGSQATMDEQNR256-273 for the proteins of SEQ No. 43, 2br No. 210 77, 78, 112, 151 SEQID IVVIYTTGSQATMDER 256-271 for the proteins of SEQ No. 1, TEM No. 2112, 3, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24,26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 37, 38, 39, 41, 42, 44, 48, 49,50, 51, 52, 53, 54, 55, 57, 58, 59, 60, 61, 62, 63, 65, 66, 67, 71, 72,73, 74, 75, 76, 79, 82, 83, 84, 85, 86, 87, 88, 90, 91, 92, 95, 96, 97,98, 99, 100, 103, 104, 105, 106, 107, 108, 110, 111, 113, 114, 115, 116,117, 118, 119, 120, 121, 122, 123, 124, 125, 127, 128, 129, 130, 132,133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146,147, 148, 149, 150, 152, 153, 154, 157, 158, 159, 161, 162, 163, 164,1837, 1838, 1839, 1843, 1844 SEQ ID LDCWEPELNEAIPNDER 160-176 for theproteins of SEQ No. 86, 2be No. 212 132, 133 SEQ ID LDHWEPELNEAIPNDER160-176 for the proteins of SEQ No. 6, 2be No. 213 11, 15, 25, 26, 27,41, 59, 70, 98, 100, 106, 109, 124, 136, 140, 141, 149, 1843 SEQ IDLDHWEPELNEAVPNDER 160-176 for the protein of SEQ No. 122 2be No. 214 SEQID LDSWEPELNEAIPNDER 160-176 for the proteins of SEQ No. 5, 2be No. 2157, 8, 9, 10, 12, 22, 24, 44, 51, 58, 60, 80, 81, 93, 105, 111, 119, 120,121, 123, 126, 127, 138, 142, 143, 146, 153, 164 SEQ IDLHCWEPELNEAIPNDER 160-176 for the protein of SEQ No. 82 2be No. 216 SEQID LLTDELLTLASR 191-202 for the protein of SEQ No. 83 2be No. 217 SEQ IDLLTGELLTLASQQQLIDWMEADK 191-213 for the protein of SEQ No. 65 TEM No.218 SEQ ID LLTGELLTLASR 191-202 for the proteins of SEQ No. 1, TEM No.219 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56,57, 58, 59, 60, 61, 62, 63, 64, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75,76, 77, 78, 79, 80, 81, 82, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94,95, 96, 97, 98, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110,111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124,125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138,139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152,153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 1837,1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID LLTSELLTLASR 191-202 forthe protein of SEQ No. 99 TEM No. 220 SEQ ID MSIQHFR 1-7 for theproteins of SEQ No. 1, 2, 3, TEM No. 221 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66,67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 83, 84, 85,86, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103,104, 105, 106, 107, 108, 109, 110, 111, 112, 115, 116, 117, 118, 119,120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133,134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147,148, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162,163, 165, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID NMGDHVTR152-159 for the proteins of SEQ No. 1, 2be No. 222 2, 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44,45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62,63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98,99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112,113, 114, 115, 116, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128,129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142,143, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157,158, 159, 160, 161, 162, 163, 164, 165, 1837, 1838, 1839, 1840, 1841,1842, 1843, 1844 SEQ ID QIAEICASLIK 274-284 for the protein of SEQ No.158 TEM No. 223 SEQ ID QIAEIGASLIK 274-284 for the proteins of SEQ No.1, TEM No. 224 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35,36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53,54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89,90, 91, 93, 94, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107,108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121,122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135,136, 137, 138, 139, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150,151, 153, 154, 155, 156, 157, 159, 160, 161, 162, 163, 164, 1837, 1838,1839, 1840, 1841, 1842, 1843, 1844; 273-283 for the protein of sequenceSEQ ID No. 165 SEQ ID QIAEIGGSLIK 274-284 for the protein of SEQ No. 1402be No. 225 SEQ ID QIVEIGASLIK 274-284 for the proteins of SEQ No. 92,2be No. 226 95 SEQ ID QQLIDWMADK 203-212 for the protein of SEQ No. 1652be No. 227 SEQ ID QQLIDWMEADK 203-213 for the proteins of SEQ No. 1,TEM No. 228 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36,37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54,55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90,91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106,107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120,121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134,135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148,149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 163, 164, 1837,1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID QQLIDWMEVDK 203-213 forthe proteins of SEQ No. TEM No. 229 160, 161, 162 SEQ ID QTAEIGASLIK274-284 for the protein of SEQ No. 152 2be No. 230 SEQ ID SALPAGWFIADK221-232 for the proteins of SEQ No. 1, TEM No. 231 2, 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44,45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62,63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80,81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98,99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112,113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126,127, 128, 129, 130, 131, 132, 133, 134, 135, 137, 138, 139, 140, 141,142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 156,157, 158, 159, 160, 161, 162, 164, 1837, 1838, 1839, 1840, 1841, 1842,1843, 1844; 220-231 for the protein of sequence SEQ ID No. 165 SEQ IDSGADER 233-238 for the protein of SEQ No. 102 TEM No. 232 SEQ ID SGAGER233-238 for the proteins of SEQ No. 1, TEM No. 233 2, 6, 7, 9, 11, 12,13, 15, 16, 17, 24, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39,41, 42, 43, 49, 51, 52, 53, 54, 55, 56, 57, 58, 60, 61, 63, 65, 68, 69,70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 82, 85, 90, 91, 93, 94, 95, 96,97, 99, 100, 101, 106, 107, 108, 109, 112, 114, 115, 116, 117, 118, 119,123, 125, 130, 132, 134, 135, 136, 137, 139, 140, 142, 144, 145, 146,147, 148, 149, 150, 151, 152, 153, 154, 156, 157, 158, 159, 160, 161,162, 163, 1837, 1838, 1839, 1843, 1844 SEQ ID SGAGVR 233-238 for theprotein of SEQ No. 138 2be No. 234 SEQ ID SGANER 233-238 for the proteinof SEQ No. 131 TEM No. 235 SEQ ID SGASER 233-238 for the proteins of SEQNo. 3, 2be No. 236 4, 8, 14, 18, 19, 20, 23, 48, 50, 62, 83, 84, 87, 89,98, 103, 104, 110, 113, 124, 128, 129, 155 SEQ ID SGASK 233-237 for theproteins of SEQ No. 40, 2be No. 237 45, 46, 47, 64, 66, 67, 88, 92,1840, 1841, 1842 SEQ ID SGGSER 233-238 for the protein of SEQ No. 21 2beNo. 238 SEQ ID SGTGER 233-238 for the proteins of SEQ No. 2be No. 239120, 121 SEQ ID SVLPAGWFIADK 221-232 for the proteins of SEQ No. 2be No.240 136, 155, 163 SEQ ID VAEPLLR 214-220 for the protein of SEQ No. 532b No. 241 SEQ ID VAGPLLR 214-220 for the proteins of SEQ No. 1, TEM No.242 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54, 55, 56, 57,58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75,76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93,94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108,109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122,123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 135, 136, 137,138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151,152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 1837,1838, 1839, 1840, 1841, 1842, 1843, 1844; 213-219 for the protein ofsequence SEQ ID No. 165 SEQ ID VAGPLMR 214-220 for the protein of SEQNo. 134 2br No. 243 SEQ ID VALIPFFAAFCFPVFAHPETLVK 8-30 for the proteinsof SEQ No. 4, 9, TEM No. 244 23, 46, 47, 51, 60, 68, 69, 70, 80, 81, 89,93, 101, 106, 108, 110, 121, 123, 147, 155, 1841, 1842 SEQ IDVALIPFFAAFCIPVFAHPETLVK 8-30 for the protein of SEQ No. 63 2br No. 245SEQ ID VALIPFFAAFCLPVFAHPDTLVK 8-30 for the protein of SEQ No. 139 TEMNo. 246 SEQ ID VALIPFFAAFCLPVFAHPETLVK 8-30 for the proteins of SEQ No.1, 2, 3, TEM No. 247 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19,20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,39, 40, 41, 42, 43, 44, 45, 48, 49, 50, 52, 53, 54, 55, 56, 57, 58, 59,61, 62, 64, 65, 66, 67, 71, 72, 73, 74, 75, 76, 77, 78, 79, 82, 83, 84,85, 86, 87, 88, 90, 91, 92, 94, 95, 96, 97, 98, 99, 100, 102, 103, 104,105, 107, 109, 111, 112, 113, 114, 116, 117, 118, 119, 120, 122, 124,125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138,140, 141, 142, 143, 144, 145, 146, 148, 149, 151, 152, 153, 154, 156,157, 158, 159, 160, 161, 162, 163, 164, 165, 1837, 1838, 1839, 1840,1843, 1844 SEQ ID VALIPFFAAFCLPVFAHPK 8-26 for the protein of SEQ No.150 TEM No. 248 SEQ ID VALIPFLAAFCLPVFAHPETLVK 8-30 for the protein ofSEQ No. 115 2be No. 249 SEQ ID VDAGQEQLDR 82-91 for the proteins of SEQNo. 55, TEM No. 250 62 SEQ ID VDAGQEQLGR 82-91 for the proteins of SEQNo. 1, 2, TEM No. 251 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52,53, 54, 56, 57, 58, 59, 60, 61, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90,91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106,108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121,122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135,136, 137, 138, 139, 140, 141, 142, 143, 144, 146, 147, 148, 149, 151,152, 153, 154, 155, 156, 157, 158, 160, 161, 162, 163, 164, 165, 1837,1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID VEDAEDQLGAR 31-41 forthe protein of SEQ No. 130 2b No. 252 SEQ ID VGYIELDLNSGK 42-53 for theproteins of SEQ No. 1, 2, TEM No. 253 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49, 50, 51, 52, 53, 54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85,86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102,103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116,117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 130, 131,132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145,146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159,160, 161, 162, 163, 164, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844SEQ ID VGYIELDPNSGK 42-53 for the protein of SEQ No. 58 2be No. 254 SEQID VGYIEMDLNSGK 42-53 for the protein of SEQ No. 129 2be No. 255 SEQ IDVKPAEDK 31-37 for the protein of SEQ No. 120 2be No. 256 SEQ IDVLLCGAELSR 72-81 for the protein of SEQ No. 99 TEM No. 257 SEQ IDVLLCGAVLSR 72-81 for the proteins of SEQ No. 1, 2, TEM No. 258 3, 4, 5,6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24,25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42,43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60,61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78,79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96,97, 98, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112,113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126,127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140,141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154,155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 1837, 1838, 1839,1840, 1841, 1842, 1843, 1844 SEQ ID WEPELNEAIPIDER 163-176 for theprotein of SEQ No. 128 2be No. 259 SEQ ID WEPELNEAIPNDER 163-176 for theproteins of SEQ No. 1, TEM No. 260 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30,31, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72, 74, 75, 76, 77, 79, 80, 81, 82, 83, 84, 85, 86, 87,88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104,105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 116, 117, 118, 119,120, 121, 123, 124, 125, 126, 127, 129, 130, 131, 132, 133, 134, 135,136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149,150, 151, 152, 153, 154, 155, 156, 158, 159, 160, 161, 162, 163, 164,1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID YSPVTEK 103-109for the proteins of SEQ No. 1, 2be No. 261 2, 3, 4, 5, 6, 7, 8, 9, 10,11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28,29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46,47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64,65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100,101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114,115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128,129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142,143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156,157, 158, 159, 160, 161, 162, 163, 164, 165, 1837, 1838, 1839, 1840,1841, 1842, 1843, 1844 SEQ ID DAEDK 33-37 for the proteins of SEQ No. 2,3, TEM No. 7, 8, 11, 13, 15, 17, 20, 21, 22, 40, 42, 44, 1923 54, 57,58, 59, 61, 62, 63, 67, 84, 92, 104, 105, 111, 119, 124, 129, 143, 148,164, 1839 SEQ ID GIIAALGPDGK 242-252 for the proteins of SEQ No. 1, TEMNo. 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 1924 16, 17, 18, 19,20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55,56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73,74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91,92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107,108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121,122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135,136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149,150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163,164, 1837, 1838, 1839, 1840, 1841, 1842, 1843, 1844; 241-251 for theprotein of sequence SEQ ID No. 165 SEQ ID GSSGIIAALGPDGK 239-252 for theproteins of SEQ No. 28, TEM No. 42, 56, 69, 72, 111, 160, 161, 1844 1925SEQ ID ILESFR 54-59 for the proteins of SEQ No. 1, 2, TEM No. 3, 4, 5,6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 1926 16, 17, 18, 19, 20, 21, 22, 23,24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59,60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77,78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95,96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110,111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124,125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138,139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152,153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 1837,1838, 1839, 1840, 1841, 1842, 1843, 1844 SEQ ID SGAGK 233-237 for theproteins of SEQ No. 10, 2be No. 25, 26, 44, 59, 80, 86, 122, 133, 141,143 1927 SEQ ID SGTGK 233-237 for the proteins of SEQ No. 5, 2be No. 22,81, 105, 111, 126, 164 1928

In the clinical interest column, the entries 2b, 2br, 2be and 2bercorrespond to the functional subgroups of TEM beta-lactamases which thecorresponding peptide makes it possible to detect. Thus, the detectionof a 2be peptide indicates the presence of a beta-lactamase with anextended spectrum (ESBL) capable of hydrolysing penicillins,first-generation cephalosporins such as cephaloridine and cefalotin, andat least one antibiotic from the oxyimino-beta-lactam class such ascefotaxime, ceftazidime or monobactams such as aztreonam.

The entry TEM indicates a common peptide between at least two of thesubgroups 2b, 2br and 2be or 2ber. The corresponding peptide indicatesthe presence of a TEM beta-lactamase and the presence of a mechanism ofresistance to at least penicillins and first-generation cephalosporins.

The detection of a mechanism of resistance to ESBL (extended-spectrumbeta-lactamase) cephalosporins, induced by the TEM protein, ischaracterised by the detection of at least one resistance-marking 2bepeptide, chosen from the sequences SEQ ID No. 168, SEQ ID No. 169, SEQID No. 179, SEQ ID No. 181, SEQ ID No. 186, SEQ ID No. 199, SEQ ID No.200, SEQ ID No. 205, SEQ ID No. 206, SEQ ID No. 208, SEQ ID No. 212, SEQID No. 213, SEQ ID No. 214, SEQ ID No. 215, SEQ ID No. 216, SEQ ID No.217, SEQ ID No. 222, SEQ ID No. 225, SEQ ID No. 226, SEQ ID No. 227, SEQID No. 230, SEQ ID No. 234, SEQ ID No. 236, SEQ ID No. 237, SEQ ID No.238, SEQ ID No. 239, SEQ ID No. 240, SEQ ID No. 249, SEQ ID No. 254, SEQID No. 255, SEQ ID No. 256, SEQ ID No. 259, SEQ ID No. 261, SEQ ID No.1927, SEQ ID No. 1928.

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the CMY protein is characterised by the detection ofat least one peptide belonging to the CMY protein and to its differentsequence variants SEQ ID No. 262 to SEQ ID No. 311 and SEQ ID No. 1844to SEQ ID No. 1870.

SEQ ID No. 262: MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 263:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG SEQ ID No. 264:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG SEQ ID No. 265:MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 266:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 267:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 268:MKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 269:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGKLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 270:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ SEQ ID No. 271:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAGAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 272:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 273:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 274:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVYVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 275:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 276:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGRLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 277:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQFPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 278:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHGSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 279:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 280:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVTDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 281:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYACGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 282:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGTLAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMAHWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGYTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 283:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPEQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 284:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 285:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFAALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 286:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 287:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALHTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 288:MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAELLRFYQNWQPQWTPGAKRLYANSSIGLFGALVVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ SEQ ID No. 289:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLELDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 290:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGEAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 291:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQFDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 292:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 293:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 294:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 295:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWSELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAAIPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPIRVEAAWRILEKLQ SEQ ID No. 296:MMKKSLCCALLLTASFSTFASAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKTYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQDISLLHLATYTAGGLPLQIPDDVTDKTALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSNVTDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 297:MMKKSLCCALLLTAPLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWIKVPQSEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 298:MMKKSICCALLLTASFSTFAATKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEEKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDEVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ SEQ ID No. 299:GPGHLFAFNYGTDFMMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHASPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRIL EKLQ SEQ ID No.300: MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 301:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG SEQ ID No. 302:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 303:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 304:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ SEQ ID No. 305:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 306:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 307:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 308:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ SEQ ID No. 309:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 310:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 311:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLNAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ SEQ ID No. 1844:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG SEQ ID No. 1845:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIEARIKAAHAILAQLAG SEQ ID No. 1846:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAFAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1847:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGNGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1848:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAYWRILEKLQ SEQ ID No. 1849:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDNKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1850:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1851:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1852:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVLYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYLPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVTPGQLDAEAYGVKSNVTDMARWIQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPTVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1853:MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYEGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQSEQKNYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPARVEAAWRILEKLQ SEQ ID No. 1854:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKTDSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1855:MMKKSLCCALLLTASLSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAIAVIYQGKPYYFTWGKADITNNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGISLLHLATYTAGGLPLQIPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKAVHVSPGQLDAEAYGVKSSVIDMARWVQVNMDASRVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1856:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYCVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1857:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFIGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1858:MMNRYAAALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1859:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFSALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1860:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 1861:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFDIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVSLEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 1862:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1863:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGAGVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLRFVKANIGGVDDKALQQAISLTHQGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRNYPNEARIKAAHAILAQLAG SEQ ID No. 1864:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1865:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ SEQ ID No. 1866:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYAWGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1867:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKNYPNPVRVEAAWRILEKLQ SEQ ID No. 1868:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEINPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1869:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIIDDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ SEQ ID No. 1870:MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLKIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKDYARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTVGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 312 to SEQ ID No. 350, SEQ ID No. 734, SEQ ID No. 735 and SEQID No. 1929 to SEQ ID No. 2007, as defined hereafter:

Peptide SEQ ID No. Amino acid sequence Position of the peptide in theCMY protein SEQ ID AALLHFYQNWQPQWTPGAK 149-167 for the proteins of SEQNo. 266, 267, 269, 270, 271, No. 312 272, 273, 274, 275, 276, 277, 278,279, 280, 281, 283, 284, 285, 286, 289, 290, 291, 292, 300, 302, 303,304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850,1851, 1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869,1870; 148-166 for the protein of sequence SEQ ID No. 268; 163-181 forthe protein of sequence SEQ ID No. 299; 148-166 for the protein ofsequence SEQ ID No. 1858 SEQ ID ADIANNHPVTQQTLFELGSV 66-87 for theproteins of SEQ No. 265, 266, 267, 269, 270, 271, No. 313 SK 272, 273,274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287,288, 289, 290, 291, 292, 295, 296, 298, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853,1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;65-86 for the protein of sequence SEQ ID No. 268; 80-101 for the proteinof sequence SEQ ID No. 299; 65-86 for the protein of sequence SEQ ID No.1858 SEQ ID ADSIINGSDSK 300-310 for the proteins of SEQ No. 265, 266,269, 270, 271, No. 314 272, 273, 274, 276, 277, 278, 279, 280, 281, 282,283, 284, 285, 286, 287, 288, 290, 291, 295, 296, 297, 298, 300, 302,303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1848, 1850, 1851,1852, 1853, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868,1869, 1870; 302-312 for the protein of sequence SEQ ID No. 289; 314-324for the protein of sequence SEQ ID No. 299; 299-309 for the protein ofsequence SEQ ID No. 1858 SEQ ID ASWVHK 330-335 for the proteins of SEQNo. 265, 266, 269, 270, 271, No. 315 272, 273, 274, 275, 276, 277, 278,279, 280, 281, 282, 283, 285, 287, 288, 290, 291, 292, 295, 296, 297,298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1848,1849, 1852, 1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866,1867, 1868, 1869, 1870; 332-337 for the protein of sequence SEQ ID No.267; 329-334 for the protein of sequence SEQ ID No. 268; 328-333 for theprotein of sequence SEQ ID No. 284; 326-331 for the protein of sequenceSEQ ID No. 286; 332-337 for the protein of sequence SEQ ID No. 289;344-349 for the protein of sequence SEQ ID No. 299; 332-337 for theprotein of sequence SEQ ID No. 1847; 328-333 for the protein of sequenceSEQ ID No. 1850; 326-331 for the protein of sequence SEQ ID No. 1851;329-334 for the protein of sequence SEQ ID No. 1858 SEQ ID DYAWGYR218-224 for the proteins of SEQ No. 265, 266, 267, 269, 270, No. 316271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 282, 283, 284, 285,286, 287, 289, 290, 291, 292, 295, 296, 297, 300, 305, 307, 1846, 1847,1848, 1849, 1850, 1851, 1852, 1854, 1855, 1856, 1857, 1859, 1862, 1866;217-223 for the protein of sequence SEQ ID No. 268; 232-238 for theprotein of sequence SEQ ID No. 299; 217-223 for the protein of sequenceSEQ ID No. 1858 SEQ ID IGDMYQGLGWEMLNWPLK 282-299 for the proteins ofSEQ No. 265, 266, 267, 269, 270, No. 317 271, 272, 273, 274, 275, 276,277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 290, 291,292, 295, 296, 297, 298, 300, 302, 303, 304, 305, 306, 307, 308, 309,310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;281-298 for the protein of sequence SEQ ID No. 268; 284-301 for theprotein of sequence SEQ ID No. 289; 296-313 for the protein of sequenceSEQ ID No. 299; 281-298 for the protein of sequence SEQ ID No. 1858 SEQID LAHTWITVPQNEQK 204-217 for the proteins of SEQ No. 265, 266, 267,269, 270, No. 318 271, 272, 273, 274, 275, 276, 277, 278, 280, 281, 283,284, 285, 286, 287, 289, 290, 291, 292, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1854,1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;203-216 for the protein of sequence SEQ ID No. 268; 218-231 for theprotein of sequence SEQ ID No. 299; 203-216 for the protein of sequenceSEQ ID No. 1858 SEQ ID LLHLATYTAGGLPLQIPDDVR 126-146 for the proteins ofSEQ No. 266, 267, 269, 270, 271, No. 319 273, 274, 275, 276, 278, 279,281, 283, 284, 285, 286, 289, 290, 291, 292, 300, 302, 303, 304, 305,306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1854,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869; 140-160 forthe protein of sequence SEQ ID No. 299; 125-145 for the protein ofsequence SEQ ID No. 1858 SEQ ID LSDPVTK 105-111 for the proteins of SEQNo. 265, 266, 267, 269, 270, No. 320 271, 272, 273, 274, 275, 276, 277,278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291,292, 295, 296, 297, 298, 300, 302, 303, 304, 305, 306, 308, 309, 310,311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856,1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 104-110 forthe protein of sequence SEQ ID No. 268; 119-125 for the protein ofsequence SEQ ID No. 299; 104-110 for the protein of sequence SEQ ID No.1858 SEQ ID LYANSSIGLFGALAVK 169-184 for the proteins of SEQ No. 265,266, 267, 270, 271, No. 321 272, 273, 274, 276, 278, 279, 280, 281, 283,284, 286, 287, 289, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303,306, 307, 308, 309, 311, 1846, 1847, 1848, 1850, 1851, 1852, 1853, 1854,1855, 1856, 1857, 1862, 1864, 1867, 1868; 168-183 for the protein ofsequence SEQ ID No. 268; 183-198 for the protein of sequence SEQ ID No.299; 168-183 for the protein of sequence SEQ ID No. 1858 SEQ IDNLGIVMLANK 353-362 for the proteins of SEQ No. 265, 266, 269, 270, 271,No. 322 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285,287, 288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305,306, 307, 308, 309, 310, 311, 1846, 1848, 1849, 1852, 1853, 1854, 1855,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;355-364 for the protein of sequence SEQ ID No. 267; 352-361 for theprotein of sequence SEQ ID No. 268; 351-360 for the protein of sequenceSEQ ID No. 284; 349-358 for the protein of sequence SEQ ID No. 286;355-364 for the protein of sequence SEQ ID No. 289; 367-376 for theprotein of sequence SEQ ID No. 299; 355-364 for the protein of sequenceSEQ ID No. 1847; 351-360 for the protein of sequence SEQ ID No. 1850;349-358 for the protein of sequence SEQ ID No. 1851; 352-361 for theprotein of sequence SEQ ID No. 1858 SEQ ID QWQGIR 120-125 for theproteins of SEQ No. 266, 267, 269, 270, 271, No. 323 273, 274, 275, 276,277, 278, 279, 280, 281, 283, 284, 285, 286, 289, 290, 291, 292, 300,302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848,1849, 1850, 1851, 1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867,1868, 1869, 1870; 134-139 for the protein of sequence SEQ ID No. 299;119-124 for the protein of sequence SEQ ID No. 1858 SEQ IDSLCCALLLTASFSTFAAAK 5-23 for the proteins of SEQ No. 266, 267, 269, 270,271, 272, No. 324 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,284, 285, 286, 287, 289, 290, 291, 292, 295, 300, 302, 303, 304, 305,306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852,1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;4-22 for the protein of sequence SEQ ID No. 268; 19-37 for the proteinof sequence SEQ ID No. 299 SEQ ID SSVIDMAR 245-252 for the proteins ofSEQ No. 266, 267, 269, 270, 271, No. 325 272, 273, 274, 275, 276, 277,278, 279, 280, 281, 283, 284, 285, 286, 288, 290, 291, 292, 295, 297,298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,1848, 1849, 1850, 1851, 1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864,1865, 1866, 1867, 1868, 1869, 1870; 244-251 for the protein of sequenceSEQ ID No. 268; 247-254 for the protein of sequence SEQ ID No. 289;259-266 for the protein of sequence SEQ ID No. 299; 244-251 for theprotein of sequence SEQ ID No. 1858 SEQ ID SYPNPVR 363-369 for theproteins of SEQ No. 265, 266, 269, 270, 271, No. 326 272, 273, 274, 275,276, 277, 278, 279, 280, 281, 282, 283, 285, 287, 290, 291, 292, 296,297, 300, 302, 303, 305, 306, 307, 309, 310, 1846, 1848, 1849, 1852,1854, 1855, 1856, 1857, 1859, 1862, 1864, 1866, 1868, 1869, 1870;365-371 for the protein of sequence SEQ ID No. 267; 362-368 for theprotein of sequence SEQ ID No. 268; 361-367 for the protein of sequenceSEQ ID No. 284; 359-365 for the protein of sequence SEQ ID No. 286;365-371 for the protein of sequence SEQ ID No. 289; 377-383 for theprotein of sequence SEQ ID No. 299; 365-371 for the protein of sequenceSEQ ID No. 1847; 361-367 for the protein of sequence SEQ ID No. 1850;359-365 for the protein of sequence SEQ ID No. 1851; 362-368 for theprotein of sequence SEQ ID No. 1858 SEQ ID TEQQIADIVNR 24-34 for theproteins of SEQ No. 265, 266, 267, 269, 270, 271, No. 327 272, 273, 274,275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288,289, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853,1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869,1870; 23-33 for the protein of sequence SEQ ID No. 268; 38-48 for theprotein of sequence SEQ ID No. 299; 23-33 for the protein of sequenceSEQ ID No. 1858 SEQ ID TFNGVLGGDAIAR 88-100 for the proteins of SEQ No.265, 266, 267, 269, 270, No. 328 271, 272, 273, 274, 275, 276, 277, 278,280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 291, 292, 295, 296,297, 298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846,1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1859, 1862,1864, 1865, 1866, 1867, 1868, 1869, 1870; 87-99 for the protein ofsequence SEQ ID No. 268; 102-114 for the protein of sequence SEQ ID No.299; 87-99 for the protein of sequence SEQ ID No. 1858 SEQ IDTGSTGGFGSYVAFVPEK 336-352 for the proteins of SEQ No. 265, 266, 269,270, 271, No. 329 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 283,285, 288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305,306, 307, 308, 309, 310, 311, 1846, 1848, 1849, 1852, 1853, 1854, 1855,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869; 338-354 forthe protein of sequence SEQ ID No. 267; 335-351 for the protein ofsequence SEQ ID No. 268; 334-350 for the protein of sequence SEQ ID No.284; 332-348 for the protein of sequence SEQ ID No. 286; 338-354 for theprotein of sequence SEQ ID No. 289; 350-366 for the protein of sequenceSEQ ID No. 299; 338-354 for the protein of sequence SEQ ID No. 1847;334-350 for the protein of sequence SEQ ID No. 1850; 332-348 for theprotein of sequence SEQ ID No. 1851; 335-351 for the protein of sequenceSEQ ID No. 1858 SEQ ID TITPLMQEQAIPGMAVAVIYQ 35-57 for the proteins ofSEQ No. 266, 267, 269, 270, 271, 272, No. 330 GK 273, 274, 275, 276,277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 289, 290, 291, 292,295, 296, 297, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311,1846, 1847, 1848, 1849, 1850, 1851, 1854, 1856, 1857, 1859, 1862, 1864,1865, 1866, 1867, 1868, 1869, 1870; 34-56 for the protein of sequenceSEQ ID No. 268; 49-71 for the protein of sequence SEQ ID No. 299; 34-56for the protein of sequence SEQ ID No. 1858 SEQ ID TLQQGIALAQSR 267-278for the proteins of SEQ No. 265, 266, 267, 269, 270, No. 331 271, 272,273, 274, 275, 276, 277, 278, 279, 280, 281, 283, 284, 285, 286, 287,290, 291, 292, 295, 296, 297, 300, 302, 303, 304, 305, 306, 307, 308,309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1854, 1855,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;266-277 for the protein of sequence SEQ ID No. 268; 269-280 for theprotein of sequence SEQ ID No. 289; 281-292 for the protein of sequenceSEQ ID No. 299; 266-277 for the protein of sequence SEQ ID No. 1858 SEQID VALAALPAVEVNPPAPAVK 311-329 for the proteins of SEQ No. 265, 269,270, 271, 272, No. 332 273, 274, 275, 276, 277, 278, 279, 280, 281, 282,283, 285, 288, 290, 291, 292, 296, 297, 298, 300, 302, 303, 304, 305,306, 307, 308, 310, 311, 1848, 1849, 1853, 1854, 1855, 1856, 1857, 1859,1862, 1864, 1865, 1866, 1867, 1869, 1870; 313-331 for the protein ofsequence SEQ ID No. 267; 310-328 for the protein of sequence SEQ ID No.268; 313-331 for the protein of sequence SEQ ID No. 289; 325-343 for theprotein of sequence SEQ ID No. 299; 313-331 for the protein of sequenceSEQ ID No. 1847; 310-328 for the protein of sequence SEQ ID No. 1858 SEQID VEAAWR 370-375 for the proteins of SEQ No. 265, 266, 269, 271, 272,No. 333 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285, 287,288, 290, 291, 292, 295, 296, 297, 298, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 311, 1846, 1849, 1852, 1853, 1854, 1855, 1856, 1857,1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 372-377 for theprotein of sequence SEQ ID No. 267; 369-374 for the protein of sequenceSEQ ID No. 268; 368-373 for the protein of sequence SEQ ID No. 284;366-371 for the protein of sequence SEQ ID No. 286; 372-377 for theprotein of sequence SEQ ID No. 289; 384-389 for the protein of sequenceSEQ ID No. 299; 372-377 for the protein of sequence SEQ ID No. 1847;368-373 for the protein of sequence SEQ ID No. 1850; 366-371 for theprotein of sequence SEQ ID No. 1851; 369-374 for the protein of sequenceSEQ ID No. 1858 SEQ ID VLQPLK 198-203 for the proteins of SEQ No. 265,266, 267, 269, 270, No. 334 271, 272, 273, 274, 275, 276, 277, 278, 279,280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 295,296, 297, 298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311,1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857,1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 197-202 for theprotein of sequence SEQ ID No. 268; 212-217 for the protein of sequenceSEQ ID No. 299; 197-202 for the protein of sequence SEQ ID No. 1858 SEQID WVQANMDASHVQEK 253-266 for the proteins of SEQ No. 266, 267, 269,270, 271, No. 335 272, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,284, 285, 286, 288, 290, 291, 292, 298, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1853, 1854,1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870;252-265 for the protein of sequence SEQ ID No. 268; 255-268 for theprotein of sequence SEQ ID No. 289; 267-280 for the protein of sequenceSEQ ID No. 299; 252-265 for the protein of sequence SEQ ID No. 1858 SEQID YWPELTGK 112-119 for the proteins of SEQ No. 265, 266, 267, 269, 270,No. 336 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283,284, 285, 286, 287, 288, 289, 290, 291, 292, 296, 297, 298, 300, 302,303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849,1850, 1851, 1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866,1867, 1868, 1869, 1870; 111-118 for the protein of sequence SEQ ID No.268; 126-133 for the protein of sequence SEQ ID No. 299; 111-118 for theprotein of sequence SEQ ID No. 1858 SEQ ID AHYFNYGVANR 62-72 for theproteins of SEQ No. 262, 263, 264, 293, 294, 301, No. 337 1844, 1845,1860, 1861, 1863 SEQ ID ANIGGVDDK 261-269 for the proteins of SEQ No.262, 263, 264, 293, 294, No. 338 301, 1844, 1845, 1860, 1861, 1863 SEQID ESGSQVLFNK 326-335 for the proteins of SEQ No. 262, 263, 264, 293,294, No. 339 301, 1844, 1845, 1860, 1861, 1863 SEQ ID GAMQLDDK 105-112for the proteins of SEQ No. 262, 263, 264, 293, 294, No. 340 301, 1844,1845, 1860, 1861, 1863 SEQ ID GIGIVMLANR 353-362 for the proteins of SEQNo. 262, 263, 264, 293, 294, No. 341 301, 1844, 1845, 1860, 1861, 1863SEQ ID HAPWLK 116-121 for the proteins of SEQ No. 262, 263, 264, 293,294, No. 342 301, 1844, 1845, 1860, 1861, 1863 SEQ ID IPGMAVAVLK 49-58for the proteins of SEQ No. 262, 263, 264, 293, 294, 301, No. 343 1844,1845, 1860, 1861, 1863 SEQ ID PVVDASIQPLLK 34-45 for the proteins of SEQNo. 262, 263, 264, 293, 294, 301, No. 344 1844, 1845, 1860, 1861, 1863SEQ ID QAMASYAYGYSK 218-229 for the proteins of SEQ No. 262, 263, 264,293, 294, No. 345 301, 1844, 1845, 1860, 1861, 1863 SEQ ID QWAPVYSPGSHR161-172 for the proteins of SEQ No. 262, 263, 264, 293, 294, No. 346301, 1844, 1845, 1860, 1861, 1863 SEQ ID QYSNPSIGLFGHLAASSLK 173-191 forthe proteins of SEQ No. 262, 263, 264, 293, 294, No. 347 301, 1844,1845, 1860, 1861, 1863 SEQ ID TGSTNGFGAYVAFVPAR 336-352 for the proteinsof SEQ No. 262, 263, 264, 293, 294, No. 348 301, 1844, 1845, 1860, 1861,1863 SEQ ID TLTATLGAYAVVK 92-104 for the proteins of SEQ No. 262, 263,264, 293, 294, No. 349 301, 1844, 1845, 1860, 1861, 1863 SEQ IDVNPGMLADEAYGIK 236-249 for the proteins of SEQ No. 262, 263, 264, 293,294, No. 350 301, 1844, 1845, 1860, 1861, 1863 SEQ ID PSGMSYEEAMTR185-196 for the proteins of SEQ No. 265, 266, 267, 269, 270, No. 734271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284,285, 286, 287, 288, 289, 290, 291, 292, 295, 296, 297, 298, 300, 302,303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847, 1848, 1849,1850, 1851, 1852, 1853, 1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865,1866, 1867, 1868, 1869, 1870; 184-195 for the protein of sequence SEQ IDNo. 268; 199-210 for the protein of sequence SEQ ID No. 299; 184-195 forthe protein of sequence SEQ ID No. 1858 SEQ ID PYYFTWGK 58-65 for theproteins of SEQ No. 265, 266, 267, 269, 270, 271, No. 735 272, 273, 274,275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288,289, 290, 291, 292, 295, 297, 298, 300, 302, 303, 304, 305, 306, 307,308, 309, 310, 311, 1846, 1847, 1848, 1849, 1850, 1851, 1852, 1853,1854, 1855, 1856, 1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869,1870; 57-64 for the protein of sequence SEQ ID No. 268; 72-79 for theprotein of sequence SEQ ID No. 299; 57-64 for the protein of sequenceSEQ ID No. 1858 SEQ ID AALLR 149-153 for the proteins of SEQ No. 265,282, 287, 297, 298, No. 1852, 1853, 1855 1929 SEQ ID ADSIINGNGSDSK300-312 for the proteins of SEQ No. 267, 1847 No. 1930 SEQ IDADSIINGSDNK 300-310 for the proteins of SEQ No. 275, 1849; 299-309 forthe No. protein of sequence SEQ ID No. 268 1931 SEQ ID AELLR 149-153 forthe protein of SEQ No. 288 No. 1932 SEQ ID ALQQAISLTHK 270-280 for theproteins of SEQ No. 262, 293, 294, 1860, 1861 No. 1933 SEQ IDAVHVSPGQLDAEAYGVK 228-244 for the proteins of SEQ No. 273, 297, 1855 No.1934 SEQ ID DYACGYR 218-224 for the protein of SEQ No. 281 No. 1935 SEQID DYALGYR 218-224 for the protein of SEQ No. 306 No. 1936 SEQ ID EDKPIR230-235 for the proteins of SEQ No. 262, 263, 264, 293, 294, No. 301,1844, 1845, 1860, 1861, 1863 1937 SEQ ID EGKPVHASPGQLDAEAYGVK 239-258for the protein of SEQ No. 299 No. 1938 SEQ ID EGKPVHGSPGQLDAEAYGVK225-244 for the protein of SEQ No. 278 No. 1939 SEQ IDEGKPVHVSPEQLDAEAYGVK 225-244 for the protein of SEQ No. 283 No. 1940 SEQID EGKPVHVSPGK 225-235 for the protein of SEQ No. 269 No. 1941 SEQ IDEGKPVHVSPGQFDAEAYGVK 225-244 for the protein of SEQ No. 291 No. 1942 SEQID EGKPVHVSPGQLDAEAYCVK 225-244 for the proteins of SEQ No. 1856 No.1943 SEQ ID EGKPVHVSPGQLDAEAYGVK 225-244 for the proteins of SEQ No.265, 266, 267, 270, 272, No. 275, 277, 279, 280, 281, 282, 284, 285,286, 288, 290, 292, 295, 1944 296, 298, 300, 302, 303, 304, 305, 306,307, 308, 309, 310, 1846, 1847, 1848, 1849, 1850, 1851, 1853, 1854,1857, 1859, 1862, 1864, 1865, 1866, 1867, 1868, 1869, 1870; 224-243 forthe protein of sequence SEQ ID No. 268; 224-243 for the protein ofsequence SEQ ID No. 1858 SEQ ID EGKPVHVSPGQLDAGAYGVK 225-244 for theprotein of SEQ No. 271 No. 1945 SEQ ID EGKPVHVSPGQLNAEAYGVK 225-244 forthe protein of SEQ No. 311 No. 1946 SEQ ID EGKPVHVSPGR 225-235 for theprotein of SEQ No. 276 No. 1947 SEQ ID EGKPVHVTPGQLDAEAYGVK 225-244 forthe proteins of SEQ No. 287, 1852 No. 1948 SEQ ID EGKPVYVSPGQLDAEAYGVK225-244 for the protein of SEQ No. 274 No. 1949 SEQ IDESGAGVSEQTLFEIGSVSK 73-91 for the proteins of SEQ No. 263, 264, 301,1844, 1845, No. 1863 1950 SEQ ID ESGASVSEQTLFDIGSVSK 73-91 for theproteins of SEQ No. 293, 294, 1860, 1861 No. 1951 SEQ IDESGASVSEQTLFEIGSVSK 73-91 for the protein of SEQ No. 262 No. 1952 SEQ IDFSDPVTK 105-111 for the protein of SEQ No. 307 No. 1953 SEQ IDFYQNWQPQWAPGAK 154-167 for the proteins of SEQ No. 265, 295, 296, 297,1855 No. 1954 SEQ ID FYQNWQPQWTPGAK 154-167 for the proteins of SEQ No.266, 267, 269, 270, 271, No. 272, 273, 274, 275, 276, 277, 278, 279,280, 281, 282, 283, 284, 1955 285, 286, 287, 288, 289, 290, 291, 292,298, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,1848, 1849, 1850, 1851, 1852, 1853, 1854, 1856, 1857, 1859, 1862, 1864,1865, 1866, 1867, 1868, 1869, 1870; 153-166 for the protein of sequenceSEQ ID No. 268; 168-181 for the protein of sequence SEQ ID No. 299;153-166 for the protein of sequence SEQ ID No. 1858 SEQ ID IPDDVR141-146 for the proteins of SEQ No. 266, 267, 269, 270, 271, No. 273,274, 275, 276, 278, 279, 281, 283, 284, 285, 286, 289, 290, 1956 291,292, 300, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 1846, 1847,1848, 1849, 1850, 1851, 1854, 1856, 1857, 1859, 1862, 1864, 1865, 1866,1867, 1868, 1869, 1870; 155-160 for the protein of sequence SEQ ID No.299; 140-145 for the protein of sequence SEQ ID No. 1858 SEQ ID LAHTWIK204-210 for the protein of SEQ No. 297 No. 1957 SEQ ID LAHTWITVPENEQK204-217 for the protein of SEQ No. 279 No. 1958 SEQ ID LAHTWITVPQSEQK204-217 for the proteins of SEQ No. 282, 288, 295, 296, 298, No. 18531959 SEQ ID LDAEAYGVK 236-244 for the proteins of SEQ No. 265, 266, 267,269, 270, No. 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282,283, 284, 1960 285, 286, 287, 288, 290, 292, 295, 296, 297, 298, 300,302, 303, 304, 305, 306, 307, 308, 309, 310, 1846, 1847, 1848, 1849,1850, 1851, 1852, 1853, 1854, 1855, 1857, 1859, 1862, 1864, 1865, 1866,1867, 1868, 1869, 1870; 235-243 for the protein of sequence SEQ ID No.268; 238-246 for the protein of sequence SEQ ID No. 289; 250-258 for theprotein of sequence SEQ ID No. 299; 235-243 for the protein of sequenceSEQ ID No. 1858 SEQ ID LLHLATYTAGGLPLK 126-140 for the proteins of SEQNo. 1870 No. 1961 SEQ ID LLHLATYTAGGLPLQFPDDVR 126-146 for the proteinof SEQ No. 277 No. 1962 SEQ ID LYANSSIGLFAALAVK 169-184 for the proteinof SEQ No. 285 No. 1963 SEQ ID LYANSSIGLFGALVVK 169-184 for the proteinof SEQ No. 288 No. 1964 SEQ ID LYANSSIGLFGELAVK 169-184 for the proteinsof SEQ No. 269, 275, 277, 305, 1849, No. 1866 1965 SEQ IDLYANSSIGLFGTLAVK 169-184 for the protein of SEQ No. 282 No. 1966 SEQ IDLYANSSIGLFSALAVK 169-184 for the proteins of SEQ No. 1859 No. 1967 SEQID LYSNSSIGLFGALAVK 169-184 for the proteins of SEQ No. 304, 310, 1865,1869, No. 1870 1968 SEQ ID NYAWGYR 218-224 for the proteins of SEQ No.288, 298, 1853 No. 1969 SEQ ID NYPIPAR 363-369 for the proteins of SEQNo. 262, 293, 294, 1860, 1861 No. 1970 SEQ ID NYPNEAR 363-369 for theproteins of SEQ No. 301, 1863 No. 1971 SEQ ID NYPNPVR 363-369 for theproteins of SEQ No. 304, 308, 311, 1865, 1867 No. 1972 SEQ IDSICCALLLTASFSTFAAAK 5-23 for the proteins of SEQ No. 288, 1853 No. 1973SEQ ID SICCALLLTASFSTFAATK 5-23 for the protein of SEQ No. 298 No. 1974SEQ ID SLCCALLLTAPLSTFAAAK 5-23 for the protein of SEQ No. 297 No. 1975SEQ ID SLCCALLLTASFSTFASAK 5-23 for the proteins of SEQ No. 265, 296 No.1976 SEQ ID SLCCALLLTASLSTFAAAK 5-23 for the proteins of SEQ No. 1855No. 1977 SEQ ID SNVTDMAR 245-252 for the proteins of SEQ No. 265, 287,296, 1852 No. 1978 SEQ ID SYPNPIR 363-369 for the protein of SEQ No. 295No. 1979 SEQ ID TALLHFYQNWQPQWAPGAK 149-167 for the proteins of SEQ No.295, 296 No. 1980 SEQ ID TDSIINGSDSK 300-310 for the proteins of SEQ No.292, 1854 No. 1981 SEQ ID TFIGVLGGDAIAR 88-100 for the proteins of SEQNo. 1857 No. 1982 SEQ ID TFNGVLGGDCIAR 88-100 for the protein of SEQ No.279 No. 1983 SEQ ID TFNGVLGGEAIAR 88-100 for the protein of SEQ No. 290No. 1984 SEQ ID TGSTVGFGSYVAFVPEK 336-352 for the proteins of SEQ No.1870 No. 1985 SEQ ID TGYTGGFGSYVAFVPEK 336-352 for the protein of SEQNo. 282 No. 1986 SEQ ID TLQQGIELAQSR 267-278 for the proteins of SEQ No.282, 288, 298, 1853 No. 1987 SEQ ID TSSADLLAFVK 250-260 for the proteinsof SEQ No. 262, 293, 294, 1860, 1861 No. 1988 SEQ ID TSSADLLR 250-257for the proteins of SEQ No. 263, 264, 301, 1844, 1845, No. 1863 1989 SEQID TYYFTWGK 58-65 for the protein of SEQ No. 296 No. 1990 SEQ IDVAALPAVEVNPPAPAVK 311-327 for the proteins of SEQ No. 284, 1850 No. 1991SEQ ID VAFAALPAVEVNPPAPAVK 311-329 for the proteins of SEQ No. 266, 1846No. 1992 SEQ ID VALAAIPAVEVNPPAPAVK 311-329 for the protein of SEQ No.295 No. 1993 SEQ ID VALAALHTVEVNPPAPAVK 311-329 for the protein of SEQNo. 287 No. 1994 SEQ ID VALAALPAVEINPPAPAVK 311-329 for the proteins ofSEQ No. 309, 1868 No. 1995 SEQ ID VALAALPTVEVNPPAPAVK 311-329 for theproteins of SEQ No. 1852 No. 1996 SEQ ID VAPAVEVNPPAPAVK 311-325 for theproteins of SEQ No. 286, 1851 No. 1997 SEQ ID VEAYWR 370-375 for theproteins of SEQ No. 270, 1848 No. 1998 SEQ ID VILEANPTAAPR 314-325 forthe proteins of SEQ No. 262, 263, 293, 301, 1844, No. 1860, 1863 1999SEQ ID VPQSEQK 211-217 for the proteins of SEQ No. 282, 288, 295, 296,297, No. 298, 1853 2000 SEQ ID VSLEANPTAAPR 314-325 for the proteins ofSEQ No. 264, 294, 1845, 1861 No. 2001 SEQ ID WIQVNMDASR 253-262 for theproteins of SEQ No. 287, 1852 No. 2002 SEQ ID WVQANMDASR 253-262 for theprotein of SEQ No. 295 No. 2003 SEQ ID WVQVNMDASR 253-262 for theproteins of SEQ No. 265, 273, 296, 297, 1855 No. 2004 SEQ IDYAAALLLTASFSTFAAAK 5-22 for the proteins of SEQ No. 1858 No. 2005 SEQ IDYLPELTGK 112-119 for the proteins of SEQ No. 1852 No. 2006 SEQ IDYWSELTGK 112-119 for the protein of SEQ No. 295 No. 2007

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the CTX-M protein is characterised by the detection ofat least one peptide belonging to the CTX-M protein and to its differentsequence variants SEQ ID No. 351 to SEQ ID No. 445 and SEQ ID No. 1871to SEQ ID No. 1908.

SEQ ID No. 351: MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIAVIWPANHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF SEQ ID No. 352:MMRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKKVLSQKVEIKSSDLINYNPITEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDNTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY SEQ ID No. 353:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 354:MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 355:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 356:MVTKRMQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTKDNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFAREIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 357:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAGLERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSPAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTVVMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRHVLAS SEQ ID No. 358:MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPSLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL SEQ ID No. 359:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 360:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 361:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 362:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAKGL SEQ ID No. 363:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 364:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 365:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 366:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 367:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 368:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIRAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 369:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 370:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYSPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 371:MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 372:MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 373:MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSCDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 374:MVKKSLRQFTLMATATVTLLLGSVPLHAQTADVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 375:MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIKSSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY SEQ ID No. 376:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAARIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 377:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGRRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 378:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTNAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 379:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGRRLGVPLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 380:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVPLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 381:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTNAVQQKLAALEKSSGGRLGVPLIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 382:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDGTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 383:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 384:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEIKPSDLVNYNPIAEKHVNGTMTFGELIAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 385:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 386:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGGYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF SEQ ID No. 387:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 388:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 389:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFPMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 390:MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELEQQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVIYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 391:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEQTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 392:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKLLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 393:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 394:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 395:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTETTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 396:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 397:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAENRRDILAAAAKIVTHGF SEQ ID No. 398:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 399:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 400:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTESTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 401:MVKKSLRQFTLMATATVTLLLGNVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 402:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYSPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 403:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLEQSETQKQLLNQPVEIQPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDHTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 404:MVKKSLRQFTLMATATVTLLLGSVPLHAQTVDVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDDTFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 405:MVKKSLRQFTLMATATVTLLLGSVPLYAQTVDVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 406:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPNAESRRDVLASAAKIVTNGL SEQ ID No. 407:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTELTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 408:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTHVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 409:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVAWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 410:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTPAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 411:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPFAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 412:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRHDVLASAAKIVTDGL SEQ ID No. 413:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 414:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 415:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTETTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 416:MMTQSIRRSMLTVMATLSLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 417:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSCGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 418:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAVAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTFGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQSLRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 419:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRTQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 420:MMRKSVRRAMLMTTACVSLLLASVPLCAQANDVQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKGLLSQRVEIKPSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARTIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQALRNLTLGNALGDTQRAQLVMWLKGNTTGAASIQAGLPTSWVVGDKTGSGGYGTTNDIAVIWPEGRAPLVLVTYFTQSEPKAESRRDVLAAAARIVTDGY SEQ ID No. 421:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 422:MMTQSIGRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 423:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 424:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF SEQ ID No. 425:MVTKRVQRMMSAAAACIPLLLGSPTLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTARAGADVASLRWVMRWAKPSGAVGDVAQRQYDRAAGIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 426:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 427:MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIKSSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAENRRDVLAAAAKIVTDGY SEQ ID No. 428:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 429:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYLADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKCWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF SEQ ID No. 430:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIRASDLVNYNPIAEKHVNGTMTLAQLGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF SEQ ID No. 431:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 432:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 433:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 434:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVAQINTADNSQILYVADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIRASDLVNYNPIAEKHVNGTMTLAELGAGALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNSAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGMPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 435:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDFLAAAAKIVTHGF SEQ ID No. 436:MVTKRVQRMMFAGGAGIPLLLGSAPFYAQTSAGQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 437:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 438:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 439:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDESFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 440:MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPSLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL SEQ ID No. 441:MVKKSLRQFTLMATAAVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPSLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDILASAAKIVTDGL SEQ ID No. 442:MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLKALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIQAGLPKSWVVGDKTGSGDYGTTNDIAIIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTRGF SEQ ID No. 443:MMRKSVRRAILMTTACVSLLLASVPLYAQANDIQQKLAALEKSSGGRLGVALINTADNTQTLYRADERFAMCSTSKVMAAAAVLKQSETQKDLLSQRVEIKSSDLINYNPIAEKHVNGTMTLGELSAAALQYSDNTAMNKLIAHLGGPGKVTAFARVIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRNLTLGNALGDTQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLVLVTYFTQPEPKAESRRDVLAAAARIVTDGY SEQ ID No. 444:MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWGVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF SEQ ID No. 445:MMTQSIRRSMLTVMATLPLLFSSATLHAQTNSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAALLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIQAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDVLAAAAKIVTHGF SEQ ID No. 1871:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1872:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1873:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAKGL SEQ ID No. 1874:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1875:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 1876:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 1877:MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIKSSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAESRRDVLAAAAKIVTDGY SEQ ID No. 1878:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1879:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1880:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAENRRDILAAAAKIVTHGF SEQ ID No. 1881:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 1882:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 1883:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPNAESRRDVLASAAKIVTNGL SEQ ID No. 1884:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRHDVLASAAKIVTDGL SEQ ID No. 1885:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1886:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKAMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1887:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTESTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLASAARIIAEGL SEQ ID No. 1888:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTQNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1889:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELIAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1890:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQREQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1891:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAVAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQREQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1892:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAENRRDVLASAARIIAEGL SEQ ID No. 1893:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDRTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRHDVLASAARIIAEG SEQ ID No. 1894:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 1895:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEEHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGNL SEQ ID No. 1896:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGQGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1897:VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDRTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT SEQ ID No. 1898:VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRAEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVT SEQ ID No. 1899:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1900:MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKRSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL SEQ ID No. 1901:VKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSRILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTK SEQ ID No. 1902:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF SEQ ID No. 1903:MRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQKNVLSQKVEIKSSDLINYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDDTFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLRHLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPEQKAENRRDVLAAAAKIVTDGY SEQ ID No. 1904:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL SEQ ID No. 1905:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF SEQ ID No. 1906:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTDGL SEQ ID No. 1907:MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDFLAAAAKIVTHGF SEQ ID No. 1908:MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVNGTMSLAELSAAALQYSDNVAMNKLIAHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGGYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 446 to SEQ ID 495 and SEQ ID No. 2008 to SEQ ID No. 2092 asdefined hereafter:

Peptide SEQ ID Clinical No. Amino acid sequence Position of the peptidein the CTX-M protein interest SEQ ID AGLPK 226-230 for the proteins ofSEQ No. 351, 386, 392, 397, 2be No. 446 415, 416, 419, 422, 424, 429,430, 432, 435, 439, 442, 444, 445, 1881, 1903, 1906, 1908 SEQ IDAGLPTSWTVGDK 226-237 for the proteins of SEQ No. 355, 356, 360, 361, 2beNo. 447 362, 367, 369, 376, 377, 378, 379, 380, 381, 398, 402, 403, 407,408, 409, 410, 411, 413, 421, 423, 436, 1872, 1873, 1874, 1877, 1882,1886, 1888, 1889, 1891, 1892, 1893, 1896, 1897, 1900, 1901; 224-235 forthe protein of sequence SEQ ID No. 425 SEQ ID AIGDETFR 157-164 for theproteins of SEQ No. 353, 355, 359, 360, 2be No. 448 361, 362, 367, 369,376, 377, 378, 379, 380, 381, 387, 398, 402, 403, 407, 408, 409, 410,411, 413, 421, 423, 425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886,1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ IDALAETQR 201-207 for the proteins of SEQ No. 351, 386, 392, 397, 2be No.449 415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439, 442, 444,445, 1881, 1903, 1906, 1908 SEQ ID ALGDSQR 201-207 for the proteins ofSEQ No. 354, 357, 358, 363, 2be No. 450 364, 365, 370, 371, 372, 373,374, 382, 385, 388, 389, 390, 391, 393, 394, 395, 396, 399, 400, 401,404, 405, 406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875, 1876,1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909;200-206 for the protein of sequence SEQ ID No. 1898; 200-206 for theprotein of sequence SEQ ID No. 1899; 200-206 for the protein of sequenceSEQ ID No. 1902 SEQ ID AMAQTLR 188-194 for the proteins of SEQ No. 352,353, 354, 355, 2be No. 451 356, 357, 358, 359, 360, 361, 362, 363, 364,365, 367, 369, 370, 371, 372, 373, 374, 376, 377, 378, 379, 380, 381,382, 385, 387, 388, 389, 390, 391, 393, 394, 395, 396, 398, 399, 400,401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 417,421, 423, 426, 428, 431, 433, 436, 437, 438, 440, 441, 443, 1872, 1873,1874, 1875, 1876, 1877, 1879, 1880, 1882, 1883, 1884, 1885, 1886, 1887,1888, 1889, 1890, 1891, 1892, 1893, 1894, 1895, 1896, 1897, 1900, 1901,1905, 1907, 1909; 187-193 for the protein of sequence SEQ ID No. 375;187-193 for the protein of sequence SEQ ID No. 427; 187-193 for theprotein of sequence SEQ ID No. 1878; 187-193 for the protein of sequenceSEQ ID No. 1898; 187-193 for the protein of sequence SEQ ID No. 1899;187-193 for the protein of sequence SEQ ID No. 1902; 187-193 for theprotein of sequence SEQ ID No. 1904 SEQ ID APLILVTYFTQPQPK 258-272 forthe proteins of SEQ No. 354, 357, 358, 363, 2be No. 452 364, 365, 370,371, 372, 373, 374, 382, 385, 388, 389, 391, 393, 394, 395, 396, 399,400, 401, 404, 405, 412, 417, 426, 428, 431, 433, 437, 438, 440, 441,1875, 1876, 1879, 1880, 1883, 1885, 1887, 1890, 1895, 1905, 1907, 1909;257-271 for the protein of sequence SEQ ID No. 1898; 257-271 for theprotein of sequence SEQ ID No. 1899; 257-271 for the protein of sequenceSEQ ID No. 1902 SEQ ID APLVLVTYFTQPQQNAE 258-276 for the proteins of SEQNo. 353, 355, 356, 359, 2be No. 453 SR 360, 361, 362, 369, 376, 377,378, 379, 380, 381, 387, 402, 403, 407, 408, 409, 410, 411, 413, 423,436, 1872, 1873, 1874, 1886, 1889, 1891, 1892, 1894, 1896, 1897, 1900,1901; 256-274 for the protein of sequence SEQ ID No. 425 SEQ ID AQLVTWLK208-215 for the proteins of SEQ No. 351, 352, 353, 355, 2be No. 454 356,359, 360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381, 386, 387,392, 397, 398, 402, 403, 407, 408, 410, 411, 413, 415, 416, 421, 422,423, 424, 428, 429, 430, 432, 434, 435, 436, 439, 442, 443, 444, 445,1872, 1873, 1874, 1877, 1881, 1882, 1886, 1888, 1889, 1893, 1894, 1896,1897, 1900, 1901, 1903, 1906, 1908; 207-214 for the protein of sequenceSEQ ID No. 375; 207-214 for the protein of sequence SEQ ID No. 427;207-214 for the protein of sequence SEQ ID No. 1878; 207-214 for theprotein of sequence SEQ ID No. 1904 SEQ ID AQLVTWMK 208-215 for theproteins of SEQ No. 354, 357, 358, 363, 2be No. 455 364, 365, 370, 371,372, 373, 374, 382, 385, 388, 389, 390, 391, 393, 394, 395, 396, 399,400, 401, 404, 405, 406, 412, 417, 426, 431, 433, 437, 438, 440, 441,1875, 1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907,1909; 207-214 for the protein of sequence SEQ ID No. 1898; 207-214 forthe protein of sequence SEQ ID No. 1899; 207-214 for the protein ofsequence SEQ ID No. 1902 SEQ ID DILAAAAK 278-285 for the proteins of SEQNo. 386, 392, 397, 415, 2be No. 456 416, 419, 422, 424, 432, 434, 439,1881, 1903, 1906 SEQ ID DTTSPR 182-187 for the proteins of SEQ No. 354,357, 358, 363, 2be No. 457 364, 365, 370, 371, 372, 373, 374, 382, 385,388, 389, 390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406,412, 417, 426, 431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880,1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909; 181-186 for theprotein of sequence SEQ ID No. 1898; 181-186 for the protein of sequenceSEQ ID No. 1899; 181-186 for the protein of sequence SEQ ID No. 1902 SEQID DTTTPLAMAQTLK 182-194 for the proteins of SEQ No. 351, 386, 392, 397,2be No. 458 415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439, 442,444, 445, 1881, 1903, 1906, 1908 SEQ ID DTTTPR 182-187 for the proteinsof SEQ No. 353, 355, 356, 359, 2be No. 459 360, 361, 362, 367, 369, 376,377, 378, 379, 380, 381, 387, 398, 402, 403, 407, 408, 409, 410, 411,413, 421, 423, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888, 1889,1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ ID DVLAAAAK 277-284for the proteins of SEQ No. 375, 427, 1878, 2be No. 460 1904; 278-285for the protein of sequence SEQ ID No. 351; 278-285 for the protein ofsequence SEQ ID No. 352; 278-285 for the protein of sequence SEQ ID No.429; 278-285 for the protein of sequence SEQ ID No. 430; 278-285 for theprotein of sequence SEQ ID No. 442; 278-285 for the protein of sequenceSEQ ID No. 444; 278-285 for the protein of sequence SEQ ID No. 445 SEQID DVLASAAK 278-285 for the proteins of SEQ No. 354, 363, 364, 365, 2beNo. 461 370, 371, 372, 373, 374, 382, 385, 388, 389, 390, 391, 393, 394,395, 396, 399, 400, 401, 404, 405, 406, 412, 417, 426, 428, 431, 433,437, 438, 1875, 1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895,1905, 1907, 1909; 277-284 for the protein of sequence SEQ ID No. 1898;277-284 for the protein of sequence SEQ ID No. 1899; 277-284 for theprotein of sequence SEQ ID No. 1902 SEQ ID DVLASAAR 278-285 for theproteins of SEQ No. 353, 355, 356, 359, 2be No. 462 360, 361, 362, 367,369, 376, 377, 378, 379, 380, 381, 387, 398, 402, 403, 407, 408, 409,410, 411, 413, 421, 423, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901; 276-283 for theprotein of sequence SEQ ID No. 425 SEQ ID FAMCSTSK 69-76 for theproteins of SEQ No. 351, 352, 354, 357, 2be No. 463 358, 363, 364, 365,366, 368, 370, 371, 372, 373, 374, 382, 383, 384, 385, 386, 388, 390,391, 392, 393, 394, 395, 396, 397, 399, 400, 401, 404, 405, 406, 412,414, 415, 416, 417, 418, 419, 420, 422, 424, 426, 429, 430, 431, 432,433, 434, 435, 437, 438, 439, 440, 441, 442, 443, 444, 445, 1875, 1876,1879, 1880, 1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905, 1906,1907, 1908, 1909; 68-75 for the protein of sequence SEQ ID No. 375;68-75 for the protein of sequence SEQ ID No. 427; 68-75 for the proteinof sequence SEQ ID No. 1878; 68-75 for the protein of sequence SEQ IDNo. 1898; 68-75 for the protein of sequence SEQ ID No. 1899; 68-75 forthe protein of sequence SEQ ID No. 1902; 68-75 for the protein ofsequence SEQ ID No. 1904 SEQ ID FPMCSTSK 69-76 for the proteins of SEQNo. 353, 355, 356, 359, 2be No. 464 360, 361, 362, 367, 369, 376, 377,378, 379, 380, 381, 387, 389, 398, 402, 403, 407, 408, 409, 410, 411,413, 421, 423, 425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888,1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ IDGNTTGAASIQAGLPASW 216-237 for the proteins of SEQ No. 354, 357, 358,363, 2be No. 465 VVGDK 364, 365, 370, 371, 372, 373, 374, 382, 385, 388,389, 390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406, 412,417, 426, 431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880, 1883,1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909; 215-236 for the proteinof sequence SEQ ID No. 1899; 215-236 for the protein of sequence SEQ IDNo. 1902 SEQ ID GNTTGAASIQAGLPTSW 215-236 for the proteins of SEQ No.375, 427, 1878, 2be No. 466 VVGDK 1904; 216-237 for the protein ofsequence SEQ ID No. 352; 216-237 for the protein of sequence SEQ ID No.366; 216-237 for the protein of sequence SEQ ID No. 383; 216-237 for theprotein of sequence SEQ ID No. 384; 216-237 for the protein of sequenceSEQ ID No. 414; 216-237 for the protein of sequence SEQ ID No. 418;216-237 for the protein of sequence SEQ ID No. 420; 216-237 for theprotein of sequence SEQ ID No. 443 SEQ ID GNTTGAASIR 216-225 for theproteins of SEQ No. 353, 355, 356, 359, 2be No. 467 360, 361, 362, 367,368, 369, 377, 378, 379, 380, 381, 387, 398, 402, 403, 407, 408, 409,410, 411, 413, 421, 423, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886,1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ IDGNTTGSASIR 216-225 for the proteins of SEQ No. 351, 386, 392, 397, 2beNo. 468 415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439, 444,1881, 1903, 1906, 1908 SEQ ID HLLNQR 92-97 for the proteins of SEQ No.351, 386, 397, 415, 2be No. 469 416, 419, 422, 424, 429, 430, 432, 434,435, 439, 442, 444, 445, 1881, 1903, 1906, 1908 SEQ ID LAALEK 36-41 forthe proteins of SEQ No. 375, 427, 1878, 1904; 2be No. 470 37-42 for theproteins of sequence SEQ ID No. 352, 353, 355, 356, 359, 360, 361, 362,366, 367, 368, 369, 376, 377, 378, 379, 380, 381, 383, 384, 387, 398,402, 403, 407, 408, 409, 410, 411, 413, 414, 418, 420, 421, 423, 425,436, 443, 1872, 1873, 1874, 1877, 1882, 1886, 1888, 1889, 1891, 1892,1893, 1894, 1896, 1897, 1900, 1901 SEQ ID LAELER 37-42 for the proteinsof SEQ No. 358, 363, 364, 365, 2be No. 471 370, 371, 372, 382, 385, 388,389, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406, 412, 417,426, 428, 431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880, 1883,1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909; 36-41 for the protein ofsequence SEQ ID No. 1898; 36-41 for the protein of sequence SEQ ID No.1899; 36-41 for the protein of sequence SEQ ID No. 1902 SEQ IDLGVALIDTADNTQVLYR 48-64 for the proteins of SEQ No. 353, 355, 359, 360,2be No. 472 361, 362, 367, 369, 376, 377, 378, 387, 398, 402, 403, 407,409, 410, 411, 413, 421, 423, 425, 436, 1872, 1873, 1874, 1877, 1882,1886, 1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ IDLGVALINTADNSQILYR 48-64 for the proteins of SEQ No. 351, 354, 357, 358,2be No. 473 363, 364, 365, 370, 371, 372, 373, 374, 382, 385, 386, 388,389, 390, 391, 392, 393, 394, 395, 396, 397, 399, 400, 401, 404, 405,406, 412, 415, 416, 417, 419, 422, 424, 426, 428, 431, 432, 433, 435,437, 438, 439, 440, 441, 442, 444, 445, 1875, 1876, 1879, 1880, 1881,1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905, 1906, 1907, 1908, 1909;47-63 for the protein of sequence SEQ ID No. 1898; 47-63 for the proteinof sequence SEQ ID No. 1899 SEQ ID LIAHLGGPDK 141-150 for the proteinsof SEQ No. 351, 352, 366, 368, 2be No. 474 383, 384, 386, 392, 397, 414,415, 416, 418, 419, 420, 422, 424, 429, 430, 432, 434, 435, 439, 442,444, 445, 1881, 1903, 1906, 1908; 140-149 for the protein of sequenceSEQ ID No. 375; 140-149 for the protein of sequence SEQ ID No. 427;140-149 for the protein of sequence SEQ ID No. 1878; 140-149 for theprotein of sequence SEQ ID No. 1904 SEQ ID LIAHVGGPASVTAFAR 141-156 forthe proteins of SEQ No. 354, 357, 358, 363, 2be No. 475 364, 365, 370,371, 372, 373, 374, 382, 385, 388, 389, 390, 391, 393, 394, 399, 400,401, 404, 405, 406, 412, 417, 433, 437, 440, 441, 1875, 1876, 1879,1883, 1884, 1885, 1887, 1890, 1895, 1907, 1909; 140-155 for the proteinof sequence SEQ ID No. 1898; 140-155 for the protein of sequence SEQ IDNo. 1899; 140-155 for the protein of sequence SEQ ID No. 1902 SEQ IDLIAQLGGPGGVTAFAR 141-156 for the proteins of SEQ No. 353, 355, 356, 359,2be No. 476 360, 361, 362, 367, 369, 376, 377, 378, 379, 380, 381, 387,398, 402, 403, 407, 408, 409, 410, 411, 413, 421, 423, 425, 428, 436,1872, 1873, 1874, 1877, 1882, 1886, 1888, 1889, 1891, 1892, 1893, 1894,1896, 1900, 1901 SEQ ID NLTLGK 195-200 for the proteins of SEQ No. 351,354, 357, 358, 2be No. 477 363, 364, 365, 370, 371, 372, 373, 374, 382,385, 386, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 399, 400,401, 404, 405, 406, 412, 415, 416, 417, 419, 422, 424, 426, 429, 430,431, 432, 433, 434, 435, 437, 438, 439, 440, 441, 442, 444, 445, 1875,1876, 1879, 1880, 1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905,1906, 1907, 1908, 1909; 194-199 for the protein of sequence SEQ ID No.1898; 194-199 for the protein of sequence SEQ ID No. 1899; 194-199 forthe protein of sequence SEQ ID No. 1902 SEQ ID QLGDETFR 157-164 for theproteins of SEQ No. 354, 357, 358, 363, 2be No. 478 364, 365, 370, 371,372, 373, 374, 382, 385, 388, 389, 390, 391, 393, 394, 395, 396, 399,400, 401, 405, 406, 412, 417, 426, 431, 433, 437, 438, 440, 441, 1875,1876, 1879, 1880, 1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909;156-163 for the protein of sequence SEQ ID No. 1898; 156-163 for theprotein of sequence SEQ ID No. 1899; 156-163 for the protein of sequenceSEQ ID No. 1902 SEQ ID QLLNQPVEIK 92-101 for the proteins of SEQ No.353, 355, 356, 359, 2be No. 479 360, 361, 362, 367, 369, 376, 377, 378,379, 380, 381, 387, 398, 402, 407, 408, 409, 410, 411, 413, 421, 423,425, 428, 436, 1872, 1873, 1874, 1877, 1882, 1886, 1888, 1889, 1891,1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ ID QLTLGHALGETQR 195-207for the proteins of SEQ No. 353, 355, 356, 359, 2be No. 480 360, 361,362, 367, 369, 376, 377, 378, 379, 380, 381, 387, 398, 402, 403, 407,408, 409, 410, 411, 413, 421, 423, 428, 436, 1872, 1873, 1874, 1877,1882, 1886, 1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901SEQ ID QSESDK 86-91 for the proteins of SEQ No. 351, 386, 392, 397, 2beNo. 481 415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 439, 442, 444,445, 1881, 1903, 1906, 1908 SEQ ID QSETQK 85-90 for the proteins of SEQNo. 375, 427, 1878, 1904; 2be No. 482 86-91 for the protein of sequenceSEQ ID No. 352; 86-91 for the protein of sequence SEQ ID No. 353; 86-91for the protein of sequence SEQ ID No. 355; 86-91 for the protein ofsequence SEQ ID No. 356; 86-91 for the protein of sequence SEQ ID No.359; 86-91 for the protein of sequence SEQ ID No. 360; 86-91 for theprotein of sequence SEQ ID No. 361; 86-91 for the protein of sequenceSEQ ID No. 362; 86-91 for the protein of sequence SEQ ID No. 366; 86-91for the protein of sequence SEQ ID No. 367; 86-91 for the protein ofsequence SEQ ID No. 368; 86-91 for the protein of sequence SEQ ID No.369; 86-91 for the protein of sequence SEQ ID No. 376; 86-91 for theprotein of sequence SEQ ID No. 377; 86-91 for the protein of sequenceSEQ ID No. 378; 86-91 for the protein of sequence SEQ ID No. 379; 86-91for the protein of sequence SEQ ID No. 380; 86-91 for the protein ofsequence SEQ ID No. 381; 86-91 for the protein of sequence SEQ ID No.383; 86-91 for the protein of sequence SEQ ID No. 384; 86-91 for theprotein of sequence SEQ ID No. 387; 86-91 for the protein of sequenceSEQ ID No. 398; 86-91 for the protein of sequence SEQ ID No. 402; 86-91for the protein of sequence SEQ ID No. 403; 86-91 for the protein ofsequence SEQ ID No. 407; 86-91 for the protein of sequence SEQ ID No.408; 86-91 for the protein of sequence SEQ ID No. 409; 86-91 for theprotein of sequence SEQ ID No. 410; 86-91 for the protein of sequenceSEQ ID No. 411; 86-91 for the protein of sequence SEQ ID No. 413; 86-91for the protein of sequence SEQ ID No. 414; 86-91 for the protein ofsequence SEQ ID No. 418; 86-91 for the protein of sequence SEQ ID No.420; 86-91 for the protein of sequence SEQ ID No. 421; 86-91 for theprotein of sequence SEQ ID No. 423; 86-91 for the protein of sequenceSEQ ID No. 425; 86-91 for the protein of sequence SEQ ID No. 428; 86-91for the protein of sequence SEQ ID No. 436; 86-91 for the protein ofsequence SEQ ID No. 443; 86-91 for the protein of sequence SEQ ID No.1872; 86-91 for the protein of sequence SEQ ID No. 1873; 86-91 for theprotein of sequence SEQ ID No. 1874; 86-91 for the protein of sequenceSEQ ID No. 1877; 86-91 for the protein of sequence SEQ ID No. 1882;86-91 for the protein of sequence SEQ ID No. 1886; 86-91 for the proteinof sequence SEQ ID No. 1888; 86-91 for the protein of sequence SEQ IDNo. 1889; 86-91 for the protein of sequence SEQ ID No. 1891; 86-91 forthe protein of sequence SEQ ID No. 1892; 86-91 for the protein ofsequence SEQ ID No. 1893; 86-91 for the protein of sequence SEQ ID No.1894; 86-91 for the protein of sequence SEQ ID No. 1896; 86-91 for theprotein of sequence SEQ ID No. 1897; 86-91 for the protein of sequenceSEQ ID No. 1900 SEQ ID QSGGR 43-47 for the proteins of SEQ No. 354, 357,358, 363, 2be No. 483 364, 365, 370, 371, 372, 373, 374, 382, 385, 388,389, 390, 391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406, 412,417, 426, 428, 431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880,1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909; 42-46 for theprotein of sequence SEQ ID No. 1898; 42-46 for the protein of sequenceSEQ ID No. 1899; 42-46 for the protein of sequence SEQ ID No. 1902 SEQID SDLVNYNPIAEK 103-114 for the proteins of SEQ No. 351, 354, 357, 358,2be No. 484 363, 364, 365, 371, 372, 373, 374, 382, 384, 385, 386, 388,389, 390, 391, 392, 393, 394, 395, 396, 397, 399, 400, 401, 404, 405,406, 412, 415, 416, 417, 419, 422, 424, 426, 429, 430, 431, 432, 433,434, 435, 437, 438, 439, 440, 441, 442, 444, 445, 1875, 1876, 1879,1880, 1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905, 1906, 1907,1908, 1909; 102-113 for the protein of sequence SEQ ID No. 1898; 102-113for the protein of sequence SEQ ID No. 1899; 102-113 for the protein ofsequence SEQ ID No. 1902 SEQ ID SESEPNLLNQR 87-97 for the proteins ofSEQ No. 354, 357, 363, 364, 2be No. 485 365, 370, 371, 372, 373, 374,382, 385, 388, 389, 390, 391, 393, 394, 395, 396, 399, 400, 401, 404,405, 406, 412, 417, 426, 431, 433, 437, 438, 1875, 1876, 1879, 1880,1883, 1884, 1885, 1887, 1890, 1895, 1905, 1907, 1909; 86-96 for theprotein of sequence SEQ ID No. 1898; 86-96 for the protein of sequenceSEQ ID No. 1899; 86-96 for the protein of sequence SEQ ID No. 1902 SEQID SLGDETFR 157-164 for the proteins of SEQ No. 351, 386, 392, 397, 2beNo. 486 415, 416, 419, 422, 424, 429, 430, 432, 434, 435, 442, 444, 445,1881, 1903, 1906, 1908 SEQ ID SSGGR 43-47 for the proteins of SEQ No.351, 352, 353, 355, 2be No. 487 356, 359, 360, 361, 362, 366, 367, 368,369, 376, 378, 380, 381, 383, 384, 386, 387, 392, 397, 398, 402, 403,407, 408, 409, 410, 411, 413, 414, 415, 416, 418, 419, 420, 421, 422,423, 424, 425, 429, 430, 432, 434, 435, 436, 439, 442, 443, 444, 445,1872, 1873, 1874, 1877, 1881, 1882, 1886, 1888, 1889, 1891, 1892, 1893,1894, 1896, 1897, 1900, 1901, 1903, 1906, 1908; 42-46 for the protein ofsequence SEQ ID No. 375; 42-46 for the protein of sequence SEQ ID No.427; 42-46 for the protein of sequence SEQ ID No. 1878; 42-46 for theprotein of sequence SEQ ID No. 1904 SEQ ID SWVVGDK 231-237 for theproteins of SEQ No. 352, 354, 357, 358, 2be No. 488 363, 364, 365, 366,368, 370, 371, 372, 373, 374, 382, 383, 384, 385, 386, 388, 389, 390,391, 392, 393, 394, 395, 396, 397, 399, 400, 401, 404, 405, 406, 412,414, 415, 416, 417, 418, 419, 420, 422, 424, 426, 428, 431, 432, 433,435, 437, 438, 439, 440, 441, 442, 443, 445, 1875, 1876, 1879, 1880,1881, 1883, 1884, 1885, 1887, 1890, 1895, 1903, 1905, 1906, 1907, 1908,1909; 230-236 for the protein of sequence SEQ ID No. 375; 230-236 forthe protein of sequence SEQ ID No. 427; 230-236 for the protein ofsequence SEQ ID No. 1878; 230-236 for the protein of sequence SEQ ID No.1899; 230-236 for the protein of sequence SEQ ID No. 1902; 230-236 forthe protein of sequence SEQ ID No. 1904 SEQ ID TEPTLNTAIPGDPR 168-181for the proteins of SEQ No. 351, 352, 353, 354, 2be No. 489 355, 356,357, 358, 359, 360, 362, 363, 364, 366, 367, 368, 369, 370, 371, 372,373, 374, 376, 377, 378, 379, 380, 381, 382, 383, 384, 386, 387, 389,390, 392, 393, 394, 396, 397, 398, 399, 401, 402, 403, 404, 405, 406,408, 409, 410, 411, 412, 413, 414, 416, 417, 418, 419, 420, 422, 423,424, 425, 426, 428, 431, 432, 433, 435, 436, 437, 438, 439, 440, 441,442, 443, 444, 445, 1872, 1874, 1875, 1876, 1877, 1879, 1880, 1881,1882, 1883, 1884, 1885, 1886, 1887, 1890, 1891, 1892, 1893, 1894, 1895,1896, 1897, 1900, 1901, 1903, 1905, 1906, 1907, 1908, 1909; 167-180 forthe protein of sequence SEQ ID No. 375; 167-180 for the protein ofsequence SEQ ID No. 427; 167-180 for the protein of sequence SEQ ID No.1878; 167-180 for the protein of sequence SEQ ID No. 1898; 167-180 forthe protein of sequence SEQ ID No. 1899; 167-180 for the protein ofsequence SEQ ID No. 1902; 167-180 for the protein of sequence SEQ ID No.1904 SEQ ID TGSGDYGTTNDIAVIWPK 238-255 for the proteins of SEQ No. 354,357, 358, 364, 2be No. 490 365, 372, 374, 382, 385, 388, 391, 395, 396,400, 401, 404, 405, 426, 431, 433, 441, 1876, 1880, 1895, 1905, 1907 SEQID TGSGDYGTTNDIAVIWP 238-257 for the proteins of SEQ No. 353, 355, 356,360, 2be No. 491 QGR 361, 362, 367, 376, 377, 378, 379, 380, 381, 387,398, 402, 403, 407, 408, 409, 410, 411, 413, 421, 436, 1872, 1873, 1874,1877, 1882, 1886, 1888, 1893, 1894, 1896, 1897, 1900, 1901; 236-255 forthe protein of sequence SEQ ID No. 425 SEQ ID TGSGGYGTTNDIAVIWPK 238-255for the proteins of SEQ No. 363, 370, 371, 389, 2be No. 492 390, 393,394, 399, 406, 412, 428, 437, 438, 440, 1875, 1879, 1883, 1884, 1885,1887, 1890, 1909; 237-254 for the protein of sequence SEQ ID No. 1898;237-254 for the protein of sequence SEQ ID No. 1899; 237-254 for theprotein of sequence SEQ ID No. 1902 SEQ ID VMAAAAVLK 77-85 for theproteins of SEQ No. 351, 352, 353, 354, 2be No. 493 355, 356, 357, 358,359, 360, 361, 362, 363, 364, 367, 368, 369, 370, 371, 372, 373, 374,376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 389, 391, 392,397, 400, 401, 402, 404, 405, 408, 409, 410, 411, 412, 415, 416, 417,419, 420, 421, 422, 424, 425, 426, 428, 429, 430, 432, 433, 434, 435,436, 437, 439, 440, 442, 443, 444, 1872, 1873, 1874, 1875, 1876, 1877,1881, 1885, 1888, 1889, 1890, 1891, 1893, 1894, 1896, 1897, 1900, 1901,1903, 1906, 1907, 1908, 1909; 76-84 for the protein of sequence SEQ IDNo. 375; 76-84 for the protein of sequence SEQ ID No. 427; 76-84 for theprotein of sequence SEQ ID No. 1878; 76-84 for the protein of sequenceSEQ ID No. 1898; 76-84 for the protein of sequence SEQ ID No. 1899;76-84 for the protein of sequence SEQ ID No. 1902; 76-84 for the proteinof sequence SEQ ID No. 1904 SEQ ID VMAVAAVLK 77-85 for the proteins ofSEQ No. 365, 366, 387, 388, 2be No. 494 390, 393, 394, 395, 396, 398,399, 406, 407, 413, 414, 418, 423, 431, 438, 441, 1879, 1880, 1882,1883, 1884, 1886, 1892, 1895, 1905 SEQ ID VTAFAR 151-156 for theproteins of SEQ No. 351, 352, 353, 354, 2be No. 495 355, 356, 357, 358,359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372,373, 374, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387,388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401,402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415,416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 428, 429, 430,431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444,445, 1872, 1873, 1874, 1875, 1876, 1877, 1879, 1880, 1881, 1882, 1883,1884, 1885, 1886, 1887, 1888, 1889, 1890, 1891, 1892, 1893, 1894, 1895,1896, 1897, 1900, 1901, 1903, 1905, 1906, 1907, 1908, 1909; 150-155 forthe protein of sequence SEQ ID No. 375; 150-155 for the protein ofsequence SEQ ID No. 427; 150-155 for the protein of sequence SEQ ID No.1878; 150-155 for the protein of sequence SEQ ID No. 1898; 150-155 forthe protein of sequence SEQ ID No. 1899; 150-155 for the protein ofsequence SEQ ID No. 1902; 150-155 for the protein of sequence SEQ ID No.1904 SEQ ID AAGIR 219-223 for the protein of SEQ No. 425 2be No. 2008SEQ ID AGADVASLR 188-196 for the protein of SEQ No. 425 2be No. 2009 SEQID AGLPASWVVGDK 226-237 for the proteins of SEQ No. 354, 357, 358, 363,2be No. 2010 364, 365, 370, 371, 372, 373, 374, 382, 385, 388, 389, 390,391, 393, 394, 395, 396, 399, 400, 401, 404, 405, 406, 412, 417, 426,428, 431, 433, 437, 438, 440, 441, 1875, 1876, 1879, 1880, 1883, 1884,1885, 1887, 1890, 1895, 1905, 1907, 1909; 225-236 for the protein ofsequence SEQ ID No. 1899; 225-236 for the protein of sequence SEQ ID No.1902 SEQ ID AGLPTSWTAGDK 226-237 for the proteins of SEQ No. 353, 359,387 2be No. 2011 SEQ ID AGLPTSWTVGDR 226-237 for the proteins of SEQ No.1894 2be No. 2012 SEQ ID AGLPTSWVVGDK 225-236 for the proteins of SEQNo. 375, 427, 1878, 2be No. 2013 1904; 226-237 for the protein ofsequence SEQ ID No. 352; 226-237 for the protein of sequence SEQ ID No.366; 226-237 for the protein of sequence SEQ ID No. 368; 226-237 for theprotein of sequence SEQ ID No. 383; 226-237 for the protein of sequenceSEQ ID No. 384; 226-237 for the protein of sequence SEQ ID No. 414;226-237 for the protein of sequence SEQ ID No. 418; 226-237 for theprotein of sequence SEQ ID No. 420; 226-237 for the protein of sequenceSEQ ID No. 443 SEQ ID AGMPK 226-230 for the protein of SEQ No. 434 2beNo. 2014 SEQ ID AIGDDTFR 156-163 for the proteins of SEQ No. 375, 427,1878, 1904 2be No. 2015 SEQ ID AIGDNTFR 157-164 for the protein of SEQNo. 352 2be No. 2016 SEQ ID AMAVAAVLK 77-85 for the proteins of SEQ No.1887 2be No. 2017 SEQ ID APLILVIYFTQPQPK 258-272 for the protein of SEQNo. 390 2be No. 2018 SEQ ID APLILVTYFTQPEQK 257-271 for the proteins ofSEQ No. 375, 427, 1878, 2be No. 2019 1904; 258-272 for the protein ofsequence SEQ ID No. 352 SEQ ID APLILVTYFTQPQPNAESR 258-276 for theproteins of SEQ No. 406, 1884 2be No. 2020 SEQ ID APLVLVTYFTQPEPK258-272 for the protein of SEQ No. 443 2be No. 2021 SEQ IDAPLVLVTYFTQPQQNAE 258-276 for the proteins of SEQ No. 1893 2be No. 2022NR SEQ ID APLVLVTYFTQPQQNAER 258-275 for the proteins of SEQ No. 367,398, 421, 1877, 2be No. 2023 1882, 1888 SEQ ID APLVLVTYFTQSEPK 258-272for the proteins of SEQ No. 366, 368, 383, 384, 2be No. 2024 414, 418,420 SEQ ID AQLVAWLK 208-215 for the protein of SEQ No. 409 2be No. 2025SEQ ID AQLVMWLK 208-215 for the proteins of SEQ No. 366, 368, 383, 384,2be No. 2026 414, 418, 420 SEQ ID ASDLVNYNPIAEK 102-114 for the proteinsof SEQ No. 429, 430, 434 2be No. 2027 SEQ ID CWVVGDK 231-237 for theprotein of SEQ No. 429 2be No. 2028 SEQ ID DFLAAAAK 278-285 for theproteins of SEQ No. 435, 1908 2be No. 2029 SEQ ID DILASAAK 278-285 forthe proteins of SEQ No. 358, 440, 441 2be No. 2030 SEQ ID DLLSQR 92-97for the protein of SEQ No. 443 2be No. 2031 SEQ ID DNTQVLYR 57-64 forthe proteins of SEQ No. 353, 355, 356, 359, 2be No. 2032 360, 361, 362,367, 369, 376, 377, 378, 379, 380, 381, 387, 398, 402, 403, 407, 409,410, 411, 413, 421, 423, 425, 436, 1872, 1873, 1874, 1877, 1882, 1886,1888, 1889, 1891, 1892, 1893, 1894, 1896, 1897, 1900, 1901 SEQ ID DTTTAR182-187 for the protein of SEQ No. 425 2be No. 2033 SEQ ID DTTTPLAMAQALR182-194 for the proteins of SEQ No. 366, 368, 383, 384, 2be No. 2034414, 420 SEQ ID DTTTPLAMAQSLR 182-194 for the protein of SEQ No. 418 2beNo. 2035 SEQ ID DTTTPLAMAQTLR 181-193 for the proteins of SEQ No. 375,427, 1878, 2be No. 2036 1904; 182-194 for the protein of sequence SEQ IDNo. 352; 182-194 for the protein of sequence SEQ ID No. 443 SEQ IDDVLAAAAR 278-285 for the proteins of SEQ No. 366, 368, 383, 384, 2be No.2037 414, 418, 420, 443 SEQ ID EIGDETFR 157-164 for the protein of SEQNo. 356 2be No. 2038 SEQ ID EQLVTWLK 208-215 for the proteins of SEQ No.1891, 1892 2be No. 2039 SEQ ID GLLSQR 92-97 for the proteins of SEQ No.366, 368, 383, 384, 2be No. 2040 414, 418, 420 SEQ ID GNTTGAAR 216-223for the protein of SEQ No. 376 2be No. 2041 SEQ ID GNTTGSASIQAGLPK216-230 for the proteins of SEQ No. 442, 445 2be No. 2042 SEQ IDHDVLASAAK 277-285 for the proteins of SEQ No. 412, 1885 2be No. 2043 SEQID HDVLASAAR 277-285 for the proteins of SEQ No. 1894 2be No. 2044 SEQID HLTLGSALGETQR 194-206 for the proteins of SEQ No. 375, 427, 1878,1904 2be No. 2045 SEQ ID LAELEQQSGGR 37-47 for the proteins of SEQ No.354, 373, 374, 390 2be No. 2046 SEQ ID LAGLER 37-42 for the protein ofSEQ No. 357 2be No. 2047 SEQ ID LDGTEPTLNTAIPGDPR 165-181 for theprotein of SEQ No. 382 2be No. 2048 SEQ ID LGVALIDTADNAQTLYR 47-63 forthe proteins of SEQ No. 375, 427, 1878, 1904; 2be No. 2049 48-64 for theprotein of sequence SEQ ID No. 352 SEQ ID LGVALIDTADNTHVLYR 48-64 forthe protein of SEQ No. 408 2be No. 2050 SEQ ID LGVALIDTK 48-56 for theprotein of SEQ No. 356 2be No. 2051 SEQ ID LGVALINTADNSQILYLAD 48-68 forthe protein of SEQ No. 429 2be No. 2052 ER SEQ ID LGVALINTADNSQILYVA48-68 for the protein of SEQ No. 430 2be No. 2053 DER SEQ IDLGVALINTADNSR 47-59 for the proteins of SEQ No. 1902 2be No. 2054 SEQ IDLGVALINTADNTQTLYR 48-64 for the proteins of SEQ No. 366, 368, 383, 384,2be No. 2055 414, 418, 420, 443 SEQ ID LGVAQINTADNSQILYVA 48-68 for theprotein of SEQ No. 434 2be No. 2056 DER SEQ ID LGVPLIDTADNTQVLYR 48-64for the proteins of SEQ No. 379, 380, 381 2be No. 2057 SEQ ID LIAHLGGPGK141-150 for the protein of SEQ No. 443 2be No. 2058 SEQ IDLIAQLGGQGGVTAFAR 141-156 for the proteins of SEQ No. 1897 2be No. 2059SEQ ID LISHVGGPASVTAFAR 141-156 for the proteins of SEQ No. 395, 396,426, 431, 2be No. 2060 438, 1880, 1905 SEQ ID LLLNQR 92-97 for theprotein of SEQ No. 392 2be No. 2061 SEQ ID NLTLGNALGDTQR 195-207 for theproteins of SEQ No. 366, 368, 383, 384, 2be No. 2062 414, 418, 420, 443SEQ ID NLTLGSALGETQR 195-207 for the protein of SEQ No. 352 2be No. 2063SEQ ID NVLSQK 91-96 for the proteins of SEQ No. 375, 427, 1878, 1904 2beNo. 2064 SEQ ID QLGDDTFR 157-164 for the protein of SEQ No. 404 2be No.2065 SEQ ID SDLVNYSPIAEK 103-114 for the protein of SEQ No. 370 2be No.2066 SEQ ID SESEPSLLNQR 87-97 for the proteins of SEQ No. 358, 440, 4412be No. 2067 SEQ ID SETQK 86-90 for the proteins of SEQ No. 375, 427,1878, 1904; 2be No. 2068 87-91 for the protein of sequence SEQ ID No.352; 87-91 for the protein of sequence SEQ ID No. 353; 87-91 for theprotein of sequence SEQ ID No. 355; 87-91 for the protein of sequenceSEQ ID No. 356; 87-91 for the protein of sequence SEQ ID No. 359; 87-91for the protein of sequence SEQ ID No. 360; 87-91 for the protein ofsequence SEQ ID No. 361; 87-91 for the protein of sequence SEQ ID No.362; 87-91 for the protein of sequence SEQ ID No. 366; 87-91 for theprotein of sequence SEQ ID No. 367; 87-91 for the protein of sequenceSEQ ID No. 368; 87-91 for the protein of sequence SEQ ID No. 369; 87-91for the protein of sequence SEQ ID No. 376; 87-91 for the protein ofsequence SEQ ID No. 377; 87-91 for the protein of sequence SEQ ID No.378; 87-91 for the protein of sequence SEQ ID No. 379; 87-91 for theprotein of sequence SEQ ID No. 380; 87-91 for the protein of sequenceSEQ ID No. 381; 87-91 for the protein of sequence SEQ ID No. 383; 87-91for the protein of sequence SEQ ID No. 384; 87-91 for the protein ofsequence SEQ ID No. 387; 87-91 for the protein of sequence SEQ ID No.398; 87-91 for the protein of sequence SEQ ID No. 402; 87-91 for theprotein of sequence SEQ ID No. 403; 87-91 for the protein of sequenceSEQ ID No. 407; 87-91 for the protein of sequence SEQ ID No. 408; 87-91for the protein of sequence SEQ ID No. 409; 87-91 for the protein ofsequence SEQ ID No. 410; 87-91 for the protein of sequence SEQ ID No.411; 87-91 for the protein of sequence SEQ ID No. 413; 87-91 for theprotein of sequence SEQ ID No. 414; 87-91 for the protein of sequenceSEQ ID No. 418; 87-91 for the protein of sequence SEQ ID No. 420; 87-91for the protein of sequence SEQ ID No. 421; 87-91 for the protein ofsequence SEQ ID No. 423; 87-91 for the protein of sequence SEQ ID No.425; 87-91 for the protein of sequence SEQ ID No. 428; 87-91 for theprotein of sequence SEQ ID No. 436; 87-91 for the protein of sequenceSEQ ID No. 443; 87-91 for the protein of sequence SEQ ID No. 1872; 87-91for the protein of sequence SEQ ID No. 1873; 87-91 for the protein ofsequence SEQ ID No. 1874; 87-91 for the protein of sequence SEQ ID No.1877; 87-91 for the protein of sequence SEQ ID No. 1882; 87-91 for theprotein of sequence SEQ ID No. 1886; 87-91 for the protein of sequenceSEQ ID No. 1888; 87-91 for the protein of sequence SEQ ID No. 1889;87-91 for the protein of sequence SEQ ID No. 1891; 87-91 for the proteinof sequence SEQ ID No. 1892; 87-91 for the protein of sequence SEQ IDNo. 1893; 87-91 for the protein of sequence SEQ ID No. 1894; 87-91 forthe protein of sequence SEQ ID No. 1896; 87-91 for the protein ofsequence SEQ ID No. 1897; 87-91 for the protein of sequence SEQ ID No.1900; 87-91 for the protein of sequence SEQ ID No. 1901 SEQ ID SLGDESFR157-164 for the protein of SEQ No. 439 2be No. 2069 SEQ ID SSDLINYNPIAEK101-113 for the proteins of SEQ No. 375, 427, 1878, 2be No. 2070 1904;102-114 for the protein of sequence SEQ ID No. 443 SEQ ID SSDLINYNPITEK102-114 for the protein of SEQ No. 352 2be No. 2071 SEQ ID SWGVGDK231-237 for the proteins of SEQ No. 351, 430, 434, 444 2be No. 2072 SEQID TELTLNTAIPGDPR 168-181 for the protein of SEQ No. 407 2be No. 2073SEQ ID TEPTLNSAIPGDPR 168-181 for the proteins of SEQ No. 429, 430, 4342be No. 2074 SEQ ID TEPTQNTAIPGDPR 168-181 for the proteins of SEQ No.1889 2be No. 2075 SEQ ID TEQTLNTAIPGDPR 168-181 for the protein of SEQNo. 391 2be No. 2076 SEQ ID TESTLNTAIPGDPR 168-181 for the proteins ofSEQ No. 361, 388, 400, 421, 2be No. 2077 1873, 1888 SEQ IDTETTLNTAIPGDPR 168-181 for the proteins of SEQ No. 365, 385, 395, 4152be No. 2078 SEQ ID TGSCDYGTTNDIAVIWPK 238-255 for the protein of SEQNo. 373 2be No. 2079 SEQ ID TGSCGYGTTNDIAVIWPK 238-255 for the proteinof SEQ No. 417 2be No. 2080 SEQ ID TGSGDYGTTNDIAVIWPE 237-256 for theproteins of SEQ No. 375, 427, 1878, 2be No. 2081 GR 1904; 238-257 forthe protein of sequence SEQ ID No. 352; 238-257 for the protein ofsequence SEQ ID No. 368; 238-257 for the protein of sequence SEQ ID No.383; 238-257 for the protein of sequence SEQ ID No. 414; 238-257 for theprotein of sequence SEQ ID No. 418; 238-257 for the protein of sequenceSEQ ID No. 443 SEQ ID TGSGGYGTTNDIAVIWPE 238-257 for the proteins of SEQNo. 366, 384, 420 2be No. 2082 GR SEQ ID TGSGGYGTTNDIAVIWP 238-257 forthe proteins of SEQ No. 359, 369, 423, 1889, 2be No. 2083 QGR 1891, 1892SEQ ID TIGDDTFR 157-164 for the proteins of SEQ No. 366, 368, 383, 384,2be No. 2084 414, 418, 420 SEQ ID TQLVTWLK 208-215 for the protein ofSEQ No. 419 2be No. 2085 SEQ ID VEIKPSDLINYNPIAEK 98-114 for theproteins of SEQ No. 366, 368, 383, 414, 2be No. 2086 418, 420 SEQ IDVEIKPSDLVNYNPIAEK 98-114 for the protein of SEQ No. 384 2be No. 2087 SEQID VIGDDTFR 157-164 for the protein of SEQ No. 443 2be No. 2088 SEQ IDVLSQK 92-96 for the proteins of SEQ No. 375, 427, 1878, 1904; 2be No.2089 93-97 for the protein of sequence SEQ ID No. 352 SEQ ID VMAAAALLK77-85 for the protein of SEQ No. 445 2be No. 2090 SEQ ID VMAAAAVLEQSETQK77-91 for the protein of SEQ No. 403 2be No. 2091 SEQ ID WAKPSGAVGDVAQR201-214 for the protein of SEQ No. 425 2be No. 2092

In the clinical interest column, the entry 2be indicates that all of theCTX-M peptides indicates the presence of a beta-lactamase with anextended spectrum (ESBL) capable of hydrolysing penicillins,first-generation cephalosporins such as cephaloridine and cefalotin, andat least one antibiotic from the oxyimino-beta-lactam class such ascefotaxime, ceftazidime or monobactams such as aztreonam.

The detection of a mechanism of resistance to ESBL (extended-spectrumbeta-lactamase) cephalosporins, induced by the CTX-M protein ischaracterised by the detection of at least one resistance-marking 2bepeptide chosen from the sequences SEQ ID No. 446 to SEQ ID No. 478, SEQID No. 480 to SEQ ID No. 495 and SEQ ID No. 2008 to SEQ ID No. 2092.

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the SHV protein is characterised by the detection ofat least one peptide belonging to the SHV protein and to its differentsequence variants SEQ ID No. 496 to SEQ ID No. 613 and SEQ ID No. 1909to SEQ ID No. 1919.

SEQ ID No. 496:KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 497: LRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSASSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.498: MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 499: MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNNAERMVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 500: MRFIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 501: MRIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.502: MRYARLCIISLLATLPLVVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE HWQR SEQ IDNo. 503: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 504: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 505: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 506: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 507: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 508: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 509: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 510: MRYFRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGSVGMIEMDLASGRTLTAWRADGRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 511: MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.512: MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVEDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 513: MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQHIAGIGAALIEH WQR SEQ IDNo. 514: MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 515: MRYIRLCIISLLATLPLAVHASPQPLDQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 516: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWHADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 517: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWHADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAKRNQQIAGIGAALIEH WQR SEQ IDNo. 518: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.519: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYLQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 520: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHFADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLSAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 521: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTIGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 522: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGEFCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 523: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGEFCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAGTLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 524: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAAKLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 525: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATFGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 526: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGLAGLTAFLRQIGDNVTRLDRWETELNEALPADARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 527: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 528: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 529: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDKVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 530: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIG AALIEHWQR SEQID No. 531: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 532: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEAFPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 533: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARATTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 534: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLNSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 535: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARLQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 536: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 537: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 538: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQLQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 539: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDGVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 540: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 541: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPDNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 542: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNHKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 543: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 544: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALRGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 545: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDSPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 546: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERTVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 547: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDSPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 548: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 549: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 550: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGLGAALIEH WQR SEQ IDNo. 551: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 552: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLSAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 553: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDGRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 554: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRHLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 555: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 556: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 557: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 558: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARGTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 559: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARNTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 560: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALSGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 561: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETERNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 562: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGENVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTNQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 563: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 564: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSVANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTLASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 565: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAVITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 566: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCTAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 567: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPVGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 568: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMGDNSAANLLLRTVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRNVLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 569: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLRTVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRNVLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.570: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASSRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 571: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWCADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 572: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMISTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.573: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVALCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 574: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVLLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 575: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAMLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 576: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLAIVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 577: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 578: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLISQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ ID No.579: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDARVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 580: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKAGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 581: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 582: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 583: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGGRGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 584: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 585: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 586: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGGNIKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHW QR SEQ IDNo. 587: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAELDQQIAGIGAALIEHW QR SEQ IDNo. 588: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 589: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASRRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 590: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADRTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 591: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 592: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEVLPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 593: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGVTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 594: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPTGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 595: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGSPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 596: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 597: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLTDGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 598: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKYLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 599: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQHLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 600: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDKQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGGRGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 601: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGTVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIDDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 602: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADQRFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 603: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGSVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAAERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 604: MRYIRLCIISLLATLPLAVHSSPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 605: MRYIRLCIISLLATLPLTVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 606: MRYIRLCIISLLATLSLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 607: MRYIRLCIISLLATMPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE HWQR SEQ IDNo. 608: MRYIRLCIISLLAVLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 609: MRYIRLNIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 610: MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDMPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 611: MRYIRRCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 612: MRYVRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE HWQR SEQ IDNo. 613: MRYVRLCIISLLATLPLAVHTSPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIE HWQR SEQ IDNo. 1909: MRYIRLCIISLLAALPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQHIAGIGAALIEH WQR SEQ IDNo. 1910: ALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARGIVALLGPNNKAERIVVIYLRDS SEQ ID No. 1911:MRYIRLCIISLLAALPLVVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITVSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1912: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAELDQQIAGIGAALIEHW QR SEQ IDNo. 1913: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELRAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGTGAAPIEH WQR SEQ IDNo. 1914: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLREIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1915: MRYIRLCIISLLATLPLAVHASPQPLKQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMTATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1916: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAALTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPHNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1917: KRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYSQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1918: MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEH WQR SEQ IDNo. 1919: MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAA

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 614 to SEQ ID No. 711 and SEQ ID No. 2093 to SEQ ID No. 2096as defined hereafter:

Peptide SEQ ID Amino acid Clinical No. sequence Position of the peptidein the SHV protein interest SEQ ID AGAGER 231-236 for the protein of SEQNo. 580 SHV No. 614 SEQ ID ATTTPASMAATLR 175-187 for the protein of SEQNo. 533 2be No. 615 SEQ ID CIISLLATLPLAVH 7-30 for the proteins of SEQNo. 496, 497, 498, 499, 500, 503, SHV No. 616 ASPQPLEQIK 504, 505, 506,507, 508, 509, 510, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525,526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539,540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553,554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567,568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581,582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595,596, 597, 598, 599, 600, 601, 602, 603, 610, 611, 612, 1913, 1914, 1915,1917, 1918, 1919, 1920; 6-29 for the protein of sequence SEQ ID No. 501SEQ ID DMPASMAER 261-269 for the protein of SEQ No. 610 2b No. 617 SEQID DSPASMAER 261-269 for the proteins of SEQ No. 545, 547 SHV No. 618SEQ ID DTLASMAER 261-269 for the protein of SEQ No. 564 SHV No. 619 SEQID DTPASMAER 261-269 for the proteins of SEQ No. 496, 497, 498, 499,500, SHV No. 620 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512,513, 514, 515, 516, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527,528, 529, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542,543, 544, 546, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558,559, 560, 561, 562, 563, 565, 566, 567, 570, 571, 572, 573, 574, 575,576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 588, 589, 590,591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604,605, 606, 607, 608, 609, 611, 612, 613, 1910, 1912, 1914, 1915, 1916,1917, 1918, 1919, 1920; 260-268 for the protein of sequence SEQ ID No.501; 266-274 for the protein of sequence SEQ ID No. 530; 260-268 for theprotein of sequence SEQ ID No. 568; 260-268 for the protein of sequenceSEQ ID No. 569 SEQ ID DTPASMAK 261-268 for the protein of SEQ No. 517SHV No. 621 SEQ ID DTTTPASMAATLR 175-187 for the proteins of SEQ No.496, 497, 498, 499, 500, SHV No. 622 502, 503, 504, 505, 506, 507, 508,509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522,524, 525, 526, 527, 528, 529, 531, 532, 534, 535, 536, 537, 538, 539,540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553,560, 561, 562, 563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 575,576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589,590, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604,605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914,1915, 1917, 1918, 1919, 1920; 174-186 for the protein of sequence SEQ IDNo. 501; 180-192 for the protein of sequence SEQ ID No. 530; 174-186 forthe protein of sequence SEQ ID No. 568; 174-186 for the protein ofsequence SEQ ID No. 569; 8-20 for the protein of sequence SEQ ID No.1911 SEQ ID DTTTPASMAGTLR 175-187 for the protein of SEQ No. 523 2b No.623 SEQ ID DTTTPASMTATLR 175-187 for the proteins of SEQ No. 554, 555,556, 557, 591, SHV No. 624 1916 SEQ ID FPMISTFK 62-69 for the proteinsof SEQ No. 511, 518, 572 2br No. 625 SEQ ID FPMMSTFK 62-69 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 626 502, 503, 504,505, 506, 507, 508, 509, 510, 512, 513, 514, 515, 516, 517, 519, 520,521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534,535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562,563, 564, 565, 566, 567, 570, 571, 573, 574, 575, 576, 577, 578, 579,580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593,594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607,608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917,1918, 1919, 1920; 61-68 for the protein of sequence SEQ ID No. 501;61-68 for the protein of sequence SEQ ID No. 568; 61-68 for the proteinof sequence SEQ ID No. 569 SEQ ID GIVALLGGNIK 240-250 for the protein ofSEQ No. 586 2b No. 627 SEQ ID GIVALLGPDNK 240-250 for the protein of SEQNo. 541 SHV No. 628 SEQ ID GIVALLGPNHK 240-250 for the protein of SEQNo. 542 SHV No. 629 SEQ ID GIVALLGPNNK 240-250 for the proteins of SEQNo. 496, 497, 498, 500, 502, SHV No. 630 503, 504, 505, 506, 507, 508,509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522,523, 524, 525, 526, 527, 528, 529, 531, 532, 533, 534, 535, 536, 537,538, 539, 540, 543, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554,555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 570,571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584,585, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599,600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613,1910, 1912, 1913, 1914, 1915, 1916, 1918, 1919, 1920; 239-249 for theprotein of sequence SEQ ID No. 501; 245-255 for the protein of sequenceSEQ ID No. 530; 239-249 for the protein of sequence SEQ ID No. 568;239-249 for the protein of sequence SEQ ID No. 569; 73-83 for theprotein of sequence SEQ ID No. 1911 SEQ ID GIVALLGPNNNAER 240-253 forthe protein of SEQ No. 499 2b No. 631 SEQ ID GIVALR 240-245 for theprotein of SEQ No. 544 SHV No. 632 SEQ ID GPNNK 246-250 for the proteinsof SEQ No. 496, 497, 498, 500, 502, SHV No. 633 503, 504, 505, 506, 507,508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521,522, 523, 524, 525, 526, 527, 528, 529, 531, 532, 533, 534, 535, 536,537, 538, 539, 540, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552,553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566,567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582,583, 584, 585, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597,598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611,612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1918, 1919, 1920; 245-249for the protein of sequence SEQ ID No. 501; 251-255 for the protein ofsequence SEQ ID No. 530; 245-249 for the protein of sequence SEQ ID No.568; 245-249 for the protein of sequence SEQ ID No. 569; 79-83 for theprotein of sequence SEQ ID No. 1911 SEQ ID GTTTPASMAATLR 175-187 for theprotein of SEQ No. 558 2be No. 634 SEQ ID HLADGMTVGELC 108-132 for theprotein of SEQ No. 524 SHV No. 635 AAAITMSDNSAAK SEQ ID HLLQWMVDDR202-211 for the protein of SEQ No. 554 SHV No. 636 SEQ ID IHYLQQDLVDYSP91-107 for the protein of SEQ No. 519 SHV No. 637 VSEK SEQ ID IVVIYLR254-260 for the proteins of SEQ No. 496, 497, 498, 500, 502, SHV No. 638503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516,517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 531,532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545,547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560,561, 562, 563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 575, 576,577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604,605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914,1915, 1916, 1917, 1918, 1919, 1920; 253-259 for the protein of sequenceSEQ ID No. 501; 259-265 for the protein of sequence SEQ ID No. 530;253-259 for the protein of sequence SEQ ID No. 568; 253-259 for theprotein of sequence SEQ ID No. 569; 87-93 for the protein of sequenceSEQ ID No. 1911 SEQ ID LCIISLLAALPLAV 6-30 for the proteins of SEQ No.511, 512, 513, 514, 1910 2b No. 639 HASPQPLEQIK SEQ ID LCIISLLATLPLAV6-30 for the protein of SEQ No. 515 2b No. 640 HASPQPLDQIK SEQ IDLCIISLLATLPLAV 6-30 for the proteins of SEQ No. 496, 497, 498, 499, 500,503, SHV No. 641 HASPQPLEQIK 504, 505, 506, 507, 508, 509, 510, 516,517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530,531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544,545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558,559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572,573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586,587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600,601, 602, 603, 612, 1913, 1914, 1915, 1917, 1918, 1919, 1920; 5-29 forthe protein of sequence SEQ ID No. 501 SEQ ID LCIISLLATLPLAV 6-30 forthe protein of SEQ No. 604 SHV No. 642 HSSPQPLEQIK SEQ ID LCIISLLATLPLAV6-30 for the protein of SEQ No. 613 SHV No. 643 HTSPQPLEQIK SEQ IDLCIISLLATLPLTV 6-30 for the protein of SEQ No. 605 2b No. 644HASPQPLEQIK SEQ ID LCIISLLATLPLVV 6-30 for the protein of SEQ No. 502 2bNo. 645 HASPQPLEQIK SEQ ID LCIISLLATLSLAV 6-30 for the protein of SEQNo. 606 2be No. 646 HASPQPLEQIK SEQ ID LCIISLLATMPLAV 6-30 for theprotein of SEQ No. 607 SHV No. 647 HASPQPLEQIK SEQ ID LCIISLLAVLPLAV6-30 for the protein of SEQ No. 608 2b No. 648 HASPQPLEQIK SEQ ID LLISQR189-194 for the protein of SEQ No. 578 SHV No. 649 SEQ ID LLLATVGGPAGLT133-149 for the proteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 650AFLR 502, 503, 505, 506, 507, 508, 509, 510, 512, 513, 514, 515, 516,517, 518, 519, 521, 522, 523, 524, 527, 528, 529, 530, 531, 532, 533,534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547,548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,562, 564, 565, 566, 570, 571, 573, 574, 575, 577, 578, 579, 580, 581,582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 596, 597, 598,599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612,613, 1910, 1912, 1913, 1914, 1915, 1916, 1918, 1919, 1920 SEQ ID LLNSQR189-194 for the protein of SEQ No. 534 2be No. 651 SEQ ID LLTNQR 189-194for the protein of SEQ No. 562 SHV No. 652 SEQ ID LLTSQR 189-194 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 653 502, 503, 504,505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518,519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 531, 532, 533,535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 563,564, 565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 579, 580,581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594,595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608,609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918,1919, 1920; 188-193 for the protein of sequence SEQ ID No. 501; 194-199for the protein of sequence SEQ ID No. 530; 22-27 for the protein ofsequence SEQ ID No. 1911 SEQ ID LNIISLLATLPLAV 6-30 for the protein ofSEQ No. 609 2b No. 654 HASPQPLEQIK SEQ ID LSASSQR 195-201 for theprotein of SEQ No. 497 SHV No. 655 SEQ ID LSESQLSGR 31-39 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 656 503, 504, 515,516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529,530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543,544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557,558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 604,606, 609, 1917, 1918, 1919; 30-38 for the protein of sequence SEQ ID No.501 SEQ ID LSESQLSGSVGM 31-51 for the proteins of SEQ No. 505, 506, 507,508, 509, 510 SHV No. 657 IEMDLASGR SEQ ID MVVIYLR 254-260 for theprotein of SEQ No. 499 2b No. 658 SEQ ID NEALPGDAR 166-174 for theproteins of SEQ No. 496, 497, 498, 499, 500, 2be No. 659 502, 503, 504,505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518,519, 520, 521, 523, 524, 525, 527, 528, 529, 533, 534, 535, 536, 537,538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551,552, 553, 554, 555, 556, 557, 558, 559, 561, 562, 563, 564, 565, 566,567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582,583, 584, 585, 586, 587, 588, 589, 590, 591, 593, 594, 595, 596, 597,598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611,612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920;165-173 for the protein of sequence SEQ ID No. 501; 171-179 for theprotein of sequence SEQ ID No. 530; 165-173 for the protein of sequenceSEQ ID No. 568; 165-173 for the protein of sequence SEQ ID No. 569 SEQID NQHIAGIGAALIE 270-286 for the proteins of SEQ No. 513, 1910 SHV No.660 HWQR SEQ ID NQQIAGIGAALIE 270-286 for the proteins of SEQ No. 496,497, 498, 499, 500, SHV No. 661 HWQR 502, 503, 504, 505, 506, 507, 508,509, 510, 511, 512, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523,524, 525, 526, 527, 528, 529, 531, 532, 533, 534, 535, 536, 537, 538,539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 551, 552, 553,554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567,570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583,584, 585, 586, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598,599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612,613, 1912, 1915, 1916, 1917, 1918, 1919; 269-285 for the protein ofsequence SEQ ID No. 501; 275-291 for the protein of sequence SEQ ID No.530; 269-285 for the protein of sequence SEQ ID No. 568; 269-285 for theprotein of sequence SEQ ID No. 569 SEQ ID NQQIAGLGAALIE 270-286 for theprotein of SEQ No. 550 SHV No. 662 HWQR SEQ ID NTTTPASMAATLR 175-187 forthe protein of SEQ No. 559 2be No. 663 SEQ ID NVLTSQR 187-193 for theproteins of SEQ No. 568, 569 SHV No. 664 SEQ ID QIDDNVTR 150-157 for theproteins of SEQ No. 505, 527, 528, 565, 577, 2be No. 665 601 SEQ IDQIGDK 150-154 for the protein of SEQ No. 529 2b No. 666 SEQ ID QIGDNVTR150-157 for the proteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 667502, 503, 504, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516,517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 530, 531, 532, 533,534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547,548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561,563, 564, 566, 567, 570, 571, 572, 573, 574, 575, 576, 578, 579, 580,581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594,595, 596, 597, 598, 599, 600, 602, 603, 604, 605, 606, 607, 608, 609,610, 611, 612, 613, 1910, 1912, 1913, 1914, 1916, 1917, 1918, 1919,1920; 149-156 for the protein of sequence SEQ ID No. 501; 149-156 forthe protein of sequence SEQ ID No. 568; 149-156 for the protein ofsequence SEQ ID No. 569 SEQ ID QIGENVTR 150-157 for the protein of SEQNo. 562 2b No. 668 SEQ ID QLLQWMVDAR 202-211 for the protein of SEQ No.579 SHV No. 669 SEQ ID QLLQWMVDDGV 202-218 for the protein of SEQ No.539 SHV No. 670 AGPLIR SEQ ID QLLQWMVDDR 202-211 for the proteins of SEQNo. 496, 497, 498, 499, 500, SHV No. 671 502, 503, 504, 505, 506, 507,508, 509, 510, 511, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522,523, 524, 525, 526, 527, 528, 529, 531, 532, 533, 534, 535, 536, 537,538, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552,555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 570,571, 572, 573, 574, 575, 576, 577, 578, 580, 581, 582, 583, 584, 585,586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599,600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613,1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 201-210 forthe protein of sequence SEQ ID No. 501; 207-216 for the protein ofsequence SEQ ID No. 530; 201-210 for the protein of sequence SEQ ID No.568; 201-210 for the protein of sequence SEQ ID No. 569; 35-44 for theprotein of sequence SEQ ID No. 1911 SEQ ID QLLQWMVDGR 202-211 for theprotein of SEQ No. 553 2b No. 672 SEQ ID QLLQWMVEDR 202-211 for theprotein of SEQ No. 512 SHV No. 673 SEQ ID QQDLVDYSPVSEK 95-107 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 674 502, 503, 504,505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518,519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532,533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546,547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560,561, 562, 563, 564, 565, 566, 567, 570, 571, 572, 573, 574, 575, 576,577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590,591, 592, 593, 594, 595, 596, 597, 598, 600, 601, 602, 603, 604, 605,606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915,1916, 1917, 1918, 1919, 1920; 94-106 for the protein of sequence SEQ IDNo. 501; 94-106 for the protein of sequence SEQ ID No. 568; 94-106 forthe protein of sequence SEQ ID No. 569 SEQ ID QQHLVDYSPVSEK 95-107 forthe protein of SEQ No. 599 2b No. 675 SEQ ID QSESQLSGR 31-39 for theproteins of SEQ No. 502, 511, 512, 513, 514, SHV No. 676 571, 572, 573,574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601,602, 605, 607, 608, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915,1916, 1920 SEQ ID QSESQLSGSVGM 31-51 for the protein of SEQ No. 603 2bNo. 677 IEMDLASGR SEQ ID SQLQLLQWMVD 199-211 for the proteins of SEQ No.536, 537, 538 2be No. 678 DR SEQ ID SVLPAGWFIADK 219-230 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 679 502, 503, 505,506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519,520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 531, 532, 533, 534,535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,549, 550, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564,565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,581, 582, 583, 584, 585, 586, 587, 588, 589, 591, 592, 593, 594, 595,596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609,610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918,1919, 1920; 224-235 for the protein of sequence SEQ ID No. 530; 218-229for the protein of sequence SEQ ID No. 568; 218-229 for the protein ofsequence SEQ ID No. 569; 52-63 for the protein of sequence SEQ ID No.1911 SEQ ID SVLPAGWFIADR 219-230 for the proteins of SEQ No. 504, 551,590; 218-229 SHV No. 680 for the protein of sequence SEQ ID No. 501 SEQID SVLSAGWFIADK 219-230 for the protein of SEQ No. 552 2b No. 681 SEQ IDTGAAER 231-236 for the proteins of SEQ No. 540, 581, 603 SHV No. 682 SEQID TGAAK 231-235 for the protein of SEQ No. 506 2be No. 683 SEQ IDTGAGER 231-236 for the proteins of SEQ No. 496, 497, 498, 499, 502, SHVNo. 684 504, 507, 511, 512, 513, 514, 516, 518, 519, 520, 521, 524, 525,526, 527, 531, 533, 535, 536, 539, 541, 542, 543, 544, 551, 552, 553,554, 555, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 570, 571,572, 573, 576, 577, 578, 579, 582, 583, 590, 591, 592, 593, 594, 595,596, 597, 598, 599, 600, 601, 604, 605, 607, 608, 609, 610, 611, 612,613, 1910, 1912, 1916, 1917, 1918; 230-235 for the protein of sequenceSEQ ID No. 501; 236-241 for the protein of sequence SEQ ID No. 530 SEQID TGAGK 231-235 for the proteins of SEQ No. 517, 545, 546, 556, 584,SHV No. 685 606 SEQ ID TGASER 64-69 for the proteins of SEQ No. 1911;231-236 for the 2be No. 686 protein of sequence SEQ ID No. 503; 231-236for the protein of sequence SEQ ID No. 508; 231-236 for the protein ofsequence SEQ ID No. 510; 231-236 for the protein of sequence SEQ ID No.522; 231-236 for the protein of sequence SEQ ID No. 532; 231-236 for theprotein of sequence SEQ ID No. 537; 231-236 for the protein of sequenceSEQ ID No. 547; 231-236 for the protein of sequence SEQ ID No. 548;231-236 for the protein of sequence SEQ ID No. 585 SEQ ID TGASK 231-235for the proteins of SEQ No. 500, 505, 509, 515, 523, SHV No. 687 528,529, 534, 538, 549, 550, 557, 574, 575, 586, 587, 588, 602, 1913, 1914,1915, 1919, 1920; 230-234 for the protein of sequence SEQ ID No. 568;230-234 for the protein of sequence SEQ ID No. 569 SEQ ID TGASR 231-235for the protein of SEQ No. 589 SHV No. 688 SEQ ID TLTAWCADER 52-61 forthe protein of SEQ No. 571 SHV No. 689 SEQ ID TLTAWHADER 52-61 for theproteins of SEQ No. 516, 517 2be No. 690 SEQ ID TLTAWR 52-57 for theproteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 691 502, 503, 504,505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 518, 519, 520,521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534,535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562,563, 564, 565, 566, 567, 570, 572, 573, 574, 575, 576, 577, 578, 579,580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593,594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607,608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917,1918, 1919, 1920; 51-56 for the protein of sequence SEQ ID No. 501;51-56 for the protein of sequence SEQ ID No. 568; 51-56 for the proteinof sequence SEQ ID No. 569 SEQ ID TVGGPAGLTAFLR 137-149 for the proteinsof SEQ No. 496, 497, 498, 499, 500, SHV No. 692 502, 503, 505, 506, 507,508, 509, 510, 512, 513, 514, 515, 516, 517, 518, 519, 521, 522, 523,524, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539,540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553,554, 555, 556, 557, 558, 559, 560, 561, 562, 564, 565, 566, 570, 571,573, 574, 575, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,588, 589, 590, 591, 592, 596, 597, 598, 599, 600, 601, 602, 603, 604,605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913, 1914,1915, 1916, 1918, 1919, 1920; 136-148 for the protein of sequence SEQ IDNo. 568; 136-148 for the protein of sequence SEQ ID No. 569 SEQ IDTVVIYLR 254-260 for the protein of SEQ No. 546 SHV No. 693 SEQ IDVAGPLIR 212-218 for the proteins of SEQ No. 496, 497, 498, 499, 500, SHVNo. 694 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514,515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528,529, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543,544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557,558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 570, 571, 572, 573,574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587,588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601,602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912,1913, 1914, 1915, 1916, 1917, 1918, 1919, 1920; 211-217 for the proteinof sequence SEQ ID No. 501; 217-223 for the protein of sequence SEQ IDNo. 530; 211-217 for the protein of sequence SEQ ID No. 568; 211-217 forthe protein of sequence SEQ ID No. 569; 45-51 for the protein ofsequence SEQ ID No. 1911 SEQ ID VALCGAVLAR 70-79 for the protein of SEQNo. 573 2b No. 695 SEQ ID VDAGDEQLER 80-89 for the proteins of SEQ No.496, 497, 498, 499, 500, SHV No. 696 502, 503, 504, 505, 506, 507, 508,509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522,523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536,537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550,551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564,565, 566, 567, 570, 571, 572, 573, 574, 576, 577, 578, 579, 580, 581,582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595,596, 597, 598, 599, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610,611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919,1920; 79-88 for the protein of sequence SEQ ID No. 501; 79-88 for theprotein of sequence SEQ ID No. 568; 79-88 for the protein of sequenceSEQ ID No. 569 SEQ ID VDAGDK 80-85 for the proteins of SEQ No. 575, 600SHV No. 697 SEQ ID VGMIEMDLASGR 40-51 for the proteins of SEQ No. 496,497, 498, 499, 500, SHV No. 698 502, 503, 504, 505, 506, 507, 508, 509,510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523,524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537,538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551,552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565,566, 567, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582,583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596,597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610,611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918, 1919,1920; 39-50 for the protein of sequence SEQ ID No. 501 SEQ IDVGMIEMDLASR 40-50 for the proteins of SEQ No. 568, 569 SHV No. 699 SEQID VGMIEMDLASSR 40-51 for the protein of SEQ No. 570 SHV No. 700 SEQ IDVLLCGAVLAR 70-79 for the protein of SEQ No. 574 SHV No. 701 SEQ IDVVLCGAMLAR 70-79 for the protein of SEQ No. 575 2be No. 702 SEQ IDVVLCGAVLAR 70-79 for the proteins of SEQ No. 496, 497, 498, 499, 500,SHV No. 703 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513,514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527,528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541,542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555,556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 570, 571,572, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588,589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 602, 603,604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 1910, 1912, 1913,1914, 1915, 1916, 1917, 1918, 1919, 1920; 69-78 for the protein ofsequence SEQ ID No. 501; 69-78 for the protein of sequence SEQ ID No.568; 69-78 for the protein of sequence SEQ ID No. 569 SEQ ID VVLCGTVLAR70-79 for the protein of SEQ No. 601 2b No. 704 SEQ ID WETDR 161-165 forthe protein of SEQ No. 530 2be No. 705 SEQ ID WETELNEAFPGD 161-174 forthe proteins of SEQ No. 522, 531, 532 SHV No. 706 AR SEQ ID WETELNEALPAD161-174 for the protein of SEQ No. 526 2b No. 707 AR SEQ ID WETELNEALPGD161-174 for the proteins of SEQ No. 496, 497, 498, 499, 500, SHV No. 708AR 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515,516, 517, 518, 519, 520, 521, 523, 524, 525, 527, 528, 529, 533, 534,535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548,549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 562, 563, 564,565, 566, 567, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580,581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 593, 594, 595,596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609,610, 611, 612, 613, 1910, 1912, 1913, 1914, 1915, 1916, 1917, 1918,1919, 1920; 160-173 for the protein of sequence SEQ ID No. 501; 166-179for the protein of sequence SEQ ID No. 530; 160-173 for the protein ofsequence SEQ ID No. 568; 160-173 for the protein of sequence SEQ ID No.569 SEQ ID WETELNEALSGD 161-174 for the protein of SEQ No. 560 2b No.709 AR SEQ ID WETELNEVLPGD 161-174 for the protein of SEQ No. 592 SHVNo. 710 AR SEQ ID WETER 161-165 for the protein of SEQ No. 561 SHV No.711 SEQ ID EIGDNVTR 150-157 for the proteins of SEQ No. 1915 SHV No.2093 SEQ ID GIVALLGPHNK 240-250 for the proteins of SEQ No. 1917 SHV No.2094 SEQ ID HLADGMTVGELR 108-119 for the proteins of SEQ No. 1914 2beNo. 2095 SEQ ID IHYSQQDLVDYS 91-107 for the proteins of SEQ No. 1918 SHVNo. 2096 PVSEK

In the clinical interest column, the entries 2b, 2br, 2be and 2bercorrespond to the functional subgroups of the SHV beta-lactamases whichthe corresponding peptide makes it possible to detect. Thus, thedetection of a 2be peptide will indicate the presence of abeta-lactamase with an extended spectrum (ESBL) capable of hydrolysingpenicillins, first-generation cephalosporins such as cephaloridine andcefalotin, and at least one antibiotic from the oxyimino-beta-lactamclass such as cefotaxime, ceftazidime or monobactams such as aztreonam.

The entry SHV indicates a common peptide between at least two of thesubgroups 2b, 2br and 2be or 2ber. The corresponding peptide indicatesthe presence of an SHV beta-lactamase and the presence of a mechanism ofresistance at least to penicillins and to first-generationcephalosporins.

The detection of a mechanism of resistance to ESBL (extended-spectrumbeta-lactamase) cephalosporins, induced by the SHV protein, ischaracterised by the detection of at least one resistance-marking 2bepeptide, chosen from the sequences SEQ ID No. 616, SEQ ID No. 617, SEQID No. 627, SEQ ID No. 629, SEQ ID No. 634, SEQ ID No. 647, SEQ ID No.648, SEQ ID No. 653, SEQ ID No. 654, SEQ ID No. 656, SEQ ID No. 660, SEQID No. 661, SEQ ID No. 662, SEQ ID No. 663, SEQ ID No. 664, SEQ ID No.665, SEQ ID No. 670, SEQ ID No. 673, SEQ ID No. 674, SEQ ID No. 675, SEQID No. 678, SEQ ID No. 682, SEQ ID No. 684, SEQ ID No. 685, SEQ ID No.686, SEQ ID No. 687, SEQ ID No. 688, SEQ ID No. 697, SEQ ID No. 702, SEQID No. 703, SEQ ID No. 704, SEQ ID No. 707, SEQ ID No. 708, SEQ ID No.709, SEQ ID No. 711, SEQ ID No. 2095.

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the FOX protein is characterised by the detection ofat least one peptide belonging to the FOX protein and to its differentsequence variants SEQ ID No. 712 to SEQ ID No. 718 and SEQ ID No. 1920to SEQ ID No. 1922.

SEQ ID No. 712: MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 713:MQQRRAFALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMVNYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNAPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 14:MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRVTPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 715:MQQRRALALLTLGSLLLAPCTYASGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEKLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 716:MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 717:MQQRRALALLMLGSLLLAPCTYASGEAPLTATVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRATPGVLAAEAYGIKTGSADLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 718:MQQRRAFALLTLGSLLLAPCTYARGEAPLTAAVDGIIQPMLKEYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAIANYAYGYSKEDKPVRATPGVLAAEAYGIKTGSADLLKFTEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 1920:MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSLQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 1921:MQQRRAFALLTLGSLLLAPCTYASGEAPLTVTVDGIIQPMLKAYRIPGMAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAGGLPLQFPEEVDSNDKMRTYYRSWSPVYPAGTHRQYANTSIGLFGYLAANSLGQSFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEEKPIRVTPGMLAAEAYGIKTGSADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYDYPVTEQVLLADNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE SEQ ID No. 1922:MQQRRAFALLTLGSLLLAPCTYASGEAPLTATVDGIIQPMLKEYRIPGIAVAVLKDGKAHYFNYGVANRESGQRVSEQTLFEIGSVSKTLTATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAGGLPLQFPDKVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLMSQTLLPKLGLHHTYIQVPESAMANYAYGYSKEDKPIRVTPGVLAAEAYGIKTGSADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRNYPIEARVKAAHAILSQLAE

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 719 to SEQ ID No. 733 and SEQ ID No. 2097 to SEQ ID No. 2113as defined hereafter:

Peptide SEQ ID No. Amino acid sequence Position of the peptide in theFOX protein SEQ ID No. AHYFNYGVANR 59-69 for the proteins of SEQ No.712, 713, 719 714, 715, 716, 717, 718, 1920, 1921, 1922 SEQ ID No.AMGEQR 326-331 for the proteins of SEQ No. 712, 713, 720 714, 715, 716,717, 718, 1920, 1921, 1922 SEQ ID No. ESGQR 70-74 for the proteins ofSEQ No. 712, 713, 721 714, 715, 716, 717, 718, 1920, 1921, 1922 SEQ IDNo. FAVPK 321-325 for the proteins of SEQ No. 712, 713, 722 714, 715,716, 717, 718, 1920, 1921, 1922 SEQ ID No. GGFELDDK 102-109 for theproteins of SEQ No. 712, 713, 723 714, 715, 717, 718, 1921 SEQ ID No.GIAIVMLANR 353-362 for the proteins of SEQ No. 712, 713, 724 714, 715,716, 717, 718, 1920, 1921, 1922 SEQ ID No. IPGMAVAVLK 46-55 for theproteins of SEQ No. 712, 713, 725 714, 715, 717, 718, 1921 SEQ ID No.NYPIEAR 363-369 for the proteins of SEQ No. 712, 713, 726 714, 715, 716,717, 718, 1920, 1921, 1922 SEQ ID No. SWSPVYPAGTHR 158-169 for theproteins of SEQ No. 712, 713, 727 715, 716, 717, 1920, 1921, 1922 SEQ IDNo. TGSADLLK 247-254 for the proteins of SEQ No. 712, 713, 728 714, 715,716, 717, 718, 1920, 1921, 1922 SEQ ID No. TGSTGGFGAYVAFVPAR 336-352 forthe proteins of SEQ No. 712, 713, 729 714, 715, 716, 717, 718, 1920,1921, 1922 SEQ ID No. TLTATLGAYAAVK 89-101 for the proteins of SEQ No.712, 713, 730 714, 715, 716, 717, 718, 1920, 1921, 1922 SEQ ID No.VSEQTLFEIGSVSK 75-88 for the proteins of SEQ No. 712, 713, 731 714, 715,716, 717, 718, 1920, 1921, 1922 SEQ ID No. VSQHAPWLK 110-118 for theproteins of SEQ No. 712, 713, 732 714, 716, 717, 718, 1920, 1921, 1922SEQ ID No. VTPGVLAAEAYGIK 233-246 for the proteins of SEQ No. 712, 713,733 714, 715, 716, 1920, 1922 SEQ ID No. AFALLTLGSLLLAPCTYAR 6-24 forthe proteins of SEQ No. 714, 718 2097 SEQ ID No. ATPGVLAAEAYGIK 233-246for the proteins of SEQ No. 717, 718 2098 SEQ ID No. EDKPVR 227-232 forthe proteins of SEQ No. 712, 713, 2099 714, 718 SEQ ID No. EEKPIR227-232 for the proteins of SEQ No. 1921 2100 SEQ ID No. FAEANMGYQGDAAVK255-269 for the proteins of SEQ No. 712, 713, 2101 1921 SEQ ID No.FAEANMGYQGDALVK 255-269 for the proteins of SEQ No. 716, 2102 1920, 1922SEQ ID No. FTEANMGYQGDAALK 255-269 for the proteins of SEQ No. 714, 7182103 SEQ ID No. FVEANMGYQGDAALK 255-269 for the proteins of SEQ No. 715,717 2104 SEQ ID No. GEAPLTAAVDGIIQPMLK 25-42 for the proteins of SEQ No.712, 713, 2105 714, 715, 718 SEQ ID No. GGFVLDDK 102-109 for theproteins of SEQ No. 716, 2106 1920, 1922 SEQ ID No. HWSPVYPAGTHR 158-169for the proteins of SEQ No. 714, 718 2107 SEQ ID No. IPGIAVAVLK 46-55for the proteins of SEQ No. 716, 1920, 2108 1922 SEQ ID No. LMSQTLLPK194-202 for the proteins of SEQ No. 712, 713, 2109 714, 715, 716, 717,718, 1920, 1921, 1922 SEQ ID No. MQTYYR 152-157 for the proteins of SEQNo. 715, 716, 2110 717, 1920, 1922 SEQ ID No. VDSNDK 146-151 for theproteins of SEQ No. 712, 713, 2111 714, 715, 716, 717, 718, 1920, 1921,1922 SEQ ID No. VSHHAPWLK 110-118 for the protein of SEQ No. 715 2112SEQ ID No. VTPGMLAAEAYGIK 233-246 for the proteins of SEQ No. 1921 2113

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the ACC protein is characterised by the detection ofat least one peptide belonging to the ACC protein and to its differentsequence variants SEQ ID No. 736 to SEQ ID No. 739.

SEQ ID No. 736: MRKKMQNTLKLLSVITCLAATAQGAMAANIDESKIKDTVDGLIQPLMQKNNIPGMSVAVTIRGRNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEQTILPLLGMNQTYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDGNAKIQHALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEVNK SEQ ID No. 737:MRKKMQNTLKMLSVITCLALTAQGAMASEMDQAKIKDTVDSLIQPLMQKNNIPGMSVAVTLNGKNYIYNYGLASKQPQQPVTDNTLFEVGSLSKTFAATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEEVKNTDQLMAYLKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAIEKTLLPKLGMTHTYLNVPADQAENYAWGYNKKNEPIHVNMEVLGNEAYGIRTNASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWEQLPYPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVT SEQ ID No. 738:MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHGNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK SEQ ID No. 739:MQNTLKLLSVITCLAATVQGALAANIDESKIKDTVDDLIQPLMQKNNIPGMSVAVTVNGKNYIYNYGLAAKQPQQPVTENTLFEVGSLSKTFAATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQLFMPEDIKNTTQLMAYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAIEKTLLPQLGMHHSYLKVPADQMENYAWGYNKKDEPVHVNMEILGNEAYGIKTTSSDLLRYVQANMGQLKLDANAKMQQALTATHTGYFKSGEITQDLMWEQLPYPVSLPNLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKNYSIDQRVTVAYKILSSLEGNK

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 740 to SEQ ID No. 787 as defined hereafter:

Peptide SEQ ID Position of the peptide in the ACC No. Amino acidsequence protein(s) SEQ ID ALTDTHIGYFK 279-289 for the protein of SEQNo. 737 No. 740 SEQ ID AWKPADAAGTHR 159-170 for the proteins of SEQ No.738, No. 741 739; 163-174 for the protein of sequence SEQ ID No. 736 SEQID AWKPADPAGTHR 163-174 for the protein of SEQ No. 737 No. 742 SEQ IDDEPVHGNMEILGNEAYGIK 229-247 for the protein of SEQ No. 738 No. 743 SEQID DEPVHVNMEILGNEAYGIK 229-247 for the protein of SEQ No. 739; 233-251No. 744 for the protein of sequence SEQ ID No. 736 SEQ ID DTVDDLIQPLMQK33-45 for the proteins of SEQ No. 738, 739 No. 745 SEQ ID DTVDGLIQPLMQK37-49 for the protein of SEQ No. 736 No. 746 SEQ ID DTVDSLIQPLMQK 37-49for the protein of SEQ No. 737 No. 747 SEQ ID IQHALTATHTGYFK 276-289 forthe protein of SEQ No. 736 No. 748 SEQ ID LDANAK 266-271 for theproteins of SEQ No. 738, 739 No. 749 SEQ ID LDGNAK 270-275 for theprotein of SEQ No. 736 No. 750 SEQ ID LDGNSTLQK 270-278 for the proteinof SEQ No. 737 No. 751 SEQ ID LGMTHTYLNVPADQAENYAWGYNK 208-231 for theprotein of SEQ No. 737 No. 752 SEQ ID LLSVITCLAATAQGAMAANIDESK 11-34 forthe protein of SEQ No. 736 No. 753 SEQ ID LLSVITCLAATVQGALAANIDESK 7-30for the proteins of SEQ No. 738, 739 No. 754 SEQ ID LSLDK 110-114 forthe protein of SEQ No. 737 No. 755 SEQ ID LSLDQSVSHYVPELR 106-120 forthe proteins of SEQ No. 738, 739 No. 756 SEQ ID LSLEQSVSHYVPELR 110-124for the protein of SEQ No. 736 No. 757 SEQ ID MGIVMLANK 356-364 for theproteins of SEQ No. 738, No. 758 739; 360-368 for the proteins ofsequence SEQ ID No. 736, 737 SEQ ID MLSVITCLALTAQGAMASEMDQAK 11-34 forthe protein of SEQ No. 737 No. 759 SEQ ID MQNTLK 1-6 for the proteins ofSEQ No. 738, 739; 5-10 No. 760 10 for the proteins of sequence SEQ IDNo. 736, 737 SEQ ID MQQALTATHTGYFK 272-285 for the proteins of SEQ No.738, 739 No. 761 SEQ ID NEPIHVNMEVLGNEAYGIR 233-251 for the protein ofSEQ No. 737 No. 762 SEQ ID NNIPGMSVAVTIR 50-62 for the protein of SEQNo. 736 No. 763 SEQ ID NNIPGMSVAVTLNGK 50-64 for the protein of SEQ No.737 No. 764 SEQ ID NNIPGMSVAVTVNGK 46-60 for the proteins of SEQ No.738, 739 No. 765 SEQ ID NTDQLMAYLK 153-162 for the protein of SEQ No.737 No. 766 SEQ ID NTTQLMAYLK 149-158 for the proteins of SEQ No. 738,739 No. 767 SEQ ID NTTQLMTYLK 153-162 for the protein of SEQ No. 736 No.768 SEQ ID NYIYNYGLAAK 61-71 for the proteins of SEQ No. 738, 739; No.769 65-75 for the protein of sequence SEQ ID No. 736 SEQ ID NYIYNYGLASK65-75 for the protein of SEQ No. 737 No. 770 SEQ ID NYSIDQR 365-371 forthe proteins of SEQ No. 738, No. 771 739; 369-375 for the protein ofsequence SEQ ID No. 736, 737 SEQ ID QPQQPVTDNTLFEVGSLSK 76-94 for theprotein of SEQ No. 737 No. 772 SEQ ID QPQQPVTENTLFEVGSLSK 72-90 for theproteins of SEQ No. 738, 739; No. 773 76-94 for the protein of sequenceSEQ ID No. 736 SEQ ID SISHYVPELR 115-124 for the protein of SEQ No. 737No. 774 SEQ ID SLGVSYEDAIEK 187-198 for the proteins of SEQ No. 738, 739No. 775 SEQ ID SVATPIVPPLPPQENVWINK 318-337 for the proteins of SEQ No.738, No. 776 739; 322-341 for the protein of sequence SEQ ID No. 736,737 SEQ ID TFAAILASYAQASGK 95-109 for the protein of SEQ No. 736 No. 777SEQ ID TFAATLASYAQVSGK 91-105 for the proteins of SEQ No. 738, 739; No.778 95-109 for the protein of sequence SEQ ID No. 737 SEQ IDTGSTNGFGAYIAFVPAK 338-354 for the proteins of SEQ No. 738, No. 779 739;342-358 for the protein of sequence SEQ ID No. 736, 737 SEQ ID TLLPK203-207 for the protein of SEQ No. 737 No. 780 SEQ ID TLLPQLGMHHSYLK199-212 for the proteins of SEQ No. 738, 739 No. 781 SEQ ID TNASDLIR252-259 for the protein of SEQ No. 737 No. 782 SEQ ID TTSSDLLR 248-255for the proteins of SEQ No. 738, No. 783 739; 252-259 for the protein ofsequence SEQ ID No. 736 SEQ ID VPADQMENYAWGYNK 213-227 for the proteinsof SEQ No. 738, No. 784 739; 217-231 for the protein of sequence SEQ IDNo. 736 SEQ ID VTVAYK 372-377 for the proteins of SEQ No. 738, No. 785739; 376-381 for the protein of sequence SEQ ID No. 736 SEQ IDVYSNIGTGLLGMIAAK 171-186 for the proteins of SEQ No. 738, No. 786 739;175-190 for the protein of sequence SEQ ID No. 736 SEQ ID YVQANMGQLK256-265 for the proteins of SEQ No. 738, No. 787 739; 260-269 for theprotein of sequence SEQ ID No. 736, 737

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the ACT protein is characterised by the detection ofat least one peptide belonging to the ACT protein and to its differentsequence variants SEQ ID No. 788 to SEQ ID No. 794.

SEQ ID No. 788: MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL SEQ ID No. 789:MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAIHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL SEQ ID No. 790:MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVADNASLLRFYQNWQPQWKPGTTRLYANTSIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL SEQ ID No. 791:MMTKSLCCALLLSTSCSVLAAPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVKDMANWVMVNMKPDSLQDSSLKEGITLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ SEQ ID No. 792:MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ SEQ ID No. 793:MMKKSLCCALLLGISCSALAAPVSEKQLAEVVANTVTPLMKAQSIPGMAVAVIYQGKPHYYTFGKADIAASKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPFEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGMKTNVQDMANWVMANMAPENVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKSYPNPARVEAAYPILDALQ SEQ ID No. 794:MMMTKSLCCALLLSTSCSVLATPMSEKQLAEVVERTVTPLMKAQAIPGMAVAVIYEGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAITTRVFKPLKLDHTWINVPKAEEAHYAWGYRDGKAVHVSPGMLDAEAYGVKTNVQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEGSDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILSAL

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 795 to SEQ ID No. 841 as defined hereafter:

Peptide SEQ ID Position of the peptide in the ACT No. Amino acidsequence protein(s) SEQ ID ADIAANK 66-72 for the protein of SEQ No. 792No. 795 SEQ ID ADIAASK 66-72 for the protein of SEQ No. 793 No. 796 SEQID ADVAANK 67-73 for the proteins of SEQ No. 788, No. 797 789, 794;66-72 for the protein of sequence SEQ ID No. 790, 791 SEQ ID AEEAHYAWGYR215-225 for the proteins of SEQ No. 788, No. 798 789, 794; 214-224 forthe proteins of sequence SEQ ID No. 790, 791, 792, 793 SEQ IDAIHVSPGMLDAEAYGVK 229-245 for the protein of SEQ No. 789 No. 799 SEQ IDAQSIPGMAVAVIYQGK 42-57 for the protein of SEQ No. 793 No. 800 SEQ IDAQSVPGMAVAVIYQGK 42-57 for the protein of SEQ No. 792 No. 801 SEQ IDAVHVSPGMLDAEAYGVK 229-245 for the proteins of SEQ No. 788, No. 802 794;228-244 for the proteins of sequence SEQ ID No. 790, 791 SEQ IDDMANWVMVNMK 249-259 for the protein of SEQ No. 791 No. 803 SEQ IDDMANWVMVNMKPDSLQDSSLK 249-269 for the protein of SEQ No. 791 No. 804 SEQID DNASLLR 148-154 for the proteins of SEQ No. 788, No. 805 789, 794;147-153 for the proteins of sequence SEQ ID No. 790, 791, 792 SEQ IDEGITLAQSR 270-278 for the protein of SEQ No. 791 No. 806 SEQ IDEVNPPAPPVNASWVHK 321-336 for the proteins of SEQ No. 788, No. 807 789,794; 320-335 for the proteins of sequence SEQ ID No. 790, 791 SEQ IDFYQNWQPQWK 155-164 for the proteins of SEQ No. 788, No. 808 789, 794;154-163 for the proteins of sequence SEQ ID No. 790, 791, 792, 793 SEQID FYQNWQPQWKPGTTR 155-169 for the proteins of SEQ No. 788, No. 809 789,794; 154-168 for the proteins of sequence SEQ ID No. 790, 791, 792, 793SEQ ID GEISLDDPVTR 101-111 for the proteins of SEQ No. 792, No. 810 793SEQ ID GEISLGDPVTK 102-112 for the proteins of SEQ No. 788, No. 811 789,794; 101-111 for the proteins of sequence SEQ ID No. 790, 791 SEQ IDGLTLAQSR 272-279 for the proteins of SEQ No. 788, No. 812 789, 794 SEQID LDHTWINVPK 205-214 for the proteins of SEQ No. 788, No. 813 789, 794;204-213 the proteins of sequence SEQ ID No. 791, 792, 793 SEQ IDLYANASIGLFGALAVK 170-185 for the proteins of SEQ No. 788, No. 814 789,794; 169-184 for the proteins of sequence SEQ ID No. 791, 792, 793 SEQID LYANTSIGLFGALAVK 169-184 for the protein of SEQ No. 790 No. 815 SEQID MLDLATYTAGGLPLQVPDEVK 127-147 for the protein of SEQ No. 788 No. 816SEQ ID QGIALAQSR 270-278 for the proteins of SEQ No. 790, No. 817 792SEQ ID QGISLAQSR 270-278 for the protein of SEQ No. 793 No. 818 SEQ IDQIGIVMLANK 353-362 for the protein of SEQ No. 793 No. 819 SEQ IDQIGIVMLANTSYPNPAR 353-369 for the protein of SEQ No. 792 No. 820 SEQ IDQLAEVVANTVTPLMK 27-41 for the proteins of SEQ No. 792, No. 821 793 SEQID QLAEVVER 28-35 for the proteins of SEQ No. 788, No. 822 789, 794;27-34 for the proteins of sequence SEQ ID No. 790, 791 SEQ ID QLGIVMLANK354-363 for the proteins of SEQ No. 788, No. 823 789, 794; 353-362 forthe proteins of sequence SEQ ID No. 790, 791 SEQ ID SYPNPAR 364-370 forthe proteins of SEQ No. 788, No. 824 789, 794; 363-369 for the proteinsof sequence SEQ ID No. 790, 791, 792, 793 SEQ ID TFTGVLGGDAIAR 89-101for the proteins of SEQ No. 788, No. 825 789, 794; 88-100 for theproteins of sequence SEQ ID No. 790, 791, 792, 793 SEQ IDTGSTGGFGSYVAFIPEK 337-353 for the proteins of SEQ No. 788, No. 826 789,794; 336-352 for the proteins of sequence SEQ ID No. 790, 791, 792, 793SEQ ID TNVQDMASWVMVNMK 246-260 for the proteins of SEQ No. 788, No. 827789, 794; 245-259 for the protein of sequence SEQ ID No. 790 SEQ IDTVTPLMK 36-42 for the proteins of SEQ No. 788, No. 828 789, 794; 35-41for the proteins of sequence SEQ ID No. 790, 791, 792, 793 SEQ IDTVVEGSDNK 303-311 for the proteins of SEQ No. 788, No. 829 789, 794;302-310 for the proteins of sequence SEQ ID No. 790, 791 SEQ IDVALAPLPAR 312-320 for the proteins of SEQ No. 788, No. 830 789, 794;311-319 for the proteins of sequence SEQ ID No. 790, 791 SEQ IDVALAPLPVAEVNPPAPPVK 311-329 for the proteins of SEQ No. 792, No. 831 793SEQ ID VEAAYR 371-376 for the proteins of SEQ No. 788, No. 832 789, 794;370-375 for the proteins of sequence SEQ ID No. 790, 791 SEQ ID VFKPLK199-204 for the proteins of SEQ No. 788, No. 833 789, 794; 198-203 forthe proteins of sequence SEQ ID No. 790, 791 SEQ ID VGAMYQGLGWEMLNWPVDAK283-302 for the proteins of SEQ No. 788, No. 834 789, 794; 282-301 forthe proteins of sequence SEQ ID No. 790, 791 SEQ ID VLKPLK 198-203 forthe proteins of SEQ No. 792, No. 835 793 SEQ ID VSPGMLDAQAYGMK 231-244for the protein of SEQ No. 793 No. 836 SEQ ID VSPGMLDAQAYGVK 231-244 forthe protein of SEQ No. 792 No. 837 SEQ ID YWPQLTGK 112-119 for theproteins of SEQ No. 792, No. 838 793 SEQ ID ASWVHK 331-336 for theproteins of SEQ No. 788, No. 839 789, 794; 330-335 for the proteins ofsequence SEQ ID No. 790, 791, 792, 793 SEQ ID QWQGIR 121-126 for theproteins of SEQ No. 788, No. 840 789, 794; 120-125 for the proteins ofsequence SEQ ID No. 790, 791, 792, 793 SEQ ID YWPELTGK 113-120 for theproteins of SEQ No. 788, No. 841 789, 794; 112-119 for the proteins ofsequence SEQ ID No. 790, 791

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the CARB protein is characterised by the detection ofat least one peptide belonging to the CARB protein and to its differentsequence variants SEQ ID No. 842 to SEQ ID No. 852.

SEQ ID No. 842: MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYT SQSR SEQ ID No. 843:MLLYKMCDNQNYGVTYMKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKLLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYT SQSR SEQ ID No. 844:MKLLLVFSLLIPSMVFANSSKFQQVEQDAKVIEASLSAHIGISVLDTQTGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGEINPKSTIEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNAAANIILNALGGPESVTDFLRQIGDKETRLDRIEPELNEGKLGDLRDTTTPNAIVNTLNELLFGSTLSQDGQKKLEYWMVNNQVTGNLLRSVLPEGWNIADRSGAGGFGARSITAVVWSEAQSPIIVSIYLAQTEASIADRNDAIVKIGRSIFEVYSSQSR SEQ ID No. 845:MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTEKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNQLLFGSTLSEASQKKLESWMVNNQVTGNLLRSVLPVKWSIADRSGAGGFGARSITAIVWSEEKKTIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR SEQ ID No. 846:MNVRKHKASFFSVVITFLCLTLSLNANATDSVLEAVTNAETELGARIGLAVHDLETGKRWEHKSNERFPLSSTFKTLACANVLQRVDLGKERIDRVVRFSESNLVTYSPVTEKHVGKKGMSLAELCQATLSTSDNSAANFILQAIGGPKALTKFLRSIGDDTTRLDRWETELNEAVPGDKRDTTTPIAMVTTLEKLLIDETLSIKSRQQLESWLKGNEVGDALFRKGVPSDWIVADRTGAGGYGSRAITAVMWPPNRKPIVAALYITETDASFEERNAVIAKIGEQIAKTVLMENSRN SEQ ID No. 847:MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNSNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGHSIFDVYTSQSR SEQ ID No. 848:MKFLLAFSLLIPSVVFASSSKFQQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGPKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNQKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMEERNDAIVKIGHSIFDVYTSQSR SEQ ID No. 849:MKSLLVFALLMPSVVFASSSKFQSVEQEIKGIESSLSARIGVAILDTQNGESWDYNGDQRFPLTSTFKTIACAKLLYDAEHGKVNLNSTVEIKKADLVTYSPVLEKQVGKPITLSDACLATMTTSDNTAANIVINAVGDPKSITDFLRQIGDKETRLDRVEPELNEGKLGDLRDTTTPNAITSTLNQLLFGSTLSEASQKKLESWMVNNQVTGNLLRSVLPVKWSIADRSGAGGFGARSITAIVWSEEKKPIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR SEQ ID No. 850:MDVRKHKASFFSWITFLCLTLSLNANATDSVLEAVTNAETELGARIGLAVHDLETGKRWEHKSNERFPLSSTFKTLACANVLQRVDLGKERIDRVVRFSESNLVTYSPVTEKHVGKKGMSLAELCQATLSTSDNSAANFILQAIGGPKALTKFLRSIGDDTTRLDRWETELNEAVPGDKRDTTTPIAMVTTLEKLLIDETLSIKSRQQLESWLKGNEVGDALFRKGVPSDWIVADRTGAGGYGSRAITAVMWPPNRKPIVAALYITETDASFEERNAVIAKIGEQIAKTILMENSRN SEQ ID No. 851:MKSLLVFALLMPSVVFASSSKFQSVEQEIKGIESSLSARIGVAILDTQNGESWDYNGDQRFPLTSTFKTIACAKLLYDAEHGKVNLNSTVEVKKADLVTYSPVLEKQVGKPITLSDACFATMTTSDNTAANIVINAVGDPKSITDFLRQIGDKETRLDRVEPELNEGKLGDLRDTTTPNAITSTLNQLLFGSTLSEASQKKLESWMVNNQVTGNLLRSVLPVTWSIADRSGAGGFGARSITAIVWSEEKKPIIVSIYLAQTEASMAERNDAIVKIGRSIFEVYTSQSR SEQ ID No. 852:MKFLLVFSLLIPSVVFASSSKFRQVEQDVKAIEVSLSARIGVSVLDTQNGEYWDYNGNQRFPLTSTFKTIACAKLLYDAEQGKVNPNSTVEIKKADLVTYSPVIEKQVGQAITLDDACFATMTTSDNTAANIILSAVGGSKGVTDFLRQIGDKETRLDRIEPDLNEGKLGDLRDTTTPKAIASTLNKFLFGSALSEMNKKKLESWMVNNQVTGNLLRSVLPAGWNIADRSGAGGFGARSITAVVWSEHQAPIIVSIYLAQTQASMAERNDAIVKIGRSIFDVYTSQSR

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 853 to SEQ ID No. 921 as defined hereafter:

Peptide SEQ ID Position of the peptide in the CARB No. Amino acidsequence protein(s) SEQ ID ADLVTYSPVIEK 95-106 for the proteins of SEQNo. 844, No. 853 845, 847, 848, 852; 111-122 for the protein of sequenceSEQ ID No. 842; 111-122 for the protein of sequence SEQ ID No. 843 SEQID ADLVTYSPVLEK 95-106 for the proteins of SEQ No. 849, No. 854 851 SEQID AIASTLNK 180-187 for the proteins of SEQ No. 847, No. 855 848, 852;196-203 for the protein of sequence SEQ ID No. 842; 196-203 for theprotein of sequence SEQ ID No. 843 SEQ ID AIASTLNQLLFGSTLSEASQK 180-200for the protein of SEQ No. 845 No. 856 SEQ ID AIEVSLSAR 31-39 for theproteins of SEQ No. 845, 847, No. 857 848, 852; 47-55 for the protein ofsequence SEQ ID No. 842; 47-55 for the protein of sequence SEQ ID No.843 SEQ ID AITAVMWPPNR 247-257 for the proteins of SEQ No. 846, No. 858850 SEQ ID DTTTPIAMVTTLEK 182-195 for the proteins of SEQ No. 846, No.859 850 SEQ ID DTTTPK 174-179 for the proteins of SEQ No. 845, No. 860847, 848, 852; 190-195 for the protein of sequence SEQ ID No. 842;190-195 for the protein of sequence SEQ ID No. 843 SEQ ID FLFGSALSEMNK188-199 for the protein of SEQ No. 852 No. 861 SEQ ID FLFGSALSEMNQK188-200 for the proteins of SEQ No. 847, No. 862 848; 204-216 for theprotein of sequence SEQ ID No. 842 SEQ ID FLLAFSLLIPSVVFASSSK 3-21 forthe proteins of SEQ No. 845, 847, No. 863 848; 19-37 for the protein ofsequence SEQ ID No. 842; 19-37 for the protein of sequence SEQ ID No.843 SEQ ID FLLVFSLLIPSVVFASSSK 3-21 for the protein of SEQ No. 852 No.864 SEQ ID FPLSSTFK 68-75 for the proteins of SEQ No. 846, 850 No. 865SEQ ID FPLTSTFK 61-68 for the proteins of SEQ No. 844, 845, No. 866 847,848, 849, 851, 852; 77-84 for the protein of sequence SEQ ID No. 842;77-84 for the protein of sequence SEQ ID No. 843 SEQ ID FQQVEQDAK 22-30for the protein of SEQ No. 844 No. 867 SEQ ID FQQVEQDAK 22-30 for theproteins of SEQ No. 845, 847, No. 868 848; 38-46 for the protein ofsequence SEQ ID No. 842; 38-46 for the protein of sequence SEQ ID No.843 SEQ ID FQSVEQEIK 22-30 for the proteins of SEQ No. 849, 851 No. 869SEQ ID FSESNLVTYSPVTEK 99-113 for the proteins of SEQ No. 846, No. 870850 SEQ ID GIESSLSAR 31-39 for the proteins of SEQ No. 849, 851 No. 871SEQ ID GNEVGDALFR 216-225 for the proteins of SEQ No. 846, No. 872 850SEQ ID GVPSDWIVADR 227-237 for the proteins of SEQ No. 846, No. 873 850SEQ ID GVTDFLR 142-148 for the proteins of SEQ No. 845, No. 874 847,848, 852; 158-164 for the protein of sequence SEQ ID No. 842; 158-164for the protein of sequence SEQ ID No. 843 SEQ ID IEPDLNEGK 160-168 forthe proteins of SEQ No. 845, No. 875 847, 848, 852; 176-184 for theprotein of sequence SEQ ID No. 842; 176-184 for the protein of sequenceSEQ ID No. 843 SEQ ID IEPELNEGK 160-168 for the protein of SEQ No. 844No. 876 SEQ ID IGEQIAK 283-289 for the proteins of SEQ No. 846, No. 877850 SEQ ID IGLAVHDLETGK 47-58 for the proteins of SEQ No. 846, 850 No.878 SEQ ID IGVAILDTQNGESWDYNGDQR 40-60 for the proteins of SEQ No. 849,851 No. 879 SEQ ID IGVSVLDTQNGEYWDYNGNQR 40-60 for the proteins of SEQNo. 845, 847, No. 880 848, 852; 56-76 for the protein of sequence SEQ IDNo. 842; 56-76 for the protein of sequence SEQ ID No. 843 SEQ IDKPIIVSIYLAQTEASMAER 250-268 for the proteins of SEQ No. 849, No. 881 851SEQ ID KPIVAALYITETDASFEER 258-276 for the proteins of SEQ No. 846, No.882 850 SEQ ID LESWMVNNQVTGNLLR 202-217 for the proteins of SEQ No. 845,No. 883 847, 848, 849, 851, 852; 218-233 for the protein of sequence SEQID No. 842; 218-233 for the protein of sequence SEQ ID No. 843 SEQ IDLEYWMVNNQVTGNLLR 202-217 for the protein of SEQ No. 844 No. 884 SEQ IDLGDLR 169-173 for the proteins of SEQ No. 844, No. 885 845, 847, 848,849, 851, 852; 185-189 for the protein of sequence SEQ ID No. 842;185-189 for the protein of sequence SEQ ID No. 843 SEQ ID LLFGSALSEMNQK204-216 for the protein of SEQ No. 843 No. 886 SEQ ID LLIDETLSIK 196-205for the proteins of SEQ No. 846, No. 887 850 SEQ ID LLLVFSLLIPSMVFANSSK3-21 for the protein of SEQ No. 844 No. 888 SEQ ID LLYDAEHGK 75-83 forthe proteins of SEQ No. 849, 851 No. 889 SEQ ID LLYDAEQGEINPK 75-87 forthe protein of SEQ No. 844 No. 890 SEQ ID LLYDAEQGK 75-83 for theproteins of SEQ No. 845, 847, No. 891 848, 852; 91-99 for the protein ofsequence SEQ ID No. 842; 91-99 for the protein of sequence SEQ ID No.843 SEQ ID MCDNQNYGVTYMK 6-18 for the proteins of SEQ No. 842, 843 No.892 SEQ ID NAVIAK 277-282 for the proteins of SEQ No. 846, No. 893 850SEQ ID NDAIVK 269-274 for the proteins of SEQ No. 844, No. 894 845, 847,848, 849, 851, 852; 285-290 for the protein of sequence SEQ ID No. 842;285-290 for the protein of sequence SEQ ID No. 843 SEQ ID QIGDK 149-153for the proteins of SEQ No. 844, No. 895 845, 847, 848, 849, 851, 852;165-169 for the protein of sequence SEQ ID No. 842; 165-169 for theprotein of sequence SEQ ID No. 843 SEQ ID QQLESWLK 208-215 for theproteins of SEQ No. 846, No. 896 850 SEQ ID QVEQDVK 24-30 for theproteins of SEQ No. 845, 847, No. 897 848, 852; 40-46 for the protein ofsequence SEQ ID No. 842; 40-46 for the protein of sequence SEQ ID No.843 SEQ ID SGAGGFGAR 230-238 for the proteins of SEQ No. 844, No. 898845, 847, 848, 849, 851, 852; 246-254 for the protein of sequence SEQ IDNo. 842; 246-254 for the protein of sequence SEQ ID No. 843 SEQ IDSIGDDTTR 157-164 for the proteins of SEQ No. 846, No. 899 850 SEQ IDSITAIVWSEEK 239-249 for the proteins of SEQ No. 845, No. 900 849, 851SEQ ID SITDFLR 142-148 for the proteins of SEQ No. 849, No. 901 851 SEQID SLLVFALLMPSVVFASSSK 3-21 for the proteins of SEQ No. 849, 851 No. 902SEQ ID STIEIK 88-93 for the protein of SEQ No. 844 No. 903 SEQ IDSVLPAGWNIADR 218-229 for the proteins of SEQ No. 847, No. 904 848, 852;234-245 for the protein of sequence SEQ ID No. 842; 234-245 for theprotein of sequence SEQ ID No. 843 SEQ ID SVLPEGWNIADR 218-229 for theprotein of SEQ No. 844 No. 905 SEQ ID SVLPVK 218-223 for the proteins ofSEQ No. 845, No. 906 849 SEQ ID SVLPVTWSIADR 218-229 for the protein ofSEQ No. 851 No. 907 SEQ ID TGAGGYGSR 238-246 for the proteins of SEQ No.846, No. 908 850 SEQ ID TIACAK 69-74 for the proteins of SEQ No. 844,845, No. 909 847, 848, 849, 851, 852; 85-90 for the protein of sequenceSEQ ID No. 842; 85-90 for the protein of sequence SEQ ID No. 843 SEQ IDTIIVSIYLAQTEASMAER 251-268 for the protein of SEQ No. 845 No. 910 SEQ IDTILMENSR 290-297 for the protein of SEQ No. 850 No. 911 SEQ IDTLACANVLQR 76-85 for the proteins of SEQ No. 846, 850 No. 912 SEQ IDTVLMENSR 290-297 for the protein of SEQ No. 846 No. 913 SEQ ID VDLGK86-90 for the proteins of SEQ No. 846, 850 No. 914 SEQ ID VEPELNEGK160-168 for the proteins of SEQ No. 849, No. 915 851 SEQ ID VNLNSTVEIK84-93 for the protein of SEQ No. 849 No. 916 SEQ ID VNLNSTVEVK 84-93 forthe protein of SEQ No. 851 No. 917 SEQ ID VNPNSTVEIK 84-93 for theproteins of SEQ No. 845, 848, No. 918 852; 100-109 for the protein ofsequence SEQ ID No. 842; 100-109 for the protein of sequence SEQ ID No.843 SEQ ID VNSNSTVEIK 84-93 for the protein of SEQ No. 847 No. 919 SEQID WETELNEAVPGDK 168-180 for the proteins of SEQ No. 846, No. 920 850SEQ ID WSIADR 224-229 for the proteins of SEQ No. 845, No. 921 849, 851

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the DHA protein is characterised by the detection ofat least one peptide belonging to the DHA protein and to its differentsequence variants SEQ ID No. 922 to SEQ ID No. 927.

SEQ ID No. 922: MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDAVKNRAELLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE SEQ ID No. 923:MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPDSAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNIEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE SEQ ID No. 924:MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGSGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE SEQ ID No. 925:MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSTSKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE SEQ ID No. 926:MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGRPYYFNYGFADVQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE SEQ ID No. 927:MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIPGMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGYKNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 928 to SEQ ID No. 948 as defined hereafter:

Peptide SEQ ID No. Amino acid sequence Position of the peptide in theDHA protein(s) SEQ ID ADLLHFYQQWQPSR 148-161 for the protein of SEQ No.926 No. 928 SEQ ID ADLLNFYQQWQPSR 148-161 for the proteins of SEQ No.923, 924, No. 929 925, 927 SEQ ID AELLHFYQQWQPSR 148-161 for the proteinof SEQ No. 922 No. 930 SEQ ID AGNADLEMAMYLAQTR 262-277 for the proteinsof SEQ No. 922, 923, No. 931 924, 925, 926, 927 SEQ ID EMALNDPAAK101-110 for the proteins of SEQ No. 923, 924, No. 932 925, 926, 927 SEQID EMMLNDPAEK 101-110 for the protein of SEQ No. 922 No. 933 SEQ IDGKPYYFNYGFADIQAK 55-70 for the proteins of SEQ No. 923, 924, No. 934925, 927 SEQ ID GKPYYFNYGFADVQAK 55-70 for the protein of SEQ No. 922No. 935 SEQ ID KPGDMR 162-167 for the proteins of SEQ No. 922, 923, No.936 924, 925, 926, 927 SEQ ID NYPNTER 361-367 for the proteins of SEQNo. 922, 923, No. 937 924, 925, 926, 927 SEQ ID QPVTENTLFELGSVSK 71-86for the proteins of SEQ No. 922, 923, No. 938 924, 925, 926, 927 SEQ IDQVAIVILANK 351-360 for the proteins of SEQ No. 922, 923, No. 939 924,925, 926, 927 SEQ ID TAAINQGLGWEMYDWPQQK 281-299 for the proteins of SEQNo. 922, 923, No. 940 924, 925, 926, 927 SEQ ID TFTGVLGAVSVAK 87-99 forthe proteins of SEQ No. 922, 923, No. 941 924, 925, 926, 927 SEQ IDTGATTGFGAYVAFIPEK 334-350 for the proteins of SEQ No. 922, 923, No. 942925, 926, 927 SEQ ID TGATTGSGAYVAFIPEK 334-350 for the protein of SEQNo. 924 No. 943 SEQ ID VSPGQLDAESYGVK 230-243 for the proteins of SEQNo. 922, 923, No. 944 924, 925, 926, 927 SEQ ID WAEMNIEPSR 252-261 forthe protein of SEQ No. 923 No. 945 SEQ ID WAEMNMEPSR 252-261 for theproteins of SEQ No. 922, 924, No. 946 925, 926, 927 SEQ ID YQPELALPQWK111-121 for the proteins of SEQ No. 922, 923, No. 947 924, 925, 926, 927SEQ ID ASWVHK 328-333 for the proteins of SEQ No. 922, 923, No. 948 924,925, 926, 927

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the MIR protein is characterised by the detection ofat least one peptide belonging to the MIR protein and to its differentsequence variants SEQ ID No. 949 to SEQ ID No. 953.

SEQ ID No. 949: MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHFAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ SEQ ID No. 950:MMTKSLSCALLLSVASAAFAAPMSETQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWVIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYHILDALQ SEQ ID No. 951:MMTKSLSCALLLSVASAAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ SEQ ID No. 952:MMTKSLSCALLLSVASAAFAAPMFEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLHAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ SEQ ID No. 953:MMTKSLSCALLLSVASSAFAAPMSEKQLAEVVERTVTPLMNAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYEQAMTTRVFKPLKLDHTWINVPKAEEAHYAWGYREGKAVHVSPGMLDAEAYGVKTNVKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKSYPNPARVEAAYRILDALQ

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 954 to SEQ ID No. 981 as defined hereafter:

Peptide SEQ ID Position of the peptide in the MIR No. Amino acidsequence protein(s) SEQ ID AEEAHFAWGYR 214-224 for the protein of SEQNo. 949 No. 954 SEQ ID DMASWLIANMK 249-259 for the proteins of SEQ No.949, No. 955 951, 952, 953 SEQ ID DMASWLIANMKPDSLHAPSLK 249-269 for theproteins of SEQ No. 951, 952 No. 956 SEQ ID DMASWLIANMKPDSLQAPSLK249-269 for the proteins of SEQ No. 949, 953 No. 957 SEQ ID DMASWVIANMK249-259 for the protein of SEQ No. 950 No. 958 SEQ IDDMASWVIANMKPDSLQAPSLK 249-269 for the protein of SEQ No. 950 No. 959 SEQID GEIALGDPVAK 101-111 for the proteins of SEQ No. 949, No. 960 950,951, 952, 953 SEQ ID TVVGGSDNK 302-310 for the proteins of SEQ No. 949,No. 961 950, 951, 952, 953 SEQ ID ADVAANK 66-72 for the proteins of SEQNo. 949, 950, No. 962 951, 952, 953 SEQ ID AEEAHYAWGYR 214-224 for theproteins of SEQ No. 950, No. 963 951, 952, 953 SEQ ID AVHVSPGMLDAEAYGVK228-244 for the proteins of SEQ No. 949, No. 964 950, 951, 952, 953 SEQID FYQNWQPQWK 154-163 for the proteins of SEQ No. 949, No. 965 950, 951,952, 953 SEQ ID FYQNWQPQWKPGTTR 154-168 for the proteins of SEQ No. 949,No. 966 950, 951, 952, 953 SEQ ID LDHTWINVPK 204-213 for the proteins ofSEQ No. 949, No. 967 950, 951, 952, 953 SEQ ID LYANASIGLFGALAVK 169-184for the proteins of SEQ No. 949, No. 968 950, 951, 952, 953 SEQ IDQGIALAQSR 270-278 for the proteins of SEQ No. 949, No. 969 950, 951,952, 953 SEQ ID QLAEVVER 27-34 for the proteins of SEQ No. 949, 950, No.970 951, 952, 953 SEQ ID QLGIVMLANK 353-362 for the proteins of SEQ No.949, No. 971 950, 951, 952, 953 SEQ ID SYPNPAR 363-369 for the proteinsof SEQ No. 949, No. 972 950, 951, 952, 953 SEQ ID TFTGVLGGDAIAR 88-100for the proteins of SEQ No. 949, 950, No. 973 951, 952, 953 SEQ IDTGSTGGFGSYVAFIPEK 336-352 for the proteins of SEQ No. 949, No. 974 950,951, 952, 953 SEQ ID VALAPLPVAEVNPPAPPVK 311-329 for the proteins of SEQNo. 949, No. 975 950, 951, 952, 953 SEQ ID VEAAYR 370-375 for theproteins of SEQ No. 949, No. 976 951, 952, 953 SEQ ID VFKPLK 198-203 forthe proteins of SEQ No. 949, No. 977 950, 951, 952, 953 SEQ IDVGAMYQGLGWEMLNWPVDAK 282-301 for the proteins of SEQ No. 949, No. 978950, 951, 952, 953 SEQ ID ASWVHK 330-335 for the proteins of SEQ No.949, No. 979 950, 951, 952, 953 SEQ ID QWQGIR 120-125 for the proteinsof SEQ No. 949, No. 980 950, 951, 952, 953 SEQ ID YWPELTGK 112-119 forthe proteins of SEQ No. 949, No. 981 950, 951, 952, 953

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the MOX protein is characterised by the detection ofat least one peptide belonging to the MOX protein and to its differentsequence variants SEQ ID No. 982 to SEQ ID No. 988.

SEQ ID No. 982: MQQRQSILWGAVATLMWAGLAHAGETSPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWERYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR SEQ ID No. 983:MQQRQSILWGALATLMWAGLAHAGDTSAVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAEVILEANPTAAPRESGNLMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR SEQ ID No. 984:MQQRQSILWGALATLMWAGLAHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGGFELDDKASLFAPWLKGSAFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSRGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLNVPEQPMGHYAYGYWKEDKPFRVTPAMLAEEPYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYPYPVSEQTLLAGNSPAMIYNANPAAPAPAAAGHPVLFKKTGSTNGFGAYVAFVPAKGIGVVMLANRNYPNEGTLKAGHAILTQLAR SEQ ID No. 985:MQQRQSILWGVLPTLMWAGLAHAGDRAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTILPGLGLYHTYLNVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANISGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSAAMIYNANPAAPAPAARGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEGTLKAGHAILTQLAR SEQ ID No. 986:MQQRQSILWGALATLMWAGLVHAGDKAATDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKTLTATLGAYAVVQGSFELDDKASLFAPWLKGSVFDNITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYANPSIGLFGYLAASSMKQPFDRLMEQTMLPGLGLYHTYLTVPEQAMGHYAYGYSKEDKPIRVTPGMLADEAYGIKTSSADLLRFVKANIGGVDNAAMQQAIDLTHQGQYAVGEMTQGLGWERYAYPVSEQTLLAGNSPAMIYNAIPAVPAPAAAGHPVLFNKTGSTNGFGAYVAFVPAKGIGIVMLANRNSPIEARIKAAHAILTQLAR SEQ ID No. 987:MQQRQSILWGAVATLMWAGLAHAGEASPVDPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVSEQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSKEDKPIRVNPGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRESGSQVLFNKTGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG SEQ ID No. 988:MQQRQSILWGALATLMWAGLAHAGETSPVDPLRPVVDASIRPLLKEHRIPGMAVAVLKDGKAHYFNYGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLLPGLGLHHTYVNVPKQAMASYAYGYSKEDKPIRVSPGMLADEAYGIKTSSADLLRFVKANISGVHDKALQQAISLTHKGHYSVGGMTQGLGWESYAYPVSEQTLLAGNSAKVILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRNYPIPARVKAAHAILTQLAR

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 989 to SEQ ID No. 1037 as defined hereafter:

Peptide SEQ ID No. Amino acid sequence Position of the peptide in theMOX protein(s) SEQ ID AATDPLR 27-33 for the proteins of SEQ No. 984,985, 986 No. 989 SEQ ID AHYFNYGVADR 62-72 for the proteins of SEQ No.982, 983, 984, No. 990 985, 986, 988 SEQ ID ANISGVDDK 261-269 for theproteins of SEQ No. 982, 983 No. 991 SEQ ID ANISGVHDK 261-269 for theprotein of SEQ No. 988 No. 992 SEQ ID ASLFAPWLK 113-121 for the proteinsof SEQ No. 984, 985, No. 993 986 SEQ ID AVGVSEQTLFEIGSVSK 75-91 for theproteins of SEQ No. 982, 983, 984, No. 994 985, 986, 988 SEQ ID EDKPFR230-235 for the protein of SEQ No. 984 No. 995 SEQ ID ESGNLMLFNK 326-335for the protein of SEQ No. 983 No. 996 SEQ ID ESGSQMLFNK 326-335 for theproteins of SEQ No. 982, 988 No. 997 SEQ ID GHPVLFNK 329-336 for theproteins of SEQ No. 985, 986 No. 998 SEQ ID GHYSVGGMTQGLGWER 281-296 forthe protein of SEQ No. 982 No. 999 SEQ ID GIGVVMLANR 354-363 for theprotein of SEQ No. 984 No. 1000 SEQ ID MQAYYR 155-160 for the proteinsof SEQ No. 982, 983, No. 984, 985, 986, 988 1001 SEQ ID NSPIEAR 364-370for the protein of SEQ No. 986 No. 1002 SEQ ID NSPIEGTLK 364-372 for theprotein of SEQ No. 985 No. 1003 SEQ ID NYPNEGTLK 364-372 for the proteinof SEQ No. 984 No. 1004 SEQ ID QPFDR 192-196 for the proteins of SEQ No.984, 985, No. 986 1005 SEQ ID QWTPAYSPGSHR 161-172 for the proteins ofSEQ No. 982, 983, No. 985, 986, 988 1006 SEQ ID QWTPAYSR 161-168 for theprotein of SEQ No. 984 No. 1007 SEQ ID QYANPSIGLFGYLAASSMK 173-191 forthe proteins of SEQ No. 984, 985, No. 986 1008 SEQ IDQYSNPSIGLFGHLAASSMK 173-191 for the proteins of SEQ No. 983, 988 No.1009 SEQ ID TGSSNGFGAYVAFVPAR 336-352 for the protein of SEQ No. 987 No.1010 SEQ ID TGSTNGFGAYVAFVPAK 337-353 for the proteins of SEQ No. 984,985, No. 986 1011 SEQ ID TGSTSGFGAYVAFVPAK 336-352 for the proteins ofSEQ No. 982, 983, No. 988 1012 SEQ ID TLTATLGAYAVVQGGFELDDK 92-112 forthe protein of SEQ No. 984 No. 1013 SEQ ID TLTATLGAYAVVQGSFELDDK 92-112for the proteins of SEQ No. 985, 986 No. 1014 SEQ ID VSPGMLADEAYGIK236-249 for the proteins of SEQ No. 982, 983, No. 988 1015 SEQ IDVTPAMLAEEPYGIK 236-249 for the protein of SEQ No. 984 No. 1016 SEQ IDVTPGMLADEAYGIK 236-249 for the proteins of SEQ No. 985, 986 No. 1017 SEQID YAYPVSEQTLLAGNSAK 297-313 for the proteins of SEQ No. 982, 988 No.1018 SEQ ID ALQQAISLTHK 270-280 for the proteins of SEQ No. 982, 983,No. 987, 988 1019 SEQ ID ANIGGVDDK 261-269 for the protein of SEQ No.987 No. 1020 SEQ ID EDKPIR 230-235 for the proteins of SEQ No. 982, 983,No. 985, 986, 987, 988 1021 SEQ ID ESGASVSEQTLFEIGSVSK 73-91 for theprotein of SEQ No. 987 No. 1022 SEQ ID ESGSQVLFNK 326-335 for theprotein of SEQ No. 987 No. 1023 SEQ ID GAMQLDDK 105-112 for the proteinsof SEQ No. 982, 983, No. 987, 988 1024 SEQ ID GIGIVMLANR 353-362 for theproteins of SEQ No. 982, 983, No. 987, 988; 354-363 for the proteins ofsequence 1025 SEQ ID No. 985, 986 SEQ ID HAPWLK 116-121 for the proteinsof SEQ No. 982, 983, No. 987, 988 1026 SEQ ID NYPIPAR 363-369 for theproteins of SEQ No. 982, 983, No. 987, 988 1027 SEQ ID QAMASYAYGYSK218-229 for the proteins of SEQ No. 982, 983, No. 987, 988 1028 SEQ IDQWAPVYSPGSHR 161-172 for the protein of SEQ No. 987 No. 1029 SEQ IDQYSNPSIGLFGHLAASSLK 173-191 for the proteins of SEQ No. 982, 987 No.1030 SEQ ID TLTATLGAYAVVK 92-104 for the protein of SEQ No. 987 No. 1031SEQ ID TSSADLLAFVK 250-260 for the protein of SEQ No. 987 No. 1032 SEQID TSSADLLR 250-257 for the proteins of SEQ No. 982, 983, No. 984, 985,986, 988 1033 SEQ ID VILEANPTAAPR 314-325 for the proteins of SEQ No.982, 983, No. 987, 988 1034 SEQ ID VNPGMLADEAYGIK 236-249 for theprotein of SEQ No. 987 No. 1035 SEQ ID AHYFNYGVANR 62-72 for the proteinof SEQ No. 987 No. 1036 SEQ ID IPGMAVAVLK 49-58 for the proteins of SEQNo. 982, 983, 984, No. 985, 986, 987, 988 1037

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the PER protein is characterised by the detection ofat least one peptide belonging to the PER protein and to its differentsequence variants SEQ ID No. 1038 to SEQ ID No. 1044.

SEQ ID No. 1038: MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSLSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK KLSALSPN SEQ ID No.1039: MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHTDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK KLSALSPN SEQ ID No.1040: MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKGQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK KLSALSPN SEQ ID No.1041: MNVIAKGVFTTTALLMLSLSSWVVSAQSPLLKEQIETIVTGKKATVGVAVWGPDDLEPLLVNPFEKFPMQSVFKMHLAMLVLHQVDQGKLDLNKTVAVNRAAVLQNTWSPMMKDHQGDEFTVTVQQLLQYSVSHSDNVACDLLFELVGGPAALHAYIQSLGIKETEVVANEAQMHADDQVQYKNWTSMKAAAQLLRKFEQKKQLSETSQALLWKWMVETTTGPQRLKGLLPAGTVVAHKTGTSGVRAGKTAATNDIGVIMLPDGRPLLVAVFVKDSAESARTNEAIIAQVAQAAYQFELK KLSAVSPD SEQ ID No.1042: MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNRAKVLQNTWAPIMKAYQGDQFSVPVQQLLQYSVSHSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGVRAGKTAATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQAAYQFELK KLSALSPN SEQ ID No.1043: MNVITKCVFTASALLMLGLSSFVVSAQSPLLKEQIETIVTGKKATVGVAVWGPDDLEPLLLNPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQSVTVNRAAVLQNTWSPMMKDHQGDEFTVAVQQLLQYSVSHSDNVACDLLFELVGGPQALHAYIQSLGVKEAAVVANEAQMHADDQVQYQNWTSMKAAAQVLQKFEQKKQLSETSQALLWKWMVETTTGPQRLKGLLPAGTIVAHKTGTSGVRAGKTAATNDAGVIMLPDGRPLLVAVFVKDSAESERTNEAIIAQVAQAAYQFELK KLSAVSPD SEQ ID No.1044: MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGKKATVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNRAKVLQNTWAPIMKAYQGDEFSVPVQQLLQYSVSHSDNVACDLLFELVGGPAALHDYIQSMGIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWMVETTTGPERLKGLLPAGTVVAHKTGTSGIKAGKTAATNDLGIILLPDGRPLLVAVFVKDSAESSRTNEAIIAQVAQTAYQFELK KLSALSPN

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 1045 to SEQ ID No. 1077 as defined hereafter:

Peptide SEQ ID Position of the peptide in the PER No. Amino acidsequence protein(s) SEQ ID AAAQLLR 190-196 for the proteins of SEQ No.1041 No. 1045 SEQ ID AAAQVLQK 190-197 for the proteins of SEQ No. 1043No. 1046 SEQ ID AAVLQNTWSPMMK 101-113 for the proteins of SEQ No. 1041,No. 1043 1047 SEQ ID DSAESAR 275-281 for the proteins of SEQ No. 1041No. 1048 SEQ ID DSAESER 275-281 for the proteins of SEQ No. 1043 No.1049 SEQ ID DSAESSR 275-281 for the proteins of SEQ No. 1038, No. 1039,1040, 1042, 1044 1050 SEQ ID EQIESIVIGK 33-42 for the proteins of SEQNo. 1038, No. 1039, 1042, 1044 1051 SEQ ID EQIETIVTGK 33-42 for theproteins of SEQ No. 1041, 1043 No. 1052 SEQ ID ETEVVANEAQMHADDQVQYK164-183 for the proteins of SEQ No. 1041 No. 1053 SEQ ID FPMQSVFK 67-74for the proteins of SEQ No. 1038, No. 1039, 1040, 1041, 1042, 1043, 10441054 SEQ ID GAAEILK 190-196 for the proteins of SEQ No. 1038, No. 1039,1040, 1042, 1044 1055 SEQ ID GLLPAGTIVAHK 228-239 for the proteins ofSEQ No. 1043 No. 1056 SEQ ID GLLPAGTVVAHK 228-239 for the proteins ofSEQ No. 1038, No. 1039, 1040, 1041, 1042, 1044 1057 SEQ ID GQIESIVIGK33-42 for the proteins of SEQ No. 1040 No. 1058 SEQ ID LDLNK 90-94 forthe proteins of SEQ No. 1041 No. 1059 SEQ ID LDLNQSVTVNR 90-100 for theproteins of SEQ No. 1043 No. 1060 SEQ ID LDLNQTVIVNR 90-100 for theproteins of SEQ No. 1038, No. 1039, 1040, 1042, 1044 1061 SEQ IDLHLAMLVLHQVDQGK 75-89 for the proteins of SEQ No. 1038, No. 1039, 1040,1042, 1043, 1044 1062 SEQ ID MHLAMLVLHQVDQGK 75-89 for the proteins ofSEQ No. 1041 No. 1063 SEQ ID NWTSMK 184-189 for the proteins of SEQ No.1038, No. 1039, 1040, 1041, 1042, 1043, 1044 1064 SEQ ID QLSETSQALLWK203-214 for the proteins of SEQ No. 1038, No. 1039, 1040, 1041, 1042,1043, 1044 1065 SEQ ID TAATNDAGVIMLPDGR 250-265 for the proteins of SEQNo. 1043 No. 1066 SEQ ID TAATNDIGVIMLPDGR 250-265 for the proteins ofSEQ No. 1041 No. 1067 SEQ ID TAATNDLGIILLPDGR 250-265 for the proteinsof SEQ No. 1038, No. 1039, 1040, 1042, 1044 1068 SEQ ID TGTSGIK 240-246for the proteins of SEQ No. 1038, No. 1039, 1040, 1044 1069 SEQ IDTGTSGVR 240-246 for the proteins of SEQ No. 1041, No. 1042, 1043 1070SEQ ID TNEAIIAQVAQAAYQFELK 282-300 for the proteins of SEQ No. 1041, No.1042, 1043 1071 SEQ ID TNEAIIAQVAQTAYQFELK 282-300 for the proteins ofSEQ No. 1038, No. 1039, 1040, 1044 1072 SEQ ID TQLSETSQALLWK 202-214 forthe proteins of SEQ No. 1038, No. 1039, 1040, 1042, 1044 1073 SEQ IDTVAVNR 95-100 for the proteins of SEQ No. 1041 No. 1074 SEQ IDVLQNTWAPIMK 103-113 for the proteins of SEQ No. 1038, No. 1039, 1040,1042, 1044 1075 SEQ ID WMVETTTGPER 215-225 for the proteins of SEQ No.1038, No. 1039, 1040, 1042, 1044 1076 SEQ ID WMVETTTGPQR 215-225 for theproteins of SEQ No. 1041, No. 1043 1077

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the PER protein indicates an ESBL resistance. It ispreferably detected with the aid of SEQ ID No. 1045 to SEQ ID No. 1065and SEQ ID No. 1069 to SEQ ID No. 1077.

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the VEB protein is characterised by the detection ofat least one peptide belonging to the VEB protein and to its differentsequence variants SEQ ID No. 1078 to SEQ ID No. 1084.

SEQ ID No. 1078: MKIVKRILLVLLSLFFTIVYSNAQTDNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYY LNK SEQ ID No. 1079:MKIVKRILLVLLSLFFTIVYSNAQADNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK SEQ ID No. 1080:MKIVKRILLVLLSLFFTVVYSNAQTDNLTLKIENVLKAKNARIGVAIFNSNEKDTFKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK SEQ ID No. 1081:MKIVKRILLVLLSLFFTIVYSNAQADNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK SEQ ID No. 1082:MKIVKRILLVLLSLFFTVEYSNAQTDNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK SEQ ID No. 1083:MKIVKRILLVLLSLFFTVVYSNAQADNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKMWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGIAAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK SEQ ID No. 1084:MKIVKRILLVLLSLFFTVEYSNAQTDNLTLKIENVLKAKNARIGVAIFNSNEKDTLKINNDFHFPMQSVMKFPIALAVLSEIDKGNLSFEQKIEITPQDLLPKTWSPIKEEFPNGTTLTIEQILNYTVSESDNIGCDILLKLIGGTDSVQKFLNANHFTDISIKANEEQMHKDWNTQYQNWATPTAMNKLLIDTYNNKNQLLSKKSYDFIWKIMRETTTGSNRLKGQLPKNTIVAHKTGTSGINNGITAATNDVGVITLPNGQLIFISVFVAESKETSEINEKIISDIAKITWNYYLNK

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 1085 to SEQ ID No. 1104 as defined hereafter:

Peptide SEQ ID No. Amino acid sequence Position of the peptide in theVEB protein(s) SEQ ID ANEEQMHK 165-172 for the proteins of SEQ No. 1078,1079, No. 1080, 1081, 1082, 1083, 1084 1085 SEQ ID DWNTQYQNWATPTAMNK173-189 for the proteins of SEQ No. 1078, 1079, No. 1080, 1081, 1082,1083, 1084 1086 SEQ ID ETSEINEK 276-283 for the proteins of SEQ No.1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1087 SEQ ID ETTTGSNR216-223 for the proteins of SEQ No. 1078, 1079, No. 1080, 1081, 1082,1083, 1084 1088 SEQ ID FLNANHFTDISIK 152-164 for the proteins of SEQ No.1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1089 SEQ ID FPIALAVLSEIDK72-84 for the proteins of SEQ No. 1078, 1079, 1080, No. 1081, 1082,1083, 1084 1090 SEQ ID GNLSFEQK 85-92 for the proteins of SEQ No. 1078,1079, 1080, No. 1081, 1082, 1083, 1084 1091 SEQ ID GQLPK 226-230 for theproteins of SEQ No. 1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1092SEQ ID IEITPQDLLPK 93-103 for the proteins of SEQ No. 1078, 1079, No.1080, 1081, 1082, 1083, 1084 1093 SEQ ID IENVLK 32-37 for the proteinsof SEQ No. 1078, 1079, 1080, No. 1081, 1082, 1083, 1084 1094 SEQ IDIGVAIFNSNEK 43-53 for the proteins of SEQ No. 1078, 1079, 1080, No.1081, 1082, 1083, 1084 1095 SEQ ID IISDIAK 284-290 for the proteins ofSEQ No. 1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1096 SEQ IDINNDFHFPMQSVMK 58-71 for the proteins of SEQ No. 1078, 1079, 1080, No.1081, 1082, 1083, 1084 1097 SEQ ID LIGGTDSVQK 142-151 for the proteinsof SEQ No. 1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1098 SEQ IDLLIDTYNNK 190-198 for the proteins of SEQ No. 1078, 1079, No. 1080,1081, 1082, 1083, 1084 1099 SEQ ID MWSPIK 104-109 for the proteins ofSEQ No. 1081, 1082, No. 1083 1100 SEQ ID NQLLSK 199-204 for the proteinsof SEQ No. 1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1101 SEQ IDNTIVAHK 231-237 for the proteins of SEQ No. 1078, 1079, No. 1080, 1081,1082, 1083, 1084 1102 SEQ ID SYDFIWK 206-212 for the proteins of SEQ No.1078, 1079, No. 1080, 1081, 1082, 1083, 1084 1103 SEQ ID TWSPIK 104-109for the proteins of SEQ No. 1078, 1079, No. 1080, 1084 1104

The detection of a mechanism of resistance to cephalosporins induced bythe expression of the VEB protein indicates an ESBL resistance.

The detection of a mechanism of resistance to cephalosporins or tocarbapenems induced by the expression of the OXA protein ischaracterised by the detection of at least one peptide belonging to theOXA protein and to its different sequence variants SEQ ID No. 1105 toSEQ ID No. 1266:

SEQ. ID. No. 1105:MSRLLLSGLLATGLLCAVPASAASGCFLYADGNGQTLSSEGDCSSQLPPASTFKIPLALMGYDSGFLVNEEHPALPYKPSYDGWLPAWRETTTPRRWETYSVVWFSQQITEWLGMERFQQYVDRFDYGNRDLSGNPGKHDGLTQAWLSSSLAISPEEQARFLGKMVSGKLPVSAQTLQYTANILKVSEVEGWQIHGKTGMGYPKKLDGSLNRDQQIGWFVGWASKPGKQLIFVHTVVQKPGKQFASIKAKEEVLAALPAQLKKL SEQ ID No. 1106:IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1107:MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSSFKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQQLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLLRFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQGWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK SEQ ID No. 1108:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAGPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1109:MQRSLSMSGKRHFIFAVSFVISTVCLTFSPANAAQKLSCTLVIDEASGDLLHREGSCDKAFAPMSTFKLPLAIMGYDADILLDATTPRWDYKPEFNGYKSQQKPTDPTIWLKDSIVWYSQELTRRLGESRFSDYVQRFDYGNKDVSGDPGKHNGLTHAWLASSLKISPEEQVRFLRRFLRGELPVSEDALEMTKAVVPHFEAGDWDVQGKTGTGSLSDAKGGKAPIGWFIGWATRDDRRVVFARLTVGARKGEQPAGPAARDEFLNTLPALSENF SEQ ID No. 1110:MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1111:IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQITREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1112:IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1113:MIIRFLALLFSAVVLVSLGHAQEKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTSVYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQNLRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISANEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGWVEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN SEQ ID No. 1114:MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRIGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1115:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1116:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1117:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFGLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1118:MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL SEQ ID No. 1119:ANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITIL SEQ ID No. 1120:IFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAYPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAIL SEQ ID No. 1121:MIIRFLALLFSAVVLVSLGHAQDKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTSVYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQNLRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISANEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGWVEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN SEQ ID No. 1122:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVEKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKLLENLGII SEQ ID No. 1123:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMTGSIRNEITYKSLENLGII SEQ ID No. 1124:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKADINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1125:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYCIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAIL SEQ ID No. 1126:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1127:MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGKDKARHYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN SEQ ID No. 1128:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSIAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1129:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII SEQ ID No. 1130:MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGEDKARRYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN SEQ ID No. 1131:MAIRFFTILLSTFFLTSFVYAQEHVVIRSDWKKFFSDLQAEGAIVIADERQAKHTLSVFDQERAAKRYSPASTFKIPHTLFALDADAVRDEFQVFRWDGVNRSFAGHNQDQDLRSAMRNSTVWVYELFAKDIGEDKARRYLKQIDYGNVDPSTIKGDYWIDGNLKISAHEQILFLRKLYRNQLPFKVEHQRLVKDLMITEAGRSWILRAKTGWEGRFGWWVGWIEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN SEQ ID No. 1132:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1133:MAIQIFAILFSTFVLATFAHAQDGTLERSDWGKFFSDFQAKGTIVVADERQADHAILVFDQARSMKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVKRSFAGHNKDQDLRSAMRNSTVWVYELFAKEIGDGKARRYLKQIGYGNADPSTSHGDYWIEGSLAISAQEQIAFLRKLYQNDLPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGSMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIARAILLSIEALPPNPAVHSDAAR SEQ ID No. 1134:MKNTIHINFAIFLIIANIIYSSASASTDISTVASQLFEGTEGCFLLYDASTNAEIAQFNKAKCAAQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKIPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVRNSAIENTIDNMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGSLGSNLTSSIKAKKNAITILNTLNL SEQ ID No. 1135:MLLFMFSIISFGNENQFMKEIFERKGLNGTFVVYDLKNDKIDYYNLDRANERFYPASSFKIFNTLIGLENGIVKNVDEMFYYYDGSKVFLDSWAKDSNLRYAIKVSQVPAYKKLARELGKERMQEGLNKLNYGNKEIGSEIDKFWLEGPLKISAMEQVKLLNLLSQSKLPFKLENQEQVKDITILEKKDDFILHGKTGWATDNIVVPIGWFVGWIETSDNIYSFAINLDISDSKFLPKREEIVREYFKNINVIK SEQ ID No. 1136:MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP SEQ ID No. 1137:MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADRTYVVDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDMALPEAIRLSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISAFEEARFTSRMALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGWWAGWVERAGHVYAFALNIDMPREGDMAKRIPLGKQLMRALEVWPAP SEQ ID No. 1138:MRPLLFSALLLLSGHTQASEWNDSQAVDKLFGAAGVKGTFVLYDVQRQRYVGHDRERAETRFVPASTYKVANSLIGLSTGAVRSADEVLPYGGKPQRFKAWEHDMSLRDAIKASNVPVYQELARRIGLERMRANVSRLGYGNAEIGQVVDNFWLVGPLKISAMEQTRFLLRLAQGELPFPAPVQSTVRAMTLLESGPGWELHGKTGWCFDCTPELGWWVGWVKRNERLYGFALNIDMPGGEADIGKRVELGKASLKALGILP SEQ ID No. 1139:MNKGLHRKRLSKRLLLPMLLCLLAQQTQAVAAEQTKVSDVCSEVTAEGWQEVRRWDKLFESAGVKGSLLLWDQKRSLGLSNNLSRAAEGFIPASTFKLPSSLIALETGAVRDETSRFSWDGKVREIAVWNRDQSFRTAMKYSVVPVYQQLAREIGPKVMAAMVRQLEYGNQDIGGQADSFWLDGQLRITAFQQVDFLRQLHDNKLPVSERSQRIVKQMMLTEASTDYIIRAKTGYGVRRTPAIGWWVGWLELDDNTVYFAVNLDLASASQLPLRQQLV KQVLKQEQLLP SEQID No. 1140: MNTIISRRWRAGLWRRLVGAVVLPATLAATPAAYAADVPKAALGRITERADWGKLFAAEGVKGTIVVLDARTQTYQAYDAARAEKRMSPASTYKIFNSLLALDSGALDNERAIIPWDGKPRRIKNWNAAMDLRTAFRVSCLPCYQVVSHKIGRRYAQAKLNEVGYGNRTIGGAPDAYWVDDSLQISAREQVDFVQRLARGTLPFSARSQDIVRQMSIVEATPDYVLHGKTGWFVDKKPDIGWWVGWIERDGNITSVAINIDMLSEADAPKRARIVKAVLKDLK LI SEQ ID No.1141: MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1142:MRVLALSAVLVVASIVGMPAMANEWQEKPSWNTHFSEHKAQGVIVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGQARMSKMLHAFDYGNEDISGNLDSFWLDGGIRISATEQVAFLRKLYHNKLHVSERSQRIVKQAMLTEANSDYIIRAKTGYSTRIEPQIGWWVGWVELDDNVWFFAMNMDMPTADGLGLRQAITKEVLKQEKIIP SEQ ID No. 1143:MKKITLFLLFLNLVFGQDKILNNWFKEYNTSGTFVFYDGKTWASNDFSRAMETFSPASTFKIFNALIALDSGVIKTKKEIFYHYRGEKVFLSSWAQDMNLSSAIKYSNVLAFKEVARRIGIKTMQEYLNKLHYGNAKISKIDTFWLDNSLKISAKEQAILLFRLSQNSLPFSQEAMNSVKEMIYLKNMENLELFGKTGFNDGQKIAWIVGFVYLKDENKYKAFALNLDIDKFEDLYKREKILEKYLDELVKKVKNDG SEQ ID No. 1144:MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKLMAKSFLESWAKDSNLRYAIKNSQVPAYKELARRIGIKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELQYPIEIQKAISDITITRANLHITLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK SEQ ID No. 1145:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1146:MNIQALLLITSAIFISACSPYIVTANPNYSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRIGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGISSSVRKEITYRGLEQLGIL SEQ ID No. 1147:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKGEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1148:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1149:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1150:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1151:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1152:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQHEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1153:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1154:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTAVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGTPSSVRKEITYKSLEQLGIL SEQ ID No. 1155:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLPRRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1156:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL SEQ ID No. 1157:MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1158:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLAGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1159:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1160:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGSVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1161:MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKAQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1162:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1163:MNIKTLLLITSAIFISACSHYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFTYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1164:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1165:MNIKALLLITSTIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALISLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1166:MNIQALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPHGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1167:MNIKALFLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1168:MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQMGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL SEQ ID No. 1169:MNIKALLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1170:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIRQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1171:MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISGDAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL SEQ ID No. 1172:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII SEQ ID No. 1173:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIESSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1174:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1175:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1176:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1177:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1178:MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1179:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1180:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1181:MNIKTLLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1182:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFPLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1183:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGGDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1184:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1185:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1186:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1187:MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK SEQ ID No. 1188:MSKKNFILIFIFVILTSCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK SEQ ID No. 1189:LLITSAIFISACSPYIVSANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL SEQ ID No. 1190:LLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTEWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL SEQ ID No. 1191:MTVRRLSCALGAALSLSALGGGPVQAAVLCTVVADAADGRILFQQGTQQACAERYTPASTFKLAIALMGADAGILQGPHEPVWNYQPAYPDWGGDAWRQPTDPARWIKYSVVWYSQLTAKALGQDRFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPLEQLAFLRKLVNRQLPVKAAAYELAENLFEAGQADGWRLYGKTGTGSPGSNGVYTAANAYGWFVGWARKDGRQLVYARLLQDERATRPNAGLRARDELVRDWPAMAGAWRP SEQ ID No. 1192:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNVLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1193:MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1194:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1195:MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1196:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNQQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1197:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEMTYKSLEQLGIL SEQ ID No. 1198:MNKYFTCYVVASLFFSGCTVQHNLINETQSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTTWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIDFGNAEIGQQVDNFWLIGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEENNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1199:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1200:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFLLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1201:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGDADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1202:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKASTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVKSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1203:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1204:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1205:MKKFILPILSISTLLSVSACSSIQTKFEDTFHTSNQQHEKAIKSYFDEAQTQGVIIIKKGKNISTYGNNLTRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDFANNRLPFKLETQEEVKKMLLIKEFNGSKIYAKSGWGMDVTPQVGWLTGWVEKSNGEKVAFSLNIEMKQGMPGSIRNEITYKSLENLGII SEQ ID No. 1206:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSILFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1207:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTSQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII SEQ ID No. 1208:MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSARIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP SEQ ID No. 1209:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1210:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNLQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1211:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL SEQ ID No. 1212:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIRNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1213:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1214:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDGVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1215:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1216:MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFLKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL SEQ ID No. 1217:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDVKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1218:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGALVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1219:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELMMKSLKQLNII SEQ ID No. 1220:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLAGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1221:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDERNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1222:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEKSNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1223:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASTRNELLMKSLKQLNII SEQ ID No. 1224:MKKFILPIFSISILLSLSACSSIQTKFEDTFHISNQKHEKAIKSYFDEAQTQGVIIIKEGKNISSYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRSYPMWEKDMTLGEAMALSAVPVYQDLARRIGLNLMQKEVKRVGFGNMNIGTQVDNFWLIGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVSPQVGWLTGWVEKSNGEKVSFSLNIEMKQGMSGSIRNEITYKSLENLGII SEQ ID No. 1225:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIAVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1226:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1227:MKILIFLPLLSCLGLTACSLPVSSLPSQSISTQAIASLFDQAQSSGVLVIQRDQQVQVYGNDLNRANTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTAWEKDMTLGQAMQASAVPVYQELARRIGLELMQQEVQRIQFGNQQIGQQVDNFWLVGPLKVTPKQEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGWLTGWVETPQAEIVAFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG SEQ ID No. 1228:MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE SEQ ID No. 1229:MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGTDKFWLEDQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1230:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1231:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1232:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAMPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1233:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1234:MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYDTKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP SEQ ID No. 1235:MSKKNFILIFIFVILISCKNTEKTSNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLEKMKENIEKLDFGNKNIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTDNYTLHGKTGLADSENMTTEPIGWLVGWLEENNNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK SEQ ID No. 1236:MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1237:MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPSSQKVQDEVQSMLFIEEKNGNKMYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1238:MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEIAYKSLEQLGIL SEQ ID No. 1239:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDCWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1240:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1241:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEYHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1242:MAIRFLTILLSTFFLTSFVHAQEHVVVRSDWKKFFSDLQAEGAIVIADERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDAGAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGEDNARRYLKQIDYGNADPSTIKGNYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKYLMITEAGRNWILRAKTGWEGRFGWWIGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN SEQ ID No. 1243:MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATQQIAFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP SEQ ID No. 1244:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKSQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1245:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1246:MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1247:MKTIAAYLVLVFYASTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAARASTAYIPASTFKIPNALIGLETGAIKDERQVFKWDGKPRAMKQWEKDLKLRGAIQVSAVPVFQQIAREVGEIRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAFNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESSPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSISTKIMASEGIIIGG SEQ ID No. 1248:MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKLACATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1249:MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR SEQ ID No. 1250:MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGSQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1251:MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII SEQ ID No. 1252:MKKLSVLLWLTLFYCGTIWAQSTCFLVQENQTVLKHEGKDCNKRFAPESTFKIALSLMGFDSGILKDTLNPEWPYKKEYELYLNVWKYPHNPRTWIRDSCVWYSQVLTQQLGMTRFKNYVDAFHYGNQDISGDKGQNNGLTHSWLSSSLAISPSEQIQFLQKIVNKKLSVNPKAFTMTKDILYIQELAGGWKLYGKTGNGRQLTKDKSQKLSLQHGWFIGWIEKDGRVITFTKHIADSKKHVTFASFRAKNETLNQLFYLINELEK SEQ ID No. 1253:MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1254:MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGNQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR SEQ ID No. 1255:MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYPVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR SEQ ID No. 1256:MRGKHTVILGAALSALFAGAAGAQMLECTLVADAASGQELYRKGACDKAFAPMSTFKVPLAVMGYDAGILVDAHNPRWDYKPEFNGYKFQQKTTDPTIWEKDSIVWYSQQLTRKMGQKRFAAYVAGFGYGNGDISGEPGKSNGLTHSWLGSSLKISPEGQVRFVRDLLSAKLPASKDAQQMTVSILPHFAAGDWAVQGKTGTGSFIDARGAKAPLGWFIGWATHEERRVVFARMTAGGKKGEQPAGPAARDAFLKALPDLAKRF SEQ ID No. 1257:MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLDRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR SEQ ID No. 1258:MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR SEQ ID No. 1259:MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPVSTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG SEQ ID No. 1260:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1261:MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1262:MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG SEQ ID No. 1263:MKTIAAYLVLVFFAGTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNATRASTAYIPASTFKIPNALIGLETGAIKDARQVFKWDGKPRAMKQWEKDLTLRGAIQVSAVPVFQQIARDIGKKRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAVNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSIPTKIMASEGIIIGG SEQ ID No. 1264:MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLIALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII SEQ ID No. 1265:MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL SEQ ID No. 1266:MNIKALLLITSAISISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQV

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 1267 to SEQ ID No. 1835 and SEQ ID No. 2160 to SEQ ID No.2171 as defined hereafter:

Peptide SEQ ID Clinical No. Amino acid sequence Position of the peptidein the OXA protein(s) interest SEQ ID AAAYELAENLFEAGQADG 183-202 for theproteins of SEQ No. 1191 2d No. 1267 WR SEQ ID AAEGFIPASTFK 86-97 forthe proteins of SEQ No. 1139 2df No. 1268 SEQ ID AALGR 41-45 for theproteins of SEQ No. 1140 2df No. 1269 SEQ ID ADGQVVAFALNMQMK 241-255 forthe proteins of SEQ No. 1168, 2df No. 1270 1171, 1216 SEQ ID ADINEIFK95-102 for the proteins of SEQ No. 1124 2df No. 1271 SEQ ID ADWGK 50-54for the proteins of SEQ No. 1140 2df No. 1272 SEQ ID AEGAIVISDER 40-50for the proteins of SEQ No. 1127, 1130 OXA No. 1273 SEQ ID AFALNLDIDK222-231 for the proteins of SEQ No. 1143 2d No. 1274 SEQ ID AFAPMSTFK49-57 for the proteins of SEQ No. 1256; 60-68 OXA No. 1275 for theprotein of sequence SEQ ID No. 1109 SEQ ID AFGYGNADVSGDPGQNNG 127-147for the proteins of SEQ No. 1254, 2d No. 1276 LDR 1255, 1257, 1258 SEQID AFTMTK 174-179 for the proteins of SEQ No. 1252 2de No. 1277 SEQ IDAGDDIALR 256-263 for the proteins of SEQ No. 1168, 2df No. 1278 1171,1216 SEQ ID AGHVYAFALNIDMPR 233-247 for the proteins of SEQ No. 1137 2dfNo. 1279 SEQ ID AGLWR 11-15 for the proteins of SEQ No. 1140 2df No.1280 SEQ ID AHTEYVPASTFK 73-84 for the proteins of SEQ No. 1205, 12242df No. 1281 SEQ ID AIIPWDGK 112-119 for the proteins of SEQ No. 11402df No. 1282 SEQ ID AIIPWDGKPR 112-121 for the proteins of SEQ No. 11402df No. 1283 SEQ ID AISDITITR 190-198 for the proteins of SEQ No. 11442d No. 1284 SEQ ID AISGK 82-86 for the proteins of SEQ No. 1228 2df No.1285 SEQ ID ALGQDR 121-126 for the proteins of SEQ No. 1191 2d No. 1286SEQ ID ALPDLAK 256-262 for the proteins of SEQ No. 1256 2d No. 1287 SEQID ALQAK 254-258 for the proteins of SEQ No. 1228 2df No. 1288 SEQ IDAMETFSPASTFK 50-61 for the proteins of SEQ No. 1143 2d No. 1289 SEQ IDAMLFLQER 196-203 for the proteins of SEQ No. 1227 2df No. 1290 SEQ IDAMLVFDPVR 55-63 for the proteins of SEQ No. 1108, 1125, OXA No. 12911128, 1173, 1201, 1239, 1246; 44-52 for the protein of sequence SEQ IDNo. 1120 SEQ ID AMTLLESGPGWELHGK 189-204 for the proteins of SEQ No.1138 2d No. 1292 SEQ ID ANLHITLHGK 199-208 for the proteins of SEQ No.1144 2d No. 1293 SEQ ID ANQLIVK 183-189 for the proteins of SEQ No.1247, OXA No. 1294 1263 SEQ ID ANTEYVPASTFK 71-82 for the proteins ofSEQ No. 1124, 1132, 2df No. 1295 1145, 1198, 1199, 1217, 1218, 1219,1220, 1221, 1222, 1223, 1244, 1251; 66-77 for the protein of sequenceSEQ ID No. 1227 SEQ ID ANVSR 133-137 for the proteins of SEQ No. 1138 2dNo. 1296 SEQ ID APIGWFIGWATR 224-235 for the proteins of SEQ No. 11092de No. 1297 SEQ ID APLGWFIGWATHEER 213-227 for the proteins of SEQ No.1256 2d No. 1298 SEQ ID AQDEVQSMLFIEEK 196-209 for the proteins of SEQNo. 1161 2df No. 1299 SEQ ID AQGVIVLWNENK 40-51 for the proteins of SEQNo. 1142 2df No. 1300 SEQ ID ASAIAVYQDLAR 126-137 for the proteins ofSEQ No. 1225 2df No. 1301 SEQ ID ASAILVYQDLAR 126-137 for the proteinsof SEQ No. 1175, 2df No. 1302 1184, 1215, 1230 SEQ ID ASAIPVYQDLAR126-137 for the proteins of SEQ No. 1146, 2df No. 1303 1147, 1148, 1149,1150, 1151, 1152, 1153, 1154, 1156, 1157, 1160, 1161, 1162, 1163, 1164,1165, 1166, 1167, 1169, 1170, 1174, 1176, 1177, 1178, 1181, 1182, 1183,1185, 1186, 1192, 1194, 1195, 1197, 1202, 1203, 1204, 1206, 1211, 1212,1213, 1214, 1226, 1233, 1236, 1237, 1238, 1240, 1241, 1253, 1260, 1261,1265, 1266; 120-131 for the protein of sequence SEQ ID No. 1189; 120-131for the protein of sequence SEQ ID No. 1190 SEQ ID ASAIPVYQDLPR 126-137for the proteins of SEQ No. 1155 2df No. 1304 SEQ ID ASAIQVYQDLAR126-137 for the proteins of SEQ No. 1179, 2df No. 1305 1231 SEQ IDASAISVYQDLAR 126-137 for the proteins of SEQ No. 1158, 2df No. 1306 1245SEQ ID ASALPVYQDLAR 126-137 for the proteins of SEQ No. 1159, 2df No.1307 1180 SEQ ID ASAMPVYQDLAR 126-137 for the proteins of SEQ No. 12322df No. 1308 SEQ ID ASAVPVYQDLAR 126-137 for the proteins of SEQ No.1196, 2df No. 1309 1209, 1210 SEQ ID ASIEYVPASTFK 72-83 for the proteinsof SEQ No. 1157, 1161 2df No. 1310 SEQ ID ASNVPVYQELAR 113-124 for theproteins of SEQ No. 1138 2d No. 1311 SEQ ID ASPASTFK 49-56 for theproteins of SEQ No. 1254, 1255, 2d No. 1312 1257, 1258 SEQ IDASTAYIPASTFK 59-70 for the proteins of SEQ No. 1247, 1263 OXA No. 1313SEQ ID ASTEYVPASTFK 72-83 for the proteins of SEQ No. 1146, 1147, 2dfNo. 1314 1148, 1149, 1150, 1151, 1152, 1153, 1154, 1155, 1156, 1158,1159, 1160, 1162, 1163, 1164, 1165, 1166, 1167, 1169, 1170, 1174, 1175,1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184, 1185, 1186, 1192,1194, 1195, 1196, 1197, 1202, 1203, 1204, 1206, 1209, 1210, 1211, 1212,1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237, 1238,1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 66-77 for the protein ofsequence SEQ ID No. 1189; 66-77 for the protein of sequence SEQ ID No.1190 SEQ ID ASTTEVFK 96-103 for the proteins of SEQ No. 1202 2df No.1315 SEQ ID ATSTEIFK 99-106 for the proteins of SEQ No. 1168, 1171, 2dfNo. 1316 1216 SEQ ID ATTNEIFK 97-104 for the proteins of SEQ No. 1122,1123, 2df No. 1317 1129, 1172, 1207, 1224, 1264; 90-97 for the proteinof sequence SEQ ID No. 1227 SEQ ID ATTTAVFK 96-103 for the proteins ofSEQ No. 1154 2df No. 1318 SEQ ID ATTTEIFK 97-104 for the proteins of SEQNo. 1205; 96-103 2df No. 1319 for the protein of sequence SEQ ID No.1157; 96-103 for the protein of sequence SEQ ID No. 1161; 96-103 for theprotein of sequence SEQ ID No. 1169 SEQ ID ATTTEVFK 96-103 for theproteins of SEQ No. 1146, 1147, 2df No. 1320 1148, 1149, 1150, 1151,1152, 1155, 1156, 1158, 1159, 1160, 1162, 1163, 1164, 1165, 1166, 1167,1170, 1174, 1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184,1185, 1192, 1194, 1195, 1196, 1197, 1203, 1204, 1206, 1209, 1210, 1211,1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237,1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 90-97 for theprotein of sequence SEQ ID No. 1189; 90-97 for the protein of sequenceSEQ ID No. 1190 SEQ ID AVSDITILEQTDNYTLHGK 191-209 for the proteins ofSEQ No. 1235 OXA No. 1321 SEQ ID AVSDITILEQTYNYTLHGK 191-209 for theproteins of SEQ No. 1187, 2d No. 1322 1188 SEQ ID AVVPHFEAGDWDVQGK195-210 for the proteins of SEQ No. 1109 2de No. 1323 SEQ ID AWEHDMSLR100-108 for the proteins of SEQ No. 1138 2d No. 1324 SEQ IDAWIGSSLQISPLEQLEFLGK 148-167 for the proteins of SEQ No. 1254, 2d No.1325 1255, 1257, 1258 SEQ ID CAAQMAPDSTFK 63-74 for the proteins of SEQNo. 1134 2d No. 1326 SEQ ID CATQMAPDSTFK 48-59 for the proteins of SEQNo. 1119; 63-74 2d No. 1327 for the protein of sequence SEQ ID No. 1118SEQ ID CTIIADAITGNTLYETGECAR 32-52 for the proteins of SEQ No. 1107 2dNo. 1328 SEQ ID DAFLK 251-255 for the proteins of SEQ No. 1256 2d No.1329 SEQ ID DDFILHGK 189-196 for the proteins of SEQ No. 1135 2d No.1330 SEQ ID DDQEVLPYGGK 92-102 for the proteins of SEQ No. 1137 2df No.1331 SEQ ID DDVLK 87-91 for the proteins of SEQ No. 1228 2df No. 1332SEQ ID DEFHVFR 90-96 for the proteins of SEQ No. 1113, 1121 2d No. 1333SEQ ID DEFQIFR 90-96 for the proteins of SEQ No. 1108, 1125, OXA No.1334 1128, 1133, 1173, 1201, 1239, 1246; 79-85 for the protein ofsequence SEQ ID No. 1120 SEQ ID DEFQVFR 90-96 for the proteins of SEQNo. 1114, 1127, 2d No. 1335 1130, 1131, 1242, 1249 SEQ ID DELVR 260-264for the proteins of SEQ No. 1191 2d No. 1336 SEQ ID DETSR 112-116 forthe proteins of SEQ No. 1139 2df No. 1337 SEQ ID DFDYGNQDFSGDK 141-153for the proteins of SEQ No. 1118, 2d No. 1338 1134; 126-138 for theprotein of sequence SEQ ID No. 1119 SEQ ID DFTLGEAMQASTVPVYQEL 120-140for the proteins of SEQ No. 1168, 2df No. 1339 AR 1171, 1216 SEQ IDDGNITSVAINIDMLSEADAPK 250-270 for the proteins of SEQ No. 1140 2df No.1340 SEQ ID DHDLITAMK 108-116 for the proteins of SEQ No. 1142, 2df No.1341 1243 SEQ ID DIAAWNR 101-107 for the proteins of SEQ No. 1142, 2dfNo. 1342 1243 SEQ ID DIGEDK 131-136 for the proteins of SEQ No. 1131 2dNo. 1343 SEQ ID DILYIQELAGGWK 180-192 for the proteins of SEQ No. 12522de No. 1344 SEQ ID DITILEK 181-187 for the proteins of SEQ No. 1135 2dNo. 1345 SEQ ID DLLSAK 166-171 for the proteins of SEQ No. 1256 2d No.1346 SEQ ID DLMITEAGR 195-203 for the proteins of SEQ No. 1127, 2d No.1347 1130, 1131 SEQ ID DLMIVEAGR 195-203 for the proteins of SEQ No.1108, OXA No. 1348 1114, 1125, 1128, 1133, 1173, 1201, 1239, 1246, 1249;184-192 for the protein of sequence SEQ ID No. 1120 SEQ ID DLMIVEAK195-202 for the proteins of SEQ No. 1113, 2d No. 1349 1121 SEQ ID DLPLR243-247 for the proteins of SEQ No. 1228 2df No. 1350 SEQ ID DLSGNPGK131-138 for the proteins of SEQ No. 1105 2d No. 1351 SEQ ID DLSLR105-109 for the proteins of SEQ No. 1115, OXA No. 1352 1116, 1117, 1126,1141, 1200, 1229, 1262; 106-110 for the protein of sequence SEQ ID No.1248 SEQ ID DLTLR 105-109 for the proteins of SEQ No. 1110, OXA No. 13531193, 1250, 1259, 1263; 96-100 for the protein of sequence SEQ ID No.1106; 96-100 for the protein of sequence SEQ ID No. 1111; 96-100 for theprotein of sequence SEQ ID No. 1112 SEQ ID DMTLGDAIK 117-125 for theproteins of SEQ No. 1226, 2df No. 1354 1266 SEQ ID DMTLGDAMALSAVPVYQE118-138 for the proteins of SEQ No. 1205 2df No. 1355 LAR SEQ IDDMTLGDAMK 117-125 for the proteins of SEQ No. 1147, 2df No. 1356 1148,1149, 1152, 1153, 1156, 1157, 1158, 1159, 1161, 1162, 1165, 1166, 1167,1169, 1170, 1175, 1176, 1178, 1179, 1181, 1183, 1184, 1185, 1186, 1194,1195, 1196, 1197, 1202, 1209, 1210, 1211, 1212, 1213, 1214, 1215, 1225,1230, 1231, 1232, 1236, 1237, 1238, 1240, 1241, 1245, 1253, 1260, 1265SEQ ID DMTLGEAMALSAVPVYQD 118-138 for the proteins of SEQ No. 1224 2dfNo. 1357 LAR SEQ ID DMTLGEAMALSAVPVYQE 118-138 for the proteins of SEQNo. 1122, 2df No. 1358 LAR 1123, 1129, 1172, 1207, 1264 SEQ ID DMTLGEAMK116-124 for the proteins of SEQ No. 1124, 2df No. 1359 1132, 1145, 1198,1199, 1217, 1218, 1219, 1220, 1221, 1222, 1223, 1244, 1251 SEQ IDDMTLGQAMQASAVPVYQE 111-131 for the proteins of SEQ No. 1227 2df No. 1360LAR SEQ ID DNNGK 214-218 for the proteins of SEQ No. 1107 2d No. 1361SEQ ID DQDLR 110-114 for the proteins of SEQ No. 1108, 2d No. 1362 1114,1125, 1127, 1128, 1130, 1131, 1133, 1173, 1201, 1239, 1242, 1246, 1249;99-103 for the protein of sequence SEQ ID No. 1120 SEQ ID DQQIGWFVGWASK213-225 for the proteins of SEQ No. 1105 2d No. 1363 SEQ IDDQQIGWFVGWASKPGK 213-228 for the proteins of SEQ No. 1105 2d No. 1364SEQ ID DQQVQVYGNDLNR 53-65 for the proteins of SEQ No. 1227 2df No. 1365SEQ ID DQSFR 132-136 for the proteins of SEQ No. 1139 2df No. 1366 SEQID DQTLESAFK 105-113 for the proteins of SEQ No. 1228 2df No. 1367 SEQID DSCVWYSQVLTQQLGMTR 98-115 for the proteins of SEQ No. 1252 2de No.1368 SEQ ID DSIVWYSQELTR 113-124 for the proteins of SEQ No. 1109 2deNo. 1369 SEQ ID DSIVWYSQQLTR 102-113 for the proteins of SEQ No. 1256 2dNo. 1370 SEQ ID DSNLR 109-113 for the proteins of SEQ No. 1187, 2d No.1371 1188, 1235; 96-100 for the protein of sequence SEQ ID No. 1135;108-112 for the protein of sequence SEQ ID No. 1144 SEQ ID DSYIAWGGEAWK81-92 for the proteins of SEQ No. 1254, 1255, 2d No. 1372 1257, 1258 SEQID DTLNPEWPYK 67-76 for the proteins of SEQ No. 1252 2de No. 1373 SEQ IDDVDEVFYK 88-95 for the proteins of SEQ No. 1144, 1187, 2d No. 1374 1188,1235 SEQ ID DVSGDPGK 144-151 for the proteins of SEQ No. 1109 2de No.1375 SEQ ID DWILR 204-208 for the proteins of SEQ No. 1113, 2d No. 13761121 SEQ ID DWPAMAGAWR 265-274 for the proteins of SEQ No. 1191 2d No.1377 SEQ ID EAFLR 256-260 for the proteins of SEQ No. 1254, 2d No. 13781255, 1257, 1258 SEQ ID EAIAR 250-254 for the proteins of SEQ No. 1113,2d No. 1379 1121, 1127, 1130, 1131, 1133, 1242 SEQ ID EAIVR 250-254 forthe proteins of SEQ No. 1108, OXA No. 1380 1114, 1125, 1128, 1173, 1201,1239, 1246, 1249; 239-243 for the protein of sequence SEQ ID No. 1120SEQ ID EAIVTEATPEYIVHSK 190-205 for the proteins of SEQ No. 1247, OXANo. 1381 1263 SEQ ID EALVTEAAPEYLVHSK 190-205 for the proteins of SEQNo. 1110, OXA No. 1382 1115, 1116, 1117, 1126, 1141, 1193, 1200, 1229,1250, 1259, 1262; 181-196 for the protein of sequence SEQ ID No. 1106;181-196 for the protein of sequence SEQ ID No. 1111; 181-196 for theprotein of sequence SEQ ID No. 1112 SEQ ID EALVTEAPEYLVHSK 191-205 forthe proteins of SEQ No. 1248 2d No. 1383 SEQ ID EEIVR 240-244 for theproteins of SEQ No. 1135 2d No. 1384 SEQ ID EEVLAALPAQLK 251-262 for theproteins of SEQ No. 1105 2d No. 1385 SEQ ID EFNGSK 209-214 for theproteins of SEQ No. 1205 2df No. 1386 SEQ ID EFSAEAVNGVFVLCK 31-45 forthe proteins of SEQ No. 1110, 1115, OXA No. 1387 1116, 1117, 1126, 1141,1193, 1200, 1229, 1248, 1250, 1259, 1262; 22-36 for the protein ofsequence SEQ ID No. 1106; 22-36 for the protein of sequence SEQ ID No.1111; 22-36 for the protein of sequence SEQ ID No. 1112 SEQ IDEFSSESVHGVFVLCK 31-45 for the proteins of SEQ No. 1247, 1263 OXA No.1388 SEQ ID EGDMAK 248-253 for the proteins of SEQ No. 1137 2df No. 1389SEQ ID EGMSGSIR 254-261 for the proteins of SEQ No. 1122, 2df No. 13901129, 1172, 1207, 1264 SEQ ID EGMTGSIR 254-261 for the proteins of SEQNo. 1123 2df No. 1391 SEQ ID EGSCDK 54-59 for the proteins of SEQ No.1109 2de No. 1392 SEQ ID EIAVWNR 125-131 for the proteins of SEQ No.1139 2df No. 1393 SEQ ID EIAYK 262-266 for the proteins of SEQ No. 12382df No. 1394 SEQ ID EIFER 20-24 for the proteins of SEQ No. 1135 2d No.1395 SEQ ID EIFYHYR 79-85 for the proteins of SEQ No. 1143 2d No. 1396SEQ ID EIGDDK 131-136 for the proteins of SEQ No. 1108, OXA No. 13971125, 1128, 1173, 1201, 1239, 1246; 120-125 for the protein of sequenceSEQ ID No. 1120 SEQ ID EIGDGK 131-136 for the proteins of SEQ No. 11332d No. 1398 SEQ ID EIGEDK 131-136 for the proteins of SEQ No. 1114, 2dNo. 1399 1130, 1249 SEQ ID EIGEDNAR 131-138 for the proteins of SEQ No.1242 OXA No. 1400 SEQ ID EIGENK 131-136 for the proteins of SEQ No.1113, 2d No. 1401 1121 SEQ ID EIGPK 153-157 for the proteins of SEQ No.1139 2df No. 1402 SEQ ID EIGSEIDK 136-143 for the proteins of SEQ No.1135 2d No. 1403 SEQ ID EITYK 262-266 for the proteins of SEQ No. 1147,2df No. 1404 1148, 1149, 1150, 1151, 1152, 1153, 1154, 1155, 1156, 1157,1158, 1159, 1160, 1161, 1162, 1163, 1164, 1165, 1166, 1167, 1169, 1170,1174, 1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184, 1185,1186, 1192, 1194, 1195, 1196, 1202, 1203, 1204, 1206, 1209, 1210, 1211,1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237,1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 263-267 for the proteinof sequence SEQ ID No. 1122; 263-267 for the protein of sequence SEQ IDNo. 1123; 263-267 for the protein of sequence SEQ ID No. 1129; 263-267for the protein of sequence SEQ ID No. 1172; 256-260 for the protein ofsequence SEQ ID No. 1189; 256-260 for the protein of sequence SEQ ID No.1190; 263-267 for the protein of sequence SEQ ID No. 1205; 263-267 forthe protein of sequence SEQ ID No. 1207; 263-267 for the protein ofsequence SEQ ID No. 1224; 263-267 for the protein of sequence SEQ ID No.1264 SEQ ID EITYR 262-266 for the proteins of SEQ No. 1146 2df No. 1405SEQ ID EMIYLK 181-186 for the proteins of SEQ No. 1143 2d No. 1406 SEQID EMLYVER 205-211 for the proteins of SEQ No. 1168, 2df No. 1407 1171,1216 SEQ ID EMTYK 262-266 for the proteins of SEQ No. 1197 2df No. 1408SEQ ID ENIEK 138-142 for the proteins of SEQ No. 1187, 2d No. 1409 1188,1235; 137-141 for the protein of sequence SEQ ID No. 1144 SEQ ID ENQLIVK183-189 for the proteins of SEQ No. 1110, OXA No. 1410 1115, 1116, 1117,1126, 1141, 1193, 1200, 1229, 1250, 1259, 1262; 174-180 for the proteinof sequence SEQ ID No. 1106; 174-180 for the protein of sequence SEQ IDNo. 1111; 174-180 for the protein of sequence SEQ ID No. 1112; 184-190for the protein of sequence SEQ ID No. 1248 SEQ ID EQAILLFR 156-163 forthe proteins of SEQ No. 1143 2d No. 1411 SEQ ID EQIQFLLR 165-172 for theproteins of SEQ No. 1107 2d No. 1412 SEQ ID EQLAPDPQVQQQVK 182-195 forthe proteins of SEQ No. 1227 2df No. 1413 SEQ ID EQVDFVQR 189-196 forthe proteins of SEQ No. 1140 2df No. 1414 SEQ ID ETEVYFFAFNMDIDNESK229-246 for the proteins of SEQ No. 1110, OXA No. 1415 1193, 1250, 1259;220-237 for the protein of sequence SEQ ID No. 1106; 220-237 for theprotein of sequence SEQ ID No. 1111; 220-237 for the protein of sequenceSEQ ID No. 1112 SEQ ID ETTTPR 90-95 for the proteins of SEQ No. 1105 2dNo. 1416 SEQ ID EVGEIR 126-131 for the proteins of SEQ No. 1247 2d No.1417 SEQ ID EVGEVR 126-131 for the proteins of SEQ No. 1110, OXA No.1418 1115, 1116, 1117, 1126, 1141, 1193, 1200, 1229, 1250, 1259, 1262;117-122 for the protein of sequence SEQ ID No. 1106; 117-122 for theprotein of sequence SEQ ID No. 1111; 117-122 for the protein of sequenceSEQ ID No. 1112; 127-132 for the protein of sequence SEQ ID No. 1248 SEQID EVNGSK 209-214 for the proteins of SEQ No. 1122, 2df No. 1419 1123,1129, 1172, 1207, 1224, 1264 SEQ ID EWQENK 24-29 for the proteins of SEQNo. 1136, 1208, 2df No. 1420 1234, 1243 SEQ ID EYELYLNVWK 78-87 for theproteins of SEQ No. 1252 2de No. 1421 SEQ ID EYVPASTFK 62-70 for theproteins of SEQ No. 1110, 1115, OXA No. 1422 1116, 1117, 1126, 1141,1193, 1200, 1229, 1250, 1262; 53-61 for the protein of sequence SEQ IDNo. 1106; 53-61 for the protein of sequence SEQ ID No. 1111; 53-61 forthe protein of sequence SEQ ID No. 1112; 63-71 for the protein ofsequence SEQ ID No. 1248 SEQ ID EYLPVSTFK 62-70 for the proteins of SEQNo. 1259 2de No. 1423 SEQ ID EYNTSGTFVFYDGK 27-40 for the proteins ofSEQ No. 1143 2d No. 1424 SEQ ID EYVPASTFK 75-83 for the proteins of SEQNo. 1146, 1147, 2df No. 1425 1148, 1149, 1150, 1151, 1152, 1153, 1154,1155, 1156, 1157, 1158, 1159, 1160, 1161, 1162, 1163, 1164, 1165, 1166,1167, 1169, 1170, 1174, 1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182,1183, 1184, 1185, 1186, 1192, 1194, 1195, 1196, 1197, 1202, 1203, 1204,1206, 1209, 1210, 1211, 1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231,1232, 1233, 1236, 1237, 1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265,1266; 76-84 for the protein of sequence SEQ ID No. 1122; 76-84 for theprotein of sequence SEQ ID No. 1123; 74-82 for the protein of sequenceSEQ ID No. 1124; 76-84 for the protein of sequence SEQ ID No. 1129;74-82 for the protein of sequence SEQ ID No. 1132; 74-82 for the proteinof sequence SEQ ID No. 1145; 76-84 for the protein of sequence SEQ IDNo. 1172; 69-77 for the protein of sequence SEQ ID No. 1189; 69-77 forthe protein of sequence SEQ ID No. 1190; 74-82 for the protein ofsequence SEQ ID No. 1198; 74-82 for the protein of sequence SEQ ID No.1199; 76-84 for the protein of sequence SEQ ID No. 1205; 76-84 for theprotein of sequence SEQ ID No. 1207; 74-82 for the protein of sequenceSEQ ID No. 1217; 74-82 for the protein of sequence SEQ ID No. 1218;74-82 for the protein of sequence SEQ ID No. 1219; 74-82 for the proteinof sequence SEQ ID No. 1220; 74-82 for the protein of sequence SEQ IDNo. 1221; 74-82 for the protein of sequence SEQ ID No. 1222; 74-82 forthe protein of sequence SEQ ID No. 1223; 76-84 for the protein ofsequence SEQ ID No. 1224; 69-77 for the protein of sequence SEQ ID No.1227; 74-82 for the protein of sequence SEQ ID No. 1244; 74-82 for theprotein of sequence SEQ ID No. 1251; 76-84 for the protein of sequenceSEQ ID No. 1264 SEQ ID FAAYVAGFGYGNGDISGEP 120-140 for the proteins ofSEQ No. 1256 2d No. 1426 GK SEQ ID FAPESTFK 45-52 for the proteins ofSEQ No. 1252 2de No. 1427 SEQ ID FAQYAK 121-126 for the proteins of SEQNo. 1254, 2d No. 1428 1255, 1257, 1258 SEQ ID FDYGNK 138-143 for theproteins of SEQ No. 1109 2de No. 1429 SEQ ID FDYGNR 146-151 for theproteins of SEQ No. 1137; 2d No. 1430 125-130 for the protein ofsequence SEQ ID No. 1105 SEQ ID FEDLYK 232-237 for the proteins of SEQNo. 1143 2d No. 1431 SEQ ID FEDTFHISNQK 27-37 for the proteins of SEQNo. 1224 2df No. 1432 SEQ ID FEDTFHTSNQQHEK 27-40 for the proteins ofSEQ No. 1205 2df No. 1433 SEQ ID FEYGNQDVSGDSGK 133-146 for the proteinsof SEQ No. 1107 2d No. 1434 SEQ ID FFSDFQAK 34-41 for the proteins ofSEQ No. 1133 2d No. 1435 SEQ ID FFSDLQAEGAIVIADER 34-50 for the proteinsof SEQ No. 1131, 1242 2d No. 1436 SEQ ID FFSDLR 34-39 for the proteinsof SEQ No. 1127, 1130 OXA No. 1437 SEQ ID FFSEFQAK 34-41 for theproteins of SEQ No. 1108, 1114, OXA No. 1438 1125, 1128, 1173, 1201,1239, 1246, 1249; 23-30 for the protein of sequence SEQ ID No. 1120 SEQID FGLEGQLR 153-160 for the proteins of SEQ No. 1117 2de No. 1439 SEQ IDFILPIFSISILVSLSACSSIK 4-24 for the proteins of SEQ No. 1122, 1123, 2dfNo. 1440 1129, 1172, 1207, 1264 SEQ ID FLALLFSAVVLVSLGHAQDK 5-24 for theproteins of SEQ No. 1121 2d No. 1441 SEQ ID FLALLFSAVVLVSLGHAQEK 5-24for the proteins of SEQ No. 1113 2d No. 1442 SEQ ID FLESLYLNNLPASK169-182 for the proteins of SEQ No. 1247, OXA No. 1443 1263 SEQ IDFLLEGQLR 153-160 for the proteins of SEQ No. 1200 2de No. 1444 SEQ IDFQQYVDR 118-124 for the proteins of SEQ No. 1105 2d No. 1445 SEQ IDFSDYVQR 131-137 for the proteins of SEQ No. 1109 2de No. 1446 SEQ IDFSTASTFK 63-70 for the proteins of SEQ No. 1228 2df No. 1447 SEQ IDFSWDGK 117-122 for the proteins of SEQ No. 1139 2df No. 1448 SEQ IDFSYGNQNISGGIDK 139-152 for the proteins of SEQ No. 1110, OXA No. 14491115, 1116, 1117, 1126, 1141, 1193, 1200, 1259, 1262; 130-143 for theprotein of sequence SEQ ID No. 1106; 130-143 for the protein of sequenceSEQ ID No. 1111; 130-143 for the protein of sequence SEQ ID No. 1112;140-153 for the protein of sequence SEQ ID No. 1248 SEQ IDFSYGNQNISGGTDK 139-152 for the proteins of SEQ No. 1229 2de No. 1450 SEQID FSYGSQNISGGIDK 139-152 for the proteins of SEQ No. 1250 2de No. 1451SEQ ID FTEYVK 126-131 for the proteins of SEQ No. 1107 2d No. 1452 SEQID FVAHK 173-177 for the proteins of SEQ No. 1107 2d No. 1453 SEQ IDFVPASTYK 62-69 for the proteins of SEQ No. 1138 2d No. 1454 SEQ IDFVYDLAQGQLPFK 184-196 for the proteins of SEQ No. 1168, 2df No. 14551171, 1216 SEQ ID FVYDLAQGQLPFKPEVQQQ 184-204 for the proteins of SEQNo. 1168, 2df No. 1456 VK 1171, 1216 SEQ ID FWLEDQLR 153-160 for theproteins of SEQ No. 1116, 2de No. 1457 1193, 1229, 1250; 144-151 for theprotein of sequence SEQ ID No. 1106; 144-151 for the protein of sequenceSEQ ID No. 1111 SEQ ID FWLEGPLK 144-151 for the proteins of SEQ No. 11352d No. 1458 SEQ ID FWLEGQLR 153-160 for the proteins of SEQ No. 1110,OXA No. 1459 1115, 1126, 1141, 1247, 1259, 1262, 1263; 144-151 for theprotein of sequence SEQ ID No. 1112; 154-161 for the protein of sequenceSEQ ID No. 1248 SEQ ID FYPASSFK 53-60 for the proteins of SEQ No. 11352d No. 1460 SEQ ID FYPASTFK 66-73 for the proteins of SEQ No. 1144,1187, 2d No. 1461 1188, 1235 SEQ ID GACDK 44-48 for the proteins of SEQNo. 1256 2d No. 1462 SEQ ID GAEVYFFAFNMDIDNENK 229-246 for the proteinsof SEQ No. 1141, 2d No. 1463 1248 SEQ ID GAIQVSAVPVFQQIAR 110-125 forthe proteins of SEQ No. 1110, OXA No. 1464 1115, 1116, 1117, 1126, 1141,1193, 1200, 1229, 1247, 1250, 1259, 1262, 1263; 101-116 for the proteinof sequence SEQ ID No. 1106; 101-116 for the protein of sequence SEQ IDNo. 1112; 111-126 for the protein of sequence SEQ ID No. 1248 SEQ IDGAIQVSAVPVFQQITR 101-116 for the proteins of SEQ No. 1111 2de No. 1465SEQ ID GDYWIDGNLEISAHEQISFLR 156-176 for the proteins of SEQ No. 1127,OXA No. 1466 1130 SEQ ID GDYWIDGNLK 156-165 for the proteins of SEQ No.1131 2d No. 1467 SEQ ID GELPVSEDALEMTK 181-194 for the proteins of SEQNo. 1109 2de No. 1468 SEQ ID GEQPAGPAAR 241-250 for the proteins of SEQNo. 1256; OXA No. 1469 252-261 for the protein of sequence SEQ ID No.1109 SEQ ID GFAGHNQDQDLR 103-114 for the proteins of SEQ No. 1108, OXANo. 1470 1125, 1128, 1173, 1201, 1239, 1246; 92-103 for the protein ofsequence SEQ ID No. 1120 SEQ ID GIPSSVR 254-260 for the proteins of SEQNo. 1147, 2df No. 1471 1148, 1149, 1150, 1151, 1152, 1153, 1155, 1156,1157, 1158, 1159, 1160, 1161, 1162, 1163, 1164, 1165, 1166, 1167, 1169,1170, 1174, 1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184,1185, 1186, 1192, 1194, 1195, 1196, 1197, 1202, 1203, 1204, 1206, 1209,1210, 1211, 1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233,1236, 1237, 1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266;248-254 for the protein of sequence SEQ ID No. 1189; 248-254 for theprotein of sequence SEQ ID No. 1190 SEQ ID GISSSVR 254-260 for theproteins of SEQ No. 1146 2df No. 1472 SEQ ID GLNGTFVVYDLK 26-37 for theproteins of SEQ No. 1135 2d No. 1473 SEQ ID GMEIWNSNHTPK 101-112 for theproteins of SEQ No. 1118, 2d No. 1474 1134; 86-97 for the protein ofsequence SEQ ID No. 1119 SEQ ID GNQTLVFAR 230-238 for the proteins ofSEQ No. 1254 2d No. 1475 SEQ ID GNYWIDGNLEISAHEQISFLR 156-176 for theproteins of SEQ No. 1242 OXA No. 1476 SEQ ID GPLEISAFEEAR 164-175 forthe proteins of SEQ No. 1137 2df No. 1477 SEQ ID GPLTITPIQEVK 172-183for the proteins of SEQ No. 1168, 2df No. 1478 1171, 1216 SEQ IDGSGWFVGWIVR 219-229 for the proteins of SEQ No. 1254, 2d No. 1479 1255,1257, 1258 SEQ ID GSLLLWDQK 66-74 for the proteins of SEQ No. 1139 2dfNo. 1480 SEQ ID GTEVYFFAFNMDIDNENK 229-246 for the proteins of SEQ No.1115, OXA No. 1481 1116, 1117, 1126, 1200, 1229, 1262 SEQ IDGTEVYFFAFNMDIDNESK 229-246 for the proteins of SEQ No. 1247, OXA No.1482 1263 SEQ ID GTFVLYDVQR 38-47 for the proteins of SEQ No. 1138 2dNo. 1483 SEQ ID GTIVVADER 42-50 for the proteins of SEQ No. 1108, 1114,OXA No. 1484 1125, 1128, 1133, 1173, 1201, 1239, 1246, 1249; 31-39 forthe protein of sequence SEQ ID No. 1120 SEQ ID GTIVVLDAR 63-71 for theproteins of SEQ No. 1140 2df No. 1485 SEQ ID GTIVVVDER 42-50 for theproteins of SEQ No. 1113, 1121 2d No. 1486 SEQ ID GTLPFSAR 200-207 forthe proteins of SEQ No. 1140 2df No. 1487 SEQ ID GTPSSVR 254-260 for theproteins of SEQ No. 1154 2df No. 1488 SEQ ID HALSSAFVLLGCIAASAHAK 5-24for the proteins of SEQ No. 1254, 1255, 2d No. 1489 1257, 1258 SEQ IDHIADSK 234-239 for the proteins of SEQ No. 1252 2de No. 1490 SEQ IDHNGLTHAWLASSLK 152-165 for the proteins of SEQ No. 1109 2de No. 1491 SEQID HNGLTQSWLMSSLTISPK 147-164 for the proteins of SEQ No. 1107 2d No.1492 SEQ ID HNGTDGAWIISSLR 148-161 for the proteins of SEQ No. 1191 2dNo. 1493 SEQ ID HTLSVFDQER 54-63 for the proteins of SEQ No. 1131 2d No.1494 SEQ ID HVTFASFR 241-248 for the proteins of SEQ No. 1252 2de No.1495 SEQ ID IAISLMGYDAGFLR 57-70 for the proteins of SEQ No. 1254, 1255,2d No. 1496 1257, 1258 SEQ ID IALSLMAFDAEIIDQK 75-90 for the proteins ofSEQ No. 1118, 1134; 2d No. 1497 60-75 for the protein of sequence SEQ IDNo. 1119 SEQ ID IALSLMGFDSGILK 53-66 for the proteins of SEQ No. 12522de No. 1498 SEQ ID IANALIGLENHK 87-98 for the proteins of SEQ No. 1168,1171, 2df No. 1499 1216 SEQ ID IAWIVGFVYLK 205-215 for the proteins ofSEQ No. 1143 2d No. 1500 SEQ ID IDTFWLDNSLK 141-151 for the proteins ofSEQ No. 1143 2d No. 1501 SEQ ID IDYYNLDR 41-48 for the proteins of SEQNo. 1135 2d No. 1502 SEQ ID IFNALIALDSGVIK 62-75 for the proteins of SEQNo. 1143 2d No. 1503 SEQ ID IFNSLLALDSGALDNER 95-111 for the proteins ofSEQ No. 1140 2df No. 1504 SEQ ID IFNTLIGLENGIVK 61-74 for the proteinsof SEQ No. 1135 2d No. 1505 SEQ ID IGLDLMQK 138-145 for the proteins ofSEQ No. 1124, 2df No. 1506 1132, 1145, 1198, 1199, 1217, 1218, 1219,1220, 1221, 1222, 1223, 1244, 1251 SEQ ID IGLEK 131-135 for the proteinsof SEQ No. 1235 OXA No. 1507 SEQ ID IGLELMQQEVQR 133-144 for theproteins of SEQ No. 1227 2df No. 1508 SEQ ID IGLELMSK 139-146 for theproteins of SEQ No. 1147, 2df No. 1509 1148, 1149, 1151, 1153, 1156,1157, 1158, 1159, 1160, 1161, 1162, 1166, 1167, 1169, 1170, 1175, 1177,1178, 1179, 1180, 1181, 1182, 1183, 1184, 1185, 1186, 1194, 1195, 1196,1197, 1209, 1210, 1211, 1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231,1232, 1236, 1237, 1238, 1240, 1241, 1245, 1253, 1260, 1266 SEQ IDIGLELMSNEVK 139-149 for the proteins of SEQ No. 1146, 2df No. 1510 1150,1152, 1154, 1155, 1163, 1164, 1165, 1174, 1176, 1192, 1202, 1203, 1204,1206, 1233, 1261, 1265; 133-143 for the protein of sequence SEQ ID No.1189; 133-143 for the protein of sequence SEQ ID No. 1190 SEQ ID IGLER126-130 for the proteins of SEQ No. 1138 2d No. 1511 SEQ ID IGLNK130-134 for the proteins of SEQ No. 1118, 2d No. 1512 1134; 115-119 forthe protein of sequence SEQ ID No. 1119 SEQ ID IGLNLMQK 140-147 for theproteins of SEQ No. 1224 2df No. 1513 SEQ ID IGPSLMQSELQR 142-153 forthe proteins of SEQ No. 1168, 2df No. 1514 1171, 1216 SEQ IDIGYGNMQIGTEVDQFWLK 154-171 for the proteins of SEQ No. 1171, 2df No.1515 1216 SEQ ID IGYGNMQMGTEVDQFWLK 154-171 for the proteins of SEQ No.1168 2df No. 1516 SEQ ID IINHNLPVK 167-175 for the proteins of SEQ No.1119; 2d No. 1517 182-190 for the protein of sequence SEQ ID No. 1118SEQ ID IINHNLPVR 182-190 for the proteins of SEQ No. 1134 2d No. 1518SEQ ID ILFQQGTQQACAER 41-54 for the proteins of SEQ No. 1191 2d No. 1519SEQ ID ILNNWFK 20-26 for the proteins of SEQ No. 1143 2d No. 1520 SEQ IDILNTLISLEEK 71-81 for the proteins of SEQ No. 1228 2df No. 1521 SEQ IDILSLVCLSISIGACAEHSMSR 6-26 for the proteins of SEQ No. 1168, 1171, 2dfNo. 1522 1216 SEQ ID INESR 219-223 for the proteins of SEQ No. 1107 2dNo. 1523 SEQ ID INIVK 255-259 for the proteins of SEQ No. 1187, 2d No.1524 1188, 1235; 254-258 for the protein of sequence SEQ ID No. 1144 SEQID INLYGNALSR 61-70 for the proteins of SEQ No. 1124, 1132, 2df No. 15251145, 1198, 1199, 1217, 1218, 1219, 1220, 1221, 1222, 1223, 1244, 1251SEQ ID IPFSLNLEMK 244-253 for the proteins of SEQ No. 1122, 2df No. 15261123, 1129, 1172, 1207, 1264 SEQ ID IPHTLFALDADAVR 76-89 for theproteins of SEQ No. 1131 2d No. 1527 SEQ ID IPHTLFALDAGAAR 76-89 for theproteins of SEQ No. 1114, 1249 2d No. 1528 SEQ ID IPHTLFALDAGAVR 76-89for the proteins of SEQ No. 1108, 1113, OXA No. 1529 1121, 1125, 1128,1133, 1173, 1201, 1239, 1246; 65-78 for the protein of sequence SEQ IDNo. 1120 SEQ ID IPLGK 255-259 for the proteins of SEQ No. 1137 2df No.1530 SEQ ID IPNAIIGLETGVIK 71-84 for the proteins of SEQ No. 1110, 1116,OXA No. 1531 1117, 1126, 1141, 1200, 1229, 1250, 1262; 62-75 for theprotein of sequence SEQ ID No. 1106; 62-75 for the protein of sequenceSEQ ID No. 1111; 72-85 for the protein of sequence SEQ ID No. 1248 SEQID IPNALIGLETGAIK 71-84 for the proteins of SEQ No. 1247, 1263 OXA No.1532 SEQ ID IPNSLIAFDTGAVR 78-91 for the proteins of SEQ No. 1137 2dfNo. 1533 SEQ ID IPSAIIGLETGVIK 71-84 for the proteins of SEQ No. 1115,1193, 2de No. 1534 1259; 62-75 for the protein of sequence SEQ ID No.1112 SEQ ID ISAFNQVK 161-168 for the proteins of SEQ No. 1247 2d No.1535 SEQ ID ISAHEQILFLR 166-176 for the proteins of SEQ No. 1131 2d No.1536 SEQ ID ISAMEQTR 160-167 for the proteins of SEQ No. 1138 2d No.1537 SEQ ID ISAMEQVK 165-172 for the proteins of SEQ No. 1187, 2d No.1538 1235; 152-159 for the protein of sequence SEQ ID No. 1135; 164-171for the protein of sequence SEQ ID No. 1144 SEQ ID ISATEQVAFLR 164-174for the proteins of SEQ No. 1142 2df No. 1539 SEQ ID ISATQQIAFLR 164-174for the proteins of SEQ No. 1243 2df No. 1540 SEQ ID ISAVNQVEFLESLFLNK161-177 for the proteins of SEQ No. 1115, OXA No. 1541 1116, 1117, 1126,1141, 1200, 1229, 1262; 162-178 for the protein of sequence SEQ ID No.1248 SEQ ID ISAVNQVEFLESLYLNK 161-177 for the proteins of SEQ No. 1110,OXA No. 1542 1193, 1250, 1259; 152-168 for the protein of sequence SEQID No. 1106; 152-168 for the protein of sequence SEQ ID No. 1111;152-168 for the protein of sequence SEQ ID No. 1112 SEQ ID ISAVNQVK161-168 for the proteins of SEQ No. 1263 2de No. 1543 SEQ ID ISPEEQIQFLR170-180 for the proteins of SEQ No. 1118, 2d No. 1544 1134; 155-165 forthe protein of sequence SEQ ID No. 1119 SEQ ID ISPEEQVR 166-173 for theproteins of SEQ No. 1109 2de No. 1545 SEQ ID ISPEGQVR 155-162 for theproteins of SEQ No. 1256 2d No. 1546 SEQ ID ISPLEQLAFLR 162-172 for theproteins of SEQ No. 1191 2d No. 1547 SEQ ID ITAFQQVDFLR 188-198 for theproteins of SEQ No. 1139 2df No. 1548 SEQ ID ITLFLLFLNLVFGQDK 4-19 forthe proteins of SEQ No. 1143 2d No. 1549 SEQ ID ITPIQEVNFADDFANNR174-190 for the proteins of SEQ No. 1205 2df No. 1550 SEQ IDITPIQEVNFADDLANNR 174-190 for the proteins of SEQ No. 1224 2df No. 1551SEQ ID ITPQQEAQFAYK 173-184 for the proteins of SEQ No. 1146, 2df No.1552 1147, 1148, 1149, 1150, 1151, 1152, 1153, 1154, 1155, 1156, 1157,1158, 1159, 1160, 1161, 1162, 1164, 1165, 1166, 1167, 1169, 1170, 1174,1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184, 1185, 1186,1192, 1194, 1195, 1196, 1197, 1202, 1203, 1204, 1206, 1209, 1210, 1211,1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237,1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 167-178 for theprotein of sequence SEQ ID No. 1189; 167-178 for the protein of sequenceSEQ ID No. 1190 SEQ ID ITPQQEAQFTYK 173-184 for the proteins of SEQ No.1163 2df No. 1553 SEQ ID ITPVQEVNFADDLAHNR 174-190 for the proteins ofSEQ No. 1122, 2df No. 1554 1123, 1129, 1172, 1207, 1264 SEQ ID IVAFALK241-247 for the proteins of SEQ No. 1124, 2df No. 1555 1145 SEQ IDIVAFALNMEMR 241-251 for the proteins of SEQ No. 1198, 2df No. 1556 1217,1218, 1219, 1220, 1221, 1222, 1223, 1244, 1251; 242-252 for the proteinof sequence SEQ ID No. 1132; 242-252 for the protein of sequence SEQ IDNo. 1199 SEQ ID IVESTTLADGTVVHGK 186-201 for the proteins of SEQ No.1254, 2d No. 1557 1255, 1257, 1258 SEQ ID IYNSLIGLNEK 74-84 for theproteins of SEQ No. 1144, 1187, 2d No. 1558 1188, 1235 SEQ IDKPDIGWWVGWIER 237-249 for the proteins of SEQ No. 1140 2df No. 1559 SEQID LACATNNLAR 50-59 for the proteins of SEQ No. 1248 2d No. 1560 SEQ IDLAQGELPFPAPVQSTVR 172-188 for the proteins of SEQ No. 1138 2d No. 1561SEQ ID LAQNELPYPIEIQK 177-190 for the proteins of SEQ No. 1187, 2d No.1562 1188, 1235 SEQ ID LAQNELQYPIEIQK 176-189 for the proteins of SEQNo. 1144 2d No. 1563 SEQ ID LDFGNK 143-148 for the proteins of SEQ No.1187, 2d No. 1564 1188, 1235; 142-147 for the protein of sequence SEQ IDNo. 1144 SEQ ID LDGSLNR 206-212 for the proteins of SEQ No. 1105 2d No.1565 SEQ ID LEIGK 244-248 for the proteins of SEQ No. 1107 2d No. 1566SEQ ID LEILQQALAELGLYPK 255-270 for the proteins of SEQ No. 1227 2df No.1567 SEQ ID LENQEQVK 173-180 for the proteins of SEQ No. 1135 2d No.1568 SEQ ID LETQEEVEK 195-203 for the proteins of SEQ No. 1122 2df No.1569 SEQ ID LETQEEVK 195-202 for the proteins of SEQ No. 1123, 2df No.1570 1129, 1172, 1205, 1207, 1224, 1264 SEQ ID LFAAEGVK 55-62 for theproteins of SEQ No. 1140 2df No. 1571 SEQ ID LFESAGVK 58-65 for theproteins of SEQ No. 1139 2df No. 1572 SEQ ID LFGAAGVK 30-37 for theproteins of SEQ No. 1138 2d No. 1573 SEQ ID LFPEWEK 110-116 for theproteins of SEQ No. 1146, 2df No. 1574 1147, 1148, 1149, 1150, 1151,1152, 1153, 1154, 1155, 1156, 1157, 1158, 1159, 1160, 1161, 1162, 1163,1164, 1165, 1166, 1167, 1169, 1170, 1174, 1175, 1176, 1177, 1178, 1179,1180, 1181, 1182, 1183, 1184, 1185, 1186, 1192, 1194, 1195, 1196, 1197,1202, 1203, 1204, 1206, 1209, 1210, 1211, 1212, 1213, 1214, 1215, 1225,1226, 1230, 1231, 1232, 1233, 1236, 1237, 1238, 1240, 1241, 1245, 1253,1260, 1261, 1265, 1266; 104-110 for the protein of sequence SEQ ID No.1189; 104-110 for the protein of sequence SEQ ID No. 1190 SEQ ID LGESR126-130 for the proteins of SEQ No. 1109 2de No. 1575 SEQ ID LGVDR121-125 for the proteins of SEQ No. 1107 2d No. 1576 SEQ ID LHVSER181-186 for the proteins of SEQ No. 1136, 2df No. 1577 1142, 1208, 1234,1243 SEQ ID LHYGNAK 131-137 for the proteins of SEQ No. 1143 2d No. 1578SEQ ID LLNLLSQSK 160-168 for the proteins of SEQ No. 1135 2d No. 1579SEQ ID LLQDER 243-248 for the proteins of SEQ No. 1191 2d No. 1580 SEQID LLVQDGDCGR 38-47 for the proteins of SEQ No. 1254, 1255, 2d No. 15811257, 1258 SEQ ID LNEVGYGNR 160-168 for the proteins of SEQ No. 1140 2dfNo. 1582 SEQ ID LNYGNADPSTK 144-154 for the proteins of SEQ No. 1113, 2dNo. 1583 1121 SEQ ID LNYGNK 130-135 for the proteins of SEQ No. 1135 2dNo. 1584 SEQ ID LPASK 178-182 for the proteins of SEQ No. 1247, 2d No.1585 1263; 172-176 for the protein of sequence SEQ ID No. 1256 SEQ IDLPHTLFALDADAVR 76-89 for the proteins of SEQ No. 1127, 1130 OXA No. 1586SEQ ID LPHTLFALDAGAVR 76-89 for the proteins of SEQ No. 1242 OXA No.1587 SEQ ID LPLAIMGFDSGILQSPK 62-78 for the proteins of SEQ No. 1107 2dNo. 1588 SEQ ID LPLAIMGYDADILLDATTPR 69-88 for the proteins of SEQ No.1109 2de No. 1589 SEQ ID LPSSLIALETGAVR 98-111 for the proteins of SEQNo. 1139 2df No. 1590 SEQ ID LPVSAQTLQYTANILK 170-185 for the proteinsof SEQ No. 1105 2d No. 1591 SEQ ID LPVSER 205-210 for the proteins ofSEQ No. 1139 2df No. 1592 SEQ ID LPVSPTAVDMTER 173-185 for the proteinsof SEQ No. 1254, 2d No. 1593 1255, 1257, 1258 SEQ ID LSASK 178-182 forthe proteins of SEQ No. 1110, OXA No. 1594 1115, 1116, 1117, 1126, 1141,1193, 1200, 1229, 1250, 1259, 1262; 169-173 for the protein of sequenceSEQ ID No. 1106; 169-173 for the protein of sequence SEQ ID No. 1111;169-173 for the protein of sequence SEQ ID No. 1112; 179-183 for theprotein of sequence SEQ ID No. 1248 SEQ ID LSAVPIYQEVAR 121-132 for theproteins of SEQ No. 1137 2df No. 1595 SEQ ID LSAVPVYQELAR 127-138 forthe proteins of SEQ No. 1122, 2df No. 1596 1123, 1129, 1172, 1205, 1207,1264; 125-136 for the protein of sequence SEQ ID No. 1124; 125-136 forthe protein of sequence SEQ ID No. 1132; 125-136 for the protein ofsequence SEQ ID No. 1145; 125-136 for the protein of sequence SEQ ID No.1198; 125-136 for the protein of sequence SEQ ID No. 1199; 125-136 forthe protein of sequence SEQ ID No. 1217; 125-136 for the protein ofsequence SEQ ID No. 1218; 125-136 for the protein of sequence SEQ ID No.1219; 125-136 for the protein of sequence SEQ ID No. 1220; 125-136 forthe protein of sequence SEQ ID No. 1221; 125-136 for the protein ofsequence SEQ ID No. 1222; 125-136 for the protein of sequence SEQ ID No.1223; 125-136 for the protein of sequence SEQ ID No. 1244; 125-136 forthe protein of sequence SEQ ID No. 1251 SEQ ID LSCTLVIDEASGDLLHR 37-53for the proteins of SEQ No. 1109 2de No. 1597 SEQ ID LSLQHGWFIGWIEK211-224 for the proteins of SEQ No. 1252 2de No. 1598 SEQ IDLSQNSLPFSQEAMNSVK 164-180 for the proteins of SEQ No. 1143 2d No. 1599SEQ ID LSVNPK 168-173 for the proteins of SEQ No. 1252 2de No. 1600 SEQID LTQDER 239-244 for the proteins of SEQ No. 1254, 2d No. 1601 1255,1257, 1258 SEQ ID LTVGAR 245-250 for the proteins of SEQ No. 1109 2deNo. 1602 SEQ ID LYGFALNIDMPGGEADIGK 228-246 for the proteins of SEQ No.1138 2d No. 1603 SEQ ID LYHNELPFR 178-186 for the proteins of SEQ No.1114, 2d No. 1604 1249 SEQ ID LYHNK 176-180 for the proteins of SEQ No.1136, 2df No. 1605 1142, 1208, 1234, 1243 SEQ ID LYQNDLPFR 178-186 forthe proteins of SEQ No. 1133 2d No. 1606 SEQ ID MDDLFK 243-248 for theproteins of SEQ No. 1108, OXA No. 1607 1114, 1125, 1128, 1133, 1173,1201, 1239, 1246, 1249; 232-237 for the protein of sequence SEQ ID No.1120 SEQ ID MEDLHK 243-248 for the proteins of SEQ No. 1113, 2d No. 16081121 SEQ ID MLIALIGLENHK 85-96 for the proteins of SEQ No. 1264 2df No.1609 SEQ ID MLLIEQQGDAALYAK 198-212 for the proteins of SEQ No. 1137 2dfNo. 1610 SEQ ID MLLIK 204-208 for the proteins of SEQ No. 1122, 2df No.1611 1123, 1129, 1172, 1205, 1207, 1224, 1264 SEQ ID MLNALIGLEHHK 84-95for the proteins of SEQ No. 1146, 1147, 2df No. 1612 1148, 1149, 1150,1151, 1152, 1153, 1154, 1155, 1156, 1157, 1158, 1159, 1160, 1161, 1162,1163, 1164, 1166, 1167, 1169, 1170, 1174, 1175, 1176, 1177, 1178, 1179,1180, 1181, 1182, 1183, 1184, 1185, 1186, 1192, 1194, 1195, 1196, 1197,1202, 1203, 1204, 1206, 1209, 1210, 1211, 1212, 1213, 1214, 1215, 1225,1226, 1230, 1231, 1232, 1233, 1236, 1237, 1238, 1240, 1245, 1253, 1260,1261, 1265, 1266; 78-89 for the protein of sequence SEQ ID No. 1189;78-89 for the protein of sequence SEQ ID No. 1190 SEQ ID MLNALIGLENHK85-96 for the proteins of SEQ No. 1122, 1123, 2df No. 1613 1129, 1172,1205, 1207, 1224 SEQ ID MLNALIGLENQK 83-94 for the proteins of SEQ No.1124, 1132, 2df No. 1614 1145, 1198, 1199, 1217, 1218, 1219, 1220, 1221,1222, 1223, 1244, 1251 SEQ ID MLNALIGLEYHK 84-95 for the proteins of SEQNo. 1241 2df No. 1615 SEQ ID MLNALIGLQHGK 78-89 for the proteins of SEQNo. 1227 2df No. 1616 SEQ ID MLNALISLEHHK 84-95 for the proteins of SEQNo. 1165 2df No. 1617 SEQ ID MQAYVDAFDYGNR 139-151 for the proteins ofSEQ No. 1137 2df No. 1618 SEQ ID MQEGLNK 123-129 for the proteins of SEQNo. 1135 2d No. 1619 SEQ ID MSPASTYK 87-94 for the proteins of SEQ No.1140 2df No. 1620 SEQ ID MTAGGK 234-239 for the proteins of SEQ No. 12562d No. 1621 SEQ ID MVSGK 165-169 for the proteins of SEQ No. 1105 2d No.1622 SEQ ID NEHDPVLPYR 71-80 for the proteins of SEQ No. 1254, 1255, 2dNo. 1623 1257, 1258 SEQ ID NEHQIFK 86-92 for the proteins of SEQ No.1248; 85-91 2d No. 1624 for the protein of sequence SEQ ID No. 1141 SEQID NEHQVFK 85-91 for the proteins of SEQ No. 1110, 1115, OXA No. 16251116, 1117, 1126, 1193, 1200, 1229, 1250, 1259, 1262; 76-82 for theprotein of sequence SEQ ID No. 1106; 76-82 for the protein of sequenceSEQ ID No. 1111; 76-82 for the protein of sequence SEQ ID No. 1112 SEQID NEITYK 262-267 for the proteins of SEQ No. 1122, 2df No. 1626 1123,1129, 1172, 1205, 1207, 1224, 1264 SEQ ID NELLMK 260-265 for theproteins of SEQ No. 1124, 2df No. 1627 1145, 1198, 1217, 1218, 1220,1221, 1222, 1223, 1244, 1251; 261-266 for the protein of sequence SEQ IDNo. 1132; 261-266 for the protein of sequence SEQ ID No. 1199 SEQ IDNELMMK 260-265 for the proteins of SEQ No. 1219 2df No. 1628 SEQ IDNELPFR 181-186 for the proteins of SEQ No. 1108, OXA No. 1629 1113,1114, 1121, 1125, 1128, 1173, 1201, 1239, 1246, 1249; 170-175 for theprotein of sequence SEQ ID No. 1120 SEQ ID NFILIFIFVILISCK 5-19 for theproteins of SEQ No. 1144, 1187, 2d No. 1630 1235 SEQ ID NFILIFIFVILTSCK5-19 for the proteins of SEQ No. 1188 2d No. 1631 SEQ ID NISSYGNNLVR62-72 for the proteins of SEQ No. 1224 2df No. 1632 SEQ ID NISTYGNNLTR62-72 for the proteins of SEQ No. 1205 2df No. 1633 SEQ IDNLFNEVHTTGVLVIR 43-57 for the proteins of SEQ No. 1170 2df No. 1634 SEQID NLSTYGNALAR 62-72 for the proteins of SEQ No. 1122, 1123, 2df No.1635 1129, 1172, 1207, 1264 SEQ ID NMENLELFGK 187-196 for the proteinsof SEQ No. 1143 2d No. 1636 SEQ ID NMLLLEENNGYK 201-212 for the proteinsof SEQ No. 1198 2df No. 1637 SEQ ID NMLLLEESNGYK 201-212 for theproteins of SEQ No. 1124, 2df No. 1638 1132, 1145, 1199, 1217, 1218,1219, 1220, 1221, 1223, 1244, 1251 SEQ ID NMLLLEK 201-207 for theproteins of SEQ No. 1222 2df No. 1639 SEQ ID NMTLGDAMK 117-125 for theproteins of SEQ No. 1146, 2df No. 1640 1150, 1151, 1154, 1155, 1160,1163, 1164, 1174, 1177, 1180, 1182, 1192, 1203, 1204, 1206, 1233, 1261;111-119 for the protein of sequence SEQ ID No. 1189; 111-119 for theprotein of sequence SEQ ID No. 1190 SEQ ID NNGLTEAWLESSLK 156-169 forthe proteins of SEQ No. 1118, 2d No. 1641 1134; 141-154 for the proteinof sequence SEQ ID No. 1119 SEQ ID NQLPFK 181-186 for the proteins ofSEQ No. 1131 2d No. 1642 SEQ ID NQLPFQVEHQR 181-191 for the proteins ofSEQ No. 1127, OXA No. 1643 1130, 1242 SEQ ID NSAIENTIDNMYLQDLENS 191-211for the proteins of SEQ No. 1134 2d No. 1644 TK SEQ IDNSAIENTIENMYLQDLDNS 191-211 for the proteins of SEQ No. 1118 2d No. 1645TK SEQ ID NSAIENTIENMYLQDLENSTK 176-196 for the proteins of SEQ No. 11192d No. 1646 SEQ ID NSAVWVYELFAK 119-130 for the proteins of SEQ No.1127, OXA No. 1647 1130, 1242 SEQ ID NSQVPAYK 118-125 for the proteinsof SEQ No. 1187, 2d No. 1648 1188, 1235; 117-124 for the protein ofsequence SEQ ID No. 1144 SEQ ID NSTVWIYELFAK 119-130 for the proteins ofSEQ No. 1114, 2d No. 1649 1249 SEQ ID NSTVWVYELFAK 119-130 for theproteins of SEQ No. 1108, OXA No. 1650 1125, 1128, 1131, 1133, 1173,1201, 1239, 1246; 108-119 for the protein of sequence SEQ ID No. 1120SEQ ID NSTVWVYQLFAK 119-130 for the proteins of SEQ No. 1113, 2d No.1651 1121 SEQ ID NTSGALVIQTDK 48-59 for the proteins of SEQ No. 1218 2dfNo. 1652 SEQ ID NTSGVLVIQTDK 48-59 for the proteins of SEQ No. 1124,1132, 2df No. 1653 1145, 1198, 1199, 1217, 1219, 1220, 1221, 1222, 1223,1244, 1251 SEQ ID NVDEMFYYYDGSK 75-87 for the proteins of SEQ No. 11352d No. 1654 SEQ ID NWILR 204-208 for the proteins of SEQ No. 1108, OXANo. 1655 1114, 1125, 1127, 1128, 1130, 1133, 1173, 1201, 1239, 1242,1246, 1249; 193-197 for the protein of sequence SEQ ID No. 1120 SEQ IDNWNAAMDLR 125-133 for the proteins of SEQ No. 1140 2df No. 1656 SEQ IDNYVDAFHYGNQDISGDK 118-134 for the proteins of SEQ No. 1252 2de No. 1657SEQ ID QADHAILVFDQAR 51-63 for the proteins of SEQ No. 1133 2d No. 1658SEQ ID QAEHALLVFGQER 51-63 for the proteins of SEQ No. 1127, 1130, OXANo. 1659 1242 SEQ ID QAITK 251-255 for the proteins of SEQ No. 1136, 2dfNo. 1660 1142, 1208, 1243; 247-251 for the protein of sequence SEQ IDNo. 1234 SEQ ID QAMLTEANSDYIIR 193-206 for the proteins of SEQ No. 11422df No. 1661 SEQ ID QEVQFVSALAR 171-181 for the proteins of SEQ No. 12272df No. 1662 SEQ ID QFASIK 243-248 for the proteins of SEQ No. 1105 2dNo. 1663 SEQ ID QGMPGSIR 254-261 for the proteins of SEQ No. 1205 2dfNo. 1664 SEQ ID QGMSGSIR 254-261 for the proteins of SEQ No. 1224 2dfNo. 1665 SEQ ID QGQTQQSYGNDLAR 58-71 for the proteins of SEQ No. 1146,1147, 2df No. 1666 1148, 1149, 1150, 1151, 1152, 1153, 1154, 1155, 1156,1157, 1158, 1159, 1160, 1161, 1162, 1163, 1164, 1165, 1166, 1167, 1169,1170, 1174, 1175, 1176, 1177, 1178, 1179, 1180, 1181, 1182, 1183, 1184,1185, 1186, 1194, 1195, 1196, 1197, 1202, 1203, 1204, 1206, 1209, 1210,1211, 1212, 1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236,1237, 1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 52-65 forthe protein of sequence SEQ ID No. 1189; 52-65 for the protein ofsequence SEQ ID No. 1190 SEQ ID QIDYGNADPSTIK 143-155 for the proteinsof SEQ No. 1127, OXA No. 1667 1130, 1242 SEQ ID QIDYGNVDPSTIK 143-155for the proteins of SEQ No. 1131 2d No. 1668 SEQ ID QIGEAR 129-134 forthe proteins of SEQ No. 1136, 2df No. 1669 1208, 1234, 1243 SEQ IDQIGQAR 129-134 for the proteins of SEQ No. 1142 2df No. 1670 SEQ IDQIMLIEQTPAFTLR 190-203 for the proteins of SEQ No. 1228 2df No. 1671 SEQID QLGSAIDQFWLR 152-163 for the proteins of SEQ No. 1137 2df No. 1672SEQ ID QLHDNK 199-204 for the proteins of SEQ No. 1139 2df No. 1673 SEQID QLIFVHTVVQK 229-239 for the proteins of SEQ No. 1105 2d No. 1674 SEQID QLIFVHTVVQKPGK 229-242 for the proteins of SEQ No. 1105 2d No. 1675SEQ ID QLPVK 178-182 for the proteins of SEQ No. 1191; OXA No. 1676184-188 for the protein of sequence SEQ ID No. 1137 SEQ ID QLPVKPR184-190 for the proteins of SEQ No. 1137 2df No. 1677 SEQ ID QLSLDVLDK265-273 for the proteins of SEQ No. 1168, 2df No. 1678 1171, 1216 SEQ IDQLVYAR 237-242 for the proteins of SEQ No. 1191 2d No. 1679 SEQ IDQMMLTEASTDYIIR 217-230 for the proteins of SEQ No. 1139 2df No. 1680 SEQID QMSIVEATPDYVLHGK 214-229 for the proteins of SEQ No. 1140 2df No.1681 SEQ ID QPTDPAR 99-105 for the proteins of SEQ No. 1191 2d No. 1682SEQ ID QPTDPTR 93-99 for the proteins of SEQ No. 1254, 1255, 2d No. 16831257, 1258 SEQ ID QPVSAGIR 246-253 for the proteins of SEQ No. 1254, 2dNo. 1684 1255, 1257, 1258 SEQ ID QQLVK 275-279 for the proteins of SEQNo. 1139 2df No. 1685 SEQ ID QTLVFAR 232-238 for the proteins of SEQ No.1254, 2d No. 1686 1255, 1257, 1258 SEQ ID QVGAEK 126-131 for theproteins of SEQ No. 1228 2df No. 1687 SEQ ID QVVFAR 238-243 for theproteins of SEQ No. 1107 2d No. 1688 SEQ ID SADEVLPYGGK 84-94 for theproteins of SEQ No. 1138 2d No. 1689 SEQ ID SADEVLPYGGKPQR 84-97 for theproteins of SEQ No. 1138 2d No. 1690 SEQ ID SCATNDLAR 50-58 for theproteins of SEQ No. 1110, 1193, OXA No. 1691 1250, 1259; 41-49 for theprotein of sequence SEQ ID No. 1106; 41-49 for the protein of sequenceSEQ ID No. 1111; 41-49 for the protein of sequence SEQ ID No. 1112 SEQID SCATNNLAR 50-58 for the proteins of SEQ No. 1115, 1116, OXA No. 16921117, 1126, 1141, 1200, 1229, 1262 SEQ ID SDIPGGSK 251-258 for theproteins of SEQ No. 1107 2d No. 1693 SEQ ID SDWGK 29-33 for the proteinsof SEQ No. 1133 2d No. 1694 SEQ ID SEDNFHISSQQHEK 27-40 for the proteinsof SEQ No. 1122, 1123, 2df No. 1695 1129, 1172, 1207, 1264 SEQ IDSEMPASIR 252-259 for the proteins of SEQ No. 1124, 2df No. 1696 1145,1198, 1217, 1218, 1219, 1220, 1221, 1222, 1244, 1251; 253-260 for theprotein of sequence SEQ ID No. 1132; 253-260 for the protein of sequenceSEQ ID No. 1199 SEQ ID SEMPASTR 252-259 for the proteins of SEQ No. 12232df No. 1697 SEQ ID SFAAHNQDQDLR 103-114 for the proteins of SEQ No.1114, 2d No. 1698 1249 SEQ ID SFAGHNK 103-109 for the proteins of SEQNo. 1133 2d No. 1699 SEQ ID SFAGHNQDQDLR 103-114 for the proteins of SEQNo. 1127, 2d No. 1700 1130, 1131, 1242 SEQ ID SFAGHNQDQNLR 103-114 forthe proteins of SEQ No. 1113, 2d No. 1701 1121 SEQ ID SFLESWAK 100-107for the proteins of SEQ No. 1144 2d No. 1702 SEQ ID SFTAWEK 109-115 forthe proteins of SEQ No. 1124, 2df No. 1703 1132, 1145, 1199, 1217, 1218,1219, 1220, 1221, 1222, 1223, 1244, 1251; 104-110 for the protein ofsequence SEQ ID No. 1227 SEQ ID SFTTWEK 109-115 for the proteins of SEQNo. 1198 2df No. 1704 SEQ ID SGSGWLR 207-213 for the proteins of SEQ No.1107 2d No. 1705 SEQ ID SGWGMAVDPQVGWYVGF 221-240 for the proteins ofSEQ No. 1168, 2df No. 1706 VEK 1171, 1216 SEQ ID SGWGMDVSPQVGWLTGW219-238 for the proteins of SEQ No. 1224 2df No. 1707 VEK SEQ IDSGWGMDVTPQVGWLTGW 219-238 for the proteins of SEQ No. 1205 2df No. 1708VEK SEQ ID SIHPASTFK 69-77 for the proteins of SEQ No. 1137 2df No. 1709SEQ ID SIPTK 252-256 for the proteins of SEQ No. 1110, OXA No. 17101115, 1116, 1117, 1126, 1141, 1193, 1200, 1229, 1248, 1250, 1259, 1262,1263; 243-247 for the protein of sequence SEQ ID No. 1106; 243-247 forthe protein of sequence SEQ ID No. 1111; 243-247 for the protein ofsequence SEQ ID No. 1112 SEQ ID SISTK 252-256 for the proteins of SEQNo. 1247 2d No. 1711 SEQ ID SLGLSNNLSR 76-85 for the proteins of SEQ No.1139 2df No. 1712 SEQ ID SLSMSGK 4-10 for the proteins of SEQ No. 11092de No. 1713 SEQ ID SMLFIEEK 202-209 for the proteins of SEQ No. 1146,2df No. 1714 1147, 1148, 1149, 1150, 1151, 1152, 1153, 1154, 1155, 1156,1157, 1158, 1159, 1160, 1161, 1162, 1163, 1164, 1165, 1166, 1167, 1169,1174, 1175, 1176, 1177, 1178, 1179, 1180, 1182, 1183, 1184, 1185, 1186,1192, 1194, 1195, 1196, 1197, 1202, 1203, 1204, 1209, 1210, 1211, 1212,1213, 1214, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237, 1238,1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 196-203 for the proteinof sequence SEQ ID No. 1189; 196-203 for the protein of sequence SEQ IDNo. 1190 SEQ ID SNGEK 239-243 for the proteins of SEQ No. 1205, 2df No.1715 1224 SEQ ID SNGLTHSWLGSSLK 141-154 for the proteins of SEQ No. 12562d No. 1716 SEQ ID SNGYK 208-212 for the proteins of SEQ No. 1124, 2dfNo. 1717 1132, 1145, 1199, 1217, 1218, 1219, 1220, 1221, 1222, 1223,1244, 1251 SEQ ID SPTWELK 79-85 for the proteins of SEQ No. 1107 2d No.1718 SEQ ID SPTWELKPEYNPSPR 79-93 for the proteins of SEQ No. 1107 2dNo. 1719 SEQ ID SQDIVR 208-213 for the proteins of SEQ No. 1140 2df No.1720 SEQ ID SQQKPTDPTIWLK 100-112 for the proteins of SEQ No. 1109 2deNo. 1721 SEQ ID SQVGWLTGWVEQPDGK 225-240 for the proteins of SEQ No.1244 2df No. 1722 SEQ ID SSSNSCTTNNAAR 46-58 for the proteins of SEQ No.1247 2d No. 1723 SEQ ID SSSNSCTTNNATR 46-58 for the proteins of SEQ No.1263 2de No. 1724 SEQ ID SVYGELR 139-145 for the proteins of SEQ No.1228 2df No. 1725 SEQ ID SWILR 204-208 for the proteins of SEQ No. 11312d No. 1726 SEQ ID SYFDEAQTQGVIIIK 44-58 for the proteins of SEQ No.1122, 1123, 2df No. 1727 1129, 1172, 1205, 1207, 1224, 1264 SEQ ID SYLEK139-143 for the proteins of SEQ No. 1113, 2d No. 1728 1121 SEQ IDSYPMWEK 111-117 for the proteins of SEQ No. 1205, 2df No. 1729 1224 SEQID TAYIPASTFK 61-70 for the proteins of SEQ No. 1247, 1263; 2df No. 173077-86 for the protein of sequence SEQ ID No. 1168; 77-86 for the proteinof sequence SEQ ID No. 1171; 77-86 for the protein of sequence SEQ IDNo. 1216 SEQ ID TDDLFK 243-248 for the proteins of SEQ No. 1127, 2d No.1731 1130, 1131, 1242 SEQ ID TDINEIFK 95-102 for the proteins of SEQ No.1132, 1145, 2df No. 1732 1198, 1199, 1217, 1218, 1219, 1220, 1221, 1222,1223, 1244, 1251 SEQ ID TFIHNDPR 51-58 for the proteins of SEQ No. 12282df No. 1733 SEQ ID TGAGFTANR 216-224 for the proteins of SEQ No. 1118,2d No. 1734 1134; 201-209 for the protein of sequence SEQ ID No. 1119SEQ ID TGFNDGQK 197-204 for the proteins of SEQ No. 1143 2d No. 1735 SEQID TGLADSK 210-216 for the proteins of SEQ No. 1187, 2d No. 1736 1188;209-215 for the protein of sequence SEQ ID No. 1144 SEQ ID TGLDLMQK140-147 for the proteins of SEQ No. 1205 2df No. 1737 SEQ ID TGLELMQK140-147 for the proteins of SEQ No. 1122, 2df No. 1738 1123, 1129, 1172,1207, 1264 SEQ ID TGMGYPK 198-204 for the proteins of SEQ No. 1105 2dNo. 1739 SEQ ID TGNGR 197-201 for the proteins of SEQ No. 1252 2de No.1740 SEQ ID TGTGSFIDAR 200-209 for the proteins of SEQ No. 1256 2d No.1741 SEQ ID TGTGSLSDAK 211-220 for the proteins of SEQ No. 1109 2de No.1742 SEQ ID TGVATEYQPEIGWWAGWV 213-232 for the proteins of SEQ No. 11372df No. 1743 ER SEQ ID TGVSYPLLADGTR 202-214 for the proteins of SEQ No.1254, 2d No. 1744 1255, 1257, 1258 SEQ ID TGWAAMDIK 217-225 for theproteins of SEQ No. 1132, 2df No. 1745 1199 SEQ ID TGWAMDIK 217-224 forthe proteins of SEQ No. 1124, 2df No. 1746 1145, 1198, 1218, 1219, 1220,1221, 1222, 1223, 1244, 1251 SEQ ID TGWAMDVK 217-224 for the proteins ofSEQ No. 1217 2df No. 1747 SEQ ID TGWATR 206-211 for the proteins of SEQNo. 1228 2df No. 1748 SEQ ID TGWCFDCTPELGWWVGW 205-223 for the proteinsof SEQ No. 1138 2d No. 1749 VK SEQ ID TGWEGR 211-216 for the proteins ofSEQ No. 1108, OXA No. 1750 1114, 1125, 1127, 1128, 1130, 1131, 1173,1201, 1239, 1242, 1246, 1249; 200-205 for the protein of sequence SEQ IDNo. 1120 SEQ ID TGWFVDK 230-236 for the proteins of SEQ No. 1140 2df No.1751 SEQ ID TGYDTK 209-214 for the proteins of SEQ No. 1234 2df No. 1752SEQ ID TGYGVR 233-238 for the proteins of SEQ No. 1139 2df No. 1753 SEQID TGYSAR 209-214 for the proteins of SEQ No. 1208 2df No. 1754 SEQ IDTGYSTR 209-214 for the proteins of SEQ No. 1136, 2df No. 1755 1142, 1243SEQ ID THESSNWGK 25-33 for the proteins of SEQ No. 1113, 1121 2d No.1756 SEQ ID TICTAIADAGTGK 25-37 for the proteins of SEQ No. 1254, 1255,2d No. 1757 1257, 1258 SEQ ID TIGGAPDAYWVDDSLQISAR 169-188 for theproteins of SEQ No. 1140 2df No. 1758 SEQ ID TLPFSASSYETLR 177-189 forthe proteins of SEQ No. 1228 2df No. 1759 SEQ ID TLPFSLK 189-195 for theproteins of SEQ No. 1157, 2df No. 1760 1161, 1169 SEQ ID TLPFSPK 189-195for the proteins of SEQ No. 1147, 2df No. 1761 1153, 1170, 1181, 1186,1197, 1203, 1225, 1240, 1241, 1253 SEQ ID TLPFSQEVQDEVQSILFIEEK 189-209for the proteins of SEQ No. 1206 2df No. 1762 SEQ IDTLPFSQEVQDEVQSMLFIEEK 189-209 for the proteins of SEQ No. 1150, 2df No.1763 1192 SEQ ID TLPFSQK 189-195 for the proteins of SEQ No. 1146, 2dfNo. 1764 1148, 1149, 1151, 1152, 1154, 1155, 1156, 1158, 1159, 1160,1162, 1163, 1164, 1165, 1166, 1167, 1174, 1175, 1176, 1177, 1178, 1179,1180, 1182, 1183, 1184, 1185, 1194, 1195, 1196, 1202, 1204, 1209, 1210,1211, 1212, 1213, 1214, 1215, 1226, 1230, 1231, 1232, 1233, 1236, 1238,1245, 1260, 1261, 1265, 1266; 183-189 for the protein of sequence SEQ IDNo. 1189; 183-189 for the protein of sequence SEQ ID No. 1190 SEQ IDTLPSSQK 189-195 for the proteins of SEQ No. 1237 2df No. 1765 SEQ IDTLQNGWFEGFIISK 225-238 for the proteins of SEQ No. 1118, 2d No. 17661134; 210-223 for the protein of sequence SEQ ID No. 1119 SEQ IDTMQEYLNK 123-130 for the proteins of SEQ No. 1143 2d No. 1767 SEQ IDTNGNSTSVYNESR 51-63 for the proteins of SEQ No. 1113, 1121 2d No. 1768SEQ ID TQTYQAYDAAR 72-82 for the proteins of SEQ No. 1140 2df No. 1769SEQ ID TTDPTIWEK 93-101 for the proteins of SEQ No. 1256 2d No. 1770 SEQID TTTTEVFK 96-103 for the proteins of SEQ No. 1153, 1186 2df No. 1771SEQ ID TWASNDFSR 41-49 for the proteins of SEQ No. 1143 2d No. 1772 SEQID TWDMVQR 191-197 for the proteins of SEQ No. 1137 2df No. 1773 SEQ IDTWMQFSVVWVSQEITQK 113-129 for the proteins of SEQ No. 1118, 2d No. 17741134; 98-114 for the protein of sequence SEQ ID No. 1119 SEQ ID TYPMWEK111-117 for the proteins of SEQ No. 1122, 2df No. 1775 1123, 1129, 1172,1207, 1264 SEQ ID TYVVDPAR 58-65 for the proteins of SEQ No. 1137 2dfNo. 1776 SEQ ID VAFSLNIEMK 244-253 for the proteins of SEQ No. 1205 2dfNo. 1777 SEQ ID VANSLIGLSTGAVR 70-83 for the proteins of SEQ No. 1138 2dNo. 1778 SEQ ID VEHQR 187-191 for the proteins of SEQ No. 1108, OXA No.1779 1113, 1114, 1121, 1125, 1127, 1128, 1130, 1131, 1133, 1173, 1201,1239, 1242, 1246, 1249; 176-180 for the protein of sequence SEQ ID No.1120 SEQ ID VELGK 248-252 for the proteins of SEQ No. 1138 2d No. 1780SEQ ID VFDDAGVSGTFVLMDITADR 38-57 for the proteins of SEQ No. 1137 2dfNo. 1781 SEQ ID VFLDSWAK 88-95 for the proteins of SEQ No. 1135 2d No.1782 SEQ ID VFLESWAK 101-108 for the proteins of SEQ No. 1187, 2d No.1783 1188, 1235 SEQ ID VFLSSWAQDMNLSSAIK 89-105 for the proteins of SEQNo. 1143 2d No. 1784 SEQ ID VGFER 134-138 for the proteins of SEQ No.1137 2df No. 1785 SEQ ID VILVFDQVR 55-63 for the proteins of SEQ No.1114, 1249 2d No. 1786 SEQ ID VITFTK 228-233 for the proteins of SEQ No.1252 2de No. 1787 SEQ ID VMAAMVR 158-164 for the proteins of SEQ No.1139 2df No. 1788 SEQ ID VPLAVMGYDAGILVDAHN 58-77 for the proteins ofSEQ No. 1256 2d No. 1789 PR SEQ ID VQANVK 195-200 for the proteins ofSEQ No. 1124, 2df No. 1790 1132, 1145, 1198, 1199, 1217, 1218, 1219,1220, 1221, 1222, 1223, 1244, 1251 SEQ ID VQDEVK 196-201 for theproteins of SEQ No. 1202 2df No. 1791 SEQ ID VQDEVQSMLFIEEK 196-209 forthe proteins of SEQ No. 1146, 2df No. 1792 1147, 1148, 1149, 1150, 1151,1153, 1154, 1155, 1156, 1157, 1158, 1159, 1160, 1162, 1163, 1164, 1165,1166, 1167, 1169, 1174, 1175, 1176, 1177, 1178, 1179, 1180, 1182, 1183,1184, 1185, 1186, 1192, 1194, 1195, 1196, 1197, 1203, 1204, 1209, 1210,1211, 1212, 1213, 1215, 1225, 1226, 1230, 1231, 1232, 1233, 1236, 1237,1238, 1240, 1241, 1245, 1253, 1260, 1261, 1265, 1266; 190-203 for theprotein of sequence SEQ ID No. 1189; 190-203 for the protein of sequenceSEQ ID No. 1190 SEQ ID VQDEVQSMLFIEEMNGNK 196-213 for the proteins ofSEQ No. 1170, 2df No. 1793 1181 SEQ ID VQDGVQSMLFIEEK 196-209 for theproteins of SEQ No. 1214 2df No. 1794 SEQ ID VQHEVQSMLFIEEK 196-209 forthe proteins of SEQ No. 1152 2df No. 1795 SEQ ID VSCLPCYQVVSHK 138-150for the proteins of SEQ No. 1140 2df No. 1796 SEQ ID VSCVWCYQALAR114-125 for the proteins of SEQ No. 1228 2df No. 1797 SEQ IDVSDVCSEVTAEGWQEVR 37-53 for the proteins of SEQ No. 1139 2df No. 1798SEQ ID VSEVEGWQIHGK 186-197 for the proteins of SEQ No. 1105 2d No. 1799SEQ ID VSFSLNIEMK 244-253 for the proteins of SEQ No. 1224 2df No. 1800SEQ ID VSPCSSFK 54-61 for the proteins of SEQ No. 1107 2d No. 1801 SEQID VSQVPAYK 105-112 for the proteins of SEQ No. 1135 2d No. 1802 SEQ IDVVFAR 229-233 for the proteins of SEQ No. 1256; OXA No. 1803 239-243 forthe protein of sequence SEQ ID No. 1107; 240-244 for the protein ofsequence SEQ ID No. 1109 SEQ ID WDGAK 97-101 for the proteins of SEQ No.1113, 1121 2d No. 1804 SEQ ID WDGEK 104-108 for the proteins of SEQ No.1151, 2df No. 1805 1160, 1177, 1180, 1182 SEQ ID WDGHIYDFPDWNR 92-104for the proteins of SEQ No. 1228 2df No. 1806 SEQ ID WDGIK 97-101 forthe proteins of SEQ No. 1114, 1249 2d No. 1807 SEQ ID WDGKPR 92-97 forthe proteins of SEQ No. 1110, 1115, OXA No. 1808 1116, 1117, 1126, 1141,1193, 1200, 1229, 1247, 1250, 1259, 1262, 1263; 83-88 for the protein ofsequence SEQ ID No. 1106; 83-88 for the protein of sequence SEQ ID No.1111; 83-88 for the protein of sequence SEQ ID No. 1112; 116-121 for theprotein of sequence SEQ ID No. 1140; 107-112 for the protein of sequenceSEQ ID No. 1168; 107-112 for the protein of sequence SEQ ID No. 1171;107-112 for the protein of sequence SEQ ID No. 1216; 93-98 for theprotein of sequence SEQ ID No. 1248 SEQ ID WDGQK 104-108 for theproteins of SEQ No. 1146, 2df No. 1809 1147, 1150, 1153, 1154, 1155,1157, 1161, 1163, 1164, 1165, 1169, 1170, 1181, 1186, 1192, 1197, 1203,1204, 1206, 1225, 1226, 1240, 1241, 1253, 1261, 1266; 98-102 for theprotein of sequence SEQ ID No. 1189; 98-102 for the protein of sequenceSEQ ID No. 1190 SEQ ID WDGQTR 95-100 for the proteins of SEQ No. 1136,1142, 2df No. 1810 1208, 1234, 1243 SEQ ID WDGVK 97-101 for the proteinsof SEQ No. 1127, 1130, 2d No. 1811 1133, 1242 SEQ ID WDGVNR 97-102 forthe proteins of SEQ No. 1108, 1125, OXA No. 1812 1128, 1131, 1173, 1201,1239, 1246; 86-91 for the protein of sequence SEQ ID No. 1120 SEQ IDWDYKPEFNGYK 78-88 for the proteins of SEQ No. 1256; 89-99 OXA No. 1813for the protein of sequence SEQ ID No. 1109 SEQ ID WETYSVVWFSQQITEWLG97-117 for the proteins of SEQ No. 1105 2d No. 1814 MER SEQ ID WNGQK104-108 for the proteins of SEQ No. 1152, 2df No. 1815 1176, 1202, 1265SEQ ID YAQAK 155-159 for the proteins of SEQ No. 1140 2df No. 1816 SEQID YFSDFNAK 34-41 for the proteins of SEQ No. 1113, 1121 2d No. 1817 SEQID YGTHLDR 68-74 for the proteins of SEQ No. 1168, 1171, 2df No. 18181216 SEQ ID YIIHNK 54-59 for the proteins of SEQ No. 1144, 1187, 2d No.1819 1188, 1235 SEQ ID YLDELVK 245-251 for the proteins of SEQ No. 11432d No. 1820 SEQ ID YLMITEAGR 195-203 for the proteins of SEQ No. 1242OXA No. 1821 SEQ ID YLNLFSYGNANIGGGIDK 135-152 for the proteins of SEQNo. 1247, OXA No. 1822 1263 SEQ ID YNGEK 96-100 for the proteins of SEQNo. 1187, 1188, 2d No. 1823 1235 SEQ ID YPHNPR 88-93 for the proteins ofSEQ No. 1252 2de No. 1824 SEQ ID YPVVWYSQQVAHHLGAQR 103-120 for theproteins of SEQ No. 1255 2d No. 1825 SEQ ID YSNVLAFK 106-113 for theproteins of SEQ No. 1143 2d No. 1826 SEQ ID YSPASTFK 68-75 for theproteins of SEQ No. 1108, 1113, OXA No. 1827 1114, 1121, 1125, 1127,1128, 1130, 1131, 1133, 1173, 1201, 1239, 1242, 1246, 1249; 57-64 forthe protein of sequence SEQ ID No. 1120 SEQ ID YSVVPVYQQLAR 141-152 forthe proteins of SEQ No. 1139 2df No. 1828 SEQ ID YSVVWYSQLTAK 109-120for the proteins of SEQ No. 1191 2d No. 1829 SEQ ID YSVVWYSQQVAHHLGAQR103-120 for the proteins of SEQ No. 1254, 2d No. 1830 1257, 1258 SEQ IDYTPASTFK 55-62 for the proteins of SEQ No. 1191 2d No. 1831 SEQ IDYTSAFGYGNADVSGEPGK 130-147 for the proteins of SEQ No. 1191 2d No. 1832SEQ ID YVFVSALTGNLGSNLTSSIK 228-247 for the proteins of SEQ No. 1119; 2dNo. 1833 243-262 for the protein of sequence SEQ ID No. 1118 SEQ IDYVFVSALTGSLGSNLTSSIK 243-262 for the proteins of SEQ No. 1134 2d No.1834 SEQ ID YVGHDR 50-55 for the proteins of SEQ No. 1138 2d No. 1835SEQ ID ANQAFLPASTFK 62-73 for the proteins of SEQ No. 1136, 1142, 2dfNo. 2160 1208, 1234, 1243 SEQ ID DEHQVFK 88-94 for the proteins of SEQNo. 1136, 1142, 2df No. 2161 1208, 1234, 1243 SEQ ID DHNLITAMK 108-116for the proteins of SEQ No. 1136, 2df No. 2162 1208, 1234 SEQ ID DIATWNR101-107 for the proteins of SEQ No. 1136, 2df No. 2163 1208, 1234 SEQ IDIPNSLIALDLGVVK 74-87 for the proteins of SEQ No. 1136, 1142, 2df No.2164 1208, 1234, 1243 SEQ ID ISATEQISFLR 164-174 for the proteins of SEQNo. 1136, 2df No. 2165 1208, 1234 SEQ ID QAMLTEANGDYIIR 193-206 for theproteins of SEQ No. 1136, 2df No. 2166 1208, 1234, 1243 SEQ ID QQGFTNNLK52-60 for the proteins of SEQ No. 1136, 1142, 2df No. 2167 1208, 1234,1243 SEQ ID SQGVVVLWNENK 40-51 for the proteins of SEQ No. 1136, 1208,2df No. 2168 1234, 1243 SEQ ID SWNAHFTEHK 30-39 for the proteins of SEQNo. 1136, 1208, 2df No. 2169 1234, 1243 SEQ ID VLALSAVFLVASIIGMPAVAK3-23 for the proteins of SEQ No. 1136, 1208, 2df No. 2170 1234, 1243 SEQID YSVVPVYQEFAR 117-128 for the proteins of SEQ No. 1136, 2df No. 21711142, 1208, 1234, 1243

In the clinical interest column, the entries 2d, 2de, 2df correspond tothe functional subgroups of OXA beta-lactamases which the correspondingpeptide makes it possible to detect. Therefore, the detection of a 2dfpeptide will indicate the presence of a carbapenemase beta-lactamasecapable of hydrolysing carbapenems.

The entry 2de will indicate the presence of a beta-lactamase with anextended spectrum (ESBL) capable of hydrolysing penicillins,first-generation cephalosporins such as cephaloridine and cefalotin, andat least one antibiotic from the oxyimino-beta-lactam class such ascefotaxime, ceftazidime or monobactams such as aztreonam.

The entry OXA indicates a common peptide between at least two of thesubgroups 2d, 2de and 2df. The corresponding peptide indicates thepresence of an OXA beta-lactamase and the presence of a mechanism ofresistance at least to penicillins and to first-generationcephalosporins.

The detection of a mechanism of resistance to ESBL (extended-spectrumbeta-lactamase) cephalosporins, induced by the OXA protein, ischaracterised by the detection of at least one resistance-marking 2depeptide chosen from the sequences SEQ ID No. 1277, 1297, 1323, 1344,1368, 1369, 1373, 1375, 1392, 1421, 1423, 1427, 1429, 1439, 1444, 1446,1450, 1451, 1457, 1465, 1468, 1490, 1491, 1495, 1498, 1534, 1543, 1545,1575, 1589, 1597, 1598, 1600, 1602, 1657, 1713, 1721, 1724, 1740, 1742,1787, 1824, 1268, 1269, 1270, 1271, 1272, 1278, 1279, 1280, 1281, 1283,1285, 1288, 1290, 1295, 1299, 1300, 1301, 1302, 1303, 1304, 1305, 1306,1307, 1308, 1309, 1310, 1314, 1315, 1316, 1317, 1318, 1319, 1320, 1332,1337, 1339, 1340, 1341, 1342, 1350, 1354, 1355, 1356, 1357, 1358, 1359,1360, 1365, 1366, 1367, 1386, 1389, 1390, 1391, 1393, 1394, 1402, 1404,1405, 1407, 1408, 1413, 1414, 1419, 1420, 1425, 1432, 1433, 1440, 1447,1448, 1456, 1471, 1472, 1477, 1478, 1480, 1485, 1487, 1488, 1499, 1504,1506, 1508, 1509, 1510, 1513, 1514, 1515, 1516, 1521, 1522, 1525, 1526,1530, 1533, 1539, 1540, 1548, 1550, 1551, 1552, 1553, 1554, 1555, 1556,1559, 1567, 1569, 1570, 1571, 1572, 1574, 1577, 1582, 1590, 1592, 1595,1596, 1605, 1609, 1610, 1611, 1612, 1613, 1614, 1615, 1616, 1617, 1618,1620, 1626, 1627, 1628, 1632, 1633, 1634, 1635, 1637, 1638, 1639, 1640,1652, 1653, 1656, 1660, 1661, 1662, 1664, 1665, 1666, 1669, 1670, 1671,1672, 1673, 1677, 1678, 1680, 1681, 1685, 1687, 1695, 1696, 1697, 1703,1704, 1706, 1707, 1708, 1709, 1712, 1714, 1715, 1717, 1720, 1722, 1725,1727, 1729, 1730, 1732, 1733, 1737, 1738, 1743, 1746, 1748, 1751, 1752,1753, 1754, 1755, 1758, 1759, 1760, 1761, 1762, 1763, 1764, 1765, 1769,1771, 1773, 1775, 1776, 1777, 1781, 1785, 1788, 1790, 1791, 1792, 1793,1794, 1795, 1796, 1797, 1798, 1800, 1805, 1806, 1809, 1810, 1815, 1816,1818, 1828, 2160, 2161, 2162, 2163, 2164, 2165, 2166, 2167, 2168, 2169,2170, 2171.

The detection of a mechanism of resistance to carbapenems or tocephalosporins, induced by the expression of the GES protein, ischaracterised by the detection of at least one peptide belonging to theGES protein and to its different sequence variants SEQ ID No. 2114 toSEQ ID No. 2130.

SEQ ID No. 2114:MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2115: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2116: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQLAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2117: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2118: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2119: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2120: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGSRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2121: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2122: MRFIHALLLAGTAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLCDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2123: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2124: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKESEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2125: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2126: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAEIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2127: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2128: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2129: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK SEQ ID No.2130: MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGACANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILS TDK

said peptides being chosen, preferably, from the peptides of sequenceSEQ ID No. 2131 to SEQ ID No. 2159 as defined hereafter:

Peptide SEQ ID Clinical No. Amino acid sequence Position of the peptidein the GES protein(s) interest SEQ ID AAEIGVAIVDPQGEIVAGHR 36-55 for theproteins of SEQ No. 2126 carba No. 2131 SEQ ID AAQIGVAIVDPQGEIVAGHR36-55 for the proteins of SEQ No. 2114, 2115, ESBL No. 2132 2116, 2117,2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125, 2127, 2128, 2129, 2130SEQ ID AGFPK 218-222 for the proteins of SEQ No. 2114, ESBL No. 21332115, 2116, 2117, 2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125, 2126,2127, 2128, 2129, 2130 SEQ ID DTTTPIAMAR 174-183 for the proteins of SEQNo. 2114, ESBL No. 2134 2115, 2116, 2117, 2118, 2119, 2120, 2121, 2122,2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ ID DWVVGEK 223-229for the proteins of SEQ No. 2114, ESBL No. 2135 2115, 2116, 2117, 2118,2119, 2120, 2121, 2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130SEQ ID DYAVAVYTTAPK 250-261 for the proteins of SEQ No. 2114, ESBL No.2136 2115, 2116, 2117, 2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125,2126, 2127, 2128, 2129, 2130 SEQ ID EIGGPAAMTQYFR 136-148 for theproteins of SEQ No. 2114, ESBL No. 2137 2115, 2116, 2117, 2118, 2119,2120, 2121, 2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ IDEPEMGDNTPGDLR 161-173 for the proteins of SEQ No. 2114, ESBL No. 21382115, 2116, 2120, 2121, 2122, 2127, 2128, 2130 SEQ ID EPEMNDNTPGDLR161-173 for the proteins of SEQ No. 2117, 2123 carba No. 2139 SEQ IDEPEMSDNTPGDLR 161-173 for the proteins of SEQ No. 2118, carba No. 21402119, 2125, 2126, 2129 SEQ ID ESEMSDNTPGDLR 161-173 for the proteins ofSEQ No. 2124 carba No. 2141 SEQ ID FAMCSTFK 60-67 for the proteins ofSEQ No. 2114, 2115, ESBL No. 2142 2116, 2117, 2118, 2119, 2120, 2121,2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ IDFIHALLLAGIAHSAYASEK 3-21 for the proteins of SEQ No. 2114, 2115, ESBLNo. 2143 2116, 2117, 2118, 2119, 2120, 2121, 2123, 2124, 2125, 2126,2127, 2128, 2129, 2130 SEQ ID FIHALLLAGTAHSAYASEK 3-21 for the proteinsof SEQ No. 2122 carba No. 2144 SEQ ID FPLAALVFER 68-77 for the proteinsof SEQ No. 2114, 2115, ESBL No. 2145 2116, 2117, 2118, 2119, 2120, 2121,2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ ID IDSGTER78-84 for the proteins of SEQ No. 2114, 2115, ESBL No. 2146 2116, 2117,2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129,2130 SEQ ID IGDSVSR 150-156 for the proteins of SEQ No. 2114, ESBL No.2147 2115, 2116, 2117, 2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125,2126, 2127, 2128, 2129, 2130 SEQ ID LSAVER 262-267 for the proteins ofSEQ No. 2114, ESBL No. 2148 2115, 2116, 2117, 2118, 2119, 2120, 2121,2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ IDLSYGPDMIVEWSPATER 89-105 for the proteins of SEQ No. 2114, 2116, ESBLNo. 2149 2117, 2118, 2120, 2121, 2122, 2124, 2125, 2126, 2130 SEQ IDLSYGPDMIVK 89-98 for the proteins of SEQ No. 2115, 2119, carba No. 21502123, 2127, 2128, 2129 SEQ ID NDIGFFK 239-245 for the proteins of SEQNo. 2114, ESBL No. 2151 2115, 2116, 2117, 2118, 2119, 2120, 2121, 2122,2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ ID TDLEK 26-30 forthe proteins of SEQ No. 2114, 2115, ESBL No. 2152 2116, 2117, 2118,2119, 2120, 2121, 2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130SEQ ID TGACANGAR 230-238 for the proteins of SEQ No. 2130 carba No. 2153SEQ ID TGTCANGAR 230-238 for the proteins of SEQ No. 2121, carba No.2154 2125, 2127 SEQ ID TGTCANGGR 230-238 for the proteins of SEQ No.2114, ESBL No. 2155 2115, 2116, 2117, 2118, 2119, 2122, 2123, 2124,2126, 2128, 2129 SEQ ID TGTCANGSR 230-238 for the proteins of SEQ No.2120 carba No. 2156 SEQ ID VLYGGALTSTSTHTIER 188-204 for the proteins ofSEQ No. 2114, ESBL No. 2157 2115, 2116, 2117, 2118, 2119, 2120, 2121,2122, 2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130 SEQ IDWLIGNQTGDATLR 205-217 for the proteins of SEQ No. 2114, ESBL No. 21582115, 2116, 2117, 2118, 2119, 2120, 2121, 2122, 2123, 2124, 2125, 2126,2127, 2128, 2129, 2130 SEQ ID WSPATER 99-105 for the proteins of SEQ No.2114, 2115, carba No. 2159 2116, 2117, 2118, 2119, 2120, 2121, 2122,2123, 2124, 2125, 2126, 2127, 2128, 2129, 2130

In the clinical interest column, the ESBL and carba entries correspondto the GES beta-lactamase activities which the corresponding peptidemakes it possible to detect. Therefore, the detection of a carba peptidewill indicate the presence of a carbapenemase beta-lactamase capable ofhydrolysing carbapenems, penicillins, first-generation cephalosporinssuch as cephaloridine and cefalotin, and at least one antibiotic fromthe oxyimino-beta-lactam class such as cefotaxime, ceftazidime or themonobactames such as aztreonam.

If no peptide referred to as carba is detected, the detection of apeptide referred to as ESBL will indicate the presence of abeta-lactamase with an extended spectrum (ESBL) capable of hydrolysingpenicillins, first-generation cephalosporins such as cephaloridine andcefalotin, and at least one antibiotic from the oxyimino-beta-lactamclass such as cefotaxime, ceftazidime or monobactams such as aztreonam.

The detection of a mechanism of resistance to cephalosporinases with anextended spectrum (ESBL) induced by the GES protein is thuscharacterised by the detection of at least one resistance-marking ESBLpeptide chosen from the sequences SEQ ID No. 2131 to SEQ ID No. 2159.

Certain peptide sequences can be common to several resistancemechanisms. Therefore, the following sequences are identical:

SEQ ID No. 834 and SEQ ID No. 978

SEQ ID No. 833 and SEQ ID No. 977

SEQ ID No. 832 and SEQ ID No. 976

SEQ ID No. 831 and SEQ ID No. 975

SEQ ID No. 826 and SEQ ID No. 974

SEQ ID No. 825 and SEQ ID No. 973

SEQ ID No. 824 and SEQ ID No. 972

SEQ ID No. 823 and SEQ ID No. 971

SEQ ID No. 822 and SEQ ID No. 970

SEQ ID No. 817 and SEQ ID No. 969

SEQ ID No. 813 and SEQ ID No. 967

SEQ ID No. 802 and SEQ ID No. 964

SEQ ID No. 798 and SEQ ID No. 963

SEQ ID No. 666 and SEQ ID No. 895

SEQ ID No. 350 and SEQ ID No. 1035

SEQ ID No. 349 and SEQ ID No. 1031

SEQ ID No. 347 and SEQ ID No. 1030

SEQ ID No. 346 and SEQ ID No. 1029

SEQ ID No. 345 and SEQ ID No. 1028

SEQ ID No. 343 and SEQ ID No. 1037 and SEQ ID No. 725

SEQ ID No. 342 and SEQ ID No. 1026

SEQ ID No. 341 and SEQ ID No. 1025

SEQ ID No. 340 and SEQ ID No. 1024

SEQ ID No. 339 and SEQ ID No. 1023

SEQ ID No. 338 and SEQ ID No. 1020

SEQ ID No. 337 and SEQ ID No. 1036 and SEQ ID No. 719

SEQ ID No. 337 and SEQ ID No. 1036

SEQ ID No. 336 and SEQ ID No. 841 and SEQ ID No. 981

SEQ ID No. 323 and SEQ ID No. 840 and SEQ ID No. 980

SEQ ID No. 315 and SEQ ID No. 839 and SEQ ID No. 948 and SEQ ID No. 979

SEQ ID No. 240 and SEQ ID No. 679

SEQ ID No. 184 and SEQ ID No. 626

SEQ ID No. 182 and SEQ ID No. 625

SEQ ID No. 1034 and SEQ ID No. 1999

SEQ ID No. 1032 and SEQ ID No. 1988

SEQ ID No. 1027 and SEQ ID No. 1970

SEQ ID No. 1022 and SEQ ID No. 1952

SEQ ID No. 1021 and SEQ ID No. 1937

SEQ ID No. 1019 and SEQ ID No. 1933

SEQ ID No. 809 and SEQ ID No. 966

SEQ ID No. 1033 and SEQ ID No. 1989

In all cases, the sequences above indicate the expression of a mechanismof resistance to cephalosporins.

The method of the invention and its advantages will become apparent fromthe rest of the present description which presents several non-limitingexamples of implementation of said method.

EXAMPLE 1 Identification of Microorganisms from a Sample by BiochemicalProfile

1. Culturing of the Sample on a Culture Medium

The optimum culture media and the optimum culture conditions aredifferent according to the species of microorganism. By default, thesample is seeded on different media:

-   -   sheep blood Columbia agar (bioMérieux ref. 43041) for 18 to 24 h        at 35° C., in an aerobic or anaerobic atmosphere;    -   TSA agar (bioMérieux ref. 43011) for 18 to 24 h at 37° C.

2. Identification of the Microorganisms

The identification is performed as follows:

-   -   1. Selection of isolated colonies    -   2. While maintaining the aseptic conditions, transfer of 3.0 mL        of aqueous sterile saline solution (0.45-0.50% NaCl, pH 4.5 to        7.0) into a transparent plastic (polystyrene) test tube    -   3. With the aid of a stirrer or a sterile swab, transfer of a        sufficient number of identical colonies into the saline solution        tube prepared in step 2, and adjustment of the bacterial        suspension between 0.50 and 0.63 McFarland with a calibrated        DENSICHEK from VITEK®    -   4. Positioning of the bacterial suspension tube and of a VITEK®        identification card on a VITEK® cartridge    -   5. Loading of the cartridge into the VITEK® instrument    -   6. The filling, sealing, incubation and reading operations are        automatic    -   7. Acquisition of a biochemical profile    -   8. Identification with the VITEK® system performed by comparing        to the biochemical profiles of known strains

EXAMPLE 2 Preparation of a Primary Urine Sample by MicroorganismEnrichment

The following protocol is performed in 16 steps (steps 5 to 12 areoptional and could be omitted if the enriched sample is subsequentlytreated according to examples 4 and onwards):

-   -   1. Centrifuging of 5 mL of contaminated urine, at 2000 g for 30        seconds    -   2. Recovery of the supernatant    -   3. Centrifuging at 15000 g for 5 minutes    -   4. Elimination of the supernatant    -   5. Washing of the pellet with 3 mL of distilled water by        resuspension    -   6. Centrifuging at 15000 g for 5 minutes    -   7. Elimination of the supernatant    -   8. Place the pellet in the presence of solvent (8 acetone        volumes for 1 methanol volume) for 1/10 dilution    -   9. Leave for 1 hour at −20° C.    -   10. Centrifuging at 15000 g for 5 minutes    -   11. Elimination of the supernatant    -   12. Place the pellet in the presence of solvent (8 acetone        volumes for 1 methanol volume) for 1/10 dilution    -   13. Leave for 1 hour at −20° C.    -   14. Centrifuging at 15000 g for 5 minutes    -   15. Elimination of the supernatant    -   16. The pellet constitutes the microorganism-enriched sample

EXAMPLE 3 Identification of Microorganisms from a Sample by MALDI-TOF

The identification is performed as follows:

-   -   1. Transfer, with the aid of a 1 μl oese, of a portion of        microorganism colony obtained according to example 1, or of an        enriched sample according to example 2, and uniform deposition        on a plate for MALDI-TOF mass spectrometry    -   2. Covering the deposit with 1 μl of matrix. The matrix used is        a saturated solution of HCCA (alpha-cyano-4-hydroxycinnamic        acid) in organic solvent (50% acetonitrile and 2.5%        trifluoroacetic acid)    -   3. Drying at ambient temperature    -   4. Introducing the plate into the mass spectrometer    -   5. Acquiring a mass spectrum    -   6. Comparing the obtained spectrum with the spectra contained in        a knowledge base    -   7. Identification of the microorganism by comparing the obtained        peaks with those in the knowledge base

EXAMPLE 4 Identification of Microorganisms from a Sample by ESI-TOF

The identification is performed as follows:

-   -   1. Sampling of a microorganism colony, obtained according to        example 1, or of an enriched sample according to example 2, and        suspension in 100 μl of demineralised water.    -   2. Centrifuging at 3000 g for 5 minutes.    -   3. Elimination of the supernatant.    -   4. Resuspension in 100 μl of demineralised water.    -   5. Centrifuging at 3000 g for 5 minutes.    -   6. Elimination of the supernatant.    -   7. Resuspension in 100 μl of an acetonitrile, demineralised        water and formic acid mixture (50/50/0.1%).    -   8. Filtration with a filter with a porosity of 0.45 μm.    -   9. Injection into a mass spectrometer in single MS mode.    -   10. Acquisition of a mass spectrum.    -   11. Comparing the obtained spectrum with the spectra contained        in a knowledge base.    -   12. Identification of the microorganism by referring to        reference spectra.

EXAMPLE 5 Obtaining Digested Proteins from Microorganisms

The following protocol is conventionally performed in 17 steps:

-   -   1. Sampling of a microorganism colony, obtained according to        example 1, or of an enriched sample according to example 2, and        suspension in 10 to 100 μl of a 6M guanidine hydrochloride        solution, 50 mM Tris-HCl, pH=8.0.    -   2. Addition of dithiothreitol (DTT) to achieve an end        concentration of 5 mM.    -   3. Reduction for 20 minutes at 95° C. in a water bath.    -   4. Cooling the tubes to ambient temperature    -   5. Addition of iodoacetamide to obtain an end concentration of        12.5 mM.    -   6. Alkylation for 40 minutes at ambient temperature and in the        dark.    -   7. Dilution by a factor of 6 with a 50 mM NH₄HCO₃ solution,        pH=8.0 to obtain an end guanidine hydrochloride concentration of        1M.    -   8. Addition of 1 μg of trypsin.    -   9. Digestion at 37° C. for between 6 hours and one night.    -   10. Addition of formic acid down to a pH below 4 to stop the        reaction.    -   11. The sample volume is made up to 1 mL with water/0.5% (v/v)        formic acid    -   12. Balancing of the Waters Oasis HLB columns with 1 ml of        methanol and then 1 ml of H₂O/0.1% (v/v) formic acid    -   13. Deposition of the sample which runs off by gravity    -   14. Washing with 1 ml of H₂O/0.1% (v/v) formic acid    -   15. Elution with 1 ml of a mixture of 80% methanol and 20%        water/0.1% (v/v) formic acid    -   16. The eluate is evaporated with a SpeedVac® SPD2010 evaporator        (Thermo Electron Corporation, Waltham, Mass., United States of        America) over 2 hours, in order to obtain a volume of around 100        μl.    -   17. The eluate is then taken up in a water/0.5% (v/v) formic        acid solution in a quantity sufficient for (QSF) 250 μl

EXAMPLE 6 Identification of a Resistance to TEM Beta-Lactams

Samples Sam10 to Sam61 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 1.

TABLE 1 Names Species Sam10 P. mirabilis Sam11 E. coli Sam12 E.aerogenes Sam13 E. coli Sam14 E. coli Sam15 E. coli Sam16 S. marcescensSam17 E. coli Sam18 E. coli Sam19 P. mirabilis Sam20 C. freundii Sam21E. coli Sam22 P. mirabilis Sam23 E. coli Sam24 K. pneumoniae Sam25 E.coli Sam26 K. oxytoca Sam27 P. mirabilis Sam28 E. coli Sam29 P.mirabilis Sam30 P. rettgeri Sam31 P. stuartii Sam32 S. Derby Sam33 E.coli Sam34 E. coli Sam35 E. coli Sam36 E. coli Sam37 E. coli Sam38 E.coli Sam39 E. coli Sam40 E. coli Sam41 E. coli Sam42 E. coli Sam43 E.coli Sam44 E. coli Sam45 K. pneumoniae Sam46 E. coli Sam47 K. pneumoniaeSam48 P. mirabilis Sam49 P. mirabilis Sam50 P. mirabilis Sam51 P.mirabilis Sam52 P. mirabilis Sam53 K. pneumoniae Sam54 P. mirabilisSam55 E. coli Sam56 E. coli Sam57 P. mirabilis Sam58 E. aerogenes Sam59E. aerogenes Sam60 E. coli Sam61 E. coli

Samples Sam10 to Sam61 correspond to a species able to comprise a TEMresistance mechanism (Enterobacteriaceae . . . ). The following methodis then performed to search for such a mechanism.

Each sample is treated according to example 5, then a volume of 50 μl ofdigested proteins is injected and analysed according to the followingconditions:

-   -   Dionex Ultimate 3000 chromatographic channel from the Dionex        Corporation (Sunnyvale, United States of America).    -   Waters BEH130 C18 Column, 2.1 mm inner diameter, 100 mm length,        3.5 μm particle size (Waters, Saint-Quentin En Yvelines,        France).    -   Solvent A: H₂O+0.1% formic acid.    -   Solvent B: ACN+0.1% formic acid.

HPLC gradient defined in Table 2 hereafter:

TABLE 2 Time (min) Flow (μl) Solvent A (%) Solvent B (%) 0 300 98 2 3300 98 2 34 300 54.6 45.4 35 300 0 100 55 300 0 100 55.1 300 98 2 74 30098 2

-   -   The eluate coming from the chromatographic column is directly        injected into the ionising source of the QTRAP® 5500 mass        spectrometer from Applied Biosystems (Foster City, United States        of America).    -   The peptides coming from the digestion of the microorganism        proteins are analysed by the mass spectrometer in MRM mode. Only        the peptides indicated in TABLE 3 are detected. To this end, the        fragment(s) of the peptides indicated in TABLE 3 is/are        detected. The charge state of the precursor, and the possible        existence of an oxidised methionine, are also indicated in TABLE        3.

TABLE 3 Transition Methionine Charge state of Clinical number Peptideoxidation Fragment ion the precursor interest 1 DAENQLGAR no y4monocharged 2 TEM 2 DAENQLGAR no y6 monocharged 2 TEM 3 DAENQLGAR no y7monocharged 2 TEM 4 ELTAFLHNIGDHVTR no y4 monocharged 2 TEM 5ELTAFLHNIGDHVTR no y8 monocharged 2 TEM 6 ELTAFLHNIGDHVTR no y9monocharged 2 TEM 7 ELTAFLHNMGDNVTR no y7 monocharged 2 2b 8ELTAFLHNMGDNVTR no y8 monocharged 2 2b 9 ELTAFLHNMGDNVTR no y9monocharged 2 2b 10 FPMISTFK yes y5 monocharged 2 2br 11 FPMISTFK yes y6monocharged 2 2br 12 FPMISTFK yes y7 monocharged 2 2br 13 FPMISTFK no y5monocharged 2 2br 14 FPMISTFK no y6 monocharged 2 2br 15 FPMISTFK no y7monocharged 2 2br 16 GEPELNEAIPNDER no y12 dicharged 2 2be 17GEPELNEAIPNDER no y5 monocharged 2 2be 18 GEPELNEAIPNDER no y7monocharged 2 2be 19 GSLGIIAALGPDGKPSR no y10 monocharged 2 2br 20GSLGIIAALGPDGKPSR no y8 monocharged 2 2br 21 GSLGIIAALGPDGKPSR no y9monocharged 2 2br 22 IHYSQNDLVEYSPVTEK no y6 monocharged 3 TEM 23IHYSQNDLVEYSPVTEK no y7 monocharged 3 TEM 24 IHYSQNDLVEYSPVTEK no y8monocharged 3 TEM 25 ILESFRPEER no b6 monocharged 2 TEM 26 ILESFRPEER nob8 monocharged 2 TEM 27 ILESFRPEER no y7 dicharged 2 TEM 28IVVIYTTGGQATMDER yes y7 monocharged 2 2be 29 IVVIYTTGGQATMDER yes y8monocharged 2 2be 30 IVVIYTTGGQATMDER yes y9 monocharged 2 2be 31IVVIYTTGGQATMDER no y6 monocharged 2 2be 32 IVVIYTTGGQATMDER no y8monocharged 2 2be 33 IVVIYTTGGQATMDER no y9 monocharged 2 2be 34LDSWEPELNEAIPNDER no y5 monocharged 3 2be 35 LDSWEPELNEAIPNDER no y6monocharged 3 2be 36 LDSWEPELNEAIPNDER no y7 monocharged 3 2be 37QIAEICASLIK no y6 monocharged 2 TEM 38 QIAEICASLIK no y7 monocharged 2TEM 39 QIAEICASLIK no y8 monocharged 2 TEM 40 SGANER no y3 monocharged 2TEM 41 SGANER no y4 monocharged 2 TEM 42 SGANER no y5 monocharged 2 TEM43 SGGSER no y3 monocharged 2 2be 44 SGGSER no y4 monocharged 2 2be 45SGGSER no y5 monocharged 2 2be 46 VDAGQEQLDR no y7 monocharged 2 TEM 47VDAGQEQLDR no y8 monocharged 2 TEM 48 VDAGQEQLDR no y9 monocharged 2 TEM49 VKPAEDK no y4 monocharged 2 2be 50 VKPAEDK no y5 monocharged 2 2be 51VKPAEDK no y6 monocharged 2 2be 52 WEPELNEAIPIDER no y12 dicharged 2 2be53 WEPELNEAIPIDER no y5 monocharged 2 2be 54 WEPELNEAIPIDER no y7monocharged 2 2be 55 DTTMPAAMATK yes y7 monocharged 2 TEM 56 DTTMPAAMATKyes y8 monocharged 2 TEM 57 DTTMPAAMATK yes y9 monocharged 2 TEM 58DTTMPAAMATK no y7 monocharged 2 TEM 59 DTTMPAAMATK no y8 monocharged 2TEM 60 DTTMPAAMATK no y9 monocharged 2 TEM 61 ELTAFLHNMGDHVTR no y13dicharged 2 TEM 62 ELTAFLHNMGDHVTR no y4 monocharged 2 TEM 63ELTAFLHNMGDHVTR no y8 monocharged 2 TEM 64 EPELNEAIPNDER no y5monocharged 2 TEM 65 EPELNEAIPNDER no y7 monocharged 2 TEM 66EPELNEAIPNDER no y8 monocharged 2 TEM 67 FPMMSTFK yes y6 monocharged 2TEM 68 FPMMSTFK yes y7 monocharged 2 TEM 69 FPMMSTFK yes y7 dicharged 2TEM 70 FPMMSTFK no y6 monocharged 2 TEM 71 FPMMSTFK no y7 monocharged 2TEM 72 FPMMSTFK no y7 dicharged 2 TEM 73 GIIAALGPDGKPSR no y7monocharged 2 TEM 74 GIIAALGPDGKPSR no y8 monocharged 2 TEM 75GIIAALGPDGKPSR no y9 monocharged 2 TEM 76 IDAGQEQLGR no y7 monocharged 2TEM 77 IDAGQEQLGR no y8 monocharged 2 TEM 78 IDAGQEQLGR no y9monocharged 2 TEM 79 IHYSQNDLVK no y7 monocharged 2 2be 80 IHYSQNDLVK noy8 monocharged 2 2be 81 IHYSQNDLVK no y9 dicharged 2 2be 82IHYSQSDVVEYSPVTEK no y16 dicharged 2 TEM 83 IHYSQSDVVEYSPVTEK no y5monocharged 2 TEM 84 IHYSQSDVVEYSPVTEK no y6 monocharged 2 TEM 85IVVIYMTGGQATMDER no y6 monocharged 2 2be 86 IVVIYMTGGQATMDER no y8monocharged 2 2be 87 IVVIYMTGGQATMDER no y9 monocharged 2 2be 88LDCWEPELNEAIPNDER no y5 monocharged 3 2be 89 LDCWEPELNEAIPNDER no y6monocharged 3 2be 90 LDCWEPELNEAIPNDER no y7 monocharged 3 2be 91MSIQHFR yes y4 monocharged 2 TEM 92 MSIQHFR yes y5 monocharged 2 TEM 93MSIQHFR yes y6 monocharged 2 TEM 94 MSIQHFR no y4 monocharged 2 TEM 95MSIQHFR no y5 monocharged 2 TEM 96 MSIQHFR no y6 monocharged 2 TEM 97QQLIDWMEADK no y5 monocharged 2 TEM 98 QQLIDWMEADK no y6 monocharged 2TEM 99 QQLIDWMEADK no y7 monocharged 2 TEM 100 SGASER no y3 monocharged2 2be 101 SGASER no y4 monocharged 2 2be 102 SGASER no y5 monocharged 22be 103 VALIPFLAAFCLPVFAHPETLVK no y11 dicharged 3 2ber 104VALIPFLAAFCLPVFAHPETLVK no y6 monocharged 3 2ber 105VALIPFLAAFCLPVFAHPETLVK no y8 monocharged 3 2ber 106 VGYIELDLNSGK no y7monocharged 2 TEM 107 VGYIELDLNSGK no y8 monocharged 2 TEM 108VGYIELDLNSGK no y9 monocharged 2 TEM 109 VLLCGAELSR no y6 monocharged 2TEM 110 VLLCGAELSR no y7 monocharged 2 TEM 111 VLLCGAELSR no y8monocharged 2 TEM 112 DAEDQLGAR no y5 monocharged 2 TEM 113 DAEDQLGAR noy6 monocharged 2 TEM 114 DAEDQLGAR no y7 monocharged 2 TEM 115ETTTPAAMATTLR yes y7 monocharged 2 2be 116 ETTTPAAMATTLR yes y9monocharged 2 2be 117 ETTTPAAMATTLR yes y9 dicharged 2 2be 118ETTTPAAMATTLR no y7 monocharged 2 2be 119 ETTTPAAMATTLR no y9monocharged 2 2be 120 ETTTPAAMATTLR no y9 dicharged 2 2be 121 FPMVSTFKyes y6 monocharged 2 TEM 122 FPMVSTFK yes y7 monocharged 2 TEM 123FPMVSTFK yes y7 dicharged 2 TEM 124 FPMVSTFK no y6 monocharged 2 TEM 125FPMVSTFK no y7 monocharged 2 TEM 126 FPMVSTFK no y7 dicharged 2 TEM 127GSGGIIAALGPDGKPSR no y7 monocharged 2 2br 128 GSGGIIAALGPDGKPSR no y8monocharged 2 2br 129 GSGGIIAALGPDGKPSR no y9 monocharged 2 2br 130HLTDGMTVR yes y5 monocharged 2 TEM 131 HLTDGMTVR yes y7 monocharged 2TEM 132 HLTDGMTVR yes y8 monocharged 2 TEM 133 HLTDGMTVR no y4monocharged 2 TEM 134 HLTDGMTVR no y7 monocharged 2 TEM 135 HLTDGMTVR noy8 monocharged 2 TEM 136 IVIIYTTGSQATMDER no b4 monocharged 2 2br 137IVIIYTTGSQATMDER no y2 monocharged 2 2br 138 IVIIYTTGSQATMDER no y9monocharged 2 2br 139 IVVIYTTGSQATMDEQNR yes y5 monocharged 3 2br 140IVVIYTTGSQATMDEQNR yes y6 monocharged 3 2br 141 IVVIYTTGSQATMDEQNR yesy7 monocharged 3 2br 142 IVVIYTTGSQATMDEQNR no y5 monocharged 3 2br 143IVVIYTTGSQATMDEQNR no y6 monocharged 3 2br 144 IVVIYTTGSQATMDEQNR no y7monocharged 3 2br 145 LDHWEPELNEAVPNDER no y5 monocharged 3 2be 146LDHWEPELNEAVPNDER no y6 monocharged 3 2be 147 LDHWEPELNEAVPNDER no y7monocharged 3 2be 148 LLTGELLTLASQQQLIDWMEADK yes b8 monocharged 3 TEM149 LLTGELLTLASQQQLIDWMEADK yes y6 monocharged 3 TEM 150LLTGELLTLASQQQLIDWMEADK yes y7 monocharged 3 TEM 151LLTGELLTLASQQQLIDWMEADK no b4 monocharged 3 TEM 152LLTGELLTLASQQQLIDWMEADK no y6 monocharged 3 TEM 153LLTGELLTLASQQQLIDWMEADK no y7 monocharged 3 TEM 154 QIAEIGASLIK no y7monocharged 2 TEM 155 QIAEIGASLIK no y8 monocharged 2 TEM 156QIAEIGASLIK no y9 monocharged 2 TEM 157 QTAEIGASLIK no y7 monocharged 22be 158 QTAEIGASLIK no y8 monocharged 2 2be 159 QTAEIGASLIK no y9monocharged 2 2be 160 SGADER no y3 monocharged 2 TEM 161 SGADER no y4monocharged 2 TEM 162 SGADER no y5 monocharged 2 TEM 163 SGASK no y2monocharged 2 2be 164 SGASK no y3 monocharged 2 2be 165 SGASK no y4monocharged 2 2be 166 VAGPLLR no y4 monocharged 2 TEM 167 VAGPLLR no y5monocharged 2 TEM 168 VAGPLLR no y6 monocharged 2 TEM 169 VGYIEMDLNSGKyes y10 dicharged 2 2be 170 VGYIEMDLNSGK yes y7 monocharged 2 2be 171VGYIEMDLNSGK yes y8 monocharged 2 2be 172 VGYIEMDLNSGK no y7 monocharged2 2be 173 VGYIEMDLNSGK no y8 monocharged 2 2be 174 VGYIEMDLNSGK no y9monocharged 2 2be 175 WEPELNEAIPNDER no y12 dicharged 2 TEM 176WEPELNEAIPNDER no y5 monocharged 2 TEM 177 WEPELNEAIPNDER no y7monocharged 2 TEM 178 ELTAFLHNMGEHVTR no y7 monocharged 2 2b 179ELTAFLHNMGEHVTR no y8 monocharged 2 2b 180 ELTAFLHNMGEHVTR no y9monocharged 2 2b 181 FPMLSTFK yes y6 monocharged 2 TEM 182 FPMLSTFK yesy7 monocharged 2 TEM 183 FPMLSTFK yes y7 dicharged 2 TEM 184 FPMLSTFK noy6 monocharged 2 TEM 185 FPMLSTFK no y7 monocharged 2 TEM 186 FPMLSTFKno y7 dicharged 2 TEM 187 GSCGIIAALGPDGKPSR no y7 monocharged 2 2br 188GSCGIIAALGPDGKPSR no y8 monocharged 2 2br 189 GSCGIIAALGPDGKPSR no y9monocharged 2 2br 190 GSSGIIAALGPDGKPSR no y7 monocharged 2 TEM 191GSSGIIAALGPDGKPSR no y8 monocharged 2 TEM 192 GSSGIIAALGPDGKPSR no y9monocharged 2 TEM 193 ILESFRPEK no y5 monocharged 2 TEM 194 ILESFRPEK noy6 monocharged 2 TEM 195 ILESFRPEK no y7 monocharged 2 TEM 196IVVIYTTGSQATMDELNR yes y5 monocharged 3 2br 197 IVVIYTTGSQATMDELNR yesy6 monocharged 3 2br 198 IVVIYTTGSQATMDELNR yes y7 monocharged 3 2br 199IVVIYTTGSQATMDELNR no y5 monocharged 3 2br 200 IVVIYTTGSQATMDELNR no y6monocharged 3 2br 201 IVVIYTTGSQATMDELNR no y7 monocharged 3 2br 202IVVIYTTGSQATMDER no y6 monocharged 2 TEM 203 IVVIYTTGSQATMDER no y8monocharged 2 TEM 204 IVVIYTTGSQATMDER no y9 monocharged 2 TEM 205LHCWEPELNEAIPNDER no y5 monocharged 3 2be 206 LHCWEPELNEAIPNDER no y6monocharged 3 2be 207 LHCWEPELNEAIPNDER no y7 monocharged 3 2be 208LLTGELLTLASR no y6 monocharged 2 TEM 209 LLTGELLTLASR no y7 monocharged2 TEM 210 LLTGELLTLASR no y9 monocharged 2 TEM 211 QQLIDWMADK yes y6monocharged 2 2ber 212 QQLIDWMADK yes y7 monocharged 2 2ber 213QQLIDWMADK yes y8 monocharged 2 2ber 214 QQLIDWMADK no y6 monocharged 22ber 215 QQLIDWMADK no y7 monocharged 2 2ber 216 QQLIDWMADK no y8monocharged 2 2ber 217 SALPAGWFIADK no y7 monocharged 2 TEM 218SALPAGWFIADK no y9 monocharged 2 TEM 219 SALPAGWFIADK no y9 dicharged 2TEM 220 SGAGVR no y3 monocharged 2 2be 221 SGAGVR no y4 monocharged 22be 222 SGAGVR no y5 monocharged 2 2be 223 SGTGER no y3 monocharged 22be 224 SGTGER no y4 monocharged 2 2be 225 SGTGER no y5 monocharged 22be 226 VALIPFFAAFCIPVFAHPETLVK no y11 dicharged 3 2br 227VALIPFFAAFCIPVFAHPETLVK no y6 monocharged 3 2br 228VALIPFFAAFCIPVFAHPETLVK no y7 monocharged 3 2br 229 VLLCGAVLSR no y6monocharged 2 TEM 230 VLLCGAVLSR no y7 monocharged 2 TEM 231 VLLCGAVLSRno y8 monocharged 2 TEM 232 YSPVTEK no y4 monocharged 2 2be 233 YSPVTEKno y5 monocharged 2 2be 234 YSPVTEK no y6 monocharged 2 2be 235CEPELNEAIPNDER no y12 dicharged 2 2br 236 CEPELNEAIPNDER no y5monocharged 2 2br 237 CEPELNEAIPNDER no y8 monocharged 2 2br 238DAEDQVGAR no y5 monocharged 2 2be 239 DAEDQVGAR no y6 monocharged 2 2be240 DAEDQVGAR no y7 monocharged 2 2be 241 DTTMPVAMATTLR no y7monocharged 2 TEM 242 DTTMPVAMATTLR no y9 monocharged 2 TEM 243DTTMPVAMATTLR no y9 dicharged 2 TEM 244 ELTAFLR no y4 monocharged 2 2be245 ELTAFLR no y5 monocharged 2 2be 246 ELTAFLR no y6 monocharged 2 2be247 GSTGIIAALGPDGKPSR no y10 monocharged 2 TEM 248 GSTGIIAALGPDGKPSR noy7 monocharged 2 TEM 249 GSTGIIAALGPDGKPSR no y9 monocharged 2 TEM 250HLTGGMTVR yes y5 monocharged 2 2b 251 HLTGGMTVR yes y6 monocharged 2 2b252 HLTGGMTVR yes y7 monocharged 2 2b 253 HLTGGMTVR no y5 monocharged 22b 254 HLTGGMTVR no y6 monocharged 2 2b 255 HLTGGMTVR no y7 monocharged2 2b 256 IVVIYMTGSQATMDELNR yes y6 monocharged 3 2ber 257IVVIYMTGSQATMDELNR yes y7 monocharged 3 2ber 258 IVVIYMTGSQATMDELNR yesy8 monocharged 3 2ber 259 IVVIYMTGSQATMDELNR no y5 monocharged 3 2ber260 IVVIYMTGSQATMDELNR no y6 monocharged 3 2ber 261 IVVIYMTGSQATMDELNRno y7 monocharged 3 2ber 262 LDHWEPELNEAIPNDER no y5 monocharged 3 2be263 LDHWEPELNEAIPNDER no y6 monocharged 3 2be 264 LDHWEPELNEAIPNDER noy7 monocharged 3 2be 265 LLTSELLTLASR no y10 monocharged 2 TEM 266LLTSELLTLASR no y7 monocharged 2 TEM 267 LLTSELLTLASR no y9 monocharged2 TEM 268 QIAEIGGSLIK no y7 monocharged 2 2ber 269 QIAEIGGSLIK no y8monocharged 2 2ber 270 QIAEIGGSLIK no y9 monocharged 2 2ber 271QQLIDWMEVDK yes y6 monocharged 2 TEM 272 QQLIDWMEVDK yes y7 monocharged2 TEM 273 QQLIDWMEVDK yes y8 monocharged 2 TEM 274 QQLIDWMEVDK no y5monocharged 2 TEM 275 QQLIDWMEVDK no y6 monocharged 2 TEM 276QQLIDWMEVDK no y7 monocharged 2 TEM 277 SVLPAGWFIADK no y10 dicharged 22be 278 SVLPAGWFIADK no y9 monocharged 2 2be 279 SVLPAGWFIADK no y9dicharged 2 2be 280 VAGPLMR yes y4 monocharged 2 2br 281 VAGPLMR yes y5monocharged 2 2br 282 VAGPLMR yes y6 monocharged 2 2br 283 VAGPLMR no y4monocharged 2 2br 284 VAGPLMR no y5 monocharged 2 2br 285 VAGPLMR no y6monocharged 2 2br 286 VALIPFFAAFCLPVFAHPDTLVK no y11 dicharged 3 TEM 287VALIPFFAAFCLPVFAHPDTLVK no y17 dicharged 3 TEM 288VALIPFFAAFCLPVFAHPDTLVK no y6 monocharged 3 TEM 289 VALIPFFAAFCLPVFAHPKno y15 dicharged 3 TEM 290 VALIPFFAAFCLPVFAHPK no y7 monocharged 3 TEM291 VALIPFFAAFCLPVFAHPK no y9 dicharged 3 TEM 292 VEDAEDQLGAR no y7monocharged 2 2b 293 VEDAEDQLGAR no y8 monocharged 2 2b 294 VEDAEDQLGARno y9 monocharged 2 2b 295 DAEDQLGSTSGYIELDLNSGK no y7 monocharged 32ber 296 DAEDQLGSTSGYIELDLNSGK no y8 monocharged 3 2ber 297DAEDQLGSTSGYIELDLNSGK no y9 monocharged 3 2ber 298 DTTMPAAMATTLR no y7monocharged 2 TEM 299 DTTMPAAMATTLR no y8 monocharged 2 TEM 300DTTMPAAMATTLR no y9 monocharged 2 TEM 301 DTTTPAAMATTLR yes y7monocharged 2 TEM 302 DTTTPAAMATTLR yes y8 monocharged 2 TEM 303DTTTPAAMATTLR yes y9 dicharged 2 TEM 304 DTTTPAAMATTLR no y7 monocharged2 TEM 305 DTTTPAAMATTLR no y9 monocharged 2 TEM 306 DTTTPAAMATTLR no y9dicharged 2 TEM 307 GSHGIIAALGPDGKPSR no b6 monocharged 2 2br 308GSHGIIAALGPDGKPSR no y15 dicharged 2 2br 309 GSHGIIAALGPDGKPSR no y8monocharged 2 2br 310 HLPDGMTVR no y5 monocharged 2 TEM 311 HLPDGMTVR noy7 monocharged 2 TEM 312 HLPDGMTVR no y8 monocharged 2 TEM 313IHYSQSDLVEYSPVTEK no y16 dicharged 2 2be 314 IHYSQSDLVEYSPVTEK no y7monocharged 2 2be 315 IHYSQSDLVEYSPVTEK no y8 monocharged 2 2be 316IVVIYMTGSQATMDER no y6 monocharged 2 TEM 317 IVVIYMTGSQATMDER no y8monocharged 2 TEM 318 IVVIYMTGSQATMDER no y9 monocharged 2 TEM 319LLTDELLTLASR no y5 monocharged 2 2be 320 LLTDELLTLASR no y6 monocharged2 2be 321 LLTDELLTLASR no y7 monocharged 2 2be 322 NMGDHVTR yes y4monocharged 2 2be 323 NMGDHVTR yes y5 monocharged 2 2be 324 NMGDHVTR yesy6 monocharged 2 2be 325 NMGDHVTR no y4 monocharged 2 2be 326 NMGDHVTRno y5 monocharged 2 2be 327 NMGDHVTR no y6 monocharged 2 2be 328QIVEIGASLIK no y7 monocharged 2 2be 329 QIVEIGASLIK no y8 monocharged 22be 330 QIVEIGASLIK no y9 monocharged 2 2be 331 SGAGER no y3 monocharged2 TEM 332 SGAGER no y4 monocharged 2 TEM 333 SGAGER no y5 monocharged 2TEM 334 VAEPLLR no y4 monocharged 2 2b 335 VAEPLLR no y5 monocharged 22b 336 VAEPLLR no y6 monocharged 2 2b 337 VALIPFFAAFCFPVFAHPETLVK no b113 TEM monocharged 338 VALIPFFAAFCFPVFAHPETLVK no y11 dicharged 3 TEM 339VALIPFFAAFCFPVFAHPETLVK no y6 monocharged 3 TEM 340VALIPFFAAFCLPVFAHPETLVK no b7 monocharged 3 TEM 341VALIPFFAAFCLPVFAHPETLVK no y11 dicharged 3 TEM 342VALIPFFAAFCLPVFAHPETLVK no y6 monocharged 3 TEM 343 VDAGQEQLGR no y5monocharged 2 TEM 344 VDAGQEQLGR no y7 monocharged 2 TEM 345 VDAGQEQLGRno y8 monocharged 2 TEM 346 VGYIELDPNSGK no y5 monocharged 2 2be 347VGYIELDPNSGK no y7 monocharged 2 2be 348 VGYIELDPNSGK no y8 monocharged2 2be

The transitions mentioned in TABLE 3 are detected by using theparameters set out in TABLE 4. The precursor peptide retention time andthe transitions, i.e. the (m/z)1 ratio in Q1 and (m/z)2 ratio in Q3, aswell as the collision energy used to fragment the precursor ion, areindicated in TABLE 4. The threshold above which the transition isconsidered to be detected is also indicated in TABLE 4.

TABLE 4 Retention (m/z) (m/z) Collision Transition time filteredfiltered energy Positivity number (minutes) in Q1 in Q3 (eV) threshold 19.9 487.24 416.26 26 2500 2 9.9 487.24 658.36 26 2500 3 9.9 487.24787.41 26 2500 4 19.3 861.95 512.29 43 2500 5 19.3 861.95 911.47 43 25006 19.3 861.95 1048.53 43 2500 7 19.3 859.42 792.37 43 2500 8 19.3 859.42906.41 43 2500 9 19.3 859.42 1043.47 43 2500 10 18.1 493.751 595.34 272500 11 18.1 493.751 742.38 27 2500 12 18.1 493.751 839.43 27 2500 1319.8 485.757 595.34 26 2500 14 19.8 485.757 726.39 26 2500 15 19.8485.757 823.44 26 2500 16 15 791.87 698.84 40 2500 17 15 791.87 630.2840 2500 18 15 791.87 814.41 40 2500 19 19.1 804.96 997.54 40 5000 2019.1 804.96 813.42 40 5000 21 19.1 804.96 926.51 40 5000 22 16.6 674.67660.36 38 2500 23 16.6 674.67 823.42 38 2500 24 16.6 674.67 952.46 382500 25 14.6 638.34 746.42 33 2500 26 14.6 638.34 972.51 33 2500 27 14.6638.34 460.73 33 2500 28 15.9 885.44 866.37 44 2500 29 15.9 885.44923.39 44 2500 30 15.9 885.44 980.41 44 2500 31 17 877.44 722.31 44 250032 17 877.44 907.39 44 2500 33 17 877.44 964.42 44 2500 34 19.5 676.32630.28 38 2500 35 19.5 676.32 743.37 38 2500 36 19.5 676.32 814.41 382500 37 18.6 623.35 691.38 32 2500 38 18.6 623.35 804.46 32 2500 39 18.6623.35 933.51 32 2500 40 1.3 317.15 418.2 19 6000 41 1.3 317.15 489.2419 6000 42 1.3 317.15 546.26 19 6000 43 1 296.64 391.19 18 2500 44 1296.64 448.22 18 2500 45 1 296.64 505.24 18 2500 46 10.5 565.78 845.4130 2500 47 10.6 565.78 916.45 30 2500 48 10.6 565.78 1031.48 30 2500 494.1 393.72 462.22 22 2500 50 4.1 393.72 559.27 22 2500 51 4.1 393.72687.37 22 2500 52 20.1 855.92 698.36 43 2500 53 20.1 855.92 629.33 432500 54 20.1 855.92 813.44 43 2500 55 17 585.26 705.36 31 4000 56 17585.26 852.4 31 4000 57 16.9 585.26 953.44 31 4000 58 13.2 569.27 689.3730 2500 59 13.2 569.27 820.41 30 2500 60 13.2 569.27 921.45 30 2500 6118.3 870.93 749.86 43 2500 62 18.3 870.93 512.29 43 2500 63 18.3 870.93929.43 43 2500 64 14.9 763.36 630.28 39 2500 65 14.9 763.36 814.41 392500 66 14.9 763.36 943.45 39 2500 67 14.9 510.73 776.33 27 2500 68 14.9510.73 873.38 27 2500 69 14.9 510.73 437.2 27 2500 70 18.9 494.74 744.3427 2500 71 18.9 494.74 841.39 27 2500 72 18.9 494.74 421.2 27 2500 7315.5 676.39 756.4 35 2500 74 15.5 676.39 813.42 35 2500 75 15.5 676.39926.51 35 2500 76 11.5 543.78 787.41 29 2500 77 11.5 543.78 858.44 292500 78 11.5 543.78 973.47 29 2500 79 12.5 608.82 803.43 32 2500 80 12.5608.82 966.49 32 2500 81 12.5 608.82 552.28 32 2500 82 15.5 990.98934.44 49 2500 83 15.5 990.98 573.32 49 2500 84 15.5 990.98 660.36 492500 85 19 892.44 722.31 44 2500 86 19 892.44 907.39 44 2500 87 19892.44 964.42 44 2500 88 19.4 700.65 630.28 39 2500 89 19.4 700.65743.37 39 2500 90 19.4 700.65 814.41 39 2500 91 10.4 467.73 587.3 262500 92 10.4 467.73 700.39 26 2500 93 10.4 467.73 787.42 26 2500 94 12.8459.73 587.3 25 2500 95 12.8 459.73 700.39 25 2500 96 12.8 459.73 787.4225 2500 97 20.1 688.83 593.26 35 2500 98 20.1 688.83 779.34 35 2500 9920.1 688.83 894.37 35 2500 100 1.4 303.646 391.19 18 13000 101 1.4303.646 462.23 18 13000 102 1.4 303.646 519.25 18 13000 103 31.6 851.81619.35 47 2500 104 31.6 851.81 686.41 47 2500 105 31.6 851.81 894.5 472500 106 18.8 654.35 746.4 34 2500 107 18.8 654.35 875.45 34 2500 10818.8 654.35 988.53 34 2500 109 16.3 559.31 632.34 30 2500 110 16.3559.31 792.37 30 2500 111 16.3 559.31 905.45 30 2500 112 10.5 487.73544.32 26 2500 113 10.5 487.73 659.35 26 2500 114 10.5 487.73 788.39 262500 115 12.6 690.35 779.41 35 2500 116 12.6 690.35 947.5 35 2500 11712.6 690.35 474.26 35 2500 118 15.9 682.35 763.41 35 2500 119 15.9682.35 931.5 35 2500 120 15.9 682.35 466.26 35 2500 121 19.8 486.75728.36 26 2500 122 19.8 486.75 825.42 26 2500 123 19.8 486.75 413.21 262500 124 18.4 478.75 712.37 26 2500 125 18.4 478.75 809.42 26 2500 12618.4 478.75 405.21 26 2500 127 16.3 776.93 756.4 39 2500 128 16.3 776.93813.42 39 2500 129 16.3 776.93 926.51 39 2500 130 12.2 523.26 579.3 282500 131 12.2 523.26 795.37 28 2500 132 12.2 523.26 908.45 28 2500 13312 515.26 506.28 28 2500 134 12 515.26 779.37 28 2500 135 12 515.26892.46 28 2500 136 18 899.46 439.33 36 2500 137 18 899.46 304.16 57 2500138 18 899.46 994.43 36 2500 139 15.6 681.33 661.29 38 2500 140 15.6681.33 808.33 38 2500 141 15.6 681.33 909.37 38 2500 142 16.6 676 661.2938 3100 143 16.6 676 792.33 38 3100 144 16.6 676 893.38 38 3100 145 17.2688.32 630.28 38 2500 146 17.2 688.32 729.35 38 2500 147 17.2 688.32800.39 38 2500 148 27 878.12 841.5 48 2500 149 27 878.12 795.34 48 2500150 27 878.12 910.37 48 2500 151 27.9 872.79 462.22 48 2500 152 27.9872.79 779.34 48 2500 153 27.9 872.79 894.37 48 2500 154 18.8 571.84701.46 30 2500 155 18.8 571.84 830.5 30 2500 156 18.8 571.84 901.54 302500 157 16.6 565.82 701.46 30 2500 158 16.6 565.82 830.5 30 2500 15916.6 565.82 901.54 30 2500 160 1.5 317.64 419.19 19 9000 161 1.5 317.64490.23 19 9000 162 1.5 317.64 547.25 19 9000 163 0.9 225.12 234.14 182500 164 0.9 225.12 305.18 13 2500 165 0.9 225.12 362.2 13 2500 166 14.1363.24 498.34 21 2500 167 14.1 363.24 555.36 21 2500 168 14.1 363.24626.4 21 2500 169 14.7 671.32 593.28 35 4500 170 14.7 671.32 780.36 354500 171 14.7 671.32 909.4 35 4500 172 17.5 663.32 764.36 34 2500 17317.5 663.32 893.4 34 2500 174 17.5 663.32 1006.49 34 2500 175 18 856.4698.84 43 2500 176 18 856.4 630.28 43 2500 177 18 856.4 814.41 43 2500178 18.6 877.94 829.4 44 2500 179 18.6 877.94 943.44 44 2500 180 18.6877.94 1080.5 44 2500 181 18.1 493.75 742.38 27 2500 182 18.1 493.75839.43 27 2500 183 18.1 493.75 420.22 27 2500 184 19.8 485.76 726.39 262500 185 19.8 485.76 823.44 26 2500 186 19.8 485.76 412.22 26 2500 18716.5 828.43 756.4 41 2500 188 16.5 828.43 813.42 41 2500 189 16.5 828.43926.51 41 2500 190 16.1 791.93 756.4 40 2500 191 16.1 791.93 813.42 402500 192 16.1 791.93 926.51 40 2500 193 15.7 559.81 676.38 30 2500 19414.1 559.81 763.41 30 2500 195 14.1 559.81 892.45 30 2500 196 16.6676.34 646.31 38 2500 197 16.6 676.34 793.96 38 2500 198 16.6 676.34894.4 38 2500 199 18.9 671.01 646.31 38 4000 200 18.9 671.01 777.96 384000 201 18.9 671.01 878.4 38 4000 202 16.9 892.45 722.31 44 2500 20316.9 892.45 937.4 44 2500 204 16.9 892.45 994.43 44 2500 205 17.9 707.99630.28 39 6000 206 17.9 707.99 743.37 39 6000 207 17.9 707.99 814.41 396000 208 22.5 643.89 660.4 33 2500 209 22.5 643.89 773.49 33 2500 21022.5 643.89 959.55 33 2500 211 17.5 632.31 781.32 33 3000 212 17.5632.31 894.4 33 3000 213 17.5 632.31 1007.49 33 3000 214 19.8 624.31765.32 32 2500 215 19.8 624.31 878.41 32 2500 216 19.8 624.31 991.49 322500 217 21.4 638.34 836.43 33 2500 218 21.4 638.34 1004.52 33 2500 21921.5 638.34 502.76 33 2500 220 3.2 273.65 331.21 17 2500 221 3.2 273.65402.25 17 2500 222 3.2 273.65 459.27 17 2500 223 1.3 303.65 361.18 1821000 224 1.3 303.65 462.23 18 21000 225 1.3 303.65 519.25 18 21000 22631.3 863.138 619.35 47 2500 227 31.3 863.138 686.41 47 2500 228 31.3863.138 823.47 47 2500 229 17.7 544.32 602.36 29 2500 230 17.7 544.32762.39 29 2500 231 17.7 544.32 875.48 29 2500 232 9.8 412.21 476.27 232500 233 9.8 412.21 573.32 23 2500 234 9.8 412.21 660.36 23 2500 23515.2 843.38 698.84 42 2500 236 15.2 843.38 630.28 42 2500 237 15.2843.38 943.45 42 2500 238 8.7 480.72 530.3 26 2500 239 8.7 480.72 645.3326 2500 240 8.7 480.72 774.37 26 2500 241 18.8 704.35 763.41 36 2500 24218.8 704.35 959.53 36 2500 243 18.8 704.35 480.27 36 2500 244 18.3425.25 506.31 24 2500 245 18.3 425.25 607.36 24 2500 246 18.3 425.25720.44 24 2500 247 16.4 798.94 997.54 40 2500 248 16.3 798.94 756.4 402500 249 16.3 798.94 926.51 40 2500 250 8.3 494.26 850.45 27 2500 2518.3 494.26 636.31 27 2500 252 8.3 494.26 737.36 27 2500 253 10.9 486.26834.45 26 2500 254 10.9 486.26 620.32 26 2500 255 10.9 486.26 721.37 262500 256 19.3 691.67 793.36 39 2500 257 19.3 691.67 894.4 39 2500 25819.3 691.67 965.44 39 2500 259 20.6 681.01 646.31 38 2500 260 20.6681.01 777.36 38 2500 261 20.6 681.01 878.4 38 2500 262 18 692.99 630.2839 2500 263 18 692.99 743.37 39 2500 264 18 692.99 814.41 39 2500 265 23658.89 1090.61 34 2500 266 23 658.89 773.49 34 2500 267 23 658.89 989.5634 2500 268 17.9 564.83 687.44 30 2500 269 17.9 564.83 816.48 30 2500270 17.9 564.83 887.52 30 2500 271 18.9 710.84 823.37 36 2500 272 18.9710.84 938.39 36 2500 273 18.9 710.84 1051.48 36 2500 274 20.9 702.84621.29 36 2500 275 20.9 702.84 807.37 36 2500 276 20.9 702.84 922.4 362500 277 22.6 652.36 559.31 34 2500 278 22.6 652.36 1004.52 34 2500 27922.6 652.36 502.76 34 2500 280 11.1 380.21 532.29 22 2500 281 11.1380.21 589.31 22 2500 282 11.1 380.21 660.35 22 2500 283 13.1 372.22516.3 21 2500 284 13.1 372.22 573.32 21 2500 285 13.1 372.22 644.35 212500 286 31.3 858.47 612.34 47 2500 287 31.3 858.47 967.1 47 2500 28831.3 858.47 672.39 47 2500 289 30.5 715.73 874.95 40 2500 290 30.5715.73 795.45 40 2500 291 30.6 715.73 534.79 40 2500 292 11.7 601.79788.39 31 2500 293 11.7 601.79 859.43 31 2500 294 11.7 601.79 974.45 312500 295 20 738.01 746.4 41 2500 296 20 738.01 875.45 41 2500 297 20738.01 988.53 41 2500 298 17.6 690.34 763.61 35 2500 299 17.6 690.34834.45 35 2500 300 17.6 690.34 931.5 35 2500 301 19.5 683.34 779.41 356000 302 19.5 683.34 850.45 35 6000 303 19.5 683.34 474.25 35 6000 30416.1 675.34 763.41 35 2500 305 16.1 675.34 931.5 35 2500 306 16.1 675.34466.25 35 2500 307 14.4 816.94 565.31 41 2500 308 14.4 816.94 744.92 412500 309 14.4 816.94 813.42 41 2500 310 13 513.26 563.3 28 2500 311 13513.26 775.38 28 2500 312 13 513.26 888.46 28 2500 313 16.6 997.99941.45 49 2500 314 16.6 997.99 573.32 49 2500 315 16.6 997.99 952.46 492500 316 18.9 907.44 722.32 45 2500 317 18.9 907.44 937.4 45 2500 31818.9 907.44 994.43 45 2500 319 23.7 672.89 547.32 35 2500 320 23.7672.89 660.4 35 2500 321 23.7 672.89 773.49 35 2500 322 17.1 473.21528.29 26 2500 323 17.9 473.21 627.32 26 2500 324 17.8 473.21 684.34 262500 325 8.4 465.22 512.29 25 9000 326 8.4 465.22 627.32 25 9000 327 8.4465.22 684.34 25 9000 328 19.8 585.86 701.46 31 2500 329 19.8 585.86830.5 31 2500 330 19.8 585.86 929.57 31 2500 331 1.3 288.64 361.18 188000 332 1.3 288.64 432.22 18 8000 333 1.3 288.64 489.24 18 8000 33414.5 399.25 498.34 23 6000 335 14.5 399.25 627.38 23 6000 336 14.5399.25 698.42 23 6000 337 31.3 874.47 823.47 48 2500 338 31.3 874.47619.41 48 2500 339 31.3 874.47 686.41 48 2500 340 31.3 863.14 823.47 472500 341 31.3 863.14 619.34 47 2500 342 31.3 863.14 686.41 47 2500 34310.6 536.77 602.38 29 2500 344 10.6 536.77 787.41 29 2500 345 10.6536.77 858.44 29 2500 346 16.5 646.33 502.26 33 7000 347 16.5 646.33730.37 33 7000 348 16.5 646.33 859.42 33 7000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™ (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 50.00 psiHeating gas: 40.00 psi Collision gas which induces dissociation: 9.00psi Dynamic filling: activated Declustering potential (DP): 80.00 VEntry potential before Q0 (EP): 10.00 V Collision cell exit potential(CXP): 35 V Total cycle time: 1.2 sec Detection window: 90 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the 3transitions of the same peptide are greater than or equal to thepositivity threshold described in TABLE 4, the detection of the peptideis considered to be positive and is labelled “1” in TABLE 5. When atleast one transition comprises an area less than the positivitythreshold described in TABLE 4, the corresponding peptide is considerednon-detected and is labelled 0 in TABLE 5.

TABLE 5 Transition number Sam10 Sam11 Sam12 Sam13 Sam14 Sam15 Sam16Sam17 Sam18 Sam19 Sam20 Sam21 Sam22 1-3 0 0 0 0 0 0 0 0 0 0 0 0 0 4-6 00 0 0 0 0 0 0 0 0 0 0 0 7-9 0 0 0 0 0 0 0 0 0 0 0 0 0 10-12 0 0 0 0 0 00 0 0 0 0 0 0 13-15 0 0 0 0 0 0 0 0 0 0 0 0 0 16-18 0 0 0 0 0 0 0 0 0 00 0 0 19-21 0 0 0 0 0 0 0 0 0 0 0 0 0 22-24 0 1 0 0 1 0 0 0 0 0 0 1 025-27 0 1 0 1 1 0 0 1 1 1 0 1 0 28-30 0 0 0 0 0 0 0 0 0 0 0 0 0 31-33 00 0 0 0 0 0 0 0 0 0 0 0 34-36 0 0 0 0 1 0 1 1 1 1 0 1 0 37-39 0 0 0 0 00 0 0 0 0 0 0 0 40-42 0 0 0 0 0 0 0 0 0 0 0 0 0 43-45 0 0 0 0 0 0 0 0 00 0 0 0 46-48 0 0 0 0 0 0 0 0 0 0 0 0 0 49-51 0 0 0 0 0 0 0 0 0 0 0 0 052-54 0 0 0 0 0 0 0 0 0 0 0 0 0 55-57 0 0 0 0 0 0 0 0 0 0 0 0 0 58-60 00 0 0 0 0 0 0 0 0 0 0 0 61-63 0 0 0 0 0 0 0 0 0 0 0 0 0 64-66 0 0 0 0 00 0 0 0 0 0 0 0 67-69 0 0 0 0 0 0 0 0 0 0 0 0 0 70-72 0 0 0 0 0 0 0 0 00 0 0 0 73-75 0 1 1 1 1 1 1 1 1 1 1 1 0 76-78 0 0 0 0 0 0 0 0 0 0 0 0 079-81 0 0 0 1 0 0 0 0 1 0 0 0 0 82-84 0 0 0 0 0 0 0 0 0 0 0 0 0 85-87 00 0 0 0 0 0 0 0 0 0 0 0 88-90 0 0 0 0 0 0 0 0 0 0 0 0 0 91-93 0 0 0 0 00 0 0 0 0 0 0 0 94-96 0 0 0 0 0 0 0 0 0 0 0 0 0 97-99 0 1 1 1 1 1 1 1 11 0 1 0 100-102 0 0 0 0 0 0 0 0 0 0 0 0 0 103-105 0 0 0 0 0 0 0 0 0 0 00 0 106-108 0 1 1 1 1 1 1 1 1 1 1 1 1 109-111 0 0 0 0 0 0 0 0 0 0 0 0 0112-114 0 0 0 1 1 0 0 0 1 1 0 0 0 115-117 0 0 0 0 0 0 0 0 0 0 0 0 0118-120 0 0 0 0 0 0 0 0 0 0 0 0 0 121-123 0 0 0 0 0 0 0 0 0 0 0 0 0124-126 0 0 0 0 0 0 0 0 0 0 0 0 0 127-129 0 0 0 0 0 0 0 0 0 0 0 0 0130-132 0 0 0 0 0 0 0 0 0 0 0 0 0 133-135 0 1 0 1 1 0 1 1 1 0 0 1 0136-138 0 0 0 0 0 0 0 0 0 0 0 0 0 139-141 0 0 0 0 0 0 0 0 0 0 0 0 0142-144 0 0 0 0 0 0 0 0 0 0 0 0 0 145-147 0 0 0 0 0 0 0 0 0 0 0 0 0148-150 0 0 0 0 0 0 0 0 0 0 0 0 0 151-153 0 0 0 0 0 0 0 0 0 0 0 0 0154-156 0 1 1 1 1 1 1 1 1 1 0 1 0 157-159 0 0 0 0 0 0 0 0 0 0 0 0 0160-162 0 0 0 0 0 0 0 0 0 0 0 0 0 163-165 0 0 0 0 0 0 0 0 0 0 0 0 0166-168 0 1 1 1 1 1 1 1 1 1 1 1 1 169-171 0 0 0 0 0 0 0 0 0 0 0 0 0172-174 0 0 0 0 0 0 0 0 0 0 0 0 0 175-177 0 1 0 0 0 0 0 0 0 0 0 0 0178-180 0 0 0 0 0 0 0 0 0 0 0 0 0 181-183 0 0 0 0 0 0 0 0 0 0 0 0 0184-186 0 0 0 0 0 0 0 0 0 0 0 0 0 187-189 0 0 0 0 0 0 0 0 0 0 0 0 0190-192 0 0 0 0 0 0 0 0 0 0 0 0 0 193-195 0 0 0 0 0 0 0 0 0 0 0 0 0196-198 0 0 0 0 0 0 0 0 0 0 0 0 0 199-201 0 0 0 0 0 0 0 0 0 0 0 0 0202-204 0 0 0 0 0 0 0 0 0 0 0 0 0 205-207 0 0 0 0 0 0 0 0 0 0 0 0 0208-210 0 0 1 1 1 1 0 1 1 0 1 1 0 211-213 0 0 0 0 0 0 0 0 0 0 0 0 0214-216 0 0 0 0 0 0 0 0 0 0 0 0 0 217-219 0 0 0 0 0 0 0 0 0 0 0 0 0220-222 0 0 0 0 0 0 0 0 0 0 0 0 0 223-225 0 0 0 0 0 0 0 0 0 0 0 0 0226-228 0 0 0 0 0 0 0 0 0 0 0 0 0 229-231 0 0 0 0 0 0 0 0 0 0 0 0 0232-234 0 0 1 1 0 1 0 1 1 0 1 0 0 235-237 0 0 0 0 0 0 0 0 0 0 0 0 0238-240 0 0 0 0 0 0 0 0 0 0 0 0 0 241-243 0 0 0 0 0 0 0 0 0 0 0 0 0244-246 0 0 0 0 0 0 0 0 0 0 0 0 0 247-249 0 0 0 0 0 0 0 0 0 0 0 0 0250-252 0 0 0 0 0 0 0 0 0 0 0 0 0 253-255 0 0 0 0 0 0 0 0 0 0 0 0 0256-258 0 0 0 0 0 0 0 0 0 0 0 0 0 259-261 0 0 0 0 0 0 0 0 0 0 0 0 0262-264 0 0 0 0 0 1 0 0 0 0 0 0 0 265-267 0 0 0 0 0 0 0 0 0 0 0 0 0268-270 0 0 0 0 0 0 0 0 0 0 0 0 0 271-273 0 0 0 0 0 0 0 0 0 0 0 0 0274-276 0 0 0 0 0 0 0 0 0 0 0 0 0 277-279 0 0 0 0 0 0 0 0 0 0 0 0 0280-282 0 0 0 0 0 0 0 0 0 0 0 0 0 283-285 0 0 0 0 0 0 0 0 0 0 0 0 0286-288 0 0 0 0 0 0 0 0 0 0 0 0 0 289-291 0 0 0 0 0 0 0 0 0 0 0 0 0292-294 0 0 0 0 0 0 0 0 0 0 0 0 0 295-297 0 0 0 0 0 0 0 0 0 0 0 0 0298-300 0 1 0 1 1 0 1 1 1 0 0 1 0 301-303 0 0 0 0 0 0 0 0 0 0 0 0 0304-306 0 0 0 0 0 0 0 0 0 0 0 0 0 307-309 0 0 0 0 0 0 0 0 0 0 0 0 0310-312 0 0 0 0 0 0 0 0 0 0 0 0 0 313-315 0 0 0 0 0 0 0 0 0 0 0 0 0316-318 0 0 0 0 0 0 0 0 0 0 0 0 0 319-321 0 0 0 0 0 0 0 0 0 0 0 0 0322-324 0 0 0 0 0 0 0 0 0 0 0 0 0 325-327 0 0 0 0 0 0 0 0 0 0 0 0 0328-330 0 0 0 0 0 0 0 0 0 0 0 0 0 331-333 0 0 0 0 0 0 0 0 0 0 0 0 0334-336 0 0 0 0 0 0 0 0 0 0 0 0 0 337-339 0 0 0 0 0 0 0 0 0 0 0 0 0340-342 0 0 0 0 0 0 0 0 0 0 0 0 0 343-345 0 1 1 1 1 1 1 1 1 1 0 1 0346-348 0 0 0 0 0 0 0 0 0 0 0 0 0 TEM 0 11 8 13 13 9 9 12 14 9 5 12 2peptides 2b 0 0 0 0 0 0 0 0 0 0 0 0 0 peptides 2br 0 0 0 0 0 0 0 0 0 0 00 0 peptides 2be 0 0 1 2 1 2 1 2 3 1 1 1 0 peptides 2ber 0 0 0 0 0 0 0 00 0 0 0 0 peptides Transition number Sam23 Sam24 Sam25 Sam26 Sam27 Sam28Sam29 Sam30 Sam31 Sam32 Sam33 Sam34 Sam35 1-3 0 0 0 0 0 0 0 0 0 0 0 0 04-6 0 0 0 0 0 0 0 0 0 0 0 0 0 7-9 0 0 0 0 0 0 0 0 0 0 0 0 0 10-12 0 0 00 0 0 0 0 0 0 0 0 0 13-15 0 0 0 0 0 0 0 0 0 0 0 0 0 16-18 0 0 0 0 0 0 00 0 0 0 0 0 19-21 0 0 0 0 0 0 0 0 0 0 0 0 0 22-24 0 0 0 0 0 0 0 0 0 0 01 1 25-27 1 1 0 1 1 0 0 0 0 0 0 1 1 28-30 0 0 0 0 0 0 0 0 0 0 0 0 031-33 0 0 0 0 0 0 0 0 0 0 0 0 0 34-36 1 0 0 0 0 0 0 0 0 1 0 0 0 37-39 00 0 0 0 0 0 0 0 0 0 0 0 40-42 0 0 0 0 0 0 0 0 0 0 0 0 0 43-45 0 0 0 0 00 0 0 0 0 0 0 0 46-48 0 0 0 0 0 0 0 0 0 0 0 0 0 49-51 0 0 0 0 0 0 0 0 00 0 0 0 52-54 0 0 0 0 0 0 0 0 0 0 0 0 0 55-57 0 0 0 0 0 0 0 0 0 0 0 0 058-60 0 0 0 0 0 0 0 0 0 0 0 0 0 61-63 0 0 0 0 0 0 0 0 0 0 0 0 0 64-66 00 0 0 0 0 0 0 0 0 0 0 0 67-69 0 0 0 0 0 0 0 0 0 0 0 0 0 70-72 0 0 0 0 00 0 0 0 0 0 0 0 73-75 1 1 1 1 1 0 1 1 1 1 1 0 0 76-78 0 0 0 0 0 0 0 0 00 0 0 0 79-81 0 1 0 1 1 0 0 0 0 1 0 0 0 82-84 0 0 0 0 0 0 0 0 0 0 0 0 085-87 0 0 0 0 0 0 0 0 0 0 0 0 0 88-90 0 0 0 0 0 0 0 0 0 0 0 0 0 91-93 00 0 0 0 0 0 0 0 0 0 0 0 94-96 0 0 0 0 0 0 0 0 0 0 0 0 0 97-99 1 1 0 1 10 0 1 0 0 0 1 1 100-102 0 0 0 0 0 0 0 0 0 0 0 0 0 103-105 0 0 0 0 0 0 00 0 0 0 0 0 106-108 1 1 1 1 1 0 1 1 1 1 1 1 1 109-111 0 0 0 0 0 0 0 0 00 0 0 0 112-114 1 1 0 1 0 0 0 0 0 0 0 1 1 115-117 0 0 0 0 0 0 0 0 0 0 00 0 118-120 0 0 0 0 0 0 0 0 0 0 0 0 0 121-123 0 0 0 0 0 0 0 0 0 0 0 0 0124-126 0 0 0 0 0 0 0 0 0 0 0 0 0 127-129 0 0 0 0 0 0 0 0 0 0 0 0 0130-132 0 0 0 0 0 0 0 0 0 0 0 0 0 133-135 1 1 0 1 1 0 0 0 0 1 1 1 1136-138 0 0 0 0 0 0 0 0 0 0 0 0 0 139-141 0 0 0 0 0 0 0 0 0 0 0 0 0142-144 0 0 0 0 0 0 0 0 0 0 0 0 0 145-147 0 0 0 0 0 0 0 0 0 0 0 0 0148-150 0 0 0 0 0 0 0 0 0 0 0 0 0 151-153 0 0 0 0 0 0 0 0 0 0 0 0 0154-156 1 1 0 1 1 0 1 0 0 0 0 1 1 157-159 0 0 0 0 0 0 0 0 0 0 0 0 0160-162 0 0 0 0 0 0 0 0 0 0 0 0 0 163-165 0 0 0 0 0 0 0 0 0 0 0 0 0166-168 1 1 1 1 1 1 1 1 1 1 1 1 1 169-171 0 0 0 0 0 0 0 0 0 0 0 0 0172-174 0 0 0 0 0 0 0 0 0 0 0 0 0 175-177 0 1 0 1 1 0 0 0 0 0 0 1 1178-180 0 0 0 0 0 0 0 0 0 0 0 0 0 181-183 0 0 0 0 0 0 0 0 0 0 0 0 0184-186 0 0 0 0 0 0 0 0 0 0 0 0 0 187-189 0 0 0 0 0 0 0 0 0 0 0 0 1190-192 0 0 0 0 0 0 0 0 0 0 0 1 0 193-195 0 0 0 0 0 0 0 0 0 0 0 0 0196-198 0 0 0 0 0 0 0 0 0 0 0 0 0 199-201 0 0 0 0 0 0 0 0 0 0 0 0 0202-204 0 0 0 0 0 0 0 0 0 0 0 0 0 205-207 0 0 0 0 0 0 0 0 0 0 0 0 0208-210 1 1 1 1 0 1 0 0 0 1 1 1 1 211-213 0 0 0 0 0 0 0 0 0 0 0 0 0214-216 0 0 0 0 0 0 0 0 0 0 0 0 0 217-219 0 0 0 0 0 0 0 0 0 0 0 0 0220-222 0 0 0 0 0 0 0 0 0 0 0 0 0 223-225 0 0 0 0 0 0 0 0 0 0 0 0 0226-228 0 0 0 0 0 0 0 0 0 0 0 0 0 229-231 0 0 0 0 0 0 0 0 0 0 0 0 0232-234 0 1 1 1 1 0 1 0 0 1 0 0 0 235-237 0 0 0 0 0 0 0 0 0 0 0 0 0238-240 0 0 0 0 0 0 0 0 0 0 0 0 0 241-243 0 0 0 0 0 0 0 0 0 0 0 0 0244-246 0 0 0 0 0 0 0 0 0 0 0 0 0 247-249 0 0 0 0 0 0 0 0 0 0 0 0 0250-252 0 0 0 0 0 0 0 0 0 0 0 0 0 253-255 0 0 0 0 0 0 0 0 0 0 0 0 0256-258 0 0 0 0 0 0 0 0 0 0 0 0 0 259-261 0 0 0 0 0 0 0 0 0 0 0 0 0262-264 0 0 0 0 0 0 0 0 0 0 1 0 0 265-267 0 0 0 0 0 0 0 0 0 0 0 0 0268-270 0 0 0 0 0 0 0 0 0 0 0 0 0 271-273 0 0 0 0 0 0 0 0 0 0 0 0 0274-276 0 0 0 0 0 0 0 0 0 0 0 0 0 277-279 0 0 0 0 0 0 0 0 0 0 0 0 0280-282 0 0 0 0 0 0 0 0 0 0 0 0 0 283-285 0 0 0 0 0 0 0 0 0 0 0 0 0286-288 0 0 0 0 0 0 0 0 0 0 0 0 0 289-291 0 0 0 0 0 0 0 0 0 0 0 0 0292-294 0 0 0 0 0 0 0 0 0 0 0 0 0 295-297 0 0 0 0 0 0 0 0 0 0 0 0 0298-300 1 1 0 0 0 0 0 1 0 0 0 0 0 301-303 0 0 0 0 0 0 0 0 0 0 0 0 0304-306 0 0 0 0 0 0 0 0 0 0 0 0 0 307-309 0 0 0 0 0 0 0 0 0 0 0 0 0310-312 0 0 0 0 0 0 0 0 0 0 0 0 0 313-315 0 0 0 0 0 0 0 0 0 0 0 0 0316-318 0 0 0 0 0 0 0 0 0 0 0 0 0 319-321 0 0 0 0 0 0 0 0 0 0 0 0 0322-324 0 0 0 0 0 0 0 0 0 0 0 0 0 325-327 0 0 0 0 0 0 0 0 0 0 0 0 0328-330 0 0 0 0 0 0 0 0 0 0 0 0 0 331-333 0 0 0 0 0 0 0 0 0 0 0 0 0334-336 0 0 0 0 0 0 0 0 0 0 0 0 0 337-339 0 0 0 0 0 0 0 0 0 0 0 0 0340-342 0 0 0 0 0 0 0 0 0 0 0 0 0 343-345 1 1 1 1 1 0 1 1 0 1 1 1 1346-348 0 0 0 0 0 0 0 0 0 0 0 0 0 TEM 12 14 6 13 11 2 6 6 3 9 7 12 12peptides 2b 0 0 0 0 0 0 0 0 0 0 0 0 0 peptides 2br 0 0 0 0 0 0 0 0 0 0 00 1 peptides 2be 1 2 1 2 2 0 1 0 0 3 1 0 0 peptides 2ber 0 0 0 0 0 0 0 00 0 0 0 0 peptides Transition number Sam36 Sam37 Sam38 Sam39 Sam40 Sam41Sam42 Sam43 Sam44 Sam45 Sam46 Sam47 Sam48 1-3 0 0 0 0 0 0 0 0 0 0 0 0 04-6 0 0 0 0 0 0 0 0 0 0 0 0 0 7-9 0 0 0 0 0 0 0 0 0 0 0 0 0 10-12 0 0 00 0 0 0 0 0 0 0 0 0 13-15 0 0 0 0 0 0 0 0 0 0 0 0 0 16-18 0 0 0 0 0 0 00 0 0 0 0 0 19-21 0 0 0 0 0 0 0 0 0 0 0 0 0 22-24 0 0 1 1 0 1 0 0 0 0 00 0 25-27 1 0 1 1 1 1 1 0 0 0 1 0 0 28-30 0 0 0 0 0 0 0 0 0 0 0 0 031-33 0 0 0 0 0 0 0 0 0 0 0 0 0 34-36 0 0 0 0 0 0 0 0 0 0 0 0 0 37-39 00 0 0 0 0 0 0 0 0 0 0 0 40-42 0 0 0 0 0 0 0 0 0 0 0 0 0 43-45 0 0 0 0 00 0 0 0 0 0 0 0 46-48 0 0 0 0 0 0 0 0 0 0 0 0 0 49-51 0 0 0 0 0 0 0 0 00 0 0 0 52-54 0 0 0 0 0 0 0 0 0 0 0 0 0 55-57 0 0 0 0 0 0 0 0 0 0 0 0 058-60 0 0 0 0 0 0 0 0 0 0 0 0 0 61-63 0 0 0 0 0 0 0 0 0 0 0 0 0 64-66 00 0 0 0 0 1 0 0 0 0 0 0 67-69 0 0 0 0 0 0 0 0 0 0 0 0 0 70-72 0 0 0 0 00 0 0 0 0 0 0 0 73-75 1 1 1 1 1 1 1 1 1 1 1 1 1 76-78 0 0 0 0 0 0 0 0 00 0 0 0 79-81 0 0 0 0 0 0 0 0 0 0 1 0 0 82-84 0 0 0 0 0 0 0 0 0 0 0 0 085-87 0 0 0 0 0 0 0 0 0 0 0 0 0 88-90 0 0 0 0 0 0 0 0 0 0 0 0 0 91-93 00 0 0 0 0 0 0 0 0 0 0 0 94-96 0 0 0 0 0 0 0 0 0 0 0 0 0 97-99 1 0 1 1 11 1 0 0 0 1 0 0 100-102 0 0 0 0 0 0 0 0 0 0 0 0 0 103-105 0 0 0 0 0 0 00 0 0 0 0 0 106-108 1 1 1 1 1 1 1 1 1 1 1 1 1 109-111 0 0 0 0 0 0 0 0 00 0 0 0 112-114 1 0 1 1 1 1 1 0 0 0 1 0 0 115-117 0 0 0 0 0 0 0 0 0 0 00 0 118-120 0 0 0 0 0 0 0 0 0 0 0 0 0 121-123 0 0 0 0 0 0 0 0 0 0 0 0 0124-126 0 0 0 0 0 0 0 0 0 0 0 0 0 127-129 0 0 0 0 0 0 0 0 0 0 0 0 0130-132 0 0 0 0 0 0 0 0 0 0 0 0 0 133-135 1 1 1 1 1 1 1 1 1 0 1 0 0136-138 0 0 0 0 0 0 0 0 0 0 0 0 0 139-141 0 0 0 0 0 0 0 0 0 0 0 0 0142-144 0 0 0 0 0 0 0 0 0 0 0 0 0 145-147 0 0 0 0 0 0 0 0 0 0 0 0 0148-150 0 0 0 0 0 0 0 0 0 0 0 0 0 151-153 0 0 0 0 0 0 0 0 0 0 0 0 0154-156 1 0 1 1 1 1 1 0 0 0 1 0 0 157-159 0 0 0 0 0 0 0 0 0 0 0 0 0160-162 0 0 0 0 0 0 0 0 0 0 0 0 0 163-165 0 0 0 0 0 0 0 0 0 0 0 0 0166-168 1 1 1 1 1 1 1 1 1 1 1 1 0 169-171 0 0 0 0 0 0 0 0 0 0 0 0 0172-174 0 0 0 0 0 0 0 0 0 0 0 0 0 175-177 1 0 1 1 1 1 0 0 0 1 1 0 0178-180 0 0 0 0 0 0 0 0 0 0 0 0 0 181-183 0 0 0 0 0 0 0 0 0 0 0 0 0184-186 0 0 0 0 0 0 0 0 0 0 0 0 0 187-189 0 0 0 0 0 0 0 0 0 0 0 0 0190-192 0 0 0 0 0 0 0 0 0 0 0 0 0 193-195 0 0 0 0 0 0 0 0 0 0 0 0 0196-198 0 0 0 0 0 0 0 0 0 0 0 0 0 199-201 0 0 0 0 0 0 0 0 0 0 0 0 0202-204 0 0 0 0 0 0 0 0 0 0 0 0 0 205-207 0 0 0 0 0 0 0 0 0 0 0 0 0208-210 1 1 1 1 1 1 1 1 1 1 1 1 0 211-213 0 0 0 0 0 0 0 0 0 0 0 0 0214-216 0 0 0 0 0 0 0 0 0 0 0 0 0 217-219 0 0 0 0 0 0 0 0 0 0 0 0 0220-222 0 0 0 0 0 0 0 0 0 0 0 0 0 223-225 0 0 0 0 0 0 0 0 0 0 0 0 0226-228 0 0 0 0 0 0 0 0 0 0 0 0 0 229-231 0 0 0 0 0 0 0 0 0 0 0 0 0232-234 0 0 0 0 0 0 0 0 1 0 1 0 0 235-237 0 0 0 0 0 0 0 0 0 0 0 0 0238-240 0 0 0 0 0 0 0 0 0 0 0 0 0 241-243 0 0 0 0 0 0 0 0 0 0 0 0 0244-246 0 0 0 0 0 0 0 0 0 0 0 0 0 247-249 0 0 0 0 0 0 0 0 0 0 0 0 0250-252 0 0 0 0 0 0 0 0 0 0 0 0 0 253-255 0 0 0 0 0 0 0 0 0 0 0 0 0256-258 0 0 0 0 0 0 0 0 0 0 0 0 0 259-261 0 0 0 0 0 0 0 0 0 0 0 0 0262-264 0 0 0 0 0 0 0 0 0 0 0 0 0 265-267 0 0 0 0 0 0 0 0 0 0 0 0 0268-270 0 0 0 0 0 0 0 0 0 0 0 0 0 271-273 0 0 0 0 0 0 0 0 0 0 0 0 0274-276 0 0 0 0 0 0 0 0 0 0 0 0 0 277-279 0 0 0 0 0 0 0 0 0 0 0 0 0280-282 0 0 0 0 0 0 0 0 0 0 0 0 0 283-285 0 0 0 0 0 0 0 0 0 0 0 0 0286-288 0 0 0 0 0 0 0 0 0 0 0 0 0 289-291 0 0 0 0 0 0 0 0 0 0 0 0 0292-294 0 0 0 0 0 0 0 0 0 0 0 0 0 295-297 0 0 0 0 0 0 0 0 0 0 0 0 0298-300 1 0 1 1 0 1 1 0 0 0 0 0 0 301-303 0 0 0 0 0 0 0 0 0 0 0 0 0304-306 0 0 0 0 0 0 0 0 0 0 1 0 0 307-309 0 0 0 0 0 0 0 0 0 0 0 0 0310-312 0 0 0 0 0 0 0 0 0 0 0 0 0 313-315 0 0 0 0 0 0 0 0 0 0 0 0 0316-318 0 0 0 0 0 0 0 0 0 0 0 0 0 319-321 0 0 0 0 0 0 0 0 0 0 0 0 0322-324 0 0 0 0 0 0 0 0 0 0 0 0 0 325-327 0 0 0 0 0 0 0 0 0 0 0 0 0328-330 0 0 0 0 0 0 0 0 0 0 0 0 0 331-333 0 0 0 0 0 0 0 0 0 0 0 0 0334-336 0 0 0 0 0 0 0 0 0 0 0 0 0 337-339 0 0 0 0 0 0 0 0 0 0 0 0 0340-342 0 0 0 0 0 0 0 0 0 0 0 0 0 343-345 1 1 1 1 1 1 1 1 1 1 1 1 0346-348 0 0 0 0 0 0 0 0 0 0 0 0 0 TEM 12 6 13 13 11 13 12 6 7 6 14 5 2peptides 2b 0 0 0 0 0 0 0 0 0 0 0 0 0 peptides 2br 0 0 0 0 0 0 0 0 0 0 00 0 peptides 2be 0 0 0 0 0 0 0 0 1 0 2 0 0 peptides 2ber 0 0 0 0 0 0 0 00 0 0 0 0 peptides Transition number Sam49 Sam50 Sam51 Sam52 Sam53 Sam54Sam55 Sam56 Sam57 Sam58 Sam59 Sam60 Sam61 1-3 0 0 0 0 0 0 0 0 0 0 0 0 04-6 0 0 0 0 0 0 0 0 0 0 0 0 0 7-9 0 0 0 0 0 0 0 0 0 0 0 0 0 10-12 0 0 00 0 0 0 0 0 0 0 0 0 13-15 0 0 0 0 0 0 0 0 0 0 0 0 0 16-18 0 0 0 0 0 0 00 0 0 0 0 0 19-21 0 0 0 0 0 0 0 0 0 0 0 0 0 22-24 0 0 0 0 1 0 0 1 0 0 00 0 25-27 0 1 1 1 1 0 1 1 1 1 1 1 1 28-30 0 0 0 0 0 0 0 0 0 0 0 0 031-33 0 0 0 0 0 0 0 0 0 0 0 0 0 34-36 0 0 0 0 0 0 0 0 0 1 1 0 1 37-39 00 0 0 0 0 0 0 0 0 0 0 0 40-42 0 0 0 0 0 0 0 0 0 0 0 0 0 43-45 0 0 0 0 00 0 0 0 0 0 0 0 46-48 0 0 0 0 0 0 0 0 0 0 0 0 0 49-51 0 0 0 0 0 0 0 0 00 0 0 0 52-54 0 0 0 0 0 0 0 0 0 0 0 0 0 55-57 0 0 0 0 0 0 0 0 0 0 0 0 058-60 0 0 0 0 0 0 0 0 0 0 0 0 0 61-63 0 0 0 0 0 0 0 0 0 0 0 0 0 64-66 00 0 0 0 0 0 0 0 0 0 0 0 67-69 0 0 0 0 0 0 0 0 0 0 0 0 0 70-72 0 0 0 0 00 0 0 0 0 0 0 0 73-75 0 0 0 1 1 0 1 1 1 1 0 1 1 76-78 0 0 0 0 0 0 0 0 00 0 0 0 79-81 0 0 0 1 0 0 1 0 1 0 1 0 1 82-84 0 0 0 0 0 0 0 0 0 0 0 0 085-87 0 0 0 0 0 0 0 0 0 0 0 0 0 88-90 0 0 0 0 0 0 0 0 0 0 0 0 0 91-93 00 0 0 0 0 0 0 0 0 0 0 0 94-96 0 0 0 0 0 0 0 0 0 0 0 0 0 97-99 0 1 0 0 10 0 1 1 1 1 0 0 100-102 0 0 0 0 0 0 0 0 0 0 0 0 0 103-105 0 0 0 0 0 0 00 0 0 0 0 0 106-108 1 1 1 1 1 0 1 1 1 1 1 1 1 109-111 0 0 0 0 0 0 0 0 00 0 0 0 112-114 0 1 1 1 1 0 1 1 0 0 0 0 0 115-117 0 0 0 0 0 0 0 0 0 0 00 0 118-120 0 0 0 0 0 0 0 0 0 0 0 0 0 121-123 0 0 0 0 0 0 0 0 0 0 0 0 0124-126 0 0 0 0 0 0 0 0 0 0 0 0 0 127-129 0 0 0 0 0 0 0 0 0 0 0 0 0130-132 0 0 0 0 0 0 0 0 0 0 0 0 0 133-135 0 1 0 1 1 0 1 1 1 1 1 1 0136-138 0 0 0 0 0 0 0 0 0 0 0 0 0 139-141 0 0 0 0 0 0 0 0 0 0 0 0 0142-144 0 0 0 0 0 0 0 0 0 0 0 0 0 145-147 0 0 0 0 0 0 0 0 0 0 0 0 0148-150 0 0 0 0 0 0 0 0 0 0 0 0 0 151-153 0 0 0 0 0 0 0 0 0 0 0 0 0154-156 0 1 0 1 1 0 0 1 1 1 1 1 0 157-159 0 0 0 0 0 0 0 0 0 0 0 0 0160-162 0 0 0 0 0 0 0 0 0 0 0 0 0 163-165 0 0 0 0 0 0 0 0 0 0 0 0 0166-168 1 1 1 1 1 0 1 1 1 1 1 1 1 169-171 0 0 0 0 0 0 0 0 0 0 0 0 0172-174 0 0 0 0 0 0 0 0 0 0 0 0 0 175-177 1 1 1 1 1 0 1 1 1 0 0 1 0178-180 0 0 0 0 0 0 0 0 0 0 0 0 0 181-183 0 0 0 0 0 0 0 0 0 0 0 0 0184-186 0 0 0 0 0 0 0 0 0 0 0 0 0 187-189 1 1 0 0 0 0 0 0 0 0 0 0 0190-192 0 0 1 0 0 0 0 0 0 0 1 0 0 193-195 0 0 0 0 0 0 0 0 0 0 0 0 0196-198 0 0 0 0 0 0 0 0 0 0 0 0 0 199-201 0 0 0 0 0 0 0 0 0 0 0 0 0202-204 0 0 0 0 0 0 0 0 0 0 0 0 0 205-207 0 0 0 0 0 0 0 0 0 0 0 0 0208-210 0 0 0 0 1 0 1 1 0 1 1 1 1 211-213 0 0 0 0 0 0 0 0 0 0 0 0 0214-216 0 0 0 0 0 0 0 0 0 0 0 0 0 217-219 0 0 0 0 0 0 0 0 0 0 0 0 0220-222 0 0 0 0 0 0 0 0 0 0 0 0 0 223-225 0 0 0 0 0 0 0 0 0 0 0 0 0226-228 0 0 0 0 0 0 0 0 0 0 0 0 0 229-231 0 0 0 0 0 0 0 0 0 0 0 0 0232-234 0 0 0 1 0 0 1 0 1 0 1 0 1 235-237 0 0 0 0 0 0 0 0 0 0 0 0 0238-240 0 0 0 0 0 0 0 0 0 0 0 0 0 241-243 0 0 0 0 0 0 0 0 0 0 0 0 0244-246 0 0 0 0 0 0 0 0 0 0 0 0 0 247-249 0 0 0 0 0 0 0 0 0 0 0 0 0250-252 0 0 0 0 0 0 0 0 0 0 0 0 0 253-255 0 0 0 0 0 0 0 0 0 0 0 0 0256-258 0 0 0 0 0 0 0 0 0 0 0 0 0 259-261 0 0 0 0 0 0 0 0 0 0 0 0 0262-264 0 0 0 0 0 0 0 0 0 0 0 0 0 265-267 0 0 0 0 0 0 0 0 0 0 0 0 0268-270 0 0 0 0 0 0 0 0 0 0 0 0 0 271-273 0 0 0 0 0 0 0 0 0 0 0 0 0274-276 0 0 0 0 0 0 0 0 0 0 0 0 0 277-279 0 0 0 0 0 0 0 0 0 0 0 0 0280-282 0 0 0 0 0 0 0 0 0 0 0 0 0 283-285 0 0 0 0 0 0 0 0 0 0 0 0 0286-288 0 0 0 0 0 0 0 0 0 0 0 0 0 289-291 0 0 0 0 0 0 0 0 0 0 0 0 0292-294 0 0 0 0 0 0 0 0 0 0 0 0 0 295-297 0 0 0 0 0 0 0 0 0 0 0 0 0298-300 0 0 0 0 0 0 1 1 0 0 1 0 0 301-303 0 0 0 0 0 0 0 0 0 0 0 0 0304-306 0 0 0 1 1 0 0 0 1 0 0 0 0 307-309 0 0 0 0 0 0 0 0 0 0 0 0 0310-312 0 0 0 0 0 0 0 0 0 0 0 0 0 313-315 0 0 0 0 0 0 0 0 0 0 0 0 0316-318 0 0 0 0 0 0 0 0 0 0 0 0 0 319-321 0 0 0 0 0 0 0 0 0 0 0 0 0322-324 0 0 0 0 0 0 0 0 0 0 0 0 0 325-327 0 0 0 0 0 0 0 0 0 0 0 0 0328-330 0 0 0 0 0 0 0 0 0 0 0 0 0 331-333 0 0 0 0 0 0 0 0 0 0 0 0 0334-336 0 0 0 0 0 0 0 0 0 0 0 0 0 337-339 0 0 0 0 0 0 0 0 0 0 0 0 0340-342 0 0 0 0 0 0 0 0 0 0 0 0 0 343-345 1 1 1 1 1 1 1 1 1 1 1 1 1346-348 0 0 0 0 0 0 0 0 0 0 0 0 0 TEM 5 10 7 12 13 1 12 13 12 10 13 9 9peptides 2b 0 0 0 0 0 0 0 0 0 0 0 0 0 peptides 2br 1 1 0 0 0 0 0 0 0 0 00 0 peptides 2be 0 0 0 2 0 0 2 0 2 1 3 2 3 peptides 2ber 0 0 0 0 0 0 0 00 0 0 0 0 peptides

Sample Sam10 does not present any peptide which is characteristic ofTEMs. The bacteria present in sample Sam10 may be sensitive tocephalosporins and to penicillins.

Samples Sam11 to Sam61 comprise at least one peptide which ischaracteristic of TEMs. The bacteria present in samples Sam11 to Sam61therefore express a beta-lactamase which confers on them a resistance topenicillins.

No peptide specific to phenotype 2b is observed, and no sample tested isidentified as being resistant solely to penicillins.

Samples Sam35, Sam49 and Sam50 comprise at least one peptide specific tophenotype 2br. Samples Sam35, Sam49 and Sam50 are therefore resistant topenicillins associated with an inhibitor of the clavulanic acid andtazobactam type.

No peptide specific to phenotype 2ber is observed, and no sample testedis identified as belonging only to this phenotype.

Samples Sam12 to Sam21, Sam23 to Sam27, Sam29, Sam32, Sam33, Sam44,Sam46, Sam52, Sam55 and Sam57 to Sam61 comprise at least one peptidespecific to the phenotype 2be or to the phenotype 2ber. Samples Sam12 toSam21, Sam23 to Sam27, Sam29, Sam32, Sam33, Sam44, Sam46, Sam52, Sam55,and Sam57 to Sam61 are therefore resistant to penicillins, tocephalosporins and to monobactams.

EXAMPLE 7 Identification of a Resistance to CMY Beta-Lactams

The samples corresponding to a species able to comprise a CMY resistancemechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 6 instead of thepeptides from TABLE 3.

TABLE 6 Charge state (m/z) (m/z) Transition Fragment of the Retentionfiltered in filtered Collision number Peptide ion precursor time Q1 inQ3 energy 1 LSDPVTK y6 2 10 380.22 646.34 22 2 LSDPVTK y5 2 10 380.22559.31 22 3 LSDPVTK y4 2 10 380.22 444.28 22 4 ADSIINGSDSK y9 2 10.2553.77 920.47 29 5 ADSIINGSDSK y8 2 10.2 553.77 833.44 29 6 ADSIINGSDSKy7 2 10.2 553.77 720.35 29 7 ASWVHK y5 2 11.6 364.2 656.35 21 8 ASWVHKy4 2 11.6 364.2 569.32 21 9 ASWVHK y3 2 11.6 364.2 383.24 21 10 SYPNPVRy6 2 11.6 416.72 745.4 23 11 SYPNPVR y5 2 11.6 416.72 582.34 23 12SYPNPVR y4 2 11.6 416.72 485.28 23 13 VEAAWR y5 2 12.3 366.2 632.32 2114 VEAAWR y4 2 12.3 366.2 503.27 21 15 VEAAWR y3 2 12.3 366.2 432.24 2116 QWQGIR y5 2 13.8 394.21 659.36 22 17 QWQGIR y4 2 13.8 394.21 473.2822 18 QWQGIR y3 2 13.8 394.21 345.22 22 19 VLQPLK y5 2 14 349.23 598.3920 20 VLQPLK y4 2 14 349.23 485.31 20 21 VLQPLK y3 2 14 349.23 357.25 2022 SSVIDMAR y7 2 14.2 439.72 791.41 24 23 SSVIDMAR y6 2 14.2 439.72704.38 24 24 SSVIDMAR y5 2 14.2 439.72 605.31 24 25 WVQANMDASHVQEK y9 214.4 821.89 1044.48 41 26 WVQANMDASHVQEK y8 2 14.4 821.89 913.44 41 27WVQANMDASHVQEK y7 2 14.4 821.89 798.41 41 28 TLQQGIALAQSR y9 2 15.2643.36 943.53 33 29 TLQQGIALAQSR y8 2 15.2 643.36 815.47 33 30TLQQGIALAQSR y7 2 15.2 643.36 758.45 33 31 TEQQIADIVNR y9 2 15.6 643.841056.58 33 32 TEQQIADIVNR y8 2 15.6 643.84 928.52 33 33 TEQQIADIVNR y7 215.6 643.84 800.46 33 34 LAHTWITVPQNEQK y9 2 16 832.94 1056.57 42 35LAHTWITVPQNEQK y8 2 16 832.94 943.48 42 36 LAHTWITVPQNEQK y7 2 16 832.94842.44 42 37 DYAWGYR y6 2 16.4 465.71 815.38 25 38 DYAWGYR y5 2 16.4465.71 652.32 25 39 DYAWGYR y4 2 16.4 465.71 581.28 25 40 YWPELTGK y7 217.4 497.26 830.44 27 41 YWPELTGK y6 2 17.4 497.26 644.36 27 42 YWPELTGKy5 2 17.4 497.26 547.31 27 43 TFNGVLGGDAIAR y9 2 17.6 645.84 871.5 33 44TFNGVLGGDAIAR y8 2 17.6 645.84 772.43 33 45 TFNGVLGGDAIAR y7 2 17.6645.84 659.35 33 46 NLGIVMLANK y9 2 19.1 536.81 958.58 29 47 NLGIVMLANKy8 2 19.1 536.81 845.49 29 48 NLGIVMLANK y7 2 19.1 536.81 788.47 29 49TGSTGGFGSYVAFVPEK y9 2 19.5 852.42 1039.55 43 50 TGSTGGFGSYVAFVPEK y8 219.5 852.42 952.51 43 51 TGSTGGFGSYVAFVPEK y7 2 19.5 852.42 789.45 43 52ADIANNHPVTQQTLFELGSVSK y9 3 20 790.41 979.55 44 53ADIANNHPVTQQTLFELGSVSK y8 3 20 790.41 866.46 44 54ADIANNHPVTQQTLFELGSVSK y7 3 20 790.41 719.39 44 55 VALAALPAVEVNPPAPAVKy9 2 20.4 914.04 892.53 45 56 VALAALPAVEVNPPAPAVK y8 2 20.4 914.04793.46 45 57 VALAALPAVEVNPPAPAVK y7 2 20.4 914.04 679.41 45 58LLHLATYTAGGLPLQIPDDVR y9 3 22.4 755.09 1052.57 42 59LLHLATYTAGGLPLQIPDDVR y8 3 22.4 755.09 955.52 42 60LLHLATYTAGGLPLQIPDDVR y7 3 22.4 755.09 842.44 42 61TITPLMQEQAIPGMAVAVIYQGK y9 3 22.5 820.44 948.55 45 62TITPLMQEQAIPGMAVAVIYQGK y8 3 22.5 820.44 877.51 45 63TITPLMQEQAIPGMAVAVIYQGK y7 3 22.5 820.44 778.45 45 64AALLHFYQNWQPQWTPGAK y9 3 23.2 752.72 1012.52 42 65 AALLHFYQNWQPQWTPGAKy8 3 23.2 752.72 884.46 42 66 AALLHFYQNWQPQWTPGAK y7 3 23.2 752.72787.41 42 67 LYANSSIGLFGALAVK y9 2 25.1 812.46 875.53 41 68LYANSSIGLFGALAVK y8 2 25.1 812.46 818.51 41 69 LYANSSIGLFGALAVK y7 225.1 812.46 705.43 41 70 SLCCALLLTASFSTFAAAK y9 3 25.4 678.01 929.47 3871 SLCCALLLTASFSTFAAAK y8 3 25.4 678.01 842.44 38 72 SLCCALLLTASFSTFAAAKy7 3 25.4 678.01 695.37 38 73 IGDMYQGLGWEMLNWPLK y9 3 28.5 717.681216.62 40 74 IGDMYQGLGWEMLNWPLK y8 3 28.5 717.68 1030.54 40 75IGDMYQGLGWEMLNWPLK y7 3 28.5 717.68 901.5 40 76 AHYFNYGVANR y7 2 15.5656.32 793.4 34 77 AHYFNYGVANR y8 2 15.5 656.32 940.46 34 78 AHYFNYGVANRy9 2 15.5 656.32 1103.53 34 79 ANIGGVDDK y5 2 9.6 444.72 533.26 25 80ANIGGVDDK y6 2 9.6 444.72 590.28 25 81 ANIGGVDDK y7 2 9.6 444.72 703.3625 82 ESGSQVLFNK y6 2 15.1 554.79 748.44 29 83 ESGSQVLFNK y7 2 15.1554.79 835.47 29 84 ESGSQVLFNK y8 2 15.1 554.79 892.49 29 85 GAMQLDDK y52 11.5 439.21 618.31 24 86 GAMQLDDK y6 2 11.5 439.21 749.35 24 87GAMQLDDK y7 2 11.5 439.21 820.39 24 88 GIGIVMLANR y6 2 18.7 522.31703.39 28 89 GIGIVMLANR y7 2 18.7 522.31 816.48 28 90 GIGIVMLANR y8 218.7 522.31 873.5 28 91 HAPWLK y4 2 15 376.22 543.33 22 92 HAPWLK y5 215 376.22 614.37 22 93 HAPWLK b5 2 15 376.22 605.32 22 94 IPGMAVAVLK y62 18.1 499.81 600.41 27 95 IPGMAVAVLK y7 2 18.1 499.81 731.45 27 96IPGMAVAVLK y8 2 18.1 499.81 788.47 27 97 PVVDASIQPLLK y7 2 19.3 640.38798.51 33 98 PVVDASIQPLLK y8 2 19.3 640.38 869.55 33 99 PVVDASIQPLLK y92 19.3 640.38 984.57 33 100 QAMASYAYGYSK y7 2 15.5 670.3 851.39 34 101QAMASYAYGYSK y8 2 15.5 670.3 938.43 34 102 QAMASYAYGYSK y9 2 15.5 670.31009.46 34 103 QWAPVYSPGSHR y8 2 14.8 692.84 902.45 35 104 QWAPVYSPGSHRy9 2 14.8 692.84 999.5 35 105 QWAPVYSPGSHR y10 2 14.8 692.84 1070.54 35106 QYSNPSIGLFGHLAASSLK y11 2 22 995.52 1143.65 49 107QYSNPSIGLFGHLAASSLK y12 2 22 995.52 1200.67 49 108 QYSNPSIGLFGHLAASSLKy11 2 22 664.02 1143.65 37 109 TGSTNGFGAYVAFVPAR y9 2 19.4 857.93 993.5543 110 TGSTNGFGAYVAFVPAR y10 2 19.4 857.93 1050.57 43 111TGSTNGFGAYVAFVPAR y11 2 19.4 857.93 1197.64 43 112 TLTATLGAYAVVK y8 218.3 654.38 820.49 34 113 TLTATLGAYAVVK y9 2 18.3 654.38 921.54 34 114TLTATLGAYAVVK y10 2 18.3 654.38 992.58 34 115 VNPGMLADEAYGIK y8 2 18.8739.37 866.43 38 116 VNPGMLADEAYGIK y9 2 18.8 739.37 979.51 38 117VNPGMLADEAYGIK y10 2 18.8 739.37 1110.55 38 118 PSGMSYEEAMTR y10 2 15.5679.79 1174.49 35 119 PSGMSYEEAMTR y9 2 15.5 679.79 1117.47 35 120PSGMSYEEAMTR y8 2 15.5 679.79 986.42 35 121 PYYFTWGK y7 2 20.3 531.26964.46 29 122 PYYFTWGK y6 2 20.3 531.26 801.39 29 123 PYYFTWGK y5 2 20.3531.26 638.33 29

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the 3transitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 8 Identification of a Resistance to CTX-M Beta-Lactams

The samples corresponding to a species able to comprise a CTX-Mresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 7 instead of thepeptides from TABLE 3.

TABLE 7 Charge state of first- Retention (m/z) (m/z) CollisionTransition the generation time filtered filtered energy number Peptideprecursor fragment ion (minutes) in Q1 in Q3 (eV) 1 AGLPK 2 y4 9.5243.16 414.27 16 2 AGLPK 2 y3 9.5 243.16 357.25 16 3 AGLPK 2 y2 9.5243.16 244.17 16 4 AGLPTSWTVGDK 2 y9 16.6 616.32 990.49 32 5AGLPTSWTVGDK 2 y8 16.6 616.32 893.44 32 6 AGLPTSWTVGDK 2 y7 16.6 616.32792.39 32 7 AIGDETFR 2 y7 14 454.73 837.41 25 8 AIGDETFR 2 y6 14 454.73724.33 25 9 AIGDETFR 2 y5 14 454.73 667.3 25 10 ALAETQR 2 y6 7.4 394.72717.39 22 11 ALAETQR 2 y5 7.4 394.72 604.3 22 12 ALAETQR 2 y4 7.4 394.72533.27 22 13 ALGDSQR 2 y6 7 373.69 675.34 21 14 ALGDSQR 2 y5 7 373.69562.26 21 15 ALGDSQR 2 y4 7 373.69 505.24 21 16 AMAQTLR 2 y6 12.1 395.72719.39 22 17 AMAQTLR 2 y5 12.1 395.72 588.35 22 18 AMAQTLR 2 y4 12.1395.72 517.31 22 19 APLILVTYFTQPQPK 2 y9 22.4 858.49 1109.6 43 20APLILVTYFTQPQPK 2 y8 22.4 858.49 1008.5 43 21 APLILVTYFTQPQPK 2 y7 22.4858.49 845.45 43 22 APLVLVTYFTQPQQNAESR 3 y9 21.4 721.38 1057.5 40 23APLVLVTYFTQPQQNAESR 3 y8 21.4 721.38 929.44 40 24 APLVLVTYFTQPQQNAESR 3y7 21.4 721.38 832.39 40 25 AQLVTWLK 2 y7 21 479.79 887.53 26 26AQLVTWLK 2 y6 21 479.79 759.48 26 27 AQLVTWLK 2 y5 21 479.79 646.39 2628 AQLVTWMK 2 y7 19 488.77 905.49 27 29 AQLVTWMK 2 y6 19 488.77 777.4327 30 AQLVTWMK 2 y5 19 488.77 664.35 27 31 DILAAAAK 2 y7 12.1 386.73657.43 22 32 DILAAAAK 2 y6 12.1 386.73 544.35 22 33 DILAAAAK 2 y5 12.1386.73 431.26 22 34 DTTSPR 2 y5 4.6 338.67 561.3 20 35 DTTSPR 2 y4 4.6338.67 460.25 20 36 DTTSPR 2 y3 4.6 338.67 359.2 20 37 DTTTPLAMAQTLK 2y9 17 695.87 972.55 36 38 DTTTPLAMAQTLK 2 y8 17 695.87 875.5 36 39DTTTPLAMAQTLK 2 y7 17 695.87 762.42 36 40 DTTTPR 2 y5 4.8 345.67 575.3120 41 DTTTPR 2 y4 4.8 345.67 474.27 20 42 DTTTPR 2 y3 4.8 345.67 373.2220 43 DVLAAAAK 2 y7 10.5 379.72 643.41 22 44 DVLAAAAK 2 y6 10.5 379.72544.35 22 45 DVLAAAAK 2 y5 10.5 379.72 431.26 22 46 DVLASAAK 2 y7 10.8387.72 659.41 22 47 DVLASAAK 2 y6 10.8 387.72 560.34 22 48 DVLASAAK 2 y510.8 387.72 447.26 22 49 DVLASAAR 2 y7 11.4 401.72 687.41 23 50 DVLASAAR2 y6 11.4 401.72 588.35 23 51 DVLASAAR 2 y5 11.4 401.72 475.26 23 52FAMCSTSK 2 y7 11.1 466.2 784.33 26 53 FAMCSTSK 2 y6 11.1 466.2 713.3 2654 FAMCSTSK 2 y5 11.1 466.2 582.26 26 55 FPMCSTSK 2 y7 12.1 479.21810.35 26 56 FPMCSTSK 2 y6 12.1 479.21 713.3 26 57 FPMCSTSK 2 y5 12.1479.21 582.26 26 58 GNTTGAASIQAGLPASWVVGDK 3 y9 19.5 700.7 958.5 39 59GNTTGAASIQAGLPASWVVGDK 3 y8 19.5 700.7 861.45 39 60GNTTGAASIQAGLPASWVVGDK 3 y7 19.5 700.7 790.41 39 61GNTTGAASIQAGLPTSWVVGDK 3 y9 19.3 710.7 988.51 40 62GNTTGAASIQAGLPTSWVVGDK 3 y8 19.3 710.7 891.46 40 63GNTTGAASIQAGLPTSWVVGDK 3 y7 19.3 710.7 790.41 40 64 GNTTGAASIR 2 y9 9474.25 890.47 26 65 GNTTGAASIR 2 y8 9 474.25 776.43 26 66 GNTTGAASIR 2y7 9 474.25 675.38 26 67 GNTTGSASIR 2 y9 8.5 482.25 906.46 26 68GNTTGSASIR 2 y8 8.5 482.25 792.42 26 69 GNTTGSASIR 2 y7 8.5 482.25691.37 26 70 HLLNQR 2 y5 10.2 390.73 643.39 22 71 HLLNQR 2 y4 10.2390.73 530.3 22 72 HLLNQR 2 y3 10.2 390.73 417.22 22 73 LAALEK 2 y5 11322.7 531.31 19 74 LAALEK 2 y4 11 322.7 460.28 19 75 LAALEK 2 y3 11322.7 389.24 19 76 LAELER 2 y5 12.1 365.71 617.33 21 77 LAELER 2 y4 12.1365.71 546.29 21 78 LAELER 2 y3 12.1 365.71 417.25 21 79LGVALIDTADNTQVLYR 2 y9 21.4 931.5 1079.6 46 80 LGVALIDTADNTQVLYR 2 y821.4 931.5 1008.5 46 81 LGVALIDTADNTQVLYR 2 y7 21.4 931.5 893.48 46 82LGVALINTADNSQILYR 2 y9 21.1 931.01 1079.6 46 83 LGVALINTADNSQILYR 2 y821.1 931.01 1008.5 46 84 LGVALINTADNSQILYR 2 y7 21.1 931.01 893.48 46 85LIAHLGGPDK 2 y9 12.7 510.8 907.5 27 86 LIAHLGGPDK 2 y8 12.7 510.8 794.4227 87 LIAHLGGPDK 2 y7 12.7 510.8 723.38 27 88 LIAHVGGPASVTAFAR 2 y9 17.5783.94 919.5 39 89 LIAHVGGPASVTAFAR 2 y8 17.5 783.94 822.45 39 90LIAHVGGPASVTAFAR 2 y7 17.5 783.94 751.41 39 91 LIAQLGGPGGVTAFAR 2 y919.3 764.44 875.47 39 92 LIAQLGGPGGVTAFAR 2 y8 19.3 764.44 778.42 39 93LIAQLGGPGGVTAFAR 2 y7 19.3 764.44 721.4 39 94 NLTLGK 2 y5 12.2 323.2531.35 19 95 NLTLGK 2 y4 12.2 323.2 418.27 19 96 NLTLGK 2 y3 12.2 323.2317.22 19 97 QLGDETFR 2 y7 14.4 483.24 837.41 26 98 QLGDETFR 2 y6 14.4483.24 724.33 26 99 QLGDETFR 2 y5 14.4 483.24 667.3 26 100 QLLNQPVEIK 2y9 16.2 591.35 1053.6 31 101 QLLNQPVEIK 2 y8 16.2 591.35 940.55 31 102QLLNQPVEIK 2 y7 16.2 591.35 827.46 31 103 QLTLGHALGETQR 2 y9 14.9 712.39968.49 36 104 QLTLGHALGETQR 2 y8 14.9 712.39 911.47 36 105 QLTLGHALGETQR2 y7 14.9 712.39 774.41 36 106 QSESDK 2 y5 1.7 347.16 565.25 20 107QSESDK 2 y4 1.7 347.16 478.21 20 108 QSESDK 2 y3 1.7 347.16 349.17 20109 QSETQK 2 y5 3.7 360.68 592.29 21 110 QSETQK 2 y4 3.7 360.68 505.2621 111 QSETQK 2 y3 3.7 360.68 376.22 21 112 QSGGR 2 y4 5.5 252.63 376.1916 113 QSGGR 2 y3 5.5 252.63 289.16 16 114 QSGGR 2 b4 5.5 252.63 330.1416 115 SDLVNYNPIAEK 2 y9 17.1 681.85 1047.6 35 116 SDLVNYNPIAEK 2 y817.1 681.85 948.48 35 117 SDLVNYNPIAEK 2 y7 17.1 681.85 834.44 35 118SESEPNLLNQR 2 y9 13.3 643.82 1070.6 33 119 SESEPNLLNQR 2 y8 13.3 643.82983.53 33 120 SESEPNLLNQR 2 y7 13.3 643.82 854.48 33 121 SLGDETFR 2 y714.6 462.72 837.41 25 122 SLGDETFR 2 y6 14.6 462.72 724.33 25 123SLGDETFR 2 y5 14.6 462.72 667.3 25 124 SSGGR 2 y4 5.9 232.12 376.19 15125 SSGGR 2 y3 5.9 232.12 289.16 15 126 SWVVGDK 2 y6 14.2 395.71 703.3822 127 SWVVGDK 2 y5 14.2 395.71 517.3 22 128 SWVVGDK 2 y4 14.2 395.71418.23 22 129 TEPTLNTAIPGDPR 2 y9 15.6 741.38 940.48 38 130TEPTLNTAIPGDPR 2 y8 15.6 741.38 826.44 38 131 TEPTLNTAIPGDPR 2 y7 15.6741.38 725.39 38 132 TGSGDYGTTNDIAVIWPK 2 y8 19.9 947.96 941.55 47 133TGSGDYGTTNDIAVIWPK 2 y7 19.9 947.96 826.52 47 134 TGSGDYGTTNDIAVIWPK 2y6 19.9 947.96 713.43 47 135 TGSGDYGTTNDIAVIWPQGR 3 y9 19.7 703.341039.6 39 136 TGSGDYGTTNDIAVIWPQGR 3 y8 19.7 703.34 926.52 39 137TGSGDYGTTNDIAVIWPQGR 3 y7 19.7 703.34 855.48 39 138 TGSGGYGTTNDIAVIWPK 2y9 19.5 918.96 1055.6 45 139 TGSGGYGTTNDIAVIWPK 2 y8 19.5 918.96 941.5545 140 TGSGGYGTTNDIAVIWPK 2 y7 19.5 918.96 826.52 45 141 VMAAAAVLK 2 y815.3 437.26 774.45 24 142 VMAAAAVLK 2 y7 15.3 437.26 643.41 24 143VMAAAAVLK 2 y6 15.3 437.26 572.38 24 144 VMAVAAVLK 2 y8 16.3 451.28802.49 25 145 VMAVAAVLK 2 y7 16.3 451.28 671.45 25 146 VMAVAAVLK 2 y616.3 451.28 600.41 25 147 VTAFAR 2 y5 11.6 332.69 565.31 20 148 VTAFAR 2y4 11.6 332.69 464.26 20 149 VTAFAR 2 y3 11.6 332.69 393.22 20

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the 3transitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 9 Identification of a Resistance to SHV Beta-Lactams

The samples corresponding to a species able to comprise an SHVresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 8 instead of thepeptides from TABLE 3.

TABLE 8 Charge first- state generation Retention (m/z) (m/z) CollisionTransition of the fragment time filtered filtered energy number Peptideprecursor ion (minutes) in Q1 in Q3 (eV) 1 AGAGER 2 y5 5 280.64 489.2417 2 AGAGER 2 y4 5 280.64 432.22 17 3 AGAGER 2 y3 5 280.64 361.18 17 4ATTTPASMAATLR 2 y9 15.1 646.34 917.49 33 5 ATTTPASMAATLR 2 y8 15.1646.34 820.43 33 6 ATTTPASMAATLR 2 y7 15.1 646.34 749.4 33 7CIISLLATLPLAVHASPQPLEQIK 3 y9 27.3 871.5 1039.6 48 8CIISLLATLPLAVHASPQPLEQIK 3 y8 27.3 871.5 952.55 48 9CIISLLATLPLAVHASPQPLEQIK 3 y7 27.3 871.5 855.49 48 10 DMPASMAER 2 y8 12504.22 892.4 27 11 DMPASMAER 2 y7 12 504.22 761.36 27 12 DMPASMAER 2 y612 504.22 664.31 27 13 DSPASMAER 2 y8 8.8 482.21 848.39 26 14 DSPASMAER2 y7 8.8 482.21 761.36 26 15 DSPASMAER 2 y6 8.8 482.21 664.31 26 16DTLASMAER 2 y8 13.3 497.24 878.44 27 17 DTLASMAER 2 y7 13.3 497.24777.39 27 18 DTLASMAER 2 y6 13.3 497.24 664.31 27 19 DTPASMAER 2 y8 9.2489.22 862.41 27 20 DTPASMAER 2 y7 9.2 489.22 761.36 27 21 DTPASMAER 2y6 9.2 489.22 664.31 27 22 DTPASMAK 2 y7 8.5 410.7 705.36 23 23 DTPASMAK2 y6 8.5 410.7 604.31 23 24 DTPASMAK 2 y5 8.5 410.7 507.26 23 25DTTTPASMAATLR 2 y9 15.2 668.33 917.49 34 26 DTTTPASMAATLR 2 y8 15.2668.33 820.43 34 27 DTTTPASMAATLR 2 y7 15.2 668.33 749.4 34 28DTTTPASMAGTLR 2 y9 15.1 661.32 903.47 34 29 DTTTPASMAGTLR 2 y8 15.1661.32 806.42 34 30 DTTTPASMAGTLR 2 y7 15.1 661.32 735.38 34 31DTTTPASMTATLR 2 y9 14.9 683.34 947.5 35 32 DTTTPASMTATLR 2 y8 14.9683.34 850.45 35 33 DTTTPASMTATLR 2 y7 14.9 683.34 779.41 35 34 FPMISTFK2 y7 19.7 485.76 823.44 26 35 FPMISTFK 2 y6 19.7 485.76 726.39 26 36FPMISTFK 2 y5 19.7 485.76 595.34 26 37 FPMMSTFK 2 y7 19.3 494.74 841.3927 38 FPMMSTFK 2 y6 19.3 494.74 744.34 27 39 FPMMSTFK 2 y5 19.3 494.74613.3 27 40 GIVALLGGNIK 2 y9 18.4 527.83 884.56 28 41 GIVALLGGNIK 2 y818.4 527.83 785.49 28 42 GIVALLGGNIK 2 y7 18.4 527.83 714.45 28 43GIVALLGPDNK 2 y8 16.9 548.82 827.46 29 44 GIVALLGPDNK 2 y7 16.9 548.82756.43 29 45 GIVALLGPDNK 2 y6 16.9 548.82 643.34 29 46 GIVALLGPNHK 2 y916.3 559.84 948.56 30 47 GIVALLGPNHK 2 y8 16.3 559.84 849.49 30 48GIVALLGPNHK 2 y7 16.3 559.84 778.46 30 49 GIVALLGPNNK 2 y9 16.5 548.33925.55 29 50 GIVALLGPNNK 2 y8 16.5 548.33 826.48 29 51 GIVALLGPNNK 2 y716.5 548.33 755.44 29 52 GIVALLGPNNNAER 2 y9 16.4 719.39 984.49 37 53GIVALLGPNNNAER 2 y8 16.4 719.39 871.4 37 54 GIVALLGPNNNAER 2 y7 16.4719.39 814.38 37 55 GIVALR 2 y5 14.2 314.71 571.39 19 56 GIVALR 2 y414.2 314.71 458.31 19 57 GIVALR 2 y3 14.2 314.71 359.24 19 58 GPNNK 2 y45.3 265.14 472.25 17 59 GPNNK 2 y3 5.3 265.14 375.2 17 60 GPNNK 2 b4 5.3265.14 383.17 17 61 GTTTPASMAATLR 2 y9 15.3 639.33 917.49 33 62GTTTPASMAATLR 2 y8 15.3 639.33 820.43 33 63 GTTTPASMAATLR 2 y7 15.3639.33 749.4 33 64 HLADGMTVGELCAAAITMSDNSAAK 3 y9 20 845.39 924.41 46 65HLADGMTVGELCAAAITMSDNSAAK 3 y8 20 845.39 823.36 46 66HLADGMTVGELCAAAITMSDNSAAK 3 y7 20 845.39 692.32 46 67 HLLQWMVDDR 2 y921.2 656.83 1175.6 34 68 HLLQWMVDDR 2 y8 21.2 656.83 1062.5 34 69HLLQWMVDDR 2 y7 21.2 656.83 949.42 34 70 IHYLQQDLVDYSPVSEK 3 y9 19.9678.68 1023.5 38 71 IHYLQQDLVDYSPVSEK 3 y8 19.9 678.68 924.43 38 72IHYLQQDLVDYSPVSEK 3 y7 19.9 678.68 809.4 38 73 IVVIYLR 2 y6 19.1 438.29762.49 24 74 IVVIYLR 2 y5 19.1 438.29 663.42 24 75 IVVIYLR 2 y4 19.1438.29 564.35 24 76 LCIISLLAALPLAVHASPQPLEQIK 3 y9 29.8 899.19 1039.6 4977 LCIISLLAALPLAVHASPQPLEQIK 3 y8 29.8 899.19 952.55 49 78LCIISLLAALPLAVHASPQPLEQIK 3 y7 29.8 899.19 855.49 49 79LCIISLLATLPLAVHASPQPLDQIK 3 y9 29.5 904.52 1025.6 49 80LCIISLLATLPLAVHASPQPLDQIK 3 y8 29.5 904.52 938.53 49 81LCIISLLATLPLAVHASPQPLDQIK 3 y7 29.5 904.52 841.48 49 82LCIISLLATLPLAVHASPQPLEQIK 3 y9 29.6 909.19 1039.6 49 83LCIISLLATLPLAVHASPQPLEQIK 3 y8 29.6 909.19 952.55 49 84LCIISLLATLPLAVHASPQPLEQIK 3 y7 29.6 909.19 855.49 49 85LCIISLLATLPLAVHSSPQPLEQIK 3 y9 29.3 914.53 1039.6 50 86LCIISLLATLPLAVHSSPQPLEQIK 3 y8 29.3 914.53 952.55 50 87LCIISLLATLPLAVHSSPQPLEQIK 3 y7 29.3 914.53 855.49 50 88LCIISLLATLPLAVHTSPQPLEQIK 3 y9 29.5 919.2 1039.6 50 89LCIISLLATLPLAVHTSPQPLEQIK 3 y8 29.5 919.2 952.55 50 90LCIISLLATLPLAVHTSPQPLEQIK 3 y7 29.5 919.2 855.49 50 91LCIISLLATLPLTVHASPQPLEQIK 3 y9 29.3 919.2 1039.6 50 92LCIISLLATLPLTVHASPQPLEQIK 3 y8 29.3 919.2 952.55 50 93LCIISLLATLPLTVHASPQPLEQIK 3 y7 29.3 919.2 855.49 50 94LCIISLLATLPLVVHASPQPLEQIK 3 y9 30.3 918.54 1039.6 50 95LCIISLLATLPLVVHASPQPLEQIK 3 y8 30.3 918.54 952.55 50 96LCIISLLATLPLVVHASPQPLEQIK 3 y7 30.3 918.54 855.49 50 97LCIISLLATLSLAVHASPQPLEQIK 3 y9 29.5 905.85 1039.6 49 98LCIISLLATLSLAVHASPQPLEQIK 3 y8 29.5 905.85 952.55 49 99LCIISLLATLSLAVHASPQPLEQIK 3 y7 29.5 905.85 855.49 49 100LCIISLLATMPLAVHASPQPLEQIK 3 y9 27.4 915.18 1039.6 50 101LCIISLLATMPLAVHASPQPLEQIK 3 y8 27.4 915.18 952.55 50 102LCIISLLATMPLAVHASPQPLEQIK 3 y7 27.4 915.18 855.49 50 103LCIISLLAVLPLAVHASPQPLEQIK 3 y9 30.5 908.53 1039.6 49 104LCIISLLAVLPLAVHASPQPLEQIK 3 y8 30.5 908.53 952.55 49 105LCIISLLAVLPLAVHASPQPLEQIK 3 y7 30.5 908.53 855.49 49 106 LLISQR 2 y512.9 365.23 616.38 21 107 LLISQR 2 y4 12.9 365.23 503.29 21 108 LLISQR 2y3 12.9 365.23 390.21 21 109 LLLATVGGPAGLTAFLR 2 y9 24 835.5 945.55 42110 LLLATVGGPAGLTAFLR 2 y8 24 835.5 848.5 42 111 LLLATVGGPAGLTAFLR 2 y724 835.5 777.46 42 112 LLNSQR 2 y5 9.4 365.71 617.34 21 113 LLNSQR 2 y49.4 365.71 504.25 21 114 LLNSQR 2 y3 9.4 365.71 390.21 21 115 LLTNQR 2y5 9.8 372.72 631.35 21 116 LLTNQR 2 y4 9.8 372.72 518.27 21 117 LLTNQR2 y3 9.8 372.72 417.22 21 118 LLTSQR 2 y5 9.8 359.22 604.34 21 119LLTSQR 2 y4 9.8 359.22 491.26 21 120 LLTSQR 2 y3 9.8 359.22 390.21 21121 LNIISLLATLPLAVHASPQPLEQIK 3 y9 29.6 893.87 1039.6 49 122LNIISLLATLPLAVHASPQPLEQIK 3 y8 29.6 893.87 952.55 49 123LNIISLLATLPLAVHASPQPLEQIK 3 y7 29.6 893.87 855.49 49 124 LSASSQR 2 y66.2 374.7 635.31 21 125 LSASSQR 2 y5 6.2 374.7 548.28 21 126 LSASSQR 2y4 6.2 374.7 477.24 21 127 LSESQLSGR 2 y8 10.5 488.76 863.42 27 128LSESQLSGR 2 y7 10.5 488.76 776.39 27 129 LSESQLSGR 2 y6 10.5 488.76647.35 27 130 LSESQLSGSVGMIEMDLASGR 3 y9 21.1 723.02 991.49 40 131LSESQLSGSVGMIEMDLASGR 3 y8 21.1 723.02 878.4 40 132LSESQLSGSVGMIEMDLASGR 3 y7 21.1 723.02 749.36 40 133 MVVIYLR 2 y6 18.9447.27 762.49 25 134 MVVIYLR 2 y5 18.9 447.27 663.42 25 135 MVVIYLR 2 y418.9 447.27 564.35 25 136 NEALPGDAR 2 y8 10.6 471.74 828.42 26 137NEALPGDAR 2 y7 10.6 471.74 699.38 26 138 NEALPGDAR 2 y6 10.6 471.74628.34 26 139 NQHIAGIGAALIEHWQR 2 y9 21.2 957.51 1123.6 47 140NQHIAGIGAALIEHWQR 2 y8 21.2 957.51 1052.6 47 141 NQHIAGIGAALIEHWQR 2 y721.2 957.51 981.53 47 142 NQQIAGIGAALIEHWQR 2 y9 22.1 953.01 1123.6 47143 NQQIAGIGAALIEHWQR 2 y8 22.1 953.01 1052.6 47 144 NQQIAGIGAALIEHWQR 2y7 22.1 953.01 981.53 47 145 NQQIAGLGAALIEHWQR 2 y9 22.3 953.01 1123.647 146 NQQIAGLGAALIEHWQR 2 y8 22.3 953.01 1052.6 47 147NQQIAGLGAALIEHWQR 2 y7 22.3 953.01 981.53 47 148 NTTTPASMAATLR 2 y9 15.3667.84 917.49 34 149 NTTTPASMAATLR 2 y8 15.3 667.84 820.43 34 150NTTTPASMAATLR 2 y7 15.3 667.84 749.4 34 151 NVLTSQR 2 y6 9.6 409.23703.41 23 152 NVLTSQR 2 y5 9.6 409.23 604.34 23 153 NVLTSQR 2 y4 9.6409.23 491.26 23 154 QIDDNVTR 2 y7 9.4 480.74 832.42 26 155 QIDDNVTR 2y6 9.4 480.74 719.33 26 156 QIDDNVTR 2 y5 9.4 480.74 604.3 26 157 QIGDK2 y4 5.8 280.66 432.25 17 158 QIGDK 2 y3 5.8 280.66 319.16 17 159 QIGDK2 b4 5.8 280.66 414.2 17 160 QIGDNVTR 2 y7 9.5 451.74 774.41 25 161QIGDNVTR 2 y6 9.5 451.74 661.33 25 162 QIGDNVTR 2 y5 9.5 451.74 604.3 25163 QIGENVTR 2 y7 9.5 458.75 788.43 25 164 QIGENVTR 2 y6 9.5 458.75675.34 25 165 QIGENVTR 2 y5 9.5 458.75 618.32 25 166 QLLQWMVDAR 2 y921.5 630.33 1131.6 33 167 QLLQWMVDAR 2 y8 21.5 630.33 1018.5 33 168QLLQWMVDAR 2 y7 21.5 630.33 905.43 33 169 QLLQWMVDDGVAGPLIR 2 y9 25956.01 897.52 47 170 QLLQWMVDDGVAGPLIR 2 y8 25 956.01 782.49 47 171QLLQWMVDDGVAGPLIR 2 y7 25 956.01 725.47 47 172 QLLQWMVDDR 2 y9 21.7652.33 1175.6 34 173 QLLQWMVDDR 2 y8 21.7 652.33 1062.5 34 174QLLQWMVDDR 2 y7 21.7 652.33 949.42 34 175 QLLQWMVDGR 2 y8 21.3 623.321004.5 32 176 QLLQWMVDGR 2 y7 21.3 623.32 891.41 32 177 QLLQWMVDGR 2 y621.3 623.32 763.36 32 178 QLLQWMVEDR 2 y9 21.9 659.33 1189.6 34 179QLLQWMVEDR 2 y8 21.9 659.33 1076.5 34 180 QLLQWMVEDR 2 y7 21.9 659.33963.44 34 181 QQDLVDYSPVSEK 2 y9 15.6 754.37 1023.5 38 182 QQDLVDYSPVSEK2 y8 15.6 754.37 924.43 38 183 QQDLVDYSPVSEK 2 y7 15.6 754.37 809.4 38184 QQHLVDYSPVSEK 2 y9 13.9 765.38 1023.5 39 185 QQHLVDYSPVSEK 2 y8 13.9765.38 924.43 39 186 QQHLVDYSPVSEK 2 y7 13.9 765.38 809.4 39 187QSESQLSGR 2 y8 7.6 496.24 863.42 27 188 QSESQLSGR 2 y7 7.6 496.24 776.3927 189 QSESQLSGR 2 y6 7.6 496.24 647.35 27 190 QSESQLSGSVGMIEMDLASGR 3y9 19.7 728.01 991.49 40 191 QSESQLSGSVGMIEMDLASGR 3 y8 19.7 728.01878.4 40 192 QSESQLSGSVGMIEMDLASGR 3 y7 19.7 728.01 749.36 40 193SQLQLLQWMVDDR 2 y9 26.3 816.41 1175.6 41 194 SQLQLLQWMVDDR 2 y8 26.3816.41 1062.5 41 195 SQLQLLQWMVDDR 2 y7 26.3 816.41 949.42 41 196SVLPAGWFIADK 2 y9 22.9 652.36 1004.5 34 197 SVLPAGWFIADK 2 y8 22.9652.36 907.47 34 198 SVLPAGWFIADK 2 y7 22.9 652.36 836.43 34 199SVLPAGWFIADR 2 y9 23 666.36 1032.5 34 200 SVLPAGWFIADR 2 y8 23 666.36935.47 34 201 SVLPAGWFIADR 2 y7 23 666.36 864.44 34 202 SVLSAGWFIADK 2y9 22.7 647.35 994.5 33 203 SVLSAGWFIADK 2 y8 22.7 647.35 907.47 33 204SVLSAGWFIADK 2 y7 22.7 647.35 836.43 33 205 TGAAER 2 y5 4.8 302.66503.26 18 206 TGAAER 2 y4 4.8 302.66 446.24 18 207 TGAAER 2 y3 4.8302.66 375.2 18 208 TGAAK 2 y4 6 224.13 346.21 15 209 TGAAK 2 y3 6224.13 289.19 15 210 TGAAK 2 b4 6 224.13 301.15 15 211 TGAGER 2 y5 4.9295.65 489.24 18 212 TGAGER 2 y4 4.9 295.65 432.22 18 213 TGAGER 2 y34.9 295.65 361.18 18 214 TGAGK 2 y4 6.1 217.12 332.19 15 215 TGAGK 2 y36.1 217.12 275.17 15 216 TGAGK 2 b4 6.1 217.12 287.13 15 217 TGASER 2 y54.5 310.65 519.25 19 218 TGASER 2 y4 4.5 310.65 462.23 19 219 TGASER 2y3 4.5 310.65 391.19 19 220 TGASK 2 y4 5.8 232.13 362.2 15 221 TGASK 2y3 5.8 232.13 305.18 15 222 TGASK 2 b4 5.8 232.13 317.15 15 223 TGASR 2y4 5.8 246.13 390.21 16 224 TGASR 2 y3 5.8 246.13 333.19 16 225 TGASR 2y2 5.8 246.13 262.15 16 226 TLTAWCADER 2 y9 15.9 611.78 1121.5 32 227TLTAWCADER 2 y8 15.9 611.78 1008.4 32 228 TLTAWCADER 2 y7 15.9 611.78907.37 32 229 TLTAWHADER 2 y9 14.4 600.29 1098.5 31 230 TLTAWHADER 2 y814.4 600.29 985.45 31 231 TLTAWHADER 2 y7 14.4 600.29 884.4 31 232TLTAWR 2 y5 15 374.21 646.37 21 233 TLTAWR 2 y4 15 374.21 533.28 21 234TLTAWR 2 y3 15 374.21 432.24 21 235 TVGGPAGLTAFLR 2 y9 19.7 630.36945.55 33 236 TVGGPAGLTAFLR 2 y8 19.7 630.36 848.5 33 237 TVGGPAGLTAFLR2 y7 19.7 630.36 777.46 33 238 TVVIYLR 2 y6 17.4 432.27 762.49 24 239TVVIYLR 2 y5 17.4 432.27 663.42 24 240 TVVIYLR 2 y4 17.4 432.27 564.3524 241 VAGPLIR 2 y6 14.1 363.24 626.4 21 242 VAGPLIR 2 y5 14.1 363.24555.36 21 243 VAGPLIR 2 y4 14.1 363.24 498.34 21 244 VALCGAVLAR 2 y917.2 515.3 930.52 28 245 VALCGAVLAR 2 y8 17.2 515.3 859.48 28 246VALCGAVLAR 2 y7 17.2 515.3 746.4 28 247 VDAGDEQLER 2 y9 10.9 566.271032.5 30 248 VDAGDEQLER 2 y8 10.9 566.27 917.43 30 249 VDAGDEQLER 2 y710.9 566.27 846.4 30 250 VDAGDK 2 y5 4.1 302.65 505.23 18 251 VDAGDK 2y4 4.1 302.65 390.2 18 252 VDAGDK 2 y3 4.1 302.65 319.16 18 253VGMIEMDLASGR 2 y9 18.7 639.81 991.49 33 254 VGMIEMDLASGR 2 y8 18.7639.81 878.4 33 255 VGMIEMDLASGR 2 y7 18.7 639.81 749.36 33 256VGMIEMDLASR 2 y9 18.7 611.3 1065.5 32 257 VGMIEMDLASR 2 y8 18.7 611.3934.47 32 258 VGMIEMDLASR 2 y7 18.7 611.3 821.38 32 259 VGMIEMDLASSR 2y9 18.4 654.82 1021.5 34 260 VGMIEMDLASSR 2 y8 18.4 654.82 908.41 34 261VGMIEMDLASSR 2 y7 18.4 654.82 779.37 34 262 VLLCGAVLAR 2 y9 19.3 536.32972.57 29 263 VLLCGAVLAR 2 y8 19.3 536.32 859.48 29 264 VLLCGAVLAR 2 y719.3 536.32 746.4 29 265 VVLCGAMLAR 2 y8 18.1 545.3 891.45 29 266VVLCGAMLAR 2 y7 18.1 545.3 778.37 29 267 VVLCGAMLAR 2 y6 18.1 545.3618.34 29 268 VVLCGAVLAR 2 y9 18 529.31 958.55 28 269 VVLCGAVLAR 2 y8 18529.31 859.48 28 270 VVLCGAVLAR 2 y7 18 529.31 746.4 28 271 VVLCGTVLAR 2y9 16.6 544.32 988.56 29 272 VVLCGTVLAR 2 y8 16.6 544.32 889.49 29 273VVLCGTVLAR 2 y7 16.6 544.32 776.41 29 274 WETDR 2 y4 9.8 353.66 520.2421 275 WETDR 2 y3 9.8 353.66 391.19 21 276 WETDR 2 b4 9.8 353.66 532.221 277 WETELNEAFPGDAR 2 y9 19 817.88 976.45 41 278 WETELNEAFPGDAR 2 y819 817.88 862.41 41 279 WETELNEAFPGDAR 2 y7 19 817.88 733.36 41 280WETELNEALPADAR 2 y9 18.9 807.89 956.48 41 281 WETELNEALPADAR 2 y8 18.9807.89 842.44 41 282 WETELNEALPADAR 2 y7 18.9 807.89 713.39 41 283WETELNEALPGDAR 2 y9 18.5 800.88 942.46 40 284 WETELNEALPGDAR 2 y8 18.5800.88 828.42 40 285 WETELNEALPGDAR 2 y7 18.5 800.88 699.38 40 286WETELNEALSGDAR 2 y9 18 795.87 932.44 40 287 WETELNEALSGDAR 2 y8 18795.87 818.4 40 288 WETELNEALSGDAR 2 y7 18 795.87 689.36 40 289WETELNEVLPGDAR 2 y9 19.4 814.9 970.5 41 290 WETELNEVLPGDAR 2 y8 19.4814.9 856.45 41 291 WETELNEVLPGDAR 2 y7 19.4 814.9 727.41 41 292 WETER 2y4 10.4 360.67 534.25 21 293 WETER 2 y3 10.4 360.67 405.21 21 294 WETER2 b4 10.4 360.67 546.22 21

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the 3transitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 10 Identification of a Resistance to FOX Beta-Lactams

The samples corresponding to a species able to comprise a FOX resistancemechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 9 instead of thepeptides from TABLE 3.

TABLE 9 Charge first- Retention (m/z) (m/z) Collision Transition stateof the generation time filtered filtered in energy number Peptideprecursor fragment ion (minutes) in Q1 Q3 (eV) 1 AHYFNYGVANR 2 y9 15.5656.32 1103.53 34 2 AHYFNYGVANR 2 y8 15.5 656.32 940.46 34 3 AHYFNYGVANR2 y7 15.5 656.32 793.4 34 4 AMGEQR 2 y5 5.3 346.16 620.28 20 5 AMGEQR 2y4 5.3 346.16 489.24 20 6 AMGEQR 2 y3 5.3 346.16 432.22 20 7 ESGQR 2 y44.3 288.64 447.23 18 8 ESGQR 2 y3 4.3 288.64 360.2 18 9 ESGQR 2 b4 4.3288.64 402.16 18 10 FAVPK 2 y4 11.3 281.17 414.27 17 11 FAVPK 2 y3 11.3281.17 343.23 17 12 FAVPK 2 b4 11.3 281.17 415.23 17 13 GGFELDDK 2 y714.5 440.71 823.38 24 14 GGFELDDK 2 y6 14.5 440.71 766.36 24 15 GGFELDDK2 y5 14.5 440.71 619.29 24 16 GIAIVMLANR 2 y9 19.3 529.31 1000.6 28 17GIAIVMLANR 2 y8 19.3 529.31 887.51 28 18 GIAIVMLANR 2 y7 19.3 529.31816.48 28 19 IPGMAVAVLK 2 y9 18.1 499.81 885.52 27 20 IPGMAVAVLK 2 y818.1 499.81 788.47 27 21 IPGMAVAVLK 2 y7 18.1 499.81 731.45 27 22NYPIEAR 2 y6 12.2 431.72 748.4 24 23 NYPIEAR 2 y5 12.2 431.72 585.34 2424 NYPIEAR 2 y4 12.2 431.72 488.28 24 25 SWSPVYPAGTHR 2 y9 15.5 679.34997.52 35 26 SWSPVYPAGTHR 2 y8 15.5 679.34 900.47 35 27 SWSPVYPAGTHR 2y7 15.5 679.34 801.4 35 28 TGSADLLK 2 y7 14 402.73 703.4 23 29 TGSADLLK2 y6 14 402.73 646.38 23 30 TGSADLLK 2 y5 14 402.73 559.34 23 31TGSTGGFGAYVAFVPAR 2 y9 19.5 829.42 993.55 41 32 TGSTGGFGAYVAFVPAR 2 y819.5 829.42 922.51 41 33 TGSTGGFGAYVAFVPAR 2 y7 19.5 829.42 759.45 41 34TLTATLGAYAAVK 2 y9 17.2 640.37 893.51 33 35 TLTATLGAYAAVK 2 y8 17.2640.37 792.46 33 36 TLTATLGAYAAVK 2 y7 17.2 640.37 679.38 33 37VSEQTLFEIGSVSK 2 y9 19.6 762.4 979.55 39 38 VSEQTLFEIGSVSK 2 y8 19.6762.4 866.46 39 39 VSEQTLFEIGSVSK 2 y7 19.6 762.4 719.39 39 40 VSQHAPWLK2 y8 15.3 533.3 966.52 28 41 VSQHAPWLK 2 y7 15.3 533.3 879.48 28 42VSQHAPWLK 2 y6 15.3 533.3 751.42 28 43 VTPGVLAAEAYGIK 2 y9 18.4 694.89935.52 36 44 VTPGVLAAEAYGIK 2 y8 18.4 694.89 822.44 36 45 VTPGVLAAEAYGIK2 y7 18.4 694.89 751.4 36

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 11 Identification of a Resistance to TEM or CTX-M Beta-Lactams

The samples corresponding to a species able to comprise a TEM or CTX-Mresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 10 instead of thepeptides from TABLE 3.

TABLE 10 Charge state Transition First-generation of the Clinical numberProtein Peptide fragment ion precursor interest 1 CTX-M AMAQTLR y4monocharged 2 2be 2 CTX-M AMAQTLR y5 monocharged 2 2be 3 CTX-M AMAQTLRy6 monocharged 2 2be 4 CTX-M AQLVTWLK y5 monocharged 2 2be 5 CTX-MAQLVTWLK y6 monocharged 2 2be 6 CTX-M AQLVTWLK y7 monocharged 2 2be 7CTX-M FAMCSTSK y5 monocharged 2 2be 8 CTX-M FAMCSTSK y6 monocharged 22be 9 CTX-M FAMCSTSK y7 monocharged 2 2be 10 CTX-M LAALEK y3 monocharged2 2be 11 CTX-M LAALEK y4 monocharged 2 2be 12 CTX-M LAALEK y5monocharged 2 2be 13 CTX-M LGVALINTADNSQILYR y7 monocharged 2 2be 14CTX-M LGVALINTADNSQILYR y8 monocharged 2 2be 15 CTX-M LGVALINTADNSQILYRy9 monocharged 2 2be 16 CTX-M NLTLGK y3 monocharged 2 2be 17 CTX-MNLTLGK y4 monocharged 2 2be 18 CTX-M NLTLGK y5 monocharged 2 2be 19CTX-M QSETQK y3 monocharged 2 2be 20 CTX-M QSETQK y4 monocharged 2 2be21 CTX-M QSETQK y5 monocharged 2 2be 22 CTX-M SDLVNYNPIAEK y7monocharged 2 2be 23 CTX-M SDLVNYNPIAEK y8 monocharged 2 2be 24 CTX-MSDLVNYNPIAEK y9 monocharged 2 2be 25 CTX-M TEPTLNTAIPGDPR y7 monocharged2 2be 26 CTX-M TEPTLNTAIPGDPR y8 monocharged 2 2be 27 CTX-MTEPTLNTAIPGDPR y9 monocharged 2 2be 28 CTX-M VMAAAAVLK y6 monocharged 22be 29 CTX-M VMAAAAVLK y7 monocharged 2 2be 30 CTX-M VMAAAAVLK y8monocharged 2 2be 31 TEM DAEDQLGAR y5 monocharged 2 TEM 32 TEM DAEDQLGARy6 monocharged 2 TEM 33 TEM DAEDQLGAR y7 monocharged 2 TEM 34 TEMDTTMPAAMATTLR y7 monocharged 2 TEM 35 TEM DTTMPAAMATTLR y8 monocharged 2TEM 36 TEM DTTMPAAMATTLR y9 monocharged 2 TEM 37 TEM DTTTPAAMATTLR y7monocharged 2 TEM 38 TEM DTTTPAAMATTLR y9 dicharged 2 TEM 39 TEMDTTTPAAMATTLR y9 monocharged 2 TEM 40 TEM EPELNEAIPNDER y5 monocharged 2TEM 41 TEM EPELNEAIPNDER y7 monocharged 2 TEM 42 TEM EPELNEAIPNDER y8monocharged 2 TEM 43 TEM GIIAALGPDGKPSR y7 monocharged 2 TEM 44 TEMGIIAALGPDGKPSR y8 monocharged 2 TEM 45 TEM GIIAALGPDGKPSR y9 monocharged2 TEM 46 TEM GSCGIIAALGPDGKPSR y7 monocharged 2 2br 47 TEMGSCGIIAALGPDGKPSR y8 monocharged 2 2br 48 TEM GSCGIIAALGPDGKPSR y9monocharged 2 2br 49 TEM GSSGIIAALGPDGKPSR y7 monocharged 2 TEM 50 TEMGSSGIIAALGPDGKPSR y8 monocharged 2 TEM 51 TEM GSSGIIAALGPDGKPSR y9monocharged 2 TEM 52 TEM HLTDGMTVR y4 monocharged 2 TEM 53 TEM HLTDGMTVRy7 monocharged 2 TEM 54 TEM HLTDGMTVR y8 monocharged 2 TEM 55 TEMIHYSQNDLVEYSPVTEK y6 monocharged 3 TEM 56 TEM IHYSQNDLVEYSPVTEK y7monocharged 3 TEM 57 TEM IHYSQNDLVEYSPVTEK y8 monocharged 3 TEM 58 TEMIHYSQNDLVK y7 monocharged 2 2be 59 TEM IHYSQNDLVK y8 monocharged 2 2be60 TEM IHYSQNDLVK y9 dicharged 2 2be 61 TEM ILESFRPEER b6 monocharged 2TEM 62 TEM ILESFRPEER b8 monocharged 2 TEM 63 TEM ILESFRPEER y7dicharged 2 TEM 64 TEM LDHWEPELNEAIPNDER y5 monocharged 3 2be 65 TEMLDHWEPELNEAIPNDER y6 monocharged 3 2be 66 TEM LDHWEPELNEAIPNDER y7monocharged 3 2be 67 TEM LDSWEPELNEAIPNDER y5 monocharged 3 2be 68 TEMLDSWEPELNEAIPNDER y6 monocharged 3 2be 69 TEM LDSWEPELNEAIPNDER y7monocharged 3 2be 70 TEM LLTGELLTLASR y6 monocharged 2 TEM 71 TEMLLTGELLTLASR y7 monocharged 2 TEM 72 TEM LLTGELLTLASR y9 monocharged 2TEM 73 TEM QIAEIGASLIK y7 monocharged 2 TEM 74 TEM QIAEIGASLIK y8monocharged 2 TEM 75 TEM QIAEIGASLIK y9 monocharged 2 TEM 76 TEMQQLIDWMEADK y5 monocharged 2 TEM 77 TEM QQLIDWMEADK y6 monocharged 2 TEM78 TEM QQLIDWMEADK y7 monocharged 2 TEM 79 TEM VAGPLLR y4 monocharged 2TEM 80 TEM VAGPLLR y5 monocharged 2 TEM 81 TEM VAGPLLR y6 monocharged 2TEM 82 TEM VDAGQEQLGR y5 monocharged 2 TEM 83 TEM VDAGQEQLGR y7monocharged 2 TEM 84 TEM VDAGQEQLGR y8 monocharged 2 TEM 85 TEMVGYIELDLNSGK y7 monocharged 2 TEM 86 TEM VGYIELDLNSGK y8 monocharged 2TEM 87 TEM VGYIELDLNSGK y9 monocharged 2 TEM 88 TEM WEPELNEAIPNDER y12dicharged 2 TEM 89 TEM WEPELNEAIPNDER y5 monocharged 2 TEM 90 TEMWEPELNEAIPNDER y7 monocharged 2 TEM 91 TEM YSPVTEK y4 monocharged 2 2be92 TEM YSPVTEK y5 monocharged 2 2be 93 TEM YSPVTEK y6 monocharged 2 2be

In the clinical interest column, the entries TEM, 2b, 2br, 2be and 2bercorrespond to the same meanings as in TABLE 4.

The transitions mentioned in TABLE 10 are detected by using theparameters set out in TABLE 11.

TABLE 11 Retention (m/z) (m/z) Collision Transition time filteredfiltered energy Positivity number (minutes) in Q1 in Q3 (eV) threshold 112.1 395.72 517.31 22 2500 2 12.1 395.72 588.35 22 2500 3 12.1 395.72719.39 22 2500 4 21 479.79 646.39 26 2500 5 21 479.79 759.48 26 2500 621 479.79 887.53 26 2500 7 11.1 466.2 582.26 26 2500 8 11.1 466.2 713.326 2500 9 11.1 466.2 784.33 26 2500 10 11 322.7 389.24 19 2500 11 11322.7 460.28 19 2500 12 11 322.7 531.31 19 2500 13 21.1 931.01 893.48 462500 14 21.1 931.01 1008.51 46 2500 15 21.1 931.01 1079.55 46 2500 1612.2 323.2 317.22 19 2500 17 12.2 323.2 418.27 19 2500 18 12.2 323.2531.35 19 2500 19 3.7 360.68 376.22 21 2500 20 3.7 360.68 505.26 21 250021 3.7 360.68 592.29 21 2500 22 17.1 681.85 834.44 35 2500 23 17.1681.85 948.48 35 2500 24 17.1 681.85 1047.55 35 2500 25 15.6 741.38725.39 38 2500 26 15.6 741.38 826.44 38 2500 27 15.6 741.38 940.48 382500 28 15.3 437.26 572.38 24 2500 29 15.3 437.26 643.41 24 2500 30 15.3437.26 774.45 24 2500 31 10.5 487.73 544.32 26 2500 32 10.5 487.73659.35 26 2500 33 10.5 487.73 788.39 26 2500 34 17.6 690.34 763.61 352500 35 17.6 690.34 834.45 35 2500 36 17.6 690.34 931.5 35 2500 37 16.1675.34 763.41 35 2500 38 16.1 675.34 466.25 35 2500 39 16.1 675.34 931.535 2500 40 14.9 763.36 630.28 39 2500 41 14.9 763.36 814.41 39 2500 4214.9 763.36 943.45 39 2500 43 15.5 676.39 756.4 35 2500 44 15.5 676.39813.42 35 2500 45 15.5 676.39 926.51 35 2500 46 16.5 828.43 756.4 412500 47 16.5 828.43 813.42 41 2500 48 16.5 828.43 926.51 41 2500 49 16.1791.93 756.4 40 2500 50 16.1 791.93 813.42 40 2500 51 16.1 791.93 926.5140 2500 52 12 515.26 506.28 28 2500 53 12 515.26 779.37 28 2500 54 12515.26 892.46 28 2500 55 16.6 674.67 660.36 38 2500 56 16.6 674.67823.42 38 2500 57 16.6 674.67 952.46 38 2500 58 12.5 608.82 803.43 322500 59 12.5 608.82 966.49 32 2500 60 12.5 608.82 552.28 32 2500 61 14.6638.34 746.42 33 2500 62 14.6 638.34 972.51 33 2500 63 14.6 638.34460.73 33 2500 64 18 692.99 630.28 39 2500 65 18 692.99 743.37 39 250066 18 692.99 814.41 39 2500 67 19.5 676.32 630.28 38 2500 68 19.5 676.32743.37 38 2500 69 19.5 676.32 814.41 38 2500 70 22.5 643.89 660.4 332500 71 22.5 643.89 773.49 33 2500 72 22.5 643.89 959.55 33 2500 73 18.8571.84 701.46 30 2500 74 18.8 571.84 830.5 30 2500 75 18.8 571.84 901.5430 2500 76 20.1 688.83 593.26 35 2500 77 20.1 688.83 779.34 35 2500 7820.1 688.83 894.37 35 2500 79 14.1 363.24 498.34 21 2500 80 14.1 363.24555.36 21 2500 81 14.1 363.24 626.4 21 2500 82 10.6 536.77 602.38 292500 83 10.6 536.77 787.41 29 2500 84 10.6 536.77 858.44 29 2500 85 18.8654.35 746.4 34 2500 86 18.8 654.35 875.45 34 2500 87 18.8 654.35 988.5334 2500 88 18 856.4 698.84 43 2500 89 18 856.4 630.28 43 2500 90 18856.4 814.41 43 2500 91 9.8 412.21 476.27 23 2500 92 9.8 412.21 573.3223 2500 93 9.8 412.21 660.36 23 2500

When the areas of at least two transitions of the same peptide aregreater than or equal to the positivity threshold described in TABLE 11,the detection of the peptide is considered to be positive. When morethan two transitions of the same peptide comprise an area less than thepositivity threshold described in TABLE 11, the corresponding peptide isconsidered non-detected.

A sample contains bacteria which express the TEM protein, when at leastone peptide corresponding to the TEM resistance mechanism is detected.These bacteria are resistant to penicillins.

A sample contains bacteria which express the TEM protein, phenotype 2b,when at least one peptide corresponding to the TEM resistance mechanismclinical interest 2b is detected. These bacteria are only resistant topenicillins.

A sample contains bacteria which express the TEM protein, phenotype 2br,when at least one peptide corresponding to the TEM resistance mechanismclinical interest 2br is detected. These bacteria are resistant topenicillins associated with an inhibitor of the clavulanic acid andtazobactam type.

A sample contains bacteria which express the CTX-M protein or the TEMprotein, phenotype 2be, when at least one peptide corresponding to theCTX-M or TEM resistance mechanism clinical interest 2be is detected.These bacteria are resistant to penicillins, to cephalosporins and tomonobactams.

A sample contains bacteria which express the TEM protein, phenotype2ber, when at least one peptide corresponding to the TEM resistancemechanism clinical interest 2ber, is detected. These bacteria areresistant to penicillins, to cephalosporins and to monobactams, and areinsensitive to inhibition by clavulanic acid, sulfobactam or tazobactam.

EXAMPLE 12 Identification of a Resistance to PER Beta-Lactams

Samples Sam74 to Sam78 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 12.

TABLE 12 Names Species Ech74 A. baumannii Ech75 A. baumannii Ech76 P.aeruginosa Ech77 P. aeruginosa Ech78 P. aeruginosa

Samples Sam74 to Sam78 correspond to a species able to comprise a PERresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 13 instead of the peptides from TABLE 3.

TABLE 13 Retention (m/z) (m/z) Collision Transition time filteredfiltered energy positivity number Peptide (minutes) in Q1 in Q3 (eV)threshold 1 AAAQLLR 12.91 371.73 401.29 16.9 2000 2 AAAQLLR 12.89 371.73529.35 16.9 2000 3 AAAQLLR 12.91 371.73 600.38 16.9 2000 4 AAAQVLQK10.24 414.75 487.32 19.4 2000 5 AAAQVLQK 10.24 414.75 615.38 19.4 2000 6AAAQVLQK 10.18 414.75 686.42 19.4 2000 7 AAVLQNTWSPMMK 19.35 738.87506.25 37.9 2000 8 AAVLQNTWSPMMK 19.35 738.87 593.28 37.9 2000 9AAVLQNTWSPMMK 19.35 738.87 994.45 37.9 2000 10 EQIESIVIGK 17.24 558.32317.22 27.6 2000 11 EQIESIVIGK 17.26 558.32 616.40 27.6 2000 12EQIESIVIGK 17.24 558.32 745.45 27.6 2000 13 EQIETIVTGK 15.48 559.31305.18 27.6 2000 14 EQIETIVTGK 15.48 559.31 618.38 27.6 2000 15EQIETIVTGK 15.48 559.31 747.43 27.6 2000 16 ETEVVANEAQMHADDQVQYK 14.17769.02 838.87 30.9 5000 17 ETEVVANEAQMHADDQVQYK 14.17 769.02 874.39 30.95000 18 ETEVVANEAQMHADDQVQYK 14.17 769.02 923.92 30.9 5000 19 FPMQSVFK19.09 492.26 418.72 23.8 2000 20 FPMQSVFK 19.09 492.26 739.38 23.8 200021 FPMQSVFK 19.07 492.26 836.43 23.8 2000 22 GAAEILK 12.66 351.21 322.7015.8 2000 23 GAAEILK 12.65 351.21 502.32 15.8 2000 24 GAAEILK 12.65351.21 573.36 15.8 2000 25 GLLPAGTIVAHK 16.8 588.86 447.26 29.3 2000 26GLLPAGTIVAHK 16.8 588.86 503.81 29.3 2000 27 GLLPAGTIVAHK 16.82 588.86893.52 29.3 2000 28 GLLPAGTVVAHK 15.73 581.85 440.26 28.9 2000 29GLLPAGTVVAHK 15.73 581.85 496.80 28.9 2000 30 GLLPAGTVVAHK 15.75 581.85879.51 28.9 2000 31 GQIESIVIGK 16.8 522.31 616.40 25.5 5000 32GQIESIVIGK 16.8 522.31 745.45 25.5 5000 33 GQIESIVIGK 16.8 522.31 858.5325.5 5000 34 LDLNK 10.5 301.68 342.20 12.9 2000 35 LDLNK 10.5 301.68374.24 12.9 2000 36 LDLNK 10.52 301.68 489.27 12.9 2000 37 LDLNQSVTVNR15.11 629.84 338.19 31.6 2000 38 LDLNQSVTVNR 15.11 629.84 489.28 31.62000 39 LDLNQSVTVNR 15.11 629.84 675.38 31.6 2000 40 LDLNQTVIVNR 17.29642.87 501.31 32.4 2000 41 LDLNQTVIVNR 17.29 642.87 600.38 32.4 2000 42LDLNQTVIVNR 17.28 642.87 701.43 32.4 2000 43 LHLAMLVLHQVDQGK 19.84567.99 568.83 24.7 2000 44 LHLAMLVLHQVDQGK 19.84 567.99 669.86 24.7 200045 LHLAMLVLHQVDQGK 19.84 567.99 726.41 24.7 2000 46 MHLAMLVLHQVDQGK19.35 573.97 332.19 24.9 2000 47 MHLAMLVLHQVDQGK 19.35 573.97 669.8624.9 2000 48 MHLAMLVLHQVDQGK 19.35 573.97 726.41 24.9 2000 49 NWTSMK12.59 383.68 365.19 17.6 2000 50 NWTSMK 12.59 383.68 466.23 17.6 2000 51NWTSMK 12.61 383.68 652.31 17.6 2000 52 QLSETSQALLWK 18.84 702.381162.61 35.8 2000 53 QLSETSQALLWK 18.84 702.38 446.28 35.8 2000 54QLSETSQALLWK 18.84 702.38 845.49 35.8 2000 55 TGTSGIK 3.31 332.19 404.2514.7 2000 56 TGTSGIK 3.29 332.19 505.30 14.7 2000 57 TGTSGIK 3.23 332.19562.32 14.7 2000 58 TGTSGVR 1.56 339.18 418.24 15.1 2000 59 TGTSGVR 1.56339.18 519.29 15.1 2000 60 TGTSGVR 1.56 339.18 576.31 15.1 2000 61TNEAIIAQVAQAAYQFELK 26.27 703.37 1168.60 28.9 2000 62TNEAIIAQVAQAAYQFELK 26.21 703.37 827.43 28.9 2000 63 TNEAIIAQVAQAAYQFELK26.25 703.37 898.47 28.9 2000 64 TNEAIIAQVAQTAYQFELK 25.39 713.381198.61 29.2 2000 65 TNEAIIAQVAQTAYQFELK 25.37 713.38 827.43 29.2 200066 TNEAIIAQVAQTAYQFELK 25.37 713.38 898.47 29.2 2000 67 TQLSETSQALLWK19.41 502.27 559.36 38.7 2000 68 TQLSETSQALLWK 19.41 502.27 630.40 22.72000 69 TQLSETSQALLWK 19.43 752.90 1162.61 22.7 2000 70 TVAVNR 7.08330.20 388.23 14.6 2000 71 TVAVNR 7.08 330.20 459.27 14.6 2000 72 TVAVNR7.05 330.20 558.34 14.6 2000 73 VLQNTWAPIMK 19.32 650.86 488.29 32.82000 74 VLQNTWAPIMK 19.3 650.86 559.33 32.8 2000 75 VLQNTWAPIMK 19.3650.86 745.41 32.8 2000 76 WMVETTTGPER 15.5 653.81 761.38 33 2000 77WMVETTTGPER 15.48 653.81 890.42 33 2000 78 WMVETTTGPER 15.48 653.81989.49 33 2000 79 WMVETTTGPQR 15.19 653.32 457.25 33 2000 80 WMVETTTGPQR15.19 653.32 889.44 33 2000 81 WMVETTTGPQR 15.23 653.32 988.51 33 2000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™ (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 40.00 psiHeating gas: 40.00 psi Collision gas which induces dissociation: 9.00psi Dynamic filling: activated Declustering potential (DP): 100.00 VEntry potential before Q0 (EP): 10.00 V Collision cell exit potential(CXP): 15 V Total cycle time: 1 sec Detection window: 240 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE13, the detection of the transition is considered to be positive and islabelled “1” in TABLE 14. When a transition has an area less than thepositivity threshold described in TABLE 13, the transition is considerednon-detected and is labelled “0” in TABLE 14.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 14 Transition number Sam74 Sam75 Sam76 Sam77 Sam78 1 0 0 0 0 0 2 00 0 0 0 3 0 0 0 0 0 4 0 0 0 0 0 5 0 0 0 0 0 6 0 0 0 0 0 7 0 1 0 1 0 8 00 0 0 1 9 1 1 1 1 1 10 1 1 1 1 1 11 1 1 1 1 1 12 1 1 1 1 1 13 0 0 0 0 014 0 0 0 0 0 15 0 0 0 0 0 16 0 0 0 0 0 17 1 1 0 0 0 18 0 0 0 0 0 19 1 10 0 0 20 1 1 0 0 0 21 1 1 0 0 0 22 1 1 1 1 1 23 1 1 1 1 1 24 1 1 1 1 125 0 0 0 0 0 26 0 0 0 0 0 27 0 0 0 0 0 28 1 1 1 1 1 29 1 1 1 1 1 30 1 11 1 1 31 0 0 0 0 0 32 0 0 0 0 0 33 1 1 0 0 0 34 0 0 0 0 0 35 0 0 0 0 036 0 0 0 0 0 37 0 0 1 1 1 38 0 0 0 0 0 39 0 0 0 0 0 40 1 1 1 1 1 41 1 11 1 1 42 1 1 1 1 1 43 0 0 0 0 0 44 0 0 0 0 0 45 0 0 0 0 0 46 0 0 0 0 047 0 0 0 0 0 48 0 0 0 0 0 49 0 0 0 0 0 50 0 0 0 0 0 51 0 0 0 0 0 52 0 00 0 0 53 0 0 0 0 0 54 0 0 0 0 0 55 1 1 0 1 1 56 1 1 0 0 0 57 1 1 0 0 058 0 0 0 0 0 59 0 0 0 0 0 60 0 0 0 0 0 61 0 0 0 0 0 62 0 0 0 0 0 63 0 00 0 0 64 0 0 0 0 0 65 0 0 0 0 0 66 0 0 0 0 0 67 1 1 1 1 1 68 1 1 1 1 169 1 1 1 1 0 70 0 0 0 0 0 71 0 0 0 0 0 72 0 0 0 0 0 73 1 1 1 1 1 74 1 11 1 1 75 1 1 1 1 1 76 1 1 1 1 1 77 1 1 1 1 1 78 1 1 1 1 1 79 0 0 0 0 080 0 0 0 0 0 81 0 0 0 0 0

Samples Sam74 to Sam78 comprise at least one peptide which ischaracteristic of PERs. The bacteria present in samples Sam74 to Sam78therefore express a beta-lactamase which confers on them a resistance topenicillins, cephalosporins and monobactams.

EXAMPLE 13 Identification of a Resistance to VEB Beta-Lactams

Samples Sam79 to Sam82 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 15.

TABLE 15 Names Species Sam79 A. baumannii Sam80 A. baumannii Sam81 A.baumannii Sam82 E. coli

Samples Sam79 to Sam82 correspond to a species able to comprise a VEBresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 16 instead of the peptides from TABLE 3.

TABLE 16 Retention (m/z) (m/z) Collision Transition time filtered infiltered energy Positivity number Peptide (minutes) Q1 in Q3 (eV)threshold 1 ANEEQMHK 1.44 493.72 458.20 23.9 2000 2 ANEEQMHK 1.44 493.72672.31 23.9 2000 3 ANEEQMHK 1.44 493.72 801.36 23.9 2000 4DWNTQYQNWATPTAMNK 19.05 1034.96 661.33 54.7 2000 5 DWNTQYQNWATPTAMNK 19690.31 661.33 28.5 2000 6 DWNTQYQNWATPTAMNK 19.02 690.31 762.38 28.52000 7 ETSEINEK 6.84 475.23 390.20 22.8 2000 8 ETSEINEK 6.84 475.23503.28 22.8 2000 9 ETSEINEK 6.83 475.23 719.36 22.8 2000 10 ETTTGSNR1.38 433.20 433.22 20.4 1500 11 ETTTGSNR 1.38 433.20 534.26 20.4 1500 12ETTTGSNR 1.38 433.20 635.31 20.4 1500 13 FLNANHFTDISIK 18.72 507.27573.30 22.8 2000 14 FLNANHFTDISIK 18.72 507.27 630.32 22.8 2000 15FLNANHFTDISIK 18.74 507.27 686.87 22.8 2000 16 FPIALAVLSEIDK 27.01708.41 634.88 36.1 2000 17 FPIALAVLSEIDK 27.04 708.41 704.38 36.1 200018 FPIALAVLSEIDK 27.01 708.41 874.49 36.1 2000 19 GNLSFEQK 12.65 461.74551.28 22.1 2000 20 GNLSFEQK 12.65 461.74 638.31 22.1 2000 21 GNLSFEQK12.65 461.74 751.40 22.1 2000 22 GQLPK 7.19 271.67 243.16 11.2 2000 23GQLPK 7.19 271.67 357.25 11.2 2000 24 GQLPK 7.19 271.67 485.31 11.2 200025 IEITPQDLLPK 21.67 633.87 405.74 31.9 2000 26 IEITPQDLLPK 21.67 633.87810.47 31.9 2000 27 IEITPQDLLPK 21.63 633.87 911.52 31.9 2000 28 IENVLK12.89 358.22 359.27 16.2 2000 29 IENVLK 12.91 358.22 473.31 16.2 2000 30IENVLK 12.89 358.22 602.35 16.2 2000 31 IGVAIFNSNEK 18.09 596.32 738.3429.7 2000 32 IGVAIFNSNEK 18.09 596.32 851.43 29.7 2000 33 IGVAIFNSNEK18.09 596.32 922.46 29.7 2000 34 IISDIAK 12.6 380.23 331.23 17.4 2000 35IISDIAK 12.58 380.23 533.29 17.4 2000 36 IISDIAK 12.56 380.23 646.3817.4 2000 37 INNDFHFPMQSVMK 20.04 569.94 740.84 24.8 2000 38INNDFHFPMQSVMK 20.04 569.94 797.86 24.8 2000 39 INNDFHFPMQSVMK 20.05569.94 820.41 24.8 2000 40 LIGGTDSVQK 11.48 509.28 734.37 24.8 2000 41LIGGTDSVQK 11.46 509.28 791.39 24.8 2000 42 LIGGTDSVQK 11.46 509.28904.47 24.8 2000 43 LLIDTYNNK 15.7 547.30 639.31 26.9 2000 44 LLIDTYNNK15.7 547.30 754.34 26.9 2000 45 LLIDTYNNK 15.7 547.30 867.42 26.9 200046 MWSPIK 16.91 381.20 357.25 17.5 2000 47 MWSPIK 16.91 381.20 444.2817.5 2000 48 MWSPIK 16.87 381.20 630.36 17.5 2000 49 NQLLSK 10.59 351.71347.23 15.8 2000 50 NQLLSK 10.59 351.71 460.31 15.8 2000 51 NQLLSK 10.59351.71 588.37 15.8 2000 52 NTIVAHK 23.75 391.73 454.28 18.1 2000 53NTIVAHK 23.73 391.73 567.36 18.1 2000 54 NTIVAHK 23.75 391.73 668.4118.1 2000 55 SYDFIWK 19.92 479.74 446.28 23.1 2000 56 SYDFIWK 19.9479.74 593.35 23.1 2000 57 SYDFIWK 19.9 479.74 708.37 23.1 2000 58TWSPIK 14.95 366.21 357.25 16.6 2000 59 TWSPIK 14.93 366.21 444.28 16.62000 60 TWSPIK 14.95 366.21 630.36 16.6 2000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™ (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 40.00 psiHeating gas: 40.00 psi Collision gas which induces dissociation: 9.00psi Dynamic filling: activated Declustering potential (DP): 100.00 VEntry potential before Q0 (EP): 10.00 V Collision cell exit potential(CXP): 15 V Total cycle time: 1.2 sec Detection window: 240 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE16, the detection of the transition is considered to be positive and islabelled “1” in TABLE 17. When a transition has an area less than thepositivity threshold described in TABLE 16, the transition is considerednon-detected and is labelled “0” in TABLE 17.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 17 Transition number Sam79 Sam80 Sam81 Sam82 1 0 0 0 0 2 0 0 0 0 30 0 0 0 4 0 0 0 0 5 0 0 0 0 6 0 0 0 0 7 0 0 0 0 8 0 0 0 0 9 0 0 0 0 10 11 1 1 11 1 1 1 1 12 1 1 1 0 13 0 1 1 0 14 0 1 1 0 15 0 1 1 0 16 0 0 0 017 0 0 0 0 18 0 0 0 0 19 0 0 0 0 20 0 0 0 0 21 0 0 0 0 22 0 0 0 0 23 0 00 0 24 0 0 0 0 25 1 1 1 1 26 1 1 1 1 27 1 1 1 1 28 0 0 0 0 29 0 0 0 0 300 0 0 0 31 0 0 0 0 32 0 0 0 0 33 0 0 0 0 34 0 0 0 0 35 0 0 0 0 36 0 0 00 37 0 0 0 0 38 0 0 0 0 39 0 0 0 0 40 1 1 1 0 41 0 1 0 0 42 1 0 1 0 43 00 0 0 44 0 0 0 0 45 0 0 0 0 46 0 0 0 0 47 0 0 0 0 48 0 0 0 0 49 0 0 0 050 0 0 0 0 51 0 0 0 0 52 0 0 0 0 53 0 0 0 0 54 0 0 0 0 55 1 1 1 0 56 1 11 0 57 1 1 1 0 58 0 0 0 0 59 0 0 0 0 60 0 0 0 0

Samples Sam79 to Sam82 comprise at least one peptide which ischaracteristic of VEBs. The bacteria present in samples Sam79 to Sam82therefore express a beta-lactamase which confers on them a resistance topenicillins, cephalosporins and monobactams.

EXAMPLE 14 Identification of a Resistance to MOX Beta-Lactams

Sample Sam83 is identified according to one of the methods described inexamples 1, 3 or 4. The identification of the species is set out inTABLE 18.

TABLE 18 Names Species Sam83 E. coli

Sample Sam83 corresponds to a species able to comprise a MOX resistancemechanism. Each sample is treated according to example 5, then analysedaccording to example 6 by detecting the peptides from TABLE 19 insteadof the peptides from TABLE 3.

TABLE 19 Retention (m/z) (m/z) Collision Transition time filteredfiltered in energy Positivity number Peptide (minutes) in Q1 Q3 (eV)threshold 1 AHYFNYGVADR 14.36 656.807 621.289 33.2 2000 2 AHYFNYGVADR14.36 656.807 941.448 33.2 2000 3 AHYFNYGVADR 14.34 656.807 1104.51133.2 2000 4 ANISGVDDK 9.88 459.73 533.257 21.9 2000 5 ANISGVDDK 9.86459.73 620.289 21.9 2000 6 ANISGVDDK 9.86 459.73 733.373 21.9 2000 7ANISGVHDK 7.75 470.746 555.289 22.6 2000 8 ANISGVHDK 7.67 470.746642.321 22.6 2000 9 ANISGVHDK 7.69 470.746 755.405 22.6 2000 10ASLFAPWLK 23.52 516.797 543.329 25.2 2000 11 ASLFAPWLK 23.56 516.797614.366 25.2 2000 12 ASLFAPWLK 23.56 516.797 761.434 25.2 2000 13 EDKPFR8.09 396.206 419.24 18.3 2000 14 EDKPFR 8.07 396.206 547.335 18.3 200015 EDKPFR 8.09 396.206 662.362 18.3 2000 16 ESGNLMLFNK 18.39 576.79408.224 28.6 2000 17 ESGNLMLFNK 18.39 576.79 521.308 28.6 2000 18ESGNLMLFNK 18.39 576.79 652.349 28.6 2000 19 ESGSQMLFNK 15.08 570.771408.224 28.3 2000 20 ESGSQMLFNK 15.14 570.771 521.308 28.3 2000 21ESGSQMLFNK 15.12 570.771 652.349 28.3 2000 22 GHPVLFNK 12.74 456.259408.224 21.7 2000 23 GHPVLFNK 12.78 456.259 521.308 21.7 2000 24GHPVLFNK 12.78 456.259 717.429 21.7 2000 25 GIGVVMLANR 18.19 515.297604.324 25.1 2000 26 GIGVVMLANR 18.17 515.297 703.392 25.1 2000 27GIGVVMLANR 18.17 515.297 859.482 25.1 2000 28 MQAYYR 11.12 416.195501.246 19.5 2000 29 MQAYYR 11.14 416.195 572.283 19.5 2000 30 MQAYYR11.12 416.195 700.341 19.5 2000 31 NSPIEAR 9.4 393.709 375.199 18.2 200032 NSPIEAR 9.4 393.709 488.283 18.2 2000 33 NSPIEAR 9.4 393.709 585.33518.2 2000 34 NSPIEGTLK 13.36 479.764 379.226 23.1 2000 35 NSPIEGTLK13.36 479.764 547.309 23.1 2000 36 NSPIEGTLK 13.34 479.764 757.445 23.12000 37 NYPNEGTLK 11.6 518.259 379.706 25.3 2000 38 NYPNEGTLK 11.62518.259 661.352 25.3 2000 39 NYPNEGTLK 11.58 518.259 758.404 25.3 200040 QPFDR 9.48 331.666 437.214 14.6 2000 41 QPFDR 9.5 331.666 488.21414.6 2000 42 QPFDR 9.48 331.666 534.267 14.6 2000 43 QWTPAYSPGSHR 13.34693.831 486.238 35.3 2000 44 QWTPAYSPGSHR 13.34 693.831 640.316 35.32000 45 QWTPAYSPGSHR 13.34 693.831 971.469 35.3 2000 46 QWTPAYSR 13.46504.749 496.251 24.5 2000 47 QWTPAYSR 13.48 504.749 593.304 24.5 2000 48QWTPAYSR 13.46 504.749 694.352 24.5 2000 49 QYANPSIGLFGYLAASSMK 25.46673.34 594.292 28 2000 50 QYANPSIGLFGYLAASSMK 25.5 673.34 594.31 28 200051 QYANPSIGLFGYLAASSMK 25.5 673.34 927.46 28 2000 52 QYSNPSIGLFGHLAASSMK21.21 670.003 609.819 27.9 2000 53 QYSNPSIGLFGHLAASSMK 21.17 670.003758.403 27.9 2000 54 QYSNPSIGLFGHLAASSMK 21.21 670.003 858.941 27.9 200055 TGSSNGFGAYVAFVPAR 20.79 850.923 343.209 100 2000 56 TGSSNGFGAYVAFVPAR20.78 850.923 380.229 100 2000 57 TGSSNGFGAYVAFVPAR 20.78 850.923442.277 100 2000 58 TGSTNGFGAYVAFVPAK 20.45 843.928 315.203 100 2000 59TGSTNGFGAYVAFVPAK 20.46 843.928 366.226 100 2000 60 TGSTNGFGAYVAFVPAK20.46 843.928 414.271 100 2000 61 TGSTSGFGAYVAFVPAK 20.64 553.951632.377 24.3 2000 62 TGSTSGFGAYVAFVPAK 20.66 830.422 315.203 43.1 200063 TGSTSGFGAYVAFVPAK 20.66 830.422 414.271 43.1 2000 64TLTATLGAYAVVQGSFELDDK 18.71 733.711 569.275 29.8 2000 65TLTATLGAYAVVQGSFELDDK 18.71 733.711 654.328 29.8 2000 66TLTATLGAYAVVQGSFELDDK 18.71 733.711 1137.542 29.8 2000 67 VSPGMLADEAYGIK18.63 725.866 632.816 37.1 2000 68 VSPGMLADEAYGIK 18.63 725.866 866.42537.1 2000 69 VSPGMLADEAYGIK 18.65 725.866 1167.571 37.1 2000 70VTPAMLAEEPYGIK 19.05 506.934 577.334 22.8 2000 71 VTPAMLAEEPYGIK 19.05759.897 659.839 39 2000 72 VTPAMLAEEPYGIK 19.07 759.897 906.457 39 200073 YAYPVSEQTLLAGNSAK 18.09 604.644 547.283 25.8 2000 74YAYPVSEQTLLAGNSAK 18.07 604.644 660.368 25.8 2000 75 YAYPVSEQTLLAGNSAK18.09 906.462 707.88 47.4 2000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™  (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 40.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 40.00 psiHeating gas: 40.00 psi Collision gas which 9.00 psi inducesdissociation: Dynamic filling: activated Declustering 100.00 V potential(DP): Entry potential 10.00 V before Q0 (EP): Collision cell exit 15 Vpotential (CXP): Total cycle time: 1 sec Detection window: 240 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE19, the detection of the transition is considered to be positive and islabelled “1” in TABLE 20. When a transition has an area less than thepositivity threshold described in TABLE 19, the transition is considerednon-detected and is labelled “0” in TABLE 20.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 20 Transition number Sam83  1 0  2 0  3 0  4 0  5 0  6 0  7 1  8 1 9 1 10 0 11 0 12 0 13 0 14 0 15 0 16 0 17 0 18 0 19 0 20 0 21 0 22 0 230 24 0 25 0 26 0 27 0 28 0 29 0 30 0 31 0 32 0 33 0 34 0 35 0 36 0 37 038 0 39 0 40 0 41 0 42 0 43 1 44 1 45 1 46 0 47 0 48 0 49 0 50 0 51 0 520 53 0 54 0 55 0 56 0 57 0 58 0 59 0 60 0 61 0 62 0 63 0 64 0 65 0 66 067 1 68 1 69 1 70 0 71 0 72 0 73 0 74 0 75 0

Sample Sam83 comprises at least one peptide which is characteristic ofMOXs. The bacteria present in sample Sam83 therefore express abeta-lactamase which confers on them a resistance to penicillins and tocephalosporins, with the exception of fourth-generation cephalosporins.

EXAMPLE 15 Identification of a Resistance to ACC Beta-Lactams

The samples corresponding to a species able to comprise an ACCresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 21 instead of thepeptides from TABLE 3.

TABLE 21 (m/z) (m/z) Transition Retention time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 ALTDTHIGYFK 15.83422.56 457.24 25 2 ALTDTHIGYFK 15.83 422.56 514.27 25 3 ALTDTHIGYFK15.83 422.56 627.35 25 4 AWKPADPAGTHR 10.49 436.23 470.25 26 5AWKPADPAGTHR 10.49 436.23 638.34 26 6 AWKPADPAGTHR 10.49 436.23 669.3426 7 DEPVHGNMEILGNEAYGIK 18.07 696 851.43 39 8 DEPVHGNMEILGNEAYGIK 18.07696 1009.4 39 9 DEPVHGNMEILGNEAYGIK 18.07 696 1122.49 39 10DTVDGLIQPLMQK 20.72 729.39 857.49 37 11 DTVDGLIQPLMQK 20.72 729.39970.58 37 12 DTVDGLIQPLMQK 20.72 729.39 1027.6 37 13 DTVDSLIQPLMQK 21.62744.39 857.49 38 14 DTVDSLIQPLMQK 21.62 744.39 1057.61 38 15DTVDSLIQPLMQK 21.62 744.39 1172.63 38 16 IQHALTATHTGYFK 12.76 397.71514.27 23 17 IQHALTATHTGYFK 12.76 397.71 615.31 23 18 IQHALTATHTGYFK12.76 397.71 752.37 23 19 LDGNSTLQK 9.44 488.26 576.34 26 20 LDGNSTLQK9.44 488.26 747.4 26 21 LDGNSTLQK 9.44 488.26 862.43 26 22 LSLDK 10.73288.17 375.22 18 23 LSLDK 10.73 288.17 429.23 18 24 LSLDK 10.73 288.17462.26 18 25 LSLEQSVSHYVPELR 20.3 586.31 776.43 33 26 LSLEQSVSHYVPELR20.3 586.31 913.49 33 27 LSLEQSVSHYVPELR 20.3 586.31 1000.52 33 28NEPIHVNMEVLGNEAYGIR 19.55 719.02 879.43 40 29 NEPIHVNMEVLGNEAYGIR 19.55719.02 992.52 40 30 NEPIHVNMEVLGNEAYGIR 19.55 719.02 1163.55 40 31NNIPGMSVAVTIR 18.3 457.92 559.36 27 32 NNIPGMSVAVTIR 18.3 686.37 933.5235 33 NNIPGMSVAVTIR 18.3 686.37 1030.57 35 34 NTDQLMAYLK 18.78 598.8625.34 31 35 NTDQLMAYLK 18.78 598.8 738.42 31 36 NTDQLMAYLK 18.78 598.8981.51 31 37 NTTQLMTYLK 17.75 606.82 768.43 32 38 NTTQLMTYLK 17.75606.82 896.49 32 39 NTTQLMTYLK 17.75 606.82 997.54 32 40 NYIYNYGLASK15.9 653.33 752.39 34 41 NYIYNYGLASK 15.9 653.33 915.46 34 42NYIYNYGLASK 15.9 653.33 1028.54 34 43 SISHYVPELR 15 400.88 514.3 24 44SISHYVPELR 15 400.88 613.37 24 45 SISHYVPELR 15 400.88 776.43 24 46TFAAILASYAQASGK 21.64 749.9 811.39 38 47 TFAAILASYAQASGK 21.64 749.9882.43 38 48 TFAAILASYAQASGK 21.64 749.9 995.52 38 49 TLLPK 12.05 286.19357.25 18 50 TLLPK 12.05 286.19 425.28 18 51 TLLPK 12.05 286.19 470.3318 52 TNASDLIR 12.95 445.24 516.31 25 53 TNASDLIR 12.95 445.24 603.35 2554 TNASDLIR 12.95 445.24 674.38 25 55 VTVAYK 10.34 340.7 381.21 20 56VTVAYK 10.34 340.7 480.28 20 57 VTVAYK 10.34 340.7 581.33 20

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 16 Identification of a Resistance to ACT Beta-Lactams

The samples corresponding to a species able to comprise an ACTresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 22 instead of thepeptides from TABLE 3.

TABLE 22 Retention (m/z) (m/z) Transition time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 AEEAHYAWGYR 14.21676.81 815.38 34.8 2 AEEAHYAWGYR 14.21 676.81 952.44 34.8 3 AEEAHYAWGYR14.21 676.81 1152.52 34.8 4 AIHVSPGMLDAEAYGVK 18.71 586.64 666.35 33.3 5AIHVSPGMLDAEAYGVK 18.71 586.64 737.38 33.3 6 AIHVSPGMLDAEAYGVK 18.74586.64 852.41 33.3 7 AVHVSPGMLDAEAYGVK 17.93 581.96 666.35 33.1 8AVHVSPGMLDAEAYGVK 17.93 581.96 737.38 33.1 9 AVHVSPGMLDAEAYGVK 17.93581.96 852.41 33.1 10 DMANWVMVNMKPDSLQDSSLK 22.23 803.71 896.45 44.2 11DMANWVMVNMKPDSLQDSSLK 22.21 803.71 989.49 44.2 12 DMANWVMVNMKPDSLQDSSLK22.23 803.71 1082.03 44.2 13 DNASLLR 12.76 394.72 401.29 22.4 14 DNASLLR12.76 394.72 488.32 22.4 15 DNASLLR 12.76 394.72 559.36 22.4 16EGITLAQSR 13.23 487.77 574.33 26.5 17 EGITLAQSR 13.25 487.77 675.38 26.518 EGITLAQSR 13.23 487.77 788.46 26.5 19 EVNPPAPPVNASWVHK 16.59 581.31700.38 33.1 20 EVNPPAPPVNASWVHK 16.61 581.31 757.4 33.1 21EVNPPAPPVNASWVHK 16.61 581.31 1134.61 33.1 22 FYQNWQPQWKPGTTR 17.43968.98 531.29 47.6 23 FYQNWQPQWKPGTTR 17.43 968.98 1070.57 47.6 24FYQNWQPQWKPGTTR 17.43 968.98 1198.63 47.6 25 GEISLDDPVTR 16.1 601.31702.34 31.5 26 GEISLDDPVTR 16.1 601.31 815.43 31.5 27 GEISLDDPVTR 16.12601.31 902.46 31.5 28 GEISLGDPVTK 15.7 558.3 559.31 29.6 29 GEISLGDPVTK15.68 558.3 616.33 29.6 30 GEISLGDPVTK 15.68 558.3 816.45 29.6 31GLTLAQSR 12.67 423.25 461.25 23.6 32 GLTLAQSR 12.68 423.25 574.33 23.633 GLTLAQSR 12.65 423.25 675.38 23.6 34 LDHTWINVPK 16.79 611.83 497.7831.9 35 LDHTWINVPK 16.79 611.83 756.44 31.9 36 LDHTWINVPK 16.79 611.83857.49 31.9 37 MLDLATYTAGGLPLQVPDEVK 23.87 744.39 512.79 41.2 38MLDLATYTAGGLPLQVPDEVK 23.89 744.39 587.3 41.2 39 MLDLATYTAGGLPLQVPDEVK23.89 1116.09 587.3 54.1 40 QGIALAQSR 12.72 472.27 574.33 25.8 41QGIALAQSR 12.7 472.27 645.37 25.8 42 QGIALAQSR 12.72 472.27 758.45 25.843 QGISLAQSR 12.83 480.27 661.36 26.1 44 QGISLAQSR 12.83 480.27 774.4526.1 45 QGISLAQSR 12.83 480.27 831.47 26.1 46 QIGIVMLANK 18.95 543.82576.32 28.9 47 QIGIVMLANK 18.95 543.82 675.39 28.9 48 QIGIVMLANK 18.95543.82 845.49 28.9 49 QIGIVMLANTSYPNPAR 21.86 615.66 554.31 34.8 50QIGIVMLANTSYPNPAR 21.86 615.66 717.37 34.8 51 QIGIVMLANTSYPNPAR 21.86922.99 554.31 45.6 52 QLAEVVANTVTPLMK 21.94 807.45 488.29 40.5 53QLAEVVANTVTPLMK 21.94 807.45 974.53 40.5 54 QLAEVVANTVTPLMK 21.94 807.451073.6 40.5 55 QLAEVVER 13.05 472.26 502.3 25.8 56 QLAEVVER 13.03 472.26631.34 25.8 57 QLAEVVER 13.03 472.26 702.38 25.8 58 QLGIVMLANK 19.27543.82 576.32 28.9 59 QLGIVMLANK 19.27 543.82 675.39 28.9 60 QLGIVMLANK19.27 543.82 845.49 28.9 61 SYPNPAR 9.83 402.7 343.21 22.7 62 SYPNPAR9.83 402.7 457.25 22.7 63 SYPNPAR 9.83 402.7 554.31 22.7 64TFTGVLGGDAIAR 18.42 639.35 659.35 33.1 65 TFTGVLGGDAIAR 18.39 639.35772.43 33.1 66 TFTGVLGGDAIAR 18.42 639.35 1029.57 33.1 67TGSTGGFGSYVAFIPEK 21.14 573.29 373.21 32.7 68 TGSTGGFGSYVAFIPEK 21.14573.29 633.36 32.7 69 TGSTGGFGSYVAFIPEK 21.14 573.29 704.4 32.7 70TVTPLMK 13.65 395.23 488.29 22.4 71 TVTPLMK 13.65 395.23 589.34 22.4 72TVTPLMK 13.62 395.23 688.41 22.4 73 TVVEGSDNK 4.64 474.74 520.24 25.9 74TVVEGSDNK 4.64 474.74 649.28 25.9 75 TVVEGSDNK 4.64 474.74 748.35 25.976 VALAPLPAR 15.96 454.29 553.35 25 77 VALAPLPAR 15.99 454.29 624.38 2578 VALAPLPAR 15.96 454.29 737.47 25 79 VALAPLPVAEVNPPAPPVK 21.12 627.04705.43 35.4 80 VALAPLPVAEVNPPAPPVK 21.14 627.04 762.94 35.4 81VALAPLPVAEVNPPAPPVK 21.14 627.04 819.47 35.4 82 VEAAYR 8.39 354.69409.22 20.6 83 VEAAYR 8.39 354.69 480.26 20.6 84 VEAAYR 8.39 354.69609.3 20.6 85 VFKPLK 11.66 366.24 357.25 21.1 86 VFKPLK 11.66 366.24485.35 21.1 87 VFKPLK 11.66 366.24 632.41 21.1 88 VGAMYQGLGWEMLNWPVDAK26.23 755.7 529.3 41.8 89 VGAMYQGLGWEMLNWPVDAK 26.23 755.7 829.42 41.890 VGAMYQGLGWEMLNWPVDAK 26.26 755.7 1073.55 41.8 91 VLKPLK 10.38 349.25357.25 20.4 92 VLKPLK 10.36 349.25 485.35 20.4 93 VLKPLK 10.36 349.25598.43 20.4 94 VSPGMLDAQAYGMK 17.62 734.35 641.3 37.3 95 VSPGMLDAQAYGMK17.62 734.35 883.4 37.3 96 VSPGMLDAQAYGMK 17.62 734.35 996.48 37.3 97VSPGMLDAQAYGVK 17.36 718.37 625.32 36.6 98 VSPGMLDAQAYGVK 17.36 718.37851.43 36.6 99 VSPGMLDAQAYGVK 17.36 718.37 964.51 36.6 100 YWPQLTGK17.33 496.76 322.19 26.9 101 YWPQLTGK 17.33 496.76 643.38 26.9 102YWPQLTGK 17.31 496.76 829.46 26.9

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 17 Identification of a Resistance to CMY Beta-Lactams

The samples corresponding to a species able to comprise a CMY resistancemechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 23 instead of thepeptides from TABLE 3.

TABLE 23 Retention (m/z) (m/z) Collision Transition time filtered infiltered in energy number Peptide (minutes) Q1 Q3 (eV) 1 AALLR 10.85272.18 288.2 17 2 AALLR 10.85 272.18 401.29 17 3 AALLR 10.85 272.18472.32 17 4 ADSIINGSDNK 10.62 567.28 747.36 30 5 ADSIINGSDNK 10.62567.28 860.45 30 6 ADSIINGSDNK 10.62 567.28 947.48 30 7 AELLR 11.13301.19 401.29 18 8 AELLR 11.13 301.19 427.26 18 9 AELLR 11.13 301.19530.33 18 10 ALQQAISLTHK 13.79 605.35 698.42 32 11 ALQQAISLTHK 13.79605.35 769.46 32 12 ALQQAISLTHK 13.79 605.35 897.52 32 13AVHVSPGQLDAEAYGVK 15.59 580.97 737.38 33 14 AVHVSPGQLDAEAYGVK 15.59580.97 776.4 33 15 AVHVSPGQLDAEAYGVK 15.59 580.97 852.41 33 16DYAC[CAM]GYR 9.86 452.68 555.23 25 17 DYAC[CAM]GYR 9.86 452.68 626.27 2518 DYAC[CAM]GYR 9.86 452.68 789.33 25 19 DYALGYR 13.44 429.21 508.29 2420 DYALGYR 13.44 429.21 579.32 24 21 DYALGYR 13.44 429.21 742.39 24 22EGKPVHASPGQLDAEAYGVK 13.47 685.02 737.38 38 23 EGKPVHASPGQLDAEAYGVK13.47 685.02 852.41 38 24 EGKPVHASPGQLDAEAYGVK 13.47 685.02 965.49 38 25EGKPVHGSPGQLDAEAYGVK 13.08 510.51 537.3 29 26 EGKPVHGSPGQLDAEAYGVK 13.08510.51 666.35 29 27 EGKPVHGSPGQLDAEAYGVK 13.08 510.51 737.38 29 28EGKPVHVSPEQLDAEAYGVK 15.07 539.03 737.38 30 29 EGKPVHVSPEQLDAEAYGVK15.07 539.03 852.41 30 30 EGKPVHVSPEQLDAEAYGVK 15.07 718.37 852.41 40 31EGKPVHVSPGQFDAEAYGVK 15.01 529.52 537.3 29 32 EGKPVHVSPGQFDAEAYGVK 15.01529.52 632.33 29 33 EGKPVHVSPGQFDAEAYGVK 15.01 705.69 999.48 39 34EGKPVHVSPGQLDAEAYC[CAM]VK 14.63 546.77 569.28 30 35EGKPVHVSPGQLDAEAYC[CAM]VK 14.63 546.77 640.31 30 36EGKPVHVSPGQLDAEAYC[CAM]VK 14.63 546.77 769.35 30 37 EGKPVHVSPGQLDAEAYGVK14.65 521.02 537.3 29 38 EGKPVHVSPGQLDAEAYGVK 14.65 521.02 737.38 29 39EGKPVHVSPGQLDAEAYGVK 14.65 521.02 852.41 29 40 EGKPVHVSPGQLDAGAYGVK14.19 503.02 594.32 28 41 EGKPVHVSPGQLDAGAYGVK 14.19 503.02 665.36 28 42EGKPVHVSPGQLDAGAYGVK 14.19 503.02 780.39 28 43 EGKPVHVSPGQLNAEAYGVK14.25 520.78 537.3 29 44 EGKPVHVSPGQLNAEAYGVK 14.25 520.78 737.38 29 45EGKPVHVSPGQLNAEAYGVK 14.25 520.78 834.45 29 46 EGKPVHVTPGQLDAEAYGVK14.72 524.53 848.46 29 47 EGKPVHVTPGQLDAEAYGVK 14.72 699.03 852.41 39 48EGKPVHVTPGQLDAEAYGVK 14.72 699.03 1247.63 39 49 EGKPVYVSPGQLDAEAYGVK16.73 703.03 852.41 39 50 EGKPVYVSPGQLDAEAYGVK 16.73 703.03 860.45 39 51EGKPVYVSPGQLDAEAYGVK 16.73 703.03 1247.63 39 52 ESGASVSEQTLFDIGSVSK20.37 970.98 976.42 48 53 ESGASVSEQTLFDIGSVSK 20.37 970.98 1066.58 48 54ESGASVSEQTLFDIGSVSK 20.37 970.98 1194.64 48 55 FSDPVTK 11.61 397.21559.31 22 56 FSDPVTK 11.61 397.21 646.34 22 57 FSDPVTK 11.61 397.21647.3 22 58 FYQNWQPQWAPGAK 18.61 860.92 867.38 43 59 FYQNWQPQWAPGAK18.61 860.92 982.51 43 60 FYQNWQPQWAPGAK 18.61 860.92 1168.59 43 61FYQNWQPQWTPGAK 18.53 875.92 884.46 44 62 FYQNWQPQWTPGAK 18.53 875.921012.52 44 63 FYQNWQPQWTPGAK 18.53 875.92 1198.6 44 64 HAPWLK 11.85376.22 543.33 22 65 HAPWLK 11.85 376.22 605.32 22 66 HAPWLK 11.85 376.22614.37 22 67 IPDDVR 9.9 357.69 504.24 21 68 IPDDVR 9.9 357.69 540.27 2169 IPDDVR 9.9 357.69 601.29 21 70 LAHTWIK 12.56 434.76 547.32 24 71LAHTWIK 12.56 434.76 684.38 24 72 LAHTWIK 12.56 434.76 755.42 24 73LAHTWITVPENEQK 15.87 555.96 609.31 32 74 LAHTWITVPENEQK 15.87 555.96744.35 32 75 LAHTWITVPENEQK 15.87 555.96 823.45 32 76 LAHTWITVPQSEQK15.75 546.63 1029.56 31 77 LAHTWITVPQSEQK 15.75 819.44 1029.56 41 78LAHTWITVPQSEQK 15.75 819.44 1215.64 41 79 LDAEAYGVK 12.86 483.25 537.326 80 LDAEAYGVK 12.86 483.25 737.38 26 81 LDAEAYGVK 12.86 483.25 852.4126 82 LLHLATYTAGGLPLK 19.26 523.31 584.38 30 83 LLHLATYTAGGLPLK 19.26523.31 655.41 30 84 LLHLATYTAGGLPLK 19.26 523.31 756.46 30 85LLHLATYTAGGLPLQFPDDVR 22.76 575.06 601.29 32 86 LLHLATYTAGGLPLQFPDDVR22.76 766.41 1086.56 42 87 LLHLATYTAGGLPLQFPDDVR 22.76 766.41 1098.59 4288 NYAWGYR 14.18 465.22 581.28 25 89 NYAWGYR 14.18 465.22 652.32 25 90NYAWGYR 14.18 465.22 815.38 25 91 NYPIPAR 12.32 415.73 456.29 23 92NYPIPAR 12.32 415.73 553.35 23 93 NYPIPAR 12.32 415.73 716.41 23 94NYPNEAR 6.92 432.2 489.21 24 95 NYPNEAR 6.92 432.2 586.29 24 96 NYPNEAR6.92 432.2 749.36 24 97 SLC[CAM]C[CAM]ALLLTAPLSTFAAAK 26.05 670.02905.51 38 98 SLC[CAM]C[CAM]ALLLTAPLSTFAAAK 26.05 1004.53 1077.59 49 99SLC[CAM]C[CAM]ALLLTAPLSTFAAAK 26.05 1004.53 1190.68 49 100 SNVTDMAR10.56 447.21 492.22 25 101 SNVTDMAR 10.56 447.21 593.27 25 102 SNVTDMAR10.56 447.21 692.34 25 103 TALLHFYQNWQPQWAPGAK 21.7 752.72 854.45 42 104TALLHFYQNWQPQWAPGAK 21.7 752.72 974.51 42 105 TALLHFYQNWQPQWAPGAK 21.7752.72 1088.55 42 106 TDSIINGSDSK 10.86 568.78 720.35 30 107 TDSIINGSDSK10.86 568.78 833.44 30 108 TDSIINGSDSK 10.86 568.78 920.47 30 109TFIGVLGGDAIAR 20.29 645.36 659.35 33 110 TFIGVLGGDAIAR 20.29 645.36772.43 33 111 TFIGVLGGDAIAR 20.29 645.36 928.52 33 112TFNGVLGGDC[CAM]IAR 16.85 690.34 748.34 35 113 TFNGVLGGDC[CAM]IAR 16.85690.34 861.42 35 114 TFNGVLGGDC[CAM]IAR 16.85 690.34 1131.56 35 115TFNGVLGGEAIAR 17.2 435.57 673.36 26 116 TFNGVLGGEAIAR 17.2 652.85 673.3634 117 TFNGVLGGEAIAR 17.2 652.85 786.45 34 118 TGSTVGFGSYVAFVPEK 20.65873.44 1039.55 43 119 TGSTVGFGSYVAFVPEK 20.65 873.44 1096.57 43 120TGSTVGFGSYVAFVPEK 20.65 873.44 1243.64 43 121 TGYTGGFGSYVAFVPEK 20.58890.43 1039.55 44 122 TGYTGGFGSYVAFVPEK 20.58 890.43 1096.57 44 123TGYTGGFGSYVAFVPEK 20.58 890.43 1243.64 44 124 TLQQGIELAQSR 15.04 448.58461.25 26 125 TLQQGIELAQSR 15.04 672.37 703.37 35 126 TLQQGIELAQSR 15.04672.37 873.48 35 127 TSSADLLAFVK 20.76 576.32 805.48 30 128 TSSADLLAFVK20.76 576.32 876.52 30 129 TSSADLLAFVK 20.76 576.32 963.55 30 130TSSADLLR 12.72 431.73 587.35 24 131 TSSADLLR 12.72 431.73 674.38 24 132TSSADLLR 12.72 431.73 761.42 24 133 TYYFTWGK 18.46 533.26 801.39 28 134TYYFTWGK 18.46 533.26 919.4 28 135 TYYFTWGK 18.46 533.26 964.46 28 136VAALPAVEVNPPAPAVK 18.04 821.98 964.55 41 137 VAALPAVEVNPPAPAVK 18.04821.98 1021.57 41 138 VAALPAVEVNPPAPAVK 18.04 821.98 1120.64 41 139VAFAALPAVEVNPPAPAVK 21.03 621.02 679.41 35 140 VAFAALPAVEVNPPAPAVK 21.03621.02 793.46 35 141 VAFAALPAVEVNPPAPAVK 21.03 931.03 1021.57 46 142VALAAIPAVEVNPPAPAVK 20.17 457.52 679.41 26 143 VALAAIPAVEVNPPAPAVK 20.17609.7 679.41 34 144 VALAAIPAVEVNPPAPAVK 20.17 609.7 793.46 34 145VALAALHTVEVNPPAPAVK 18 475.03 582.36 27 146 VALAALHTVEVNPPAPAVK 18475.03 679.41 27 147 VALAALHTVEVNPPAPAVK 18 633.03 679.41 36 148VALAALPAVEINPPAPAVK 21.5 614.37 679.41 35 149 VALAALPAVEINPPAPAVK 21.5614.37 793.46 35 150 VALAALPAVEINPPAPAVK 21.5 614.37 935.56 35 151VALAALPTVEVNPPAPAVK 20.41 619.7 679.41 35 152 VALAALPTVEVNPPAPAVK 20.41619.7 793.46 35 153 VALAALPTVEVNPPAPAVK 20.41 619.7 1021.57 35 154VAPAVEVNPPAPAVK 15.16 729.92 793.46 37 155 VAPAVEVNPPAPAVK 15.16 729.92892.53 37 156 VAPAVEVNPPAPAVK 15.16 729.92 1021.57 37 157 VEAYWR 13.37412.21 524.26 23 158 VEAYWR 13.37 412.21 595.3 23 159 VEAYWR 13.37412.21 724.34 23 160 VILEANPTAAPR 14.25 417.91 612.35 25 161VILEANPTAAPR 14.25 626.36 797.43 33 162 VILEANPTAAPR 14.25 626.361039.55 33 163 VSLEANPTAAPR 13.15 613.33 726.39 32 164 VSLEANPTAAPR13.15 613.33 797.43 32 165 VSLEANPTAAPR 13.15 613.33 926.47 32 166WIQVNMDASR 16.68 610.3 693.3 32 167 WIQVNMDASR 16.68 610.3 792.37 32 168WIQVNMDASR 16.68 610.3 920.43 32 169 WVQANMDASR 12.82 589.27 764.34 31170 WVQANMDASR 12.82 589.27 892.39 31 171 WVQANMDASR 12.82 589.27 991.4631 172 WVQVNMDASR 15.27 603.29 792.37 32 173 WVQVNMDASR 15.27 603.29920.43 32 174 WVQVNMDASR 15.27 603.29 1019.49 32 175 YWSELTGK 14.9492.25 547.31 27 176 YWSELTGK 14.9 492.25 634.34 27 177 YWSELTGK 14.9492.25 820.42 27

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 18 Identification of a Resistance to CTX-M Beta-Lactams

The samples corresponding to a species able to comprise a CTX-Mresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 24 instead of thepeptides from TABLE 3.

TABLE 24 Retention (m/z) (m/z) Transition time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 AGADVASLR 11.83430.24 446.27 24 2 AGADVASLR 11.83 430.24 485.24 24 3 AGADVASLR 11.83430.24 660.37 24 4 AGLPASWVVGDK 18.32 600.32 790.41 31 5 AGLPASWVVGDK18.32 600.32 861.45 31 6 AGLPASWVVGDK 18.32 600.32 958.5 31 7AGLPTSWTAGDK 15.73 602.3 764.36 32 8 AGLPTSWTAGDK 15.73 602.3 865.41 329 AGLPTSWTAGDK 15.73 602.3 962.46 32 10 AGLPTSWTVGDR 17.31 630.32 820.3933 11 AGLPTSWTVGDR 17.31 630.32 921.44 33 12 AGLPTSWTVGDR 17.31 630.321018.5 33 13 AGLPTSWVVGDK 18.62 615.33 790.41 32 14 AGLPTSWVVGDK 18.62615.33 891.46 32 15 AGLPTSWVVGDK 18.62 615.33 988.51 32 16 AIGDDTFR12.79 447.72 653.29 25 17 AIGDDTFR 12.79 447.72 710.31 25 18 AIGDDTFR12.79 447.72 823.39 25 19 AMAVAAVLK 16.36 437.26 501.34 24 20 AMAVAAVLK16.36 437.26 600.41 24 21 AMAVAAVLK 16.36 437.26 671.45 24 22APLILVTYFTQPEQK 23.95 583.33 730.37 33 23 APLILVTYFTQPEQK 23.95 874.491040.5 43 24 APLILVTYFTQPEQK 23.95 874.49 1141.55 43 25 APLVLVTYFTQPEPK23.37 568.32 699.37 32 26 APLVLVTYFTQPEPK 23.37 568.32 846.44 32 27APLVLVTYFTQPEPK 23.37 851.97 1110.55 42 28 APLVLVTYFTQPQQNAENR 22.93730.38 956.45 41 29 APLVLVTYFTQPQQNAENR 22.93 1095.07 1185.56 53 30APLVLVTYFTQPQQNAENR 22.93 1095.07 1233.69 53 31 APLVLVTYFTQPQQNAER 23.02692.37 745.36 39 32 APLVLVTYFTQPQQNAER 23.02 692.37 842.41 39 33APLVLVTYFTQPQQNAER 23.02 692.37 857.51 39 34 APLVLVTYFTQSEPK 23.53564.98 689.35 32 35 APLVLVTYFTQSEPK 23.53 846.96 1100.53 42 36APLVLVTYFTQSEPK 23.53 846.96 1199.59 42 37 AQLVAWLK 19.52 464.78 517.3125 38 AQLVAWLK 19.52 464.78 616.38 25 39 AQLVAWLK 19.52 464.78 729.47 2540 AQLVMWLK 20.53 494.79 577.32 27 41 AQLVMWLK 20.53 494.79 676.39 27 42AQLVMWLK 20.53 494.79 789.47 27 43 ASDLVNYNPIAEK 16.72 717.37 834.44 3744 ASDLVNYNPIAEK 16.72 717.37 948.48 37 45 ASDLVNYNPIAEK 16.72 717.371047.55 37 46 DFLAAAAK 14.5 403.72 431.26 23 47 DFLAAAAK 14.5 403.72518.26 23 48 DFLAAAAK 14.5 403.72 544.35 23 49 DILASAAK 12.62 394.73447.26 22 50 DILASAAK 12.62 394.73 560.34 22 51 DILASAAK 12.62 394.73571.31 22 52 DNTQVLYR 12.19 504.76 550.33 27 53 DNTQVLYR 12.19 504.76678.39 27 54 DNTQVLYR 12.19 504.76 779.44 27 55 DTTTPLAMAQALR 19.92694.86 760.41 36 56 DTTTPLAMAQALR 19.92 694.86 873.5 36 57 DTTTPLAMAQALR19.92 694.86 970.55 36 58 DTTTPLAMAQSLR 19.22 702.86 776.41 36 59DTTTPLAMAQSLR 19.22 702.86 889.49 36 60 DTTTPLAMAQSLR 19.22 702.86986.55 36 61 DTTTPLAMAQTLR 18.99 709.87 719.39 36 62 DTTTPLAMAQTLR 18.99709.87 790.42 36 63 DTTTPLAMAQTLR 18.99 709.87 1000.56 36 64 DVLAAAAR12.11 393.73 459.27 22 65 DVLAAAAR 12.11 393.73 572.35 22 66 DVLAAAAR12.11 393.73 671.42 22 67 EIGDETFR 12.99 483.73 552.28 26 68 EIGDETFR12.99 483.73 667.3 26 69 EIGDETFR 12.99 483.73 724.33 26 70 EQLVTWLK19.13 508.79 547.32 27 71 EQLVTWLK 19.13 508.79 646.39 27 72 EQLVTWLK19.13 508.79 759.48 27 73 GNTTGSASIQAGLPK 13.81 701.37 813.48 36 74GNTTGSASIQAGLPK 13.81 701.37 1028.57 36 75 GNTTGSASIQAGLPK 13.81 701.371129.62 36 76 HDVLASAAK 9.32 456.25 659.41 25 77 HDVLASAAK 9.32 456.25765.39 25 78 HDVLASAAK 9.32 456.25 774.44 25 79 HDVLASAAR 9.88 470.25588.35 26 80 HDVLASAAR 9.88 470.25 687.41 26 81 HDVLASAAR 9.88 470.25802.44 26 82 HLTLGSALGETQR 15.07 691.87 918.46 35 83 HLTLGSALGETQR 15.07691.87 1031.55 35 84 HLTLGSALGETQR 15.07 691.87 1132.6 35 85 LAELEQQSGGR11.17 594.3 761.35 31 86 LAELEQQSGGR 11.17 594.3 874.44 31 87LAELEQQSGGR 11.17 594.3 1003.48 31 88 LAGLER 11.22 329.7 474.27 20 89LAGLER 11.22 329.7 484.28 20 90 LAGLER 11.22 329.7 545.3 20 91LDGTEPTLNTAIPGDPR 16.6 589.64 1053.57 33 92 LDGTEPTLNTAIPGDPR 16.6883.95 1053.57 44 93 LDGTEPTLNTAIPGDPR 16.6 883.95 1154.62 44 94LGVALIDTADNAQTLYR 20.27 917.49 980.48 45 95 LGVALIDTADNAQTLYR 20.27917.49 1051.52 45 96 LGVALIDTADNAQTLYR 20.27 917.49 1152.56 45 97LGVALIDTADNTHVLYR 19.46 624.34 801.42 35 98 LGVALIDTADNTHVLYR 19.46624.34 902.48 35 99 LGVALIDTADNTHVLYR 19.46 624.34 1189.6 35 100LGVALIDTK 16.93 465.29 589.36 25 101 LGVALIDTK 16.93 465.29 660.39 25102 LGVALIDTK 16.93 465.29 816.48 25 103 LGVALINTADNSR 16.92 672.37777.35 35 104 LGVALINTADNSR 16.92 672.37 890.43 35 105 LGVALINTADNSR16.92 672.37 1003.52 35 106 LGVALINTADNTQTLYR 19.63 621.67 1081.53 35107 LGVALINTADNTQTLYR 19.63 932 1081.53 46 108 LGVALINTADNTQTLYR 19.63932 1182.57 46 109 LGVPLIDTADNTQVLYR 21.54 944.51 1008.51 47 110LGVPLIDTADNTQVLYR 21.54 944.51 1079.55 47 111 LGVPLIDTADNTQVLYR 21.54944.51 1180.6 47 112 LIAHLGGPGK 12.27 321.53 358.21 20 113 LIAHLGGPGK12.27 321.53 415.23 20 114 LIAHLGGPGK 12.27 321.53 528.31 20 115LIAQLGGQGGVTAFAR 18.73 779.94 963.5 39 116 LIAQLGGQGGVTAFAR 18.73 779.941020.52 39 117 LIAQLGGQGGVTAFAR 18.73 779.94 1133.61 39 118LISHVGGPASVTAFAR 16.27 528.29 565.31 30 119 LISHVGGPASVTAFAR 16.27528.29 664.38 30 120 LISHVGGPASVTAFAR 16.27 791.94 1033.54 40 121 LLLNQR12.81 378.74 417.22 22 122 LLLNQR 12.81 378.74 530.3 22 123 LLLNQR 12.81378.74 643.39 22 124 NLTLGNALGDTQR 16.67 686.86 931.46 35 125NLTLGNALGDTQR 16.67 686.86 1044.54 35 126 NLTLGNALGDTQR 16.67 686.861145.59 35 127 NLTLGSALGETQR 17.15 453.91 590.29 27 128 NLTLGSALGETQR17.15 680.36 918.46 35 129 NLTLGSALGETQR 17.15 680.36 1031.55 35 130QLGDDTFR 13.1 476.23 653.29 26 131 QLGDDTFR 13.1 476.23 710.31 26 132QLGDDTFR 13.1 476.23 823.39 26 133 SDLVNYSPIAEK 16.24 668.34 807.42 34134 SDLVNYSPIAEK 16.24 668.34 921.47 34 135 SDLVNYSPIAEK 16.24 668.341020.54 34 136 SESEPSLLNQR 13.8 630.31 730.42 33 137 SESEPSLLNQR 13.8630.31 827.47 33 138 SESEPSLLNQR 13.8 630.31 1043.55 33 139 SLGDESFR12.8 455.72 653.29 25 140 SLGDESFR 12.8 455.72 710.31 25 141 SLGDESFR12.8 455.72 823.39 25 142 SSDLINYNPIAEK 17.68 732.37 834.44 37 143SSDLINYNPIAEK 17.68 732.37 948.48 37 144 SSDLINYNPIAEK 17.68 732.371061.56 37 145 SSDLINYNPITEK 17.72 747.38 864.45 38 146 SSDLINYNPITEK17.72 747.38 978.49 38 147 SSDLINYNPITEK 17.72 747.38 1091.57 38 148SWGVGDK 11.6 374.68 475.25 21 149 SWGVGDK 11.6 374.68 602.26 21 150SWGVGDK 11.6 374.68 661.33 21 151 TELTLNTAIPGDPR 17.63 749.4 826.44 38152 TELTLNTAIPGDPR 17.63 749.4 940.48 38 153 TELTLNTAIPGDPR 17.63 749.4957.53 38 154 TEPTLNSAIPGDPR 15.33 734.38 812.43 37 155 TEPTLNSAIPGDPR15.33 734.38 926.47 37 156 TEPTLNSAIPGDPR 15.33 734.38 1237.65 37 157TEQTLNTAIPGDPR 14.47 756.89 940.48 38 158 TEQTLNTAIPGDPR 14.47 756.89972.5 38 159 TEQTLNTAIPGDPR 14.47 756.89 1154.62 38 160 TESTLNTAIPGDPR14.52 736.37 940.48 37 161 TESTLNTAIPGDPR 14.52 736.37 1053.57 37 162TESTLNTAIPGDPR 14.52 736.37 1154.62 37 163 TETTLNTAIPGDPR 14.88 743.38826.44 38 164 TETTLNTAIPGDPR 14.88 743.38 940.48 38 165 TETTLNTAIPGDPR14.88 743.38 945.49 38 166 TGSC[CAM]DYGTTNDIAVIWPK 20.38 999.47 1055.5949 167 TGSC[CAM]DYGTTNDIAVIWPK 20.38 999.47 1156.64 49 168TGSC[CAM]DYGTTNDIAVIWPK 20.38 999.47 1172.42 49 169TGSC[CAM]GYGTTNDIAVIWPK 20.21 970.46 1055.59 48 170TGSC[CAM]GYGTTNDIAVIWPK 20.21 970.46 1114.41 48 171TGSC[CAM]GYGTTNDIAVIWPK 20.21 970.46 1156.64 48 172 TGSGDYGTTNDIAVIWPEGR20.27 1055 1069.41 51 173 TGSGDYGTTNDIAVIWPEGR 20.27 1055 1155.62 51 174TGSGDYGTTNDIAVIWPEGR 20.27 1055 1182.49 51 175 TGSGGYGTTNDIAVIWPEGR20.16 684.33 757.4 38 176 TGSGGYGTTNDIAVIWPEGR 20.16 684.33 927.5 38 177TGSGGYGTTNDIAVIWPEGR 20.16 684.33 1011.4 38 178 TGSGGYGTTNDIAVIWPQGR19.81 684 756.42 38 179 TGSGGYGTTNDIAVIWPQGR 19.81 684 926.52 38 180TGSGGYGTTNDIAVIWPQGR 19.81 684 1011.4 38 181 TIGDDTFR 12.86 462.72538.26 25 182 TIGDDTFR 12.86 462.72 653.29 25 183 TIGDDTFR 12.86 462.72710.31 25 184 TQLVTWLK 19.07 494.79 646.39 27 185 TQLVTWLK 19.07 494.79759.48 27 186 TQLVTWLK 19.07 494.79 887.53 27 187 VEIKPSDLINYNPIAEK20.21 648.35 769.41 36 188 VEIKPSDLINYNPIAEK 20.21 648.35 882.49 36 189VEIKPSDLINYNPIAEK 20.21 648.35 948.48 36 190 VEIKPSDLVNYNPIAEK 19.33643.68 769.41 36 191 VEIKPSDLVNYNPIAEK 19.33 643.68 882.49 36 192VEIKPSDLVNYNPIAEK 19.33 643.68 948.48 36 193 VIGDDTFR 13.3 461.73 538.2625 194 VIGDDTFR 13.3 461.73 710.31 25 195 VIGDDTFR 13.3 461.73 823.39 25196 VMAAAALLK 17.06 444.27 586.39 25 197 VMAAAALLK 17.06 444.27 657.4325 198 VMAAAALLK 17.06 444.27 788.47 25 199 VMAAAAVLEQSETQK 16.62 788.41962.48 40 200 VMAAAAVLEQSETQK 16.62 788.41 1061.55 40 201VMAAAAVLEQSETQK 16.62 788.41 1132.58 40 202 WAKPSGAVGDVAQR 12.73 481.26628.34 28 203 WAKPSGAVGDVAQR 12.73 481.26 645.33 28 204 WAKPSGAVGDVAQR12.73 481.26 698.36 28

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 19 Identification of a Resistance to DHA Beta-Lactams

The samples corresponding to a species able to comprise a DHA resistancemechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 25 instead of thepeptides from TABLE 3.

TABLE 25 (m/z) (m/z) Transition Retention time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 ADLLHFYQQWQPSR20.9 596.97 673.34 34 2 ADLLHFYQQWQPSR 20.9 596.97 988.49 34 3ADLLHFYQQWQPSR 20.9 596.97 1116.55 34 4 AELLHFYQQWQPSR 19.23 601.64673.34 34 5 AELLHFYQQWQPSR 19.23 601.64 801.4 34 6 AELLHFYQQWQPSR 19.23601.64 1130.56 34 7 EMMLNDPAEK 13.78 589.26 786.4 31 8 EMMLNDPAEK 13.78589.26 917.44 31 9 EMMLNDPAEK 13.78 589.26 1048.48 31 10GKPYYFNYGFADVQAK 18.12 623.31 631.34 35 11 GKPYYFNYGFADVQAK 18.12 623.31778.41 35 12 GKPYYFNYGFADVQAK 18.12 623.31 835.43 35 13TAAINQGLGWEMYDWPQQK 21.57 746.02 964.45 41 14 TAAINQGLGWEMYDWPQQK 21.57746.02 1095.49 41 15 TAAINQGLGWEMYDWPQQK 21.57 1118.53 1224.54 54 16WAEMNIEPSR 15.85 616.79 715.37 32 17 WAEMNIEPSR 15.85 616.79 975.46 3218 WAEMNIEPSR 15.85 616.79 1046.49 32

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 20 Identification of a Resistance to FOX Beta-Lactams

The samples corresponding to a species able to comprise a FOX resistancemechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 26 instead of thepeptides from TABLE 3.

TABLE 26 (m/z) Transition Retention time filtered in (m/z) filteredCollision number Peptide (minutes) Q1 in Q3 energy (eV) 1 ATPGVLAAEAYGIK17.72 680.88 751.4 35 2 ATPGVLAAEAYGIK 17.72 680.88 822.44 35 3ATPGVLAAEAYGIK 17.72 680.88 935.52 35 4 FAEANMGYQGDAAVK 14.08 786.36908.45 40 5 FAEANMGYQGDAAVK 14.08 786.36 1039.49 40 6 FAEANMGYQGDAAVK14.08 786.36 1224.57 40 7 FAEANMGYQGDALVK 16.35 538.59 602.35 31 8FAEANMGYQGDALVK 16.35 538.59 730.41 31 9 FAEANMGYQGDALVK 16.35 807.38950.49 41 10 GEAPLTAAVDGIIQPMLK 25.85 912.5 1014.57 45 11GEAPLTAAVDGIIQPMLK 25.85 912.5 1113.63 45 12 GEAPLTAAVDGIIQPMLK 25.85912.5 1184.67 45 13 HWSPVYPAGTHR 12.55 469.9 541.28 27 14 HWSPVYPAGTHR12.55 469.9 607.3 27 15 HWSPVYPAGTHR 12.55 469.9 638.34 27 16 IPGIAVAVLK19.45 490.83 600.41 27 17 IPGIAVAVLK 19.45 490.83 770.51 27 18IPGIAVAVLK 19.45 490.83 867.57 27 19 LMSQTLLPK 16.18 515.8 699.44 28 20LMSQTLLPK 16.18 515.8 786.47 28 21 LMSQTLLPK 16.18 515.8 917.51 28 22MQTYYR 10.72 431.2 602.29 24 23 MQTYYR 10.72 431.2 687.28 24 24 MQTYYR10.72 431.2 730.35 24 25 VSHHAPWLK 11.49 537.8 614.37 29 26 VSHHAPWLK11.49 537.8 751.42 29 27 VSHHAPWLK 11.49 537.8 888.48 29 28VTPGMLAAEAYGIK 19 710.88 822.44 36 29 VTPGMLAAEAYGIK 19 710.88 1123.5836 30 VTPGMLAAEAYGIK 19 710.88 1220.63 36

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 21 Identification of a Resistance to MIR Beta-Lactams

The samples corresponding to a species able to comprise an MIRresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 27 instead of thepeptides from TABLE 3.

TABLE 27 (m/z) (m/z) Transition Retention time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 AEEAHFAWGYR 16.38446.21 568.77 20.9 2 AEEAHFAWGYR 16.36 446.21 633.29 20.9 3 AEEAHFAWGYR16.36 446.21 652.32 20.9 4 DMASWLIANMKPDSLHAPSLK 24.18 775.73 811.4431.1 5 DMASWLIANMKPDSLHAPSLK 24.18 775.73 867.98 31.1 6DMASWLIANMKPDSLHAPSLK 24.18 775.73 1004.54 31.1 7 DMASWLIANMKPDSLQAPSLK25.04 772.73 528.29 31 8 DMASWLIANMKPDSLQAPSLK 25.04 772.73 806.94 31 9DMASWLIANMKPDSLQAPSLK 25.04 772.73 863.48 31 10 DMASWVIANMKPDSLQAPSLK 24768.06 806.94 30.9 11 DMASWVIANMKPDSLQAPSLK 24 768.06 856.47 30.9 12DMASWVIANMKPDSLQAPSLK 24 768.06 949.51 30.9 13 GEIALGDPVAK 15.79 535.3586.32 26.2 14 GEIALGDPVAK 15.77 535.3 699.4 26.2 15 GEIALGDPVAK 15.77535.3 770.44 26.2 16 TVVGGSDNK 3.35 438.73 520.24 20.7 17 TVVGGSDNK 3.35438.73 577.26 20.7 18 TVVGGSDNK 3.35 438.73 676.33 20.7

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 22 Identification of a Resistance to SHV Beta-Lactams

The samples corresponding to a species able to comprise an SHVresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 28 instead of thepeptides from TABLE 3.

TABLE 28 (m/z) (m/z) Transition Retention time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 EIGDNVTR 10.07452.23 489.28 25 2 EIGDNVTR 10.07 452.23 529.23 25 3 EIGDNVTR 10.07452.23 661.33 25 4 GIVALLGPHNK 16.52 373.56 398.21 23 5 GIVALLGPHNK16.52 373.56 552.29 23 6 GIVALLGPHNK 16.52 373.56 665.37 23 7HLADGMTVGELR 14.93 433.56 474.27 26 8 HLADGMTVGELR 14.93 433.56 494.2426 9 HLADGMTVGELR 14.93 433.56 573.34 26 10 IHYSQQDLVDYSPVSEK 16.22669.99 872.39 37 11 IHYSQQDLVDYSPVSEK 16.22 669.99 924.43 37 12IHYSQQDLVDYSPVSEK 16.22 669.99 985.47 37

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 23 Identification of a Resistance to CARB Beta-Lactams

The samples corresponding to a species able to comprise a CARBresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 29 instead of thepeptides from TABLE 3.

TABLE 29 (m/z) (m/z) Transition Retention time filtered in filtered inCollision number Peptide (minutes) Q1 Q3 energy (eV) 1 ADLVTYSPVIEK17.48 667.86 672.39 34.4 2 ADLVTYSPVIEK 17.48 667.86 835.46 34.4 3ADLVTYSPVIEK 17.48 667.86 936.5 34.4 4 ADLVTYSPVLEK 18.01 667.86 672.3934.4 5 ADLVTYSPVLEK 18.01 667.86 835.46 34.4 6 ADLVTYSPVLEK 18.01 667.86936.5 34.4 7 AIASTLNK 10.86 409.24 475.29 23 8 AIASTLNK 10.86 409.24562.32 23 9 AIASTLNK 10.86 409.24 633.36 23 10 AIASTLNQLLFGSTLSEASQK25.39 727.06 362.2 40.4 11 AIASTLNQLLFGSTLSEASQK 25.39 727.06 649.3240.4 12 AIASTLNQLLFGSTLSEASQK 25.39 727.06 998.02 40.4 13 AIEVSLSAR15.46 473.27 533.3 25.8 14 AIEVSLSAR 15.46 473.27 632.37 25.8 15AIEVSLSAR 15.46 473.27 761.42 25.8 16 DTTTPIAMVTTLEK 21.41 507.6 591.3429.4 17 DTTTPIAMVTTLEK 21.41 507.6 690.4 29.4 18 DTTTPIAMVTTLEK 21.41507.6 892.48 29.4 19 DTTTPK 1.54 331.67 345.21 19.6 20 DTTTPK 1.54331.67 446.26 19.6 21 DTTTPK 1.54 331.67 547.31 19.6 22 FLFGSALSEMNK21.32 672.34 879.42 34.6 23 FLFGSALSEMNK 21.32 672.34 936.45 34.6 24FLFGSALSEMNK 21.32 672.34 1083.51 34.6 25 FPLSSTFK 17.51 463.75 390.2225.4 26 FPLSSTFK 17.51 463.75 682.38 25.4 27 FPLSSTFK 17.51 463.75779.43 25.4 28 FPLTSTFK 17.85 470.76 397.23 25.7 29 FPLTSTFK 17.85470.76 696.39 25.7 30 FPLTSTFK 17.85 470.76 793.45 25.7 31 FQQVEQDAK10.02 546.77 590.28 29.1 32 FQQVEQDAK 10.02 546.77 689.35 29.1 33FQQVEQDAK 10.02 546.77 817.41 29.1 34 FQQVEQDVK 11.76 560.79 618.31 29.735 FQQVEQDVK 11.76 560.79 717.38 29.7 36 FQQVEQDVK 11.76 560.79 845.4429.7 37 FQSVEQEIK 14.17 554.29 745.41 29.4 38 FQSVEQEIK 14.17 554.29832.44 29.4 39 FQSVEQEIK 14.17 554.29 960.5 29.4 40 FSESNLVTYSPVTEK17.84 567.62 462.74 32.4 41 FSESNLVTYSPVTEK 17.84 567.62 777.39 32.4 42FSESNLVTYSPVTEK 17.85 567.62 924.47 32.4 43 GIESSLSAR 12.88 460.25 533.325.3 44 GIESSLSAR 12.88 460.25 620.34 25.3 45 GIESSLSAR 12.88 460.25749.38 25.3 46 GNEVGDALFR 17.15 539.27 678.36 28.7 47 GNEVGDALFR 17.15539.27 777.43 28.7 48 GNEVGDALFR 17.15 539.27 906.47 28.7 49 GVPSDWIVADR18.32 607.81 529.77 31.7 50 GVPSDWIVADR 18.32 607.81 759.42 31.7 51GVPSDWIVADR 18.32 607.81 1058.53 31.7 52 GVTDFLR 17.69 404.22 326.1822.8 53 GVTDFLR 17.69 404.22 550.3 22.8 54 GVTDFLR 17.69 404.22 651.3522.8 55 IEPDLNEGK 12.13 507.76 386.7 27.3 56 IEPDLNEGK 12.13 507.76772.38 27.3 57 IEPDLNEGK 12.13 507.76 901.43 27.3 58 IEPELNEGK 12.2514.77 393.7 27.6 59 IEPELNEGK 12.2 514.77 786.4 27.6 60 IEPELNEGK 12.2514.77 915.44 27.6 61 IGEQIAK 10.58 379.72 459.29 21.7 62 IGEQIAK 10.58379.72 588.34 21.7 63 IGEQIAK 10.58 379.72 645.36 21.7 64 IGLAVHDLETGK16.05 626.85 799.39 32.6 65 IGLAVHDLETGK 16.05 626.85 898.46 32.6 66IGLAVHDLETGK 16.05 626.85 969.5 32.6 67 KPIVAALYITETDASFEER 21.09 718.38667.31 39.9 68 KPIVAALYITETDASFEER 21.09 718.38 787.37 39.9 69KPIVAALYITETDASFEER 21.09 718.38 853.37 39.9 70 LESWMVNNQVTGNLLR 22.01625.32 564.81 32.5 71 LESWMVNNQVTGNLLR 22.01 625.32 673.4 32.5 72LESWMVNNQVTGNLLR 22.01 625.32 772.47 32.5 73 LEYWMVNNQVTGNLLR 22.96650.67 564.81 33.6 74 LEYWMVNNQVTGNLLR 22.96 650.67 673.4 33.6 75LEYWMVNNQVTGNLLR 22.96 650.67 772.47 33.6 76 LLFGSALSEMNQK 21.03 719.37389.21 36.7 77 LLFGSALSEMNQK 21.03 719.37 736.33 36.7 78 LLFGSALSEMNQK21.03 719.37 1211.57 36.7 79 LLIDETLSIK 20.7 572.85 805.43 30.2 80LLIDETLSIK 20.7 572.85 918.51 30.2 81 LLIDETLSIK 20.7 572.85 1031.6 30.282 LLYDAEHGK 11.75 523.27 656.3 28 83 LLYDAEHGK 11.75 523.27 819.36 2884 LLYDAEHGK 11.75 523.27 932.45 28 85 LLYDAEQGEINPK 15.72 745.38 358.2137.8 86 LLYDAEQGEINPK 15.72 745.38 632.3 37.8 87 LLYDAEQGEINPK 15.72745.38 785.42 37.8 88 LLYDAEQGK 13.05 518.77 647.3 27.8 89 LLYDAEQGK13.05 518.77 810.36 27.8 90 LLYDAEQGK 13.05 518.77 923.45 27.8 91MCDNQNYGVTYMK 14.67 541.89 641.33 31.1 92 MCDNQNYGVTYMK 14.67 541.89698.35 31.1 93 MCDNQNYGVTYMK 14.67 541.89 861.42 31.1 94 NAVIAK 7.68308.2 331.23 18.6 95 NAVIAK 7.68 308.2 430.3 18.6 96 NAVIAK 7.68 308.2501.34 18.6 97 NDAIVK 8.38 330.19 359.27 19.5 98 NDAIVK 8.38 330.19430.3 19.5 99 NDAIVK 8.38 330.19 545.33 19.5 100 QQLESWLK 17.65 516.28533.31 27.7 101 QQLESWLK 17.65 516.28 662.35 27.7 102 QQLESWLK 17.65516.28 775.44 27.7 103 QVEQDVK 6.63 423.22 361.21 23.6 104 QVEQDVK 6.63423.22 489.27 23.6 105 QVEQDVK 6.63 423.22 618.31 23.6 106 SGAGGFGAR9.32 390.19 507.27 22.2 107 SGAGGFGAR 9.32 390.19 564.29 22.2 108SGAGGFGAR 9.32 390.19 635.33 22.2 109 SIGDDTTR 7.76 432.71 492.24 24 110SIGDDTTR 7.76 432.71 607.27 24 111 SIGDDTTR 7.76 432.71 664.29 24 112SITAIVWSEEK 18.92 631.84 405.2 32.8 113 SITAIVWSEEK 18.92 631.84 777.3832.8 114 SITAIVWSEEK 18.92 631.84 1062.55 32.8 115 SITDFLR 19.34 426.24435.27 23.8 116 SITDFLR 19.34 426.24 550.3 23.8 117 SITDFLR 19.34 426.24651.35 23.8 118 STIEIK 11.83 345.71 389.24 20.2 119 STIEIK 11.83 345.71502.32 20.2 120 STIEIK 11.83 345.71 603.37 20.2 121 SVLPAGWNIADR 19.61649.85 500.25 33.6 122 SVLPAGWNIADR 19.61 649.85 556.8 33.6 123SVLPAGWNIADR 19.61 649.85 999.5 33.6 124 SVLPEGWNIADR 19.62 678.85529.26 34.9 125 SVLPEGWNIADR 19.62 678.85 585.8 34.9 126 SVLPEGWNIADR19.62 678.85 1057.51 34.9 127 SVLPVK 13.24 321.71 343.23 19.2 128 SVLPVK13.24 321.71 456.32 19.2 129 SVLPVK 13.24 321.71 555.39 19.2 130SVLPVTWSIADR 21.34 672.37 522.78 34.6 131 SVLPVTWSIADR 21.34 672.371044.55 34.6 132 SVLPVTWSIADR 21.34 672.37 1157.63 34.6 133 TGAGGYGSR3.77 413.2 596.28 23.2 134 TGAGGYGSR 3.77 413.2 667.32 23.2 135TGAGGYGSR 3.77 413.2 724.34 23.2 136 TIACAK 3.86 332.18 378.18 19.6 137TIACAK 3.86 332.18 449.22 19.6 138 TIACAK 3.86 332.18 562.3 19.6 139TILMENSR 13.19 482.25 505.24 26.2 140 TILMENSR 13.19 482.25 636.28 26.2141 TILMENSR 13.19 482.25 749.36 26.2 142 TLACANVLQR 14.83 573.31 466.2430.2 143 TLACANVLQR 14.83 573.31 860.44 30.2 144 TLACANVLQR 14.83 573.31931.48 30.2 145 TVLMENSR 11.76 475.24 505.24 25.9 146 TVLMENSR 11.76475.24 636.28 25.9 147 TVLMENSR 11.76 475.24 749.36 25.9 148 VEPELNEGK11.18 507.76 393.7 27.3 149 VEPELNEGK 11.18 507.76 447.22 27.3 150VEPELNEGK 11.18 507.76 560.3 27.3 151 VNLNSTVEIK 15.48 558.82 790.4329.6 152 VNLNSTVEIK 15.48 558.82 903.52 29.6 153 VNLNSTVEIK 15.48 558.821017.56 29.6 154 VNLNSTVEVK 14.23 551.81 776.42 29.3 155 VNLNSTVEVK14.23 551.81 889.5 29.3 156 VNLNSTVEVK 14.23 551.81 1003.54 29.3 157VNPNSTVEIK 12.41 550.8 444.25 29.2 158 VNPNSTVEIK 12.41 550.8 887.4829.2 159 VNPNSTVEIK 12.41 550.8 1001.53 29.2 160 VNSNSTVEIK 11.24 545.79790.43 29 161 VNSNSTVEIK 11.24 545.79 877.46 29 162 VNSNSTVEIK 11.24545.79 991.51 29 163 WETELNEAVPGDK 16.5 744.35 358.19 37.8 164WETELNEAVPGDK 16.5 744.35 415.21 37.8 165 WETELNEAVPGDK 16.5 744.35471.75 37.8 166 WSIADR 14.14 374.19 361.18 21.5 167 WSIADR 14.14 374.19474.27 21.5 168 WSIADR 14.14 374.19 561.3 21.5

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 24 Identification of a Resistance to OXA Beta-Lactams

The samples corresponding to a species able to comprise an OXAresistance mechanism can be detected by employing the following method.

Each sample is treated according to example 5, then analysed accordingto example 6 by detecting the peptides from TABLE 30 instead of thepeptides from TABLE 3.

TABLE 30 Retention (m/z) (m/z) Collision Transition time filtered infiltered in energy number Peptide (minutes) Q1 Q3 (eV) 1AAAYELAENLFEAGQADGWR 24.48 728.01 1249.6 40 2 AAAYELAENLFEAGQADGWR 24.481091.51 1193.58 53 3 AAAYELAENLFEAGQADGWR 24.48 1091.51 1249.6 53 4AAEGFIPASTFK 17.74 619.82 763.43 32 5 AAEGFIPASTFK 17.74 619.82 910.5 326 AAEGFIPASTFK 17.74 619.82 967.52 32 7 ADGQVVAFALNMQMK 21.27 811.91982.48 41 8 ADGQVVAFALNMQMK 21.29 811.91 1053.52 41 9 ADGQVVAFALNMQMK21.27 811.91 1152.59 41 10 ADINEIFK 17.3 475.25 650.35 26 11 ADINEIFK17.3 475.25 763.43 26 12 ADINEIFK 17.3 475.25 878.46 26 13 ADWGK 6.9288.64 390.21 18 14 ADWGK 6.91 288.64 430.17 18 15 ADWGK 6.89 288.64505.24 18 16 AEGAIVISDER 13.52 387.2 419.19 23 17 AEGAIVISDER 13.53387.2 506.22 23 18 AEGAIVISDER 13.52 387.2 619.3 23 19 AFALNLDIDK 20.16560.31 717.38 30 20 AFALNLDIDK 20.16 560.31 830.46 30 21 AFALNLDIDK20.16 560.31 901.5 30 22 AFAPMSTFK 16.96 500.25 710.35 27 23 AFAPMSTFK16.96 500.25 781.39 27 24 AFAPMSTFK 16.96 500.25 928.46 27 25AFGYGNADVSGDPGQNNGLDR 15.12 708.65 873.42 39 26 AFGYGNADVSGDPGQNNGLDR15.12 708.65 970.47 39 27 AFGYGNADVSGDPGQNNGLDR 15.12 708.65 1154.47 3928 AFTMTK 11.32 349.68 480.25 20 29 AFTMTK 11.33 349.68 552.25 20 30AFTMTK 11.33 349.68 627.32 20 31 AGDDIALR 12.23 415.72 587.35 23 32AGDDIALR 12.23 415.72 702.38 23 33 AGDDIALR 12.23 415.72 759.4 23 34AGHVYAFALNIDMPR 20.63 558.95 631.32 32 35 AGHVYAFALNIDMPR 20.63 558.95745.37 32 36 AGHVYAFALNIDMPR 20.63 558.95 817.4 32 37 AGLWR 13.44 301.67361.2 18 38 AGLWR 13.44 301.67 474.28 18 39 AGLWR 13.44 301.67 531.3 1840 AHTEYVPASTFK 13.18 450.89 553.3 27 41 AHTEYVPASTFK 13.18 450.89602.26 27 42 AHTEYVPASTFK 13.18 450.89 650.35 27 43 AIIPWDGKPR 15.84384.89 428.23 23 44 AIIPWDGKPR 15.84 384.89 457.29 23 45 AIIPWDGKPR15.84 384.89 572.32 23 46 AISDITITR 14.8 495.28 603.38 27 47 AISDITITR14.8 495.28 718.41 27 48 AISDITITR 14.8 495.28 805.44 27 49 ALGQDR 11.25330.18 475.23 20 50 ALGQDR 11.25 330.18 485.24 20 51 ALGQDR 11.25 330.18588.31 20 52 ALQAK 1.86 265.67 346.21 17 53 ALQAK 1.87 265.67 384.22 1754 ALQAK 1.87 265.67 459.29 17 55 AMETFSPASTFK 17.06 658.81 737.38 34 56AMETFSPASTFK 17.05 658.81 985.5 34 57 AMETFSPASTFK 17.06 658.81 1114.5434 58 AMLFLQER 18.48 504.27 545.3 27 59 AMLFLQER 18.48 504.27 692.37 2760 AMLFLQER 18.48 504.27 805.46 27 61 AMLVFDPVR 19.87 524.29 732.4 28 62AMLVFDPVR 19.87 524.29 845.49 28 63 AMLVFDPVR 19.87 524.29 976.53 28 64AMTLLESGPGWELHGK 19.32 575.96 923.47 33 65 AMTLLESGPGWELHGK 19.32 575.96980.49 33 66 AMTLLESGPGWELHGK 19.32 575.96 1067.53 33 67 ANLHITLHGK12.18 368.55 403.24 22 68 ANLHITLHGK 12.18 368.55 555.32 22 69ANLHITLHGK 12.18 368.55 668.41 22 70 ANQLIVK 11.87 393.25 600.41 22 71ANQLIVK 11.86 393.25 639.38 22 72 ANQLIVK 11.86 393.25 714.45 22 73ANTEYVPASTFK 14.54 664.33 912.48 34 74 ANTEYVPASTFK 14.54 664.33 1041.5334 75 ANTEYVPASTFK 14.54 664.33 1142.57 34 76 ANVSR 9.57 273.65 361.2217 77 ANVSR 9.57 273.65 372.19 17 78 ANVSR 9.57 273.65 475.26 17 79APIGWFIGWATR 25.58 687.87 850.46 35 80 APIGWFIGWATR 25.58 687.87 1093.5635 81 APIGWFIGWATR 25.58 687.87 1206.64 35 82 APLGWFIGWATHEER 24.69590.63 742.35 34 83 APLGWFIGWATHEER 24.69 590.63 985.45 34 84APLGWFIGWATHEER 24.69 590.63 1098.53 34 85 AQDEVQSMLFIEEK 20.15 833.9996.51 42 86 AQDEVQSMLFIEEK 20.14 833.9 1124.57 42 87 AQDEVQSMLFIEEK20.15 833.9 1223.63 42 88 AQGVIVLWNENK 18.95 685.87 902.47 35 89AQGVIVLWNENK 18.95 685.87 1015.56 35 90 AQGVIVLWNENK 18.95 685.871171.65 35 91 ASAIAVYQDLAR 18.05 639.35 765.39 33 92 ASAIAVYQDLAR 18.05639.35 864.46 33 93 ASAIAVYQDLAR 18.05 639.35 935.49 33 94 ASAILVYQDLAR19.08 660.37 765.39 34 95 ASAILVYQDLAR 19.08 660.37 864.46 34 96ASAILVYQDLAR 19.08 660.37 977.54 34 97 ASAIPVYQDLAR 17.45 652.35 765.3934 98 ASAIPVYQDLAR 17.45 652.35 864.46 34 99 ASAIPVYQDLAR 17.45 652.35961.51 34 100 ASAIPVYQDLPR 17.59 665.36 791.4 34 101 ASAIPVYQDLPR 17.59665.36 890.47 34 102 ASAIPVYQDLPR 17.6 665.36 987.53 34 103 ASAIQVYQDLAR18.37 667.86 765.39 34 104 ASAIQVYQDLAR 18.37 667.86 864.46 34 105ASAIQVYQDLAR 18.37 667.86 992.52 34 106 ASAISVYQDLAR 17.93 647.34 765.3933 107 ASAISVYQDLAR 17.93 647.34 864.46 33 108 ASAISVYQDLAR 17.93 647.34951.49 33 109 ASALPVYQDLAR 17.77 652.35 864.46 34 110 ASALPVYQDLAR 17.77652.35 961.51 34 111 ASALPVYQDLAR 17.77 652.35 1074.59 34 112ASAMPVYQDLAR 16.64 661.33 765.39 34 113 ASAMPVYQDLAR 16.64 661.33 864.4634 114 ASAMPVYQDLAR 16.64 661.33 961.51 34 115 ASAVPVYQDLAR 16.29 645.35765.39 33 116 ASAVPVYQDLAR 16.29 645.35 864.46 33 117 ASAVPVYQDLAR 16.29645.35 961.51 33 118 ASIEYVPASTFK 16.7 656.84 749.42 34 119 ASIEYVPASTFK16.7 656.84 912.48 34 120 ASIEYVPASTFK 16.7 656.84 1041.53 34 121ASNVPVYQELAR 18.48 673.86 779.4 35 122 ASNVPVYQELAR 18.48 673.86 878.4735 123 ASNVPVYQELAR 18.48 673.86 975.53 35 124 ASPASTFK 10.29 404.71553.3 23 125 ASPASTFK 10.29 404.71 650.35 23 126 ASPASTFK 10.28 404.71737.38 23 127 ASTAYIPASTFK 15.69 628.83 763.43 33 128 ASTAYIPASTFK 15.69628.83 926.5 33 129 ASTAYIPASTFK 15.69 628.83 997.54 33 130 ASTEYVPASTFK14.59 650.82 749.42 34 131 ASTEYVPASTFK 14.59 650.82 912.48 34 132ASTEYVPASTFK 14.6 650.82 1041.53 34 133 ASTTEVFK 11.78 441.73 623.34 24134 ASTTEVFK 11.78 441.73 724.39 24 135 ASTTEVFK 11.78 441.73 811.42 24136 ATSTEIFK 13.15 448.74 637.36 25 137 ATSTEIFK 13.15 448.74 724.39 25138 ATSTEIFK 13.15 448.74 825.44 25 139 ATTNEIFK 13.21 462.25 650.35 25140 ATTNEIFK 13.21 462.25 751.4 25 141 ATTNEIFK 13.21 462.25 852.45 25142 ATTTAVFK 11.9 419.74 464.29 23 143 ATTTAVFK 11.9 419.74 565.33 23144 ATTTAVFK 11.9 419.74 666.38 23 145 ATTTEIFK 13.64 455.75 637.36 25146 ATTTEIFK 13.65 455.75 738.4 25 147 ATTTEIFK 13.65 455.75 839.45 25148 ATTTEVFK 11.98 448.74 623.34 25 149 ATTTEVFK 11.98 448.74 724.39 25150 ATTTEVFK 11.98 448.74 825.44 25 151 AVSDITILEQTDNYTLHGK 19.19 706.7974.49 39 152 AVSDITILEQTDNYTLHGK 19.19 706.7 1048.51 39 153AVSDITILEQTDNYTLHGK 19.18 706.7 1176.56 39 154 AVSDITILEQTYNYTLHGK 22.29722.71 995.49 40 155 AVSDITILEQTYNYTLHGK 22.29 722.71 998.5 40 156AVSDITILEQTYNYTLHGK 22.28 722.71 1224.6 40 157 AVVPHFEAGDWDVQGK 17.81585.62 743.34 33 158 AVVPHFEAGDWDVQGK 17.81 585.62 792.88 33 159AVVPHFEAGDWDVQGK 17.81 585.62 904.42 33 160 AWEHDMSLR 13.99 572.76758.36 30 161 AWEHDMSLR 13.99 572.76 887.4 30 162 AWEHDMSLR 13.99 572.761073.48 30 163 AWIGSSLQISPLEQLEFLGK 26.98 739.4 963.51 41 164AWIGSSLQISPLEQLEFLGK 26.99 739.4 1173.65 41 165 AWIGSSLQISPLEQLEFLGK26.98 1108.6 1173.65 54 166 DAFLK 12.42 297.17 407.27 18 167 DAFLK 12.43297.17 447.22 18 168 DAFLK 12.42 297.17 478.3 18 169 DDFILHGK 13.99472.75 714.43 26 170 DDFILHGK 13.99 472.75 798.38 26 171 DDFILHGK 13.99472.75 829.46 26 172 DDVLK 8.62 295.16 359.27 18 173 DDVLK 8.63 295.16443.21 18 174 DDVLK 8.62 295.16 474.29 18 175 DEFHVFR 15.39 475.23705.38 26 176 DEFHVFR 15.39 475.23 775.34 26 177 DEFHVFR 15.39 475.23834.43 26 178 DEFQIFR 19.02 477.74 520.2 26 179 DEFQIFR 19.02 477.74563.33 26 180 DEFQIFR 19.02 477.74 710.4 26 181 DEFQVFR 17.29 470.73549.31 26 182 DEFQVFR 17.28 470.73 619.27 26 183 DEFQVFR 17.29 470.73696.38 26 184 DELVR 9.33 316.17 387.27 19 185 DELVR 9.35 316.17 457.2319 186 DELVR 9.33 316.17 516.31 19 187 DFDYGNQDFSGDK 14.72 754.3 967.4138 188 DFDYGNQDFSGDK 14.72 754.3 1130.47 38 189 DFDYGNQDFSGDK 14.72754.3 1245.5 38 190 DFTLGEAMQASTVPVYQELAR 24.19 776.05 975.53 43 191DFTLGEAMQASTVPVYQELAR 24.19 776.05 1074.59 43 192 DFTLGEAMQASTVPVYQELAR24.19 1163.57 1175.64 56 193 DHDLITAMK 14.23 522.26 563.32 28 194DHDLITAMK 14.23 522.26 695.34 28 195 DHDLITAMK 14.23 522.26 791.43 28196 DIAAWNR 13.63 423.22 546.28 24 197 DIAAWNR 13.63 423.22 617.32 24198 DIAAWNR 13.62 423.22 730.4 24 199 DILYIQELAGGWK 24.49 753.4 888.4638 200 DILYIQELAGGWK 24.48 753.4 1001.54 38 201 DILYIQELAGGWK 24.49753.4 1164.6 38 202 DITILEK 15.9 416.24 603.37 23 203 DITILEK 15.91416.24 685.38 23 204 DITILEK 15.91 416.24 716.46 23 205 DLLSAK 12.45323.69 429.23 19 206 DLLSAK 12.44 323.69 500.27 19 207 DLLSAK 12.45323.69 531.35 19 208 DLMITEAGR 15.07 503.26 533.27 27 209 DLMITEAGR15.07 503.26 646.35 27 210 DLMITEAGR 15.07 503.26 777.39 27 211DLMIVEAGR 16.68 502.27 531.29 27 212 DLMIVEAGR 16.68 502.27 644.37 27213 DLMIVEAGR 16.68 502.27 775.41 27 214 DLMIVEAK 16.23 459.75 473.24 25215 DLMIVEAK 16.23 459.75 559.34 25 216 DLMIVEAK 16.23 459.75 690.39 25217 DLSGNPGK 6.69 394.2 472.25 22 218 DLSGNPGK 6.69 394.2 559.28 22 219DLSGNPGK 6.7 394.2 672.37 22 220 DLSLR 12.37 302.18 375.24 18 221 DLSLR12.35 302.18 429.23 18 222 DLSLR 12.36 302.18 488.32 18 223 DLTLR 12.48309.18 389.25 19 224 DLTLR 12.47 309.18 443.25 19 225 DLTLR 12.47 309.18502.33 19 226 DMTLGDAIK 15.97 482.24 503.28 26 227 DMTLGDAIK 15.97482.24 616.37 26 228 DMTLGDAIK 15.97 482.24 717.41 26 229DMTLGDAMALSAVPVYQELAR 25.76 751.04 975.53 42 230 DMTLGDAMALSAVPVYQELAR25.76 1126.06 1145.63 55 231 DMTLGDAMALSAVPVYQELAR 25.75 1126.06 1232.6655 232 DMTLGDAMK 14.46 491.22 634.32 27 233 DMTLGDAMK 14.46 491.22735.37 27 234 DMTLGDAMK 14.46 491.22 866.41 27 235 DMTLGEAMALSAVPVYQDLAR25.92 751.04 961.51 42 236 DMTLGEAMALSAVPVYQDLAR 25.92 1126.06 1131.6255 237 DMTLGEAMALSAVPVYQDLAR 25.92 1126.06 1218.65 55 238DMTLGEAMALSAVPVYQELAR 26.48 755.71 779.4 42 239 DMTLGEAMALSAVPVYQELAR26.48 755.71 975.53 42 240 DMTLGEAMALSAVPVYQELAR 26.47 1133.07 1232.6655 241 DMTLGEAMK 15.09 498.23 535.25 27 242 DMTLGEAMK 15.09 498.23648.34 27 243 DMTLGEAMK 15.09 498.23 749.39 27 244 DMTLGQAMQASAVPVYQELAR23.29 760.38 779.4 42 245 DMTLGQAMQASAVPVYQELAR 23.29 760.38 975.53 42246 DMTLGQAMQASAVPVYQELAR 23.29 760.38 976.42 42 247 DQDLR 2.54 323.66403.23 19 248 DQDLR 2.55 323.66 472.2 19 249 DQDLR 2.55 323.66 531.29 19250 DQQIGWFVGWASKPGK 21.64 601.98 830.45 34 251 DQQIGWFVGWASKPGK 21.64902.46 929.52 45 252 DQQIGWFVGWASKPGK 21.64 902.46 1076.59 45 253DQQVQVYGNDLNR 13.59 774.87 851.4 39 254 DQQVQVYGNDLNR 13.58 774.87950.47 39 255 DQQVQVYGNDLNR 13.59 774.87 1078.53 39 256 DQTLESAFK 15.21519.76 581.29 28 257 DQTLESAFK 15.21 519.76 694.38 28 258 DQTLESAFK15.21 519.76 795.42 28 259 DSIVWYSQELTR 19.61 748.87 896.45 38 260DSIVWYSQELTR 19.61 748.87 1082.53 38 261 DSIVWYSQELTR 19.61 748.871181.59 38 262 DSIVWYSQQLTR 19.1 748.38 895.46 38 263 DSIVWYSQQLTR 19.11748.38 1081.54 38 264 DSIVWYSQQLTR 19.1 748.38 1180.61 38 265 DSNLR 1.77302.66 402.25 18 266 DSNLR 1.77 302.66 430.19 18 267 DSNLR 1.77 302.66489.28 18 268 DSYIAWGGEAWK 19.67 691.82 833.39 35 269 DSYIAWGGEAWK 19.67691.82 904.43 35 270 DSYIAWGGEAWK 19.66 691.82 1017.52 35 271 DTLNPEWPYK17.3 631.81 819.4 33 272 DTLNPEWPYK 17.3 631.81 933.45 33 273 DTLNPEWPYK17.3 631.81 1046.53 33 274 DVDEVFYK 15.62 507.74 685.36 27 275 DVDEVFYK15.62 507.74 800.38 27 276 DVDEVFYK 15.62 507.74 899.45 27 277 DWILR17.44 351.7 415.2 20 278 DWILR 17.44 351.7 528.28 20 279 DWILR 17.44351.7 587.37 20 280 EAFLR 12.51 318.18 435.27 19 281 EAFLR 12.51 318.18461.24 19 282 EAFLR 12.51 318.18 506.31 19 283 EAIVR 7.84 294.18 387.2718 284 EAIVR 7.84 294.18 413.24 18 285 EAIVR 7.84 294.18 458.31 18 286EAIVTEATPEYIVHSK 16.43 596.31 746.42 34 287 EAIVTEATPEYIVHSK 16.43596.31 972.51 34 288 EAIVTEATPEYIVHSK 16.42 596.31 1073.56 34 289EALVTEAAPEYLVHSK 17.3 586.31 875.46 33 290 EALVTEAAPEYLVHSK 17.3 586.31972.51 33 291 EALVTEAAPEYLVHSK 17.3 586.31 1114.59 33 292EALVTEAPEYLVHSK 17.58 562.63 637.32 32 293 EALVTEAPEYLVHSK 17.58 562.63972.51 32 294 EALVTEAPEYLVHSK 17.58 562.63 1043.55 32 295 EEIVR 8.41323.18 387.27 19 296 EEIVR 8.4 323.18 471.24 19 297 EEIVR 8.4 323.18516.31 19 298 EEVLAALPAQLK 19.48 641.37 740.47 33 299 EEVLAALPAQLK 19.47641.37 811.5 33 300 EEVLAALPAQLK 19.47 641.37 924.59 33 301EFSAEAVNGVFVLC[CAM]K 21.1 835.42 936.5 42 302 EFSAEAVNGVFVLC[CAM]K 21.1835.42 1106.6 42 303 EFSAEAVNGVFVLC[CAM]K 21.1 835.42 1235.65 42 304EFSSESVHGVFVLC[CAM]K 18.26 575.62 666.36 33 305 EFSSESVHGVFVLC[CAM]K18.26 575.62 822.45 33 306 EFSSESVHGVFVLC[CAM]K 18.26 575.62 959.51 33307 EGMSGSIR 9.88 418.7 432.26 23 308 EGMSGSIR 9.88 418.7 519.29 23 309EGMSGSIR 9.88 418.7 707.35 23 310 EGMTGSIR 10.63 425.71 432.26 24 311EGMTGSIR 10.63 425.71 533.3 24 312 EGMTGSIR 10.63 425.71 664.34 24 313EIAVWNR 14.78 444.24 475.24 25 314 EIAVWNR 14.77 444.24 574.31 25 315EIAVWNR 14.77 444.24 645.35 25 316 EIAYK 8.46 312.17 381.21 19 317 EIAYK8.46 312.17 477.23 19 318 EIAYK 8.46 312.17 494.3 19 319 EIFER 11.7347.18 451.23 20 320 EIFER 11.7 347.18 519.24 20 321 EIFER 11.7 347.18564.31 20 322 EIFYHYR 13.31 514.25 785.37 28 323 EIFYHYR 13.31 514.25853.39 28 324 EIFYHYR 13.32 514.25 898.46 28 325 EIGDDK 1.99 338.66434.19 20 326 EIGDDK 1.99 338.66 530.21 20 327 EIGDDK 1.99 338.66 547.2720 328 EIGDGK 1.76 309.66 376.18 19 329 EIGDGK 1.75 309.66 472.2 19 330EIGDGK 1.75 309.66 489.27 19 331 EIGEDK 2.32 345.67 448.2 20 332 EIGEDK2.33 345.67 544.22 20 333 EIGEDK 2.33 345.67 561.29 20 334 EIGEDNAR10.05 452.21 604.27 25 335 EIGEDNAR 10.05 452.21 661.29 25 336 EIGEDNAR10.06 452.21 774.37 25 337 EIGENK 1.86 345.18 447.22 20 338 EIGENK 1.86345.18 543.24 20 339 EIGENK 1.86 345.18 560.3 20 340 EIGSEIDK 11.04445.73 591.3 25 341 EIGSEIDK 11.04 445.73 648.32 25 342 EIGSEIDK 11.04445.73 761.4 25 343 EMIYLK 15.11 398.72 536.34 23 344 EMIYLK 15.11398.72 650.32 23 345 EMIYLK 15.11 398.72 667.38 23 346 EMLYVER 14.12470.23 566.29 26 347 EMLYVER 14.12 470.23 679.38 26 348 EMLYVER 14.12470.23 810.42 26 349 ENIEK 11.07 316.67 389.24 19 350 ENIEK 11.07 316.67486.22 19 351 ENIEK 11.07 316.67 503.28 19 352 ENQLIVK 12.15 422.25472.35 24 353 ENQLIVK 12.15 422.25 600.41 24 354 ENQLIVK 12.15 422.25714.45 24 355 EQAILLFR 19.88 495.29 548.36 27 356 EQAILLFR 19.88 495.29661.44 27 357 EQAILLFR 19.88 495.29 732.48 27 358 EQIQFLLR 19.45 523.8548.36 28 359 EQIQFLLR 19.45 523.8 676.41 28 360 EQIQFLLR 19.45 523.8789.5 28 361 EQLAFDPQVQQQVK 16.43 829.43 954.54 41 362 EQLAFDPQVQQQVK16.42 829.43 1069.56 41 363 EQLAFDPQVQQQVK 16.42 829.43 1216.63 41 364EQVDFVQR 13.09 510.76 549.31 27 365 EQVDFVQR 13.09 510.76 664.34 27 366EQVDFVQR 13.09 510.76 763.41 27 367 EVGEIR 9.35 351.69 474.27 20 368EVGEIR 9.35 351.69 528.27 20 369 EVGEIR 9.35 351.69 573.34 20 370 EVGEVR6.91 344.68 460.25 20 371 EVGEVR 6.91 344.68 514.25 20 372 EVGEVR 6.91344.68 559.32 20 373 EYLPASTFK 15.41 528.27 553.3 28 374 EYLPASTFK 15.41528.27 650.35 28 375 EYLPASTFK 15.41 528.27 763.43 28 376 EYLPVSTFK17.16 542.29 581.33 29 377 EYLPVSTFK 17.16 542.29 678.38 29 378EYLPVSTFK 17.16 542.29 791.47 29 379 EYNTSGTFVFYDGK 18.2 814.37 1033.541 380 EYNTSGTFVFYDGK 18.2 814.37 1120.53 41 381 EYNTSGTFVFYDGK 18.2814.37 1221.58 41 382 EYVPASTFK 13.89 521.27 553.3 28 383 EYVPASTFK13.89 521.27 650.35 28 384 EYVPASTFK 13.89 521.27 749.42 28 385 FAPESTFK13.67 463.73 482.26 25 386 FAPESTFK 13.67 463.73 611.3 25 387 FAPESTFK13.67 463.73 708.36 25 388 FAQYAK 9.39 364.19 509.27 21 389 FAQYAK 9.39364.19 580.31 21 390 FAQYAK 9.39 364.19 581.27 21 391 FDYGNR 10.1 386.17509.25 22 392 FDYGNR 10.1 386.17 597.23 22 393 FDYGNR 10.09 386.17624.27 22 394 FEDLYK 13.52 407.7 423.26 23 395 FEDLYK 13.52 407.7 538.2923 396 FEDLYK 13.52 407.7 667.33 23 397 FEDTFHISNQK 14.33 455.89 476.2527 398 FEDTFHISNQK 14.33 455.89 589.33 27 399 FEDTFHISNQK 14.33 455.89726.39 27 400 FEDTFHTSNQQHEK 10.66 583.26 870.41 33 401 FEDTFHTSNQQHEK10.66 583.26 971.45 33 402 FEDTFHTSNQQHEK 10.66 583.26 1108.51 33 403FEYGNQDVSGDSGK 11.95 751.82 764.34 38 404 FEYGNQDVSGDSGK 11.95 751.821063.47 38 405 FEYGNQDVSGDSGK 11.95 751.82 1226.53 38 406 FFSDFQAK 16495.24 608.3 27 407 FFSDFQAK 16 495.24 695.34 27 408 FFSDFQAK 16 495.24842.4 27 409 FFSDLQAEGAIVIADER 20.44 627.65 1143.6 35 410FFSDLQAEGAIVIADER 20.43 940.97 1143.6 46 411 FFSDLQAEGAIVIADER 20.44940.97 1179.57 46 412 FFSDLR 15.38 392.7 490.26 22 413 FFSDLR 15.38392.7 610.29 22 414 FFSDLR 15.38 392.7 637.33 22 415 FFSEFQAK 16.13502.25 622.32 27 416 FFSEFQAK 16.13 502.25 709.35 27 417 FFSEFQAK 16.13502.25 856.42 27 418 FGLEGQLR 15.8 460.25 473.28 25 419 FGLEGQLR 15.8460.25 602.33 25 420 FGLEGQLR 15.8 460.25 772.43 25 421 FLESLYLNNLPASK20.75 804.94 856.49 40 422 FLESLYLNNLPASK 20.75 804.94 1019.55 40 423FLESLYLNNLPASK 20.75 804.94 1219.67 40 424 FLLEGQLR 18.06 488.28 602.3326 425 FLLEGQLR 18.06 488.28 715.41 26 426 FLLEGQLR 18.06 488.28 828.4926 427 FQQYVDR 11.19 478.24 552.28 26 428 FQQYVDR 11.19 478.24 680.34 26429 FQQYVDR 11.19 478.24 808.39 26 430 FSDYVQR 11.83 457.72 565.31 25431 FSDYVQR 11.83 457.72 680.34 25 432 FSDYVQR 11.83 457.72 767.37 25433 FSTASTFK 12.71 444.73 553.3 25 434 FSTASTFK 12.7 444.73 654.35 25435 FSTASTFK 12.7 444.73 741.38 25 436 FSWDGK 14.32 370.17 505.24 21 437FSWDGK 14.32 370.17 592.27 21 438 FSWDGK 14.32 370.17 593.24 21 439FSYGNQNISGGIDK 14.61 750.36 803.43 38 440 FSYGNQNISGGIDK 14.61 750.361045.53 38 441 FSYGNQNISGGIDK 14.61 750.36 1102.55 38 442 FSYGNQNISGGTDK12.74 744.34 791.39 38 443 FSYGNQNISGGTDK 12.74 744.34 1033.49 38 444FSYGNQNISGGTDK 12.74 744.34 1090.51 38 445 FSYGSQNISGGIDK 14.74 736.85803.43 37 446 FSYGSQNISGGIDK 14.74 736.85 1075.54 37 447 FSYGSQNISGGIDK14.75 736.85 1238.6 37 448 FTEYVK 11.81 393.71 538.29 22 449 FTEYVK11.81 393.71 639.33 22 450 FTEYVK 11.81 393.71 640.3 22 451 FVPASTYK11.76 456.74 498.26 25 452 FVPASTYK 11.76 456.74 569.29 25 453 FVPASTYK11.77 456.74 666.35 25 454 FVYDLAQGQLPFKPEVQQQVK 20.48 821.44 955.52 45455 FVYDLAQGQLPFKPEVQQQVK 20.48 821.44 1108.59 45 456FVYDLAQGQLPFKPEVQQQVK 20.49 821.44 1109.07 45 457 FWLEDQLR 20.39 553.79660.33 29 458 FWLEDQLR 20.39 553.79 773.42 29 459 FWLEDQLR 20.38 553.79959.49 29 460 FWLEGPLK 20.63 495.28 543.31 27 461 FWLEGPLK 20.63 495.28656.4 27 462 FWLEGPLK 20.63 495.28 842.48 27 463 FWLEGQLR 19.49 524.78602.33 28 464 FWLEGQLR 19.49 524.78 715.41 28 465 FWLEGQLR 19.48 524.78901.49 28 466 FYPASSFK 14.74 473.74 636.34 26 467 FYPASSFK 14.74 473.74799.4 26 468 FYPASSFK 14.74 473.74 800.36 26 469 FYPASTFK 14.98 480.74553.3 26 470 FYPASTFK 14.99 480.74 650.35 26 471 FYPASTFK 14.98 480.74813.41 26 472 GAIQVSAVPVFQQIAR 21.6 842.48 958.55 42 473GAIQVSAVPVFQQIAR 21.6 842.48 1057.62 42 474 GAIQVSAVPVFQQIAR 21.59842.48 1128.65 42 475 GAIQVSAVPVFQQITR 21.52 857.49 988.56 43 476GAIQVSAVPVFQQITR 21.51 857.49 1087.63 43 477 GAIQVSAVPVFQQITR 21.52857.49 1158.66 43 478 GELPVSEDALEMTK 18.1 759.87 936.43 38 479GELPVSEDALEMTK 18.11 759.87 1023.47 38 480 GELPVSEDALEMTK 18.11 759.871122.53 38 481 GISSSVR 8.65 353.2 448.25 21 482 GISSSVR 8.65 353.2535.28 21 483 GISSSVR 8.67 353.2 648.37 21 484 GNQTLVFAR 14.83 503.28605.38 27 485 GNQTLVFAR 14.83 503.28 706.42 27 486 GNQTLVFAR 14.83503.28 834.48 27 487 GPLEISAFEEAR 18.95 659.84 809.38 34 488GPLEISAFEEAR 18.94 659.84 922.46 34 489 GPLEISAFEEAR 18.94 659.841051.51 34 490 GPLTITPIQEVK 18.14 648.38 814.47 34 491 GPLTITPIQEVK18.15 648.38 927.55 34 492 GPLTITPIQEVK 18.14 648.38 1028.6 34 493GSLLLWDQK 19.61 530.3 576.28 28 494 GSLLLWDQK 19.61 530.3 689.36 28 495GSLLLWDQK 19.61 530.3 802.45 28 496 GTFVLYDVQR 17.93 599.32 680.34 31497 GTFVLYDVQR 17.93 599.32 793.42 31 498 GTFVLYDVQR 17.93 599.32 892.4931 499 GTIVVADER 11.82 480.26 490.23 26 500 GTIVVADER 11.82 480.26589.29 26 501 GTIVVADER 11.82 480.26 688.36 26 502 GTIVVLDAR 15.77472.28 573.34 26 503 GTIVVLDAR 15.77 472.28 672.4 26 504 GTIVVLDAR 15.77472.28 785.49 26 505 GTIVVVDER 13.6 494.28 518.26 27 506 GTIVVVDER 13.6494.28 617.33 27 507 GTIVVVDER 13.6 494.28 716.39 27 508 GTLPFSAR 14.96424.73 577.31 24 509 GTLPFSAR 14.96 424.73 690.39 24 510 GTLPFSAR 14.97424.73 791.44 24 511 HIADSK 11.91 335.68 420.21 20 512 HIADSK 11.9335.68 524.25 20 513 HIADSK 11.91 335.68 533.29 20 514 HNGTDGAWIISSLR19.36 509.6 575.35 29 515 HNGTDGAWIISSLR 19.35 509.6 653.26 29 516HNGTDGAWIISSLR 19.36 509.6 688.44 29 517 HTLSVFDQER 14.25 411.21 432.2225 518 HTLSVFDQER 14.25 411.21 547.25 25 519 HTLSVFDQER 14.25 411.21694.32 25 520 HVTFASFR 14.36 322.17 338.18 20 521 HVTFASFR 14.36 322.17409.22 20 522 HVTFASFR 14.36 322.17 485.25 20 523 IAISLMGYDAGFLR 23.93763.91 898.44 39 524 IAISLMGYDAGFLR 23.93 763.91 1029.48 39 525IAISLMGYDAGFLR 23.94 763.91 1229.6 39 526 IALSLMGFDSGILK 24.91 732.91836.45 37 527 IALSLMGFDSGILK 24.91 732.91 967.49 37 528 IALSLMGFDSGILK24.91 732.91 1167.61 37 529 IANALIGLENHK 15.95 431.58 697.36 26 530IANALIGLENHK 15.95 646.87 697.36 33 531 IANALIGLENHK 15.95 646.87 810.4533 532 IDTFWLDNSLK 21.79 676.35 689.38 35 533 IDTFWLDNSLK 21.79 676.35875.46 35 534 IDTFWLDNSLK 21.79 676.35 1123.58 35 535 IDYYNLDR 14.85536.26 680.34 29 536 IDYYNLDR 14.85 536.26 843.4 29 537 IDYYNLDR 14.85536.26 958.43 29 538 IFNALIALDSGVIK 24.74 737.44 802.47 37 539IFNALIALDSGVIK 24.74 737.44 915.55 37 540 IFNALIALDSGVIK 24.74 737.441028.64 37 541 IFNSLLALDSGALDNER 22.76 924.48 976.43 46 542IFNSLLALDSGALDNER 22.77 924.48 1089.52 46 543 IFNSLLALDSGALDNER 22.76924.48 1160.55 46 544 IFNTLIGLENGIVK 23.29 765.95 829.48 39 545IFNTLIGLENGIVK 23.3 765.95 942.56 39 546 IFNTLIGLENGIVK 23.3 765.951055.65 39 547 IGLDLMQK 17.7 459.26 634.32 25 548 IGLDLMQK 17.7 459.26747.41 25 549 IGLDLMQK 17.7 459.26 804.43 25 550 IGLEK 8.54 280.18389.24 17 551 IGLEK 8.55 280.18 413.24 17 552 IGLEK 8.54 280.18 446.2617 553 IGLELMQQEVQR 18.73 722.38 787.41 37 554 IGLELMQQEVQR 18.73 722.38918.45 37 555 IGLELMQQEVQR 18.73 722.38 1031.53 37 556 IGLELMSK 17.52445.75 478.27 25 557 IGLELMSK 17.52 445.75 720.4 25 558 IGLELMSK 17.52445.75 777.42 25 559 IGLELMSNEVK 18.73 616.83 707.34 32 560 IGLELMSNEVK18.73 616.83 820.42 32 561 IGLELMSNEVK 18.73 616.83 949.47 32 562 IGLER10.96 294.18 304.16 18 563 IGLER 10.96 294.18 417.25 18 564 IGLER 10.96294.18 474.27 18 565 IGLNK 9.59 272.68 374.24 17 566 IGLNK 9.59 272.68398.24 17 567 IGLNK 9.59 272.68 431.26 17 568 IGLNLMQK 17.1 458.77633.34 25 569 IGLNLMQK 17.09 458.77 746.42 25 570 IGLNLMQK 17.11 458.77803.44 25 571 IGPSLMQSELQR 17.02 679.86 760.39 35 572 IGPSLMQSELQR 17.02679.86 891.44 35 573 IGPSLMQSELQR 17.02 679.86 1188.6 35 574IGYGNMQIGTEVDQFWLK 24.31 700.35 935.5 39 575 IGYGNMQIGTEVDQFWLK 24.321050.02 1164.54 51 576 IGYGNMQIGTEVDQFWLK 24.3 1050.02 1222.61 51 577IINHNLPVK 11.88 349.88 456.32 21 578 IINHNLPVK 11.88 349.88 570.36 21579 IINHNLPVK 11.88 349.88 592.32 21 580 IINHNLPVR 12.04 359.22 598.3722 581 IINHNLPVR 12.04 538.32 598.37 29 582 IINHNLPVR 12.04 538.32849.47 29 583 ILFQQGTQQAC[CAM]AER 14.51 550.61 606.27 32 584ILFQQGTQQAC[CAM]AER 14.51 825.41 1020.45 41 585 ILFQQGTQQAC[CAM]AER14.51 825.41 1148.51 41 586 ILNNWFK 18.98 467.76 594.3 26 587 ILNNWFK18.98 467.76 708.35 26 588 ILNNWFK 18.97 467.76 821.43 26 589ILNTLISLEEK 19.98 636.87 718.4 33 590 ILNTLISLEEK 19.98 636.87 1046.5733 591 ILNTLISLEEK 19.98 636.87 1159.66 33 592 INIVK 11.43 293.7 359.2718 593 INIVK 11.43 293.7 440.29 18 594 INIVK 11.43 293.7 473.31 18 595INLYGNALSR 16.05 560.81 617.34 30 596 INLYGNALSR 16.05 560.81 780.4 30597 INLYGNALSR 16.05 560.81 893.48 30 598 IPFSLNLEMK 21.68 596.33 834.4431 599 IPFSLNLEMK 21.67 596.33 981.51 31 600 IPFSLNLEMK 21.67 596.331078.56 31 601 IPHTLFALDADAVR 20 513.62 531.29 30 602 IPHTLFALDADAVR 20513.62 646.32 30 603 IPHTLFALDADAVR 20 769.92 1191.64 39 604IPHTLFALDAGAAR 18.58 726.9 744.4 37 605 IPHTLFALDAGAAR 18.58 726.9891.47 37 606 IPHTLFALDAGAAR 18.58 726.9 1004.55 37 607 IPHTLFALDAGAVR19.72 494.28 588.31 29 608 IPHTLFALDAGAVR 19.71 494.28 780.44 29 609IPHTLFALDAGAVR 19.72 740.92 1133.63 38 610 IPNAIIGLETGVIK 21.75 719.44816.48 37 611 IPNAIIGLETGVIK 21.75 719.44 929.57 37 612 IPNAIIGLETGVIK21.75 719.44 1227.73 37 613 IPNALIGLETGAIK 20.96 705.42 788.45 36 614IPNALIGLETGAIK 20.96 705.42 901.54 36 615 IPNALIGLETGAIK 20.96 705.421014.62 36 616 IPNSLIAFDTGAVR 20.24 737.41 765.39 37 617 IPNSLIAFDTGAVR20.24 737.41 836.43 37 618 IPNSLIAFDTGAVR 20.24 737.41 949.51 37 619IPSAIIGLETGVIK 21.66 705.93 816.48 36 620 IPSAIIGLETGVIK 21.67 705.93929.57 36 621 IPSAIIGLETGVIK 21.66 705.93 1200.72 36 622 ISAFNQVK 13.02453.76 488.28 25 623 ISAFNQVK 13.02 453.76 706.39 25 624 ISAFNQVK 13.02453.76 793.42 25 625 ISAHEQILFLR 18.28 442.92 548.36 26 626 ISAHEQILFLR18.28 442.92 789.5 26 627 ISAHEQILFLR 18.28 663.88 918.54 34 628ISAMEQTR 9.84 468.23 664.31 26 629 ISAMEQTR 9.84 468.23 735.35 26 630ISAMEQTR 9.84 468.23 822.38 26 631 ISAMEQVK 11.65 453.24 634.32 25 632ISAMEQVK 11.65 453.24 705.36 25 633 ISAMEQVK 11.65 453.24 792.39 25 634ISATEQVAFLR 17.7 412.23 435.27 25 635 ISATEQVAFLR 17.71 412.23 506.31 25636 ISATEQVAFLR 17.7 412.23 605.38 25 637 ISATQQIAFLR 18.58 624.36747.45 32 638 ISATQQIAFLR 18.58 624.36 1047.59 32 639 ISATQQIAFLR 18.58624.36 1134.63 32 640 ISAVNQVEFLESLFLNK 28.77 976.03 988.51 48 641ISAVNQVEFLESLFLNK 28.77 976.03 1110.62 48 642 ISAVNQVEFLESLFLNK 28.77976.03 1239.66 48 643 ISAVNQVK 10.32 429.76 488.28 24 644 ISAVNQVK 10.32429.76 658.39 24 645 ISAVNQVK 10.32 429.76 745.42 24 646 ISPEEQIQFLR18.87 680.37 933.52 35 647 ISPEEQIQFLR 18.87 680.37 1062.56 35 648ISPEEQIQFLR 18.87 680.37 1159.61 35 649 ISPEEQVR 10.49 479.25 531.29 26650 ISPEEQVR 10.49 479.25 660.33 26 651 ISPEEQVR 10.49 479.25 757.38 26652 ISPEGQVR 9.86 443.24 459.27 25 653 ISPEGQVR 9.86 443.24 588.31 25654 ISPEGQVR 9.86 443.24 685.36 25 655 ISPLEQLAFLR 24.02 643.88 876.4933 656 ISPLEQLAFLR 24.01 643.88 989.58 33 657 ISPLEQLAFLR 24.02 643.881086.63 33 658 ITAFQQVDFLR 21.11 669.36 777.43 34 659 ITAFQQVDFLR 21.12669.36 905.48 34 660 ITAFQQVDFLR 21.12 669.36 1123.59 34 661ITPIQEVNFADDFANNR 21.25 655.32 736.34 37 662 ITPIQEVNFADDFANNR 21.25655.32 851.36 37 663 ITPIQEVNFADDFANNR 21.25 655.32 922.4 37 664ITPIQEVNFADDLANNR 20.95 643.99 817.38 36 665 ITPIQEVNFADDLANNR 20.95965.49 1149.53 47 666 ITPIQEVNFADDLANNR 20.96 965.49 1248.6 47 667ITPQQEAQFAYK 14.52 712.36 856.42 36 668 ITPQQEAQFAYK 14.52 712.36 984.4836 669 ITPQQEAQFAYK 14.52 712.36 1209.59 36 670 ITPQQEAQFTYK 14.33485.25 558.29 28 671 ITPQQEAQFTYK 14.33 727.37 1014.49 37 672ITPQQEAQFTYK 14.33 727.37 1239.6 37 673 ITPVQEVNFADDLAHNR 18.98 646.99840.4 36 674 ITPVQEVNFADDLAHNR 18.98 646.99 862.92 36 675ITPVQEVNFADDLAHNR 18.98 646.99 911.43 36 676 IVAFALK 17.21 381.25 478.322 677 IVAFALK 17.22 381.25 549.34 22 678 IVAFALK 17.21 381.25 648.41 22679 IVAFALNMEMR 17.95 647.84 864.41 34 680 IVAFALNMEMR 17.95 647.841011.48 34 681 IVAFALNMEMR 17.97 647.84 1082.51 34 682 IVESTTLADGTVVHGK13.69 542.96 697.4 31 683 IVESTTLADGTVVHGK 13.69 542.96 812.43 31 684IVESTTLADGTVVHGK 13.68 542.96 883.46 31 685 IYNSLIGLNEK 17.37 632.35673.39 33 686 IYNSLIGLNEK 17.37 632.35 786.47 33 687 IYNSLIGLNEK 17.37632.35 987.55 33 688 KPDIGWWVGWIER 24.47 547.96 660.35 31 689KPDIGWWVGWIER 24.47 547.96 883.45 31 690 KPDIGWWVGWIER 24.46 821.431188.59 41 691 LAC[CAM]ATNNLAR 11.22 552.28 688.37 29 692LAC[CAM]ATNNLAR 11.22 552.28 759.41 29 693 LAC[CAM]ATNNLAR 11.22 552.28919.44 29 694 LAQGELPFPAPVQSTVR 19.84 905.5 954.54 45 695LAQGELPFPAPVQSTVR 19.84 905.5 1101.61 45 696 LAQGELPFPAPVQSTVR 19.84905.5 1198.66 45 697 LAQNELPYPIEIQK 19.09 828.45 929.47 41 698LAQNELPYPIEIQK 19.09 828.45 987.55 41 699 LAQNELPYPIEIQK 19.08 828.451100.64 41 700 LAQNELQYPIEIQK 17.98 843.96 890.5 42 701 LAQNELQYPIEIQK17.98 843.96 1018.56 42 702 LAQNELQYPIEIQK 17.98 843.96 1131.64 42 703LDFGNK 11.75 347.18 465.25 20 704 LDFGNK 11.74 347.18 547.25 20 705LDFGNK 11.75 347.18 580.27 20 706 LDGSLNR 9.48 387.71 402.25 22 707LDGSLNR 9.48 387.71 546.3 22 708 LDGSLNR 9.48 387.71 661.33 22 709LEILQQALAELGLYPK 29.81 900.02 1003.58 45 710 LEILQQALAELGLYPK 29.81900.02 1074.62 45 711 LEILQQALAELGLYPK 29.81 900.02 1202.68 45 712LENQEQVK 7.6 494.26 631.34 27 713 LENQEQVK 7.59 494.26 745.38 27 714LENQEQVK 7.59 494.26 874.43 27 715 LETQEEVEK 9.88 552.77 633.31 29 716LETQEEVEK 9.88 552.77 862.42 29 717 LETQEEVEK 9.88 552.77 991.46 29 718LETQEEVK 9.5 488.25 504.27 26 719 LETQEEVK 9.49 488.25 733.37 26 720LETQEEVK 9.49 488.25 862.42 26 721 LFAAEGVK 13.53 417.74 503.28 23 722LFAAEGVK 13.53 417.74 574.32 23 723 LFAAEGVK 13.53 417.74 721.39 23 724LFESAGVK 12.99 425.74 461.27 24 725 LFESAGVK 12.99 425.74 590.31 24 726LFESAGVK 12.99 425.74 737.38 24 727 LFGAAGVK 13.94 381.73 445.28 22 728LFGAAGVK 13.94 381.73 502.3 22 729 LFGAAGVK 13.94 381.73 649.37 22 730LGVDR 8.51 280.16 290.15 17 731 LGVDR 8.51 280.16 389.21 17 732 LGVDR8.5 280.16 446.24 17 733 LLNLLSQSK 17.97 508.31 562.32 27 734 LLNLLSQSK17.97 508.31 789.45 27 735 LLNLLSQSK 17.97 508.31 902.53 27 736 LLQDER9.34 387.21 547.25 22 737 LLQDER 9.31 387.21 599.3 22 738 LLQDER 9.34387.21 660.33 22 739 LLVQDGDC[CAM]GR 11.92 566.77 679.25 30 740LLVQDGDC[CAM]GR 11.92 566.77 807.3 30 741 LLVQDGDC[CAM]GR 11.92 566.77906.37 30 742 LNEVGYGNR 10.74 511.26 566.27 27 743 LNEVGYGNR 10.74511.26 665.34 27 744 LNEVGYGNR 10.73 511.26 794.38 27 745 LNYGNADPSTK10.76 590.29 732.35 31 746 LNYGNADPSTK 10.76 590.29 789.37 31 747LNYGNADPSTK 10.76 590.29 952.44 31 748 LNYGNK 7.21 354.69 481.24 21 749LNYGNK 7.24 354.69 562.26 21 750 LNYGNK 7.22 354.69 595.28 21 751 LPASK1.93 258.16 305.18 16 752 LPASK 1.93 258.16 369.21 16 753 LPASK 1.93258.16 402.23 16 754 LPHTLFALDADAVR 19.98 769.92 977.51 39 755LPHTLFALDADAVR 19.98 769.92 1090.59 39 756 LPHTLFALDADAVR 19.98 769.921191.64 39 757 LPHTLFALDAGAVR 19.7 740.92 919.5 38 758 LPHTLFALDAGAVR19.67 740.92 1032.58 38 759 LPHTLFALDAGAVR 19.7 740.92 1133.63 38 760LPLAIMGFDSGILQSPK 25.08 893.99 944.5 44 761 LPLAIMGFDSGILQSPK 25.08893.99 1091.57 44 762 LPLAIMGFDSGILQSPK 25.08 893.99 1148.59 44 763LPLAIMGYDADILLDATTPR 27.86 720.39 773.42 40 764 LPLAIMGYDADILLDATTPR27.87 720.39 886.5 40 765 LPLAIMGYDADILLDATTPR 27.87 720.39 1160.57 40766 LPSSLIALETGAVR 20.6 713.92 816.46 36 767 LPSSLIALETGAVR 20.6 713.92929.54 36 768 LPSSLIALETGAVR 20.6 713.92 1216.69 36 769 LPVSAQTLQYTANILK21.84 880.5 950.53 44 770 LPVSAQTLQYTANILK 21.84 880.5 1063.61 44 771LPVSAQTLQYTANILK 21.85 880.5 1164.66 44 772 LPVSER 9.57 350.7 490.26 20773 LPVSER 9.57 350.7 526.29 20 774 LPVSER 9.57 350.7 587.31 20 775LPVSPTAVDMTER 16.21 708.36 1019.48 36 776 LPVSPTAVDMTER 16.21 708.361106.51 36 777 LPVSPTAVDMTER 16.21 708.36 1205.58 36 778 LSASK 10.72253.15 305.18 16 779 LSASK 10.71 253.15 359.19 16 780 LSASK 10.71 253.15392.21 16 781 LSAVPIYQEVAR 17.96 673.38 765.39 35 782 LSAVPIYQEVAR 17.96673.38 975.53 35 783 LSAVPIYQEVAR 17.95 673.38 1074.59 35 784LSAVPVYQELAR 18.45 449.25 616.34 26 785 LSAVPVYQELAR 18.44 673.38 779.435 786 LSAVPVYQELAR 18.44 673.38 975.53 35 787 LSC[CAM]TLVIDEASGDLLHR20.38 633.66 797.43 36 788 LSC[CAM]TLVIDEASGDLLHR 20.38 633.66 868.46 36789 LSC[CAM]TLVIDEASGDLLHR 20.38 633.66 1112.53 36 790 LSLQHGWFIGWIEK23.95 571.98 632.34 33 791 LSLQHGWFIGWIEK 23.95 571.98 892.49 33 792LSLQHGWFIGWIEK 23.95 571.98 969.49 33 793 LSQNSLPFSQEAMNSVK 18.64 627.311140.54 35 794 LSQNSLPFSQEAMNSVK 18.63 940.46 1140.54 46 795LSQNSLPFSQEAMNSVK 18.64 940.46 1237.59 46 796 LSVNPK 9.8 329.2 457.28 19797 LSVNPK 9.79 329.2 511.29 19 798 LSVNPK 9.8 329.2 544.31 19 799LTVGAR 9.51 308.69 402.25 19 800 LTVGAR 9.51 308.69 442.27 19 801 LTVGAR9.51 308.69 503.29 19 802 LYGFALNIDMPGGEADIGK 23.35 661 843.42 37 803LYGFALNIDMPGGEADIGK 23.35 990.99 1089.49 49 804 LYGFALNIDMPGGEADIGK23.35 990.99 1202.57 49 805 LYHNELPFR 15.29 396.88 414.21 24 806LYHNELPFR 15.29 396.88 419.24 24 807 LYHNELPFR 15.29 396.88 657.3 24 808LYHNK 8.54 337.68 414.21 20 809 LYHNK 8.53 337.68 528.26 20 810 LYHNK8.53 337.68 561.28 20 811 LYQNDLPFR 17.2 583.3 761.39 31 812 LYQNDLPFR17.2 583.3 889.45 31 813 LYQNDLPFR 17.2 583.3 1052.52 31 814 MDDLFK 15.5384.68 522.29 22 815 MDDLFK 15.5 384.68 622.25 22 816 MDDLFK 15.5 384.68637.32 22 817 MEDLHK 6.66 386.69 512.28 22 818 MEDLHK 6.65 386.69 626.2622 819 MEDLHK 6.66 386.69 641.33 22 820 MLIALIGLENHK 21.33 451.26 527.2627 821 MLIALIGLENHK 21.33 451.26 697.36 27 822 MLIALIGLENHK 21.33 451.26810.45 27 823 MLLIK 15.81 309.21 373.28 19 824 MLLIK 15.81 309.21 471.319 825 MLLIK 15.81 309.21 486.36 19 826 MLNALIGLEHHK 16.89 459.26 550.2727 827 MLNALIGLEHHK 16.89 459.26 720.38 27 828 MLNALIGLEHHK 16.89 459.26833.46 27 829 MLNALIGLENHK 18.39 451.58 697.36 27 830 MLNALIGLENHK 18.38676.87 697.36 35 831 MLNALIGLENHK 18.39 676.87 810.45 35 832MLNALIGLENQK 19.71 672.37 688.36 35 833 MLNALIGLENQK 19.71 672.37 801.4535 834 MLNALIGLENQK 19.71 672.37 914.53 35 835 MLNALIGLEYHK 19.6 701.38746.38 36 836 MLNALIGLEYHK 19.6 701.38 859.47 36 837 MLNALIGLEYHK 19.6701.38 1157.63 36 838 MLNALIGLQHGK 17.5 432.25 582.34 26 839MLNALIGLQHGK 17.5 432.25 639.36 26 840 MLNALIGLQHGK 17.5 432.25 752.4426 841 MLNALISLEHHK 17.2 352.2 359.17 21 842 MLNALISLEHHK 17.21 469.26750.39 27 843 MLNALISLEHHK 17.2 469.26 863.47 27 844 MQAYVDAFDYGNR 17.56775.34 957.41 39 845 MQAYVDAFDYGNR 17.56 775.34 1056.47 39 846MQAYVDAFDYGNR 17.56 775.34 1219.54 39 847 MQEGLNK 8.68 410.21 560.3 23848 MQEGLNK 8.66 410.21 673.3 23 849 MQEGLNK 8.68 410.21 688.36 23 850MSPASTYK 9.49 442.71 569.29 24 851 MSPASTYK 9.49 442.71 666.35 24 852MSPASTYK 9.49 442.71 753.38 24 853 NEHDPVLPYR 13.09 413.88 435.24 25 854NEHDPVLPYR 13.09 620.31 744.44 32 855 NEHDPVLPYR 13.09 620.31 859.47 32856 NEHQIFK 9.91 458.24 509.21 25 857 NEHQIFK 9.91 458.24 622.29 25 858NEHQIFK 9.91 458.24 672.38 25 859 NEHQVFK 7.74 451.23 658.37 25 860NEHQVFK 7.74 451.23 755.35 25 861 NEHQVFK 7.74 451.23 787.41 25 862NEITYK 9.35 384.2 524.31 22 863 NEITYK 9.35 384.2 621.29 22 864 NEITYK9.35 384.2 653.35 22 865 NELLMK 13.08 374.21 504.32 21 866 NELLMK 13.09374.21 601.3 21 867 NELLMK 13.09 374.21 633.36 21 868 NELPFR 14.39388.21 419.24 22 869 NELPFR 14.39 388.21 532.32 22 870 NELPFR 14.4388.21 661.37 22 871 NISSYGNNLVR 14.36 618.82 835.44 32 872 NISSYGNNLVR14.36 618.82 922.47 32 873 NISSYGNNLVR 14.36 618.82 1009.51 32 874NISTYGNNLTR 13.1 626.82 674.36 33 875 NISTYGNNLTR 13.09 626.82 837.42 33876 NISTYGNNLTR 13.1 626.82 1025.5 33 877 NLFNEVHTTGVLVIR 20.69 571.32757.49 33 878 NLFNEVHTTGVLVIR 20.7 571.32 858.54 33 879 NLFNEVHTTGVLVIR20.7 571.32 995.6 33 880 NLSTYGNALAR 14.34 590.31 764.4 31 881NLSTYGNALAR 14.35 590.31 865.45 31 882 NLSTYGNALAR 14.35 590.31 952.4831 883 NMENLELFGK 19.08 597.79 820.46 31 884 NMENLELFGK 19.08 597.79949.5 31 885 NMENLELFGK 19.08 597.79 1080.54 31 886 NMLLLEENNGYK 16.71719.36 853.37 37 887 NMLLLEENNGYK 16.69 719.36 966.45 37 888NMLLLEENNGYK 16.68 719.36 1079.54 37 889 NMLLLEESNGYK 18.12 705.85939.44 36 890 NMLLLEESNGYK 18.13 705.85 1052.53 36 891 NMLLLEESNGYK18.11 705.85 1165.61 36 892 NMLLLEK 16.99 430.75 502.32 24 893 NMLLLEK16.98 430.75 615.41 24 894 NMLLLEK 16.98 430.75 746.45 24 895 NMTLGDAMK14.42 490.73 521.24 27 896 NMTLGDAMK 14.42 490.73 634.32 27 897NMTLGDAMK 14.42 490.73 735.37 27 898 NNGLTEAWLESSLK 20.61 781.4 862.4739 899 NNGLTEAWLESSLK 20.6 781.4 933.5 39 900 NNGLTEAWLESSLK 20.62 781.41163.59 39 901 NQLPFK 13.49 373.71 391.23 21 902 NQLPFK 13.49 373.71504.32 21 903 NQLPFK 13.49 373.71 632.38 21 904 NQLPFQVEHQR 14.33 698.36796.41 36 905 NQLPFQVEHQR 14.33 698.36 1040.53 36 906 NQLPFQVEHQR 14.33698.36 1153.61 36 907 NSAIENTIDNMYLQDLENSTK 22.77 805.04 934.45 44 908NSAIENTIDNMYLQDLENSTK 22.77 805.04 1047.53 44 909 NSAIENTIDNMYLQDLENSTK22.77 805.04 1210.6 44 910 NSAIENTIENMYLQDLDNSTK 23.13 805.04 920.43 44911 NSAIENTIENMYLQDLDNSTK 23.13 805.04 1033.52 44 912NSAIENTIENMYLQDLDNSTK 23.14 805.04 1196.58 44 913 NSAIENTIENMYLQDLENSTK23.7 809.72 934.45 44 914 NSAIENTIENMYLQDLENSTK 23.7 809.72 1047.53 44915 NSAIENTIENMYLQDLENSTK 23.7 809.72 1217.55 44 916 NSAVWVYELFAK 24.66713.87 869.48 36 917 NSAVWVYELFAK 24.66 713.87 1055.56 36 918NSAVWVYELFAK 24.65 713.87 1154.62 36 919 NSQVPAYK 9.78 453.74 478.27 25920 NSQVPAYK 9.78 453.74 577.33 25 921 NSQVPAYK 9.78 453.74 705.39 25922 NSTVWIYELFAK 25.64 735.88 883.49 37 923 NSTVWIYELFAK 25.64 735.881069.57 37 924 NSTVWIYELFAK 25.64 735.88 1168.64 37 925 NSTVWVYELFAK24.42 728.88 770.41 37 926 NSTVWVYELFAK 24.43 728.88 869.48 37 927NSTVWVYELFAK 24.42 728.88 1055.56 37 928 NSTVWVYQLFAK 23.9 728.39 769.4237 929 NSTVWVYQLFAK 23.91 728.39 1054.57 37 930 NSTVWVYQLFAK 23.91728.39 1153.64 37 931 NTSGALVIQTDK 13.34 623.84 816.48 32 932NTSGALVIQTDK 13.34 623.84 944.54 32 933 NTSGALVIQTDK 13.34 623.841031.57 32 934 NTSGVLVIQTDK 14.9 637.85 816.48 33 935 NTSGVLVIQTDK 14.9637.85 972.57 33 936 NTSGVLVIQTDK 14.91 637.85 1059.6 33 937NVDEMFYYYDGSK 18.86 815.84 895.38 41 938 NVDEMFYYYDGSK 18.86 815.841042.45 41 939 NVDEMFYYYDGSK 18.85 815.84 1173.49 41 940 NWILR 16.3351.21 414.21 20 941 NWILR 16.29 351.21 527.3 20 942 NWILR 16.3 351.21587.37 20 943 NWNAAMDLR 16.54 545.76 605.31 29 944 NWNAAMDLR 16.55545.76 676.34 29 945 NWNAAMDLR 16.54 545.76 790.39 29 946NYVDAFHYGNQDISGDK 15.76 648.29 933.43 36 947 NYVDAFHYGNQDISGDK 15.77648.29 1096.49 36 948 NYVDAFHYGNQDISGDK 15.76 971.93 1233.55 48 949QADHAILVFDQAR 16.58 495.26 523.23 29 950 QADHAILVFDQAR 16.61 495.26636.31 29 951 QADHAILVFDQAR 16.58 495.26 735.38 29 952 QAEHALLVFGQER16.86 499.93 636.31 29 953 QAEHALLVFGQER 16.85 499.93 735.38 29 954QAEHALLVFGQER 16.87 499.93 763.41 29 955 QAITK 11 280.67 361.24 17 956QAITK 11 280.67 414.23 17 957 QAITK 11.01 280.67 432.28 17 958QAMLTEANSDYIIR 18.26 812.9 951.49 41 959 QAMLTEANSDYIIR 18.25 812.91080.53 41 960 QAMLTEANSDYIIR 18.26 812.9 1181.58 41 961 QEVQFVSALAR17.69 624.34 763.45 32 962 QEVQFVSALAR 17.68 624.34 891.5 32 963QEVQFVSALAR 17.68 624.34 990.57 32 964 QFASIK 11.66 347.2 434.2 20 965QFASIK 11.66 347.2 547.29 20 966 QFASIK 11.68 347.2 565.33 20 967QGMPGSIR 11.4 423.22 529.31 24 968 QGMPGSIR 11.43 423.22 660.35 24 969QGMPGSIR 11.4 423.22 717.37 24 970 QGMSGSIR 9.44 418.21 519.29 23 971QGMSGSIR 9.45 418.21 650.33 23 972 QGMSGSIR 9.44 418.21 707.35 23 973QGQTQQSYGNDLAR 11.16 783.37 895.43 39 974 QGQTQQSYGNDLAR 11.17 783.371023.49 39 975 QGQTQQSYGNDLAR 11.16 783.37 1151.54 39 976 QIDYGNADPSTIK13.41 711.35 845.44 36 977 QIDYGNADPSTIK 13.42 711.35 902.46 36 978QIDYGNADPSTIK 13.42 711.35 1065.52 36 979 QIDYGNVDPSTIK 15.08 725.36873.47 37 980 QIDYGNVDPSTIK 15.07 725.36 930.49 37 981 QIDYGNVDPSTIK15.07 725.36 1093.55 37 982 QIGQAR 2.3 336.69 431.24 20 983 QIGQAR 2.33336.69 498.27 20 984 QIGQAR 2.32 336.69 544.32 20 985 QIMLIEQTPAFTLR24.42 830.96 933.52 42 986 QIMLIEQTPAFTLR 24.42 830.96 1062.56 42 987QIMLIEQTPAFTLR 24.42 830.96 1175.64 42 988 QLGSAIDQFWLR 22.67 717.38864.44 37 989 QLGSAIDQFWLR 22.68 717.38 977.52 37 990 QLGSAIDQFWLR 22.67717.38 1192.61 37 991 QLPVK 9.57 292.69 343.23 18 992 QLPVK 9.58 292.69438.27 18 993 QLPVK 9.57 292.69 456.32 18 994 QLSLDVLDK 18.63 515.79589.32 28 995 QLSLDVLDK 18.62 515.79 789.44 28 996 QLSLDVLDK 18.63515.79 902.52 28 997 QLVYAR 11.04 375.22 508.29 22 998 QLVYAR 11.04375.22 575.32 22 999 QLVYAR 11.04 375.22 621.37 22 1000 QMMLTEASTDYIIR19.82 836.41 867.46 42 1001 QMMLTEASTDYIIR 19.82 836.41 1067.54 42 1002QMMLTEASTDYIIR 19.82 836.41 1168.58 42 1003 QMSIVEATPDYVLHGK 18.77894.45 1029.54 44 1004 QMSIVEATPDYVLHGK 18.77 894.45 1100.57 44 1005QMSIVEATPDYVLHGK 18.77 894.45 1229.62 44 1006 QTLVFAR 14.65 417.75492.29 23 1007 QTLVFAR 14.65 417.75 605.38 23 1008 QTLVFAR 14.65 417.75706.42 23 1009 QVVFAR 12.06 360.21 492.29 21 1010 QVVFAR 12.04 360.21545.31 21 1011 QVVFAR 12.06 360.21 591.36 21 1012 SADEVLPYGGKPQR 12.96506.26 642.37 29 1013 SADEVLPYGGKPQR 12.96 506.26 805.43 29 1014SADEVLPYGGKPQR 12.96 506.26 902.48 29 1015 SC[CAM]ATNDLAR 9.37 504.23689.36 27 1016 SC[CAM]ATNDLAR 9.37 504.23 760.39 27 1017 SC[CAM]ATNDLAR9.37 504.23 920.43 27 1018 SC[CAM]ATNNLAR 8.66 503.74 688.37 27 1019SC[CAM]ATNNLAR 8.66 503.74 759.41 27 1020 SC[CAM]ATNNLAR 8.67 503.74919.44 27 1021 SDIPGGSK 7.63 380.7 558.32 22 1022 SDIPGGSK 7.63 380.7614.28 22 1023 SDIPGGSK 7.63 380.7 673.35 22 1024 SDWGK 5.75 296.64390.21 18 1025 SDWGK 5.75 296.64 446.17 18 1026 SDWGK 5.75 296.64 505.2418 1027 SEDNFHISSQQHEK 10.36 422.19 541.27 24 1028 SEDNFHISSQQHEK 10.36422.19 730.28 24 1029 SEDNFHISSQQHEK 10.36 422.19 756.36 24 1030SEMPASIR 12.02 445.72 674.37 25 1031 SEMPASIR 12.02 445.72 716.33 251032 SEMPASIR 12.02 445.72 803.41 25 1033 SEMPASTR 8.2 439.71 662.33 241034 SEMPASTR 8.19 439.71 704.29 24 1035 SEMPASTR 8.19 439.71 791.37 241036 SFAAHNQDQDLR 10.35 467.89 531.29 27 1037 SFAAHNQDQDLR 10.35 467.89871.37 27 1038 SFAAHNQDQDLR 10.35 467.89 888.42 27 1039 SFAGHNK 9.4380.69 455.24 22 1040 SFAGHNK 9.4 380.69 526.27 22 1041 SFAGHNK 9.38380.69 673.34 22 1042 SFAGHNQDQDLR 10.18 694.32 888.42 36 1043SFAGHNQDQDLR 10.18 694.32 1025.48 36 1044 SFAGHNQDQDLR 10.18 694.321082.5 36 1045 SFAGHNQDQNLR 9.8 462.89 530.3 27 1046 SFAGHNQDQNLR 9.8462.89 773.39 27 1047 SFAGHNQDQNLR 9.8 462.89 887.43 27 1048 SFLESWAK18.27 484.25 491.26 26 1049 SFLESWAK 18.27 484.25 620.3 26 1050 SFLESWAK18.27 484.25 733.39 26 1051 SFTAWEK 14.44 434.71 462.23 24 1052 SFTAWEK14.44 434.71 533.27 24 1053 SFTAWEK 14.44 434.71 634.32 24 1054 SFTTWEK14.1 449.72 462.23 25 1055 SFTTWEK 14.1 449.72 563.28 25 1056 SFTTWEK14.1 449.72 664.33 25 1057 SGSGWLR 13.25 381.7 531.3 22 1058 SGSGWLR13.25 381.7 618.34 22 1059 SGSGWLR 13.25 381.7 675.36 22 1060SGWGMAVDPQVGWYVGFVEK 24.65 738.02 841.45 41 1061 SGWGMAVDPQVGWYVGFVEK24.65 738.02 1029.45 41 1062 SGWGMAVDPQVGWYVGFVEK 24.68 1106.53 1128.5154 1063 SGWGMDVSPQVGWLTGWVEK 26.32 1110.03 1144.51 54 1064SGWGMDVSPQVGWLTGWVEK 26.32 1110.03 1174.63 54 1065 SGWGMDVSPQVGWLTGWVEK26.32 1110.03 1201.53 54 1066 SGWGMDVTPQVGWLTGWVEK 26.61 745.03 832.4641 1067 SGWGMDVTPQVGWLTGWVEK 26.61 745.03 1018.54 41 1068SGWGMDVTPQVGWLTGWVEK 26.61 745.03 1075.56 41 1069 SIHPASTFK 10.74 494.27650.35 27 1070 SIHPASTFK 10.73 494.27 787.41 27 1071 SIHPASTFK 10.73494.27 900.49 27 1072 SISTK 10.41 268.16 335.19 17 1073 SISTK 10.42268.16 389.2 17 1074 SISTK 10.42 268.16 448.28 17 1075 SLGLSNNLSR 14.23530.79 690.35 28 1076 SLGLSNNLSR 14.23 530.79 803.44 28 1077 SLGLSNNLSR14.23 530.79 860.46 28 1078 SLSMSGK 9.31 355.18 509.24 21 1079 SLSMSGK9.32 355.18 563.25 21 1080 SLSMSGK 9.32 355.18 622.32 21 1081 SMLFIEEK17.82 498.76 518.28 27 1082 SMLFIEEK 17.82 498.76 665.35 27 1083SMLFIEEK 17.82 498.76 778.43 27 1084 SNGLTHSWLGSSLK 16.78 743.89 877.4838 1085 SNGLTHSWLGSSLK 16.78 743.89 1014.54 38 1086 SNGLTHSWLGSSLK 16.78743.89 1115.58 38 1087 SPTWELKPEYNPSPR 16.02 600.97 733.36 34 1088SPTWELKPEYNPSPR 16.02 600.97 808.91 34 1089 SPTWELKPEYNPSPR 16.02 600.97959.46 34 1090 SQDIVR 8.4 359.2 502.3 21 1091 SQDIVR 8.38 359.2 543.2821 1092 SQDIVR 8.4 359.2 630.36 21 1093 SQQKPTDPTIWLK 16.6 514.62 660.4130 1094 SQQKPTDPTIWLK 16.6 514.62 757.46 30 1095 SQQKPTDPTIWLK 16.6514.62 785.38 30 1096 SQVGWLTGWVEQPDGK 22.27 893.94 1015.5 44 1097SQVGWLTGWVEQPDGK 22.28 893.94 1116.53 44 1098 SQVGWLTGWVEQPDGK 22.28893.94 1229.62 44 1099 SSSNSC[CAM]TTNNAAR 16.84 685.29 907.41 35 1100SSSNSC[CAM]TTNNAAR 16.85 685.29 994.44 35 1101 SSSNSC[CAM]TTNNAAR 16.84685.29 1108.48 35 1102 SVYGELR 12.65 412.22 417.25 23 1103 SVYGELR 12.65412.22 474.27 23 1104 SVYGELR 12.65 412.22 637.33 23 1105 SWILR 16.33337.7 401.29 20 1106 SWILR 16.32 337.7 500.29 20 1107 SWILR 16.33 337.7587.37 20 1108 SYLEK 9.09 320.17 389.24 19 1109 SYLEK 9.09 320.17 493.2319 1110 SYLEK 9.1 320.17 552.3 19 1111 TAYIPASTFK 15.43 549.8 650.35 291112 TAYIPASTFK 15.43 549.8 763.43 29 1113 TAYIPASTFK 15.43 549.8 926.529 1114 TDDLFK 13.48 369.69 407.27 21 1115 TDDLFK 13.48 369.69 522.29 211116 TDDLFK 13.48 369.69 637.32 21 1117 TDINEIFK 17.44 490.26 650.35 271118 TDINEIFK 17.44 490.26 763.43 27 1119 TDINEIFK 17.44 490.26 878.4627 1120 TFIHNDPR 18.92 500.25 751.38 27 1121 TFIHNDPR 18.92 500.25825.39 27 1122 TFIHNDPR 18.92 500.25 898.45 27 1123 TGAGFTANR 9.64447.72 461.25 25 1124 TGAGFTANR 9.64 447.72 665.34 25 1125 TGAGFTANR9.64 447.72 793.4 25 1126 TGFNDGQK 7.5 433.7 561.26 24 1127 TGFNDGQK 7.5433.7 708.33 24 1128 TGFNDGQK 7.5 433.7 765.35 24 1129 TGLADSK 9.7346.18 533.29 20 1130 TGLADSK 9.67 346.18 545.26 20 1131 TGLADSK 9.7346.18 590.31 20 1132 TGLDLMQK 15.32 453.24 634.32 25 1133 TGLDLMQK15.32 453.24 747.41 25 1134 TGLDLMQK 15.32 453.24 804.43 25 1135TGLELMQK 15.03 460.25 648.34 25 1136 TGLELMQK 15.03 460.25 761.42 251137 TGLELMQK 15.03 460.25 818.44 25 1138 TGMGYPK 10.28 377.18 464.25 221139 TGMGYPK 10.28 377.18 595.29 22 1140 TGMGYPK 10.28 377.18 652.31 221141 TGNGR 0.8 252.63 330.14 16 1142 TGNGR 0.8 252.63 346.18 16 1143TGNGR 0.81 252.63 403.2 16 1144 TGTGSFIDAR 13.35 512.76 708.37 28 1145TGTGSFIDAR 13.35 512.76 765.39 28 1146 TGTGSFIDAR 13.35 512.76 866.44 281147 TGTGSLSDAK 8.32 468.74 620.32 26 1148 TGTGSLSDAK 8.32 468.74 677.3526 1149 TGTGSLSDAK 8.32 468.74 778.39 26 1150 TGVATEYQPEIGWWAGWVER 25.49779.04 903.45 43 1151 TGVATEYQPEIGWWAGWVER 25.5 779.04 1146.55 43 1152TGVATEYQPEIGWWAGWVER 25.52 1168.06 1189.57 56 1153 TGVSYPLLADGTR 17.4675.36 842.47 35 1154 TGVSYPLLADGTR 17.41 675.36 1005.54 35 1155TGVSYPLLADGTR 17.4 675.36 1092.57 35 1156 TGWAMDIK 16.71 461.23 577.3 251157 TGWAMDIK 16.71 461.23 763.38 25 1158 TGWAMDIK 16.72 461.23 820.4 251159 TGWATR 9.71 346.18 517.24 20 1160 TGWATR 9.69 346.18 533.28 20 1161TGWATR 9.69 346.18 590.3 20 1162 TGWC[CAM]FDC[CAM]TPELGWWVGWVK 28.39795.36 960.51 44 1163 TGWC[CAM]FDC[CAM]TPELGWWVGWVK 28.39 795.36 1017.5344 1164 TGWC[CAM]FDC[CAM]TPELGWWVGWVK 28.38 795.36 1028.36 44 1165TGWEGR 9.1 353.17 531.22 21 1166 TGWEGR 9.09 353.17 547.26 21 1167TGWEGR 9.09 353.17 604.28 21 1168 TGWFVDK 16.08 426.72 694.36 24 1169TGWFVDK 16.1 426.72 706.32 24 1170 TGWFVDK 16.08 426.72 751.38 24 1171TGYDTK 2.09 342.66 526.25 20 1172 TGYDTK 2.09 342.66 538.21 20 1173TGYDTK 2.08 342.66 583.27 20 1174 TGYGVR 8.09 326.67 478.23 19 1175TGYGVR 8.1 326.67 494.27 19 1176 TGYGVR 8.1 326.67 551.29 19 1177 TGYSAR2.24 327.66 480.21 19 1178 TGYSAR 2.24 327.66 496.25 19 1179 TGYSAR 2.24327.66 553.27 19 1180 TGYSTR 2.08 342.67 510.22 20 1181 TGYSTR 2.08342.67 526.26 20 1182 TGYSTR 2.08 342.67 583.28 20 1183 THESSNWGK 5.36523.24 678.32 28 1184 THESSNWGK 5.37 523.24 807.36 28 1185 THESSNWGK5.37 523.24 944.42 28 1186 TIC[CAM]TAIADAGTGK 14.35 639.82 732.39 331187 TIC[CAM]TAIADAGTGK 14.35 639.82 904.47 33 1188 TIC[CAM]TAIADAGTGK14.35 639.82 1064.5 33 1189 TIGGAPDAYWVDDSLQISAR 21.22 712.35 1004.5 401190 TIGGAPDAYWVDDSLQISAR 21.22 712.35 1103.57 40 1191TIGGAPDAYWVDDSLQISAR 21.21 1068.02 1103.57 52 1192 TLPFSASSYETLR 18.73736.37 855.42 37 1193 TLPFSASSYETLR 18.73 736.37 1013.49 37 1194TLPFSASSYETLR 18.73 736.37 1160.56 37 1195 TLPFSPK 15 395.23 478.27 221196 TLPFSPK 15 395.23 575.32 22 1197 TLPFSPK 15 395.23 688.4 22 1198TLPFSQEVQDEVQSILFIEEK 28.55 827.09 891.52 45 1199 TLPFSQEVQDEVQSILFIEEK28.56 827.09 978.55 45 1200 TLPFSQEVQDEVQSILFIEEK 28.56 827.09 1106.6145 1201 TLPFSQEVQDEVQSMLFIEEK 27.7 833.08 996.51 46 1202TLPFSQEVQDEVQSMLFIEEK 27.69 833.08 1124.57 46 1203 TLPFSQEVQDEVQSMLFIEEK27.7 833.08 1223.63 46 1204 TLQNGWFEGFIISK 24.12 820.43 940.51 41 1205TLQNGWFEGFIISK 24.11 820.43 1126.59 41 1206 TLQNGWFEGFIISK 24.11 820.431183.61 41 1207 TMQEYLNK 12.6 513.75 666.35 28 1208 TMQEYLNK 12.6 513.75794.4 28 1209 TMQEYLNK 12.6 513.75 925.44 28 1210 TQTYQAYDAAR 11.2 644.3666.32 33 1211 TQTYQAYDAAR 11.2 644.3 957.44 33 1212 TQTYQAYDAAR 11.2644.3 1058.49 33 1213 TTDPTIWEK 14.39 545.77 676.37 29 1214 TTDPTIWEK14.39 545.77 773.42 29 1215 TTDPTIWEK 14.39 545.77 888.45 29 1216TTTTEVFK 12.06 463.75 522.29 25 1217 TTTTEVFK 12.06 463.75 623.34 251218 TTTTEVFK 12.06 463.75 724.39 25 1219 TWASNDFSR 13.73 542.25 638.2929 1220 TWASNDFSR 13.73 542.25 725.32 29 1221 TWASNDFSR 13.73 542.25796.36 29 1222 TWDMVQR 14.28 468.22 648.31 26 1223 TWDMVQR 14.28 468.22761.33 26 1224 TWDMVQR 14.28 468.22 834.39 26 1225 TYVVDPAR 12.15 460.75557.3 25 1226 TYVVDPAR 12.14 460.75 656.37 25 1227 TYVVDPAR 12.15 460.75819.44 25 1228 VAFSLNIEMK 20.65 576.31 747.41 30 1229 VAFSLNIEMK 20.65576.31 834.44 30 1230 VAFSLNIEMK 20.65 576.31 981.51 30 1231VANSLIGLSTGAVR 17.97 679.39 760.43 35 1232 VANSLIGLSTGAVR 17.97 679.39873.52 35 1233 VANSLIGLSTGAVR 17.97 679.39 986.6 35 1234 VELGK 7.74273.17 342.2 17 1235 VELGK 7.75 273.17 399.22 17 1236 VELGK 7.74 273.17446.26 17 1237 VFLDSWAK 18.2 483.26 606.29 26 1238 VFLDSWAK 18.2 483.26719.37 26 1239 VFLDSWAK 18.2 483.26 866.44 26 1240 VFLESWAK 18.11 490.27620.3 27 1241 VFLESWAK 18.11 490.27 733.39 27 1242 VFLESWAK 18.11 490.27880.46 27 1243 VFLSSWAQDMNLSSAIK 23.66 948.98 978.49 47 1244VFLSSWAQDMNLSSAIK 23.66 948.98 1106.55 47 1245 VFLSSWAQDMNLSSAIK 23.66948.98 1177.59 47 1246 VGFER 10.32 304.16 433.21 18 1247 VGFER 10.32304.16 451.23 18 1248 VGFER 10.32 304.16 508.25 18 1249 VILVFDQVR 19.69544.83 664.34 29 1250 VILVFDQVR 19.69 544.83 763.41 29 1251 VILVFDQVR19.69 544.83 876.49 29 1252 VMAAMVR 12.3 389.21 476.26 22 1253 VMAAMVR12.3 389.21 547.3 22 1254 VMAAMVR 12.3 389.21 678.34 22 1255VPLAVMGYDAGILVDAHNPR 21.61 703.37 709.34 39 1256 VPLAVMGYDAGILVDAHNPR21.61 703.37 808.41 39 1257 VPLAVMGYDAGILVDAHNPR 21.61 703.37 921.49 391258 VQDEVQSMLFIEEK 20.48 847.92 996.51 42 1259 VQDEVQSMLFIEEK 20.48847.92 1124.57 42 1260 VQDEVQSMLFIEEK 20.47 847.92 1223.63 42 1261VQDGVQSMLFIEEK 20.26 811.91 996.51 41 1262 VQDGVQSMLFIEEK 20.27 811.911124.57 41 1263 VQDGVQSMLFIEEK 20.25 811.91 1223.63 41 1264VSC[CAM]LPC[CAM]YQVVSHK 14.32 526.26 569.34 30 1265VSC[CAM]LPC[CAM]YQVVSHK 14.32 526.26 860.46 30 1266VSC[CAM]LPC[CAM]YQVVSHK 14.31 526.26 1020.49 30 1267VSC[CAM]VWC[CAM]YQALAR 18.41 756.86 881.43 38 1268VSC[CAM]VWC[CAM]YQALAR 18.41 756.86 1067.51 38 1269VSC[CAM]VWC[CAM]YQALAR 18.41 756.86 1166.58 38 1270VSDVC[CAM]SEVTAEGWQEVR 17.33 650.97 774.39 37 1271VSDVC[CAM]SEVTAEGWQEVR 17.34 975.95 1075.52 48 1272VSDVC[CAM]SEVTAEGWQEVR 17.34 975.95 1174.59 48 1273 VSEVEGWQIHGK 13.92456.9 582.34 27 1274 VSEVEGWQIHGK 13.92 456.9 768.42 27 1275VSEVEGWQIHGK 13.92 456.9 825.44 27 1276 VSFSLNIEMK 20.65 584.31 834.4431 1277 VSFSLNIEMK 20.64 584.31 981.51 31 1278 VSFSLNIEMK 20.65 584.311068.54 31 1279 VSPC[CAM]SSFK 11.04 456.22 468.25 25 1280 VSPC[CAM]SSFK11.04 456.22 628.28 25 1281 VSPC[CAM]SSFK 11.04 456.22 725.33 25 1282VSQVPAYK 10.68 446.25 478.27 25 1283 VSQVPAYK 10.68 446.25 577.33 251284 VSQVPAYK 10.68 446.25 705.39 25 1285 VVFAR 11.17 296.18 393.22 181286 VVFAR 11.17 296.18 417.25 18 1287 VVFAR 11.17 296.18 492.29 18 1288WDGAK 4.9 288.64 302.11 18 1289 WDGAK 4.9 288.64 390.2 18 1290 WDGAK 4.9288.64 430.17 18 1291 WDGHIYDFPDWNR 20.52 574.25 590.27 33 1292WDGHIYDFPDWNR 20.52 574.25 687.32 33 1293 WDGHIYDFPDWNR 20.52 574.25887.37 33 1294 WDGIK 12.03 309.67 359.13 19 1295 WDGIK 12.03 309.67432.25 19 1296 WDGIK 12.03 309.67 472.22 19 1297 WDGKPR 6.36 379.7457.29 22 1298 WDGKPR 6.35 379.7 572.32 22 1299 WDGKPR 6.36 379.7 584.2822 1300 WDGQTR 7.41 381.68 461.25 22 1301 WDGQTR 7.41 381.68 576.27 221302 WDGQTR 7.41 381.68 588.24 22 1303 WDGVK 10.1 302.66 359.13 18 1304WDGVK 10.1 302.66 418.23 18 1305 WDGVK 10.1 302.66 458.2 18 1306 WDGVNR10.39 373.68 445.25 21 1307 WDGVNR 10.39 373.68 560.28 21 1308 WDGVNR10.42 373.68 572.25 21 1309 YAQAK 12.58 290.66 363.17 18 1310 YAQAK12.58 290.66 417.25 18 1311 YAQAK 12.58 290.66 434.2 18 1312 YFSDFNAK14.21 496.23 681.32 27 1313 YFSDFNAK 14.21 496.23 828.39 27 1314YFSDFNAK 14.21 496.23 828.39 27 1315 YGTHLDR 8.51 431.21 641.34 24 1316YGTHLDR 8.52 431.21 687.31 24 1317 YGTHLDR 8.51 431.21 698.36 24 1318YLDELVK 15.52 440.24 488.31 24 1319 YLDELVK 15.53 440.24 603.33 24 1320YLDELVK 15.52 440.24 716.42 24 1321 YLMITEAGR 15.86 527.27 533.27 281322 YLMITEAGR 15.86 527.27 646.35 28 1323 YLMITEAGR 15.86 527.27 777.3928 1324 YLNLFSYGNANIGGGIDK 22.16 639.32 773.42 36 1325YLNLFSYGNANIGGGIDK 22.16 958.48 1015.52 47 1326 YLNLFSYGNANIGGGIDK 22.16958.48 1178.58 47 1327 YPVVWYSQQVAHHLGAQR 18.11 535.53 544.32 30 1328YPVVWYSQQVAHHLGAQR 18.11 535.53 681.38 30 1329 YPVVWYSQQVAHHLGAQR 18.11535.53 889.48 30 1330 YSNVLAFK 16.44 471.26 478.3 26 1331 YSNVLAFK 16.44471.26 691.41 26 1332 YSNVLAFK 16.44 471.26 778.45 26 1333 YSPASTFK12.22 450.73 553.3 25 1334 YSPASTFK 12.22 450.73 650.35 25 1335 YSPASTFK12.22 450.73 737.38 25 1336 YSVVPVYQQLAR 18.42 711.89 778.42 36 1337YSVVPVYQQLAR 18.42 711.89 974.54 36 1338 YSVVPVYQQLAR 18.43 711.891073.61 36 1339 YSVVWYSQLTAK 19.75 722.88 810.44 37 1340 YSVVWYSQLTAK19.76 722.88 996.51 37 1341 YSVVWYSQLTAK 19.76 722.88 1095.58 37 1342YSVVWYSQQVAHHLGAQR 18.61 533.02 544.32 30 1343 YSVVWYSQQVAHHLGAQR 18.61533.02 681.38 30 1344 YSVVWYSQQVAHHLGAQR 18.61 533.02 889.48 30 1345YTPASTFK 11.95 305.49 553.3 19 1346 YTPASTFK 11.98 457.73 553.3 25 1347YTPASTFK 11.98 457.73 650.35 25 1348 YTSAFGYGNADVSGEPGK 15.03 607.28673.35 34 1349 YTSAFGYGNADVSGEPGK 15.02 607.28 788.38 34 1350YTSAFGYGNADVSGEPGK 15.02 910.41 1030.48 45 1351 YVFVSALTGNLGSNLTSSIK23.66 691.04 906.49 39 1352 YVFVSALTGNLGSNLTSSIK 23.66 1036.06 1165.6351 1353 YVFVSALTGNLGSNLTSSIK 23.67 1036.06 1190.64 51 1354YVFVSALTGSLGSNLTSSIK 24.04 682.04 906.49 38 1355 YVFVSALTGSLGSNLTSSIK24.04 1022.55 1106.61 50 1356 YVFVSALTGSLGSNLTSSIK 24.04 1022.55 1163.6350

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the threetransitions of the same peptide are greater than or equal to 2500, thedetection of the peptide is considered to be positive and is labelled“1”. When at least one transition comprises an area less than 2500, thecorresponding peptide is considered non-detected and is labelled “0”.

EXAMPLE 25 Identification of a Resistance to ACC Beta-Lactams

Samples Sam96 to Sam101 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 31.

TABLE 31 Names Species Sam96 K. oxytoca Sam97 S. livingstone Sam98Salmonella spp Sam99 S. enterica ssp enterica Sam100 K. pneumoniaeSam101 H. alvei

Samples Sam96 to Sam101 correspond to a species able to comprise an ACCresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 32 instead of the peptides from TABLE 3.

TABLE 32 Charge Colli- state of Retention (m/z) (m/z) sion Transitionthe time filtered filtered energy Positivity number Peptide precursorFragment ion (minutes) in Q1 in Q3 (eV) threshold 1 ANIDESK 2 y4monocharged 2.45 388.69 478.21 17.9 2500 2 ANIDESK 2 y5 monocharged 2.37388.69 591.3 17.9 2500 3 ANIDESK 2 y6 monocharged 2.41 388.69 705.3417.9 2500 4 AWKPADAAGTHR 3 y9 dicharged 10.61 427.56 448.22 20.3 2500 5AWKPADAAGTHR 3 y4 monocharged 10.61 427.56 470.25 20.3 2500 6AWKPADAAGTHR 3 y10 dicharged 10.61 427.56 512.27 20.3 2500 7DEPVHVNMEILGNEAYGIK 3 y9 dicharged 20.81 710.02 482.76 29.1 2500 8DEPVHVNMEILGNEAYGIK 3 y8 monocharged 20.81 710.02 851.43 29.1 2500 9DEPVHVNMEILGNEAYGIK 3 y9 monocharged 20.81 710.02 964.51 29.1 2500 10DTVDDLIQPLMQK 3 y5 monocharged 22.36 505.93 616.35 22.8 2500 11DTVDDLIQPLMQK 2 y5 monocharged 22.36 758.39 616.35 39 2500 12DTVDDLIQPLMQK 2 y10 monocharged 22.36 758.39 1200.63 39 2500 13ILSSLEGNK 2 y6 monocharged 13.47 480.77 647.34 23.1 2500 14 ILSSLEGNK 2y7 monocharged 13.47 480.77 734.37 23.1 2500 15 ILSSLEGNK 2 y8monocharged 13.47 480.77 847.45 23.1 2500 16 LSLDQSVSHYVPELR 3 y12dicharged 20.27 581.64 715.36 25.1 2500 17 LSLDQSVSHYVPELR 3 y13dicharged 20.27 581.64 771.9 25.1 2500 18 LSLDQSVSHYVPELR 3 y14dicharged 20.27 581.64 815.42 25.1 2500 19 MGIVMLANK 2 y5 monocharged18.15 488.77 576.32 23.6 2500 20 MGIVMLANK 2 y6 monocharged 18.15 488.77675.39 23.6 2500 21 MGIVMLANK 2 y8 monocharged 18.13 488.77 845.49 23.62500 22 MQQALTATHTGYFK 3 y9 dicharged 15.01 532.93 513.26 23.6 2500 23MQQALTATHTGYFK 3 y11 dicharged 15.01 532.93 605.32 23.6 2500 24MQQALTATHTGYFK 3 y12 dicharged 15.01 532.93 669.35 23.6 2500 25NNIPGMSVAVTVNGK 2 y5 monocharged 17.45 750.9 518.29 38.5 2500 26NNIPGMSVAVTVNGK 2 y12 dicharged 17.43 750.9 580.31 38.5 2500 27NNIPGMSVAVTVNGK 2 y12 monocharged 17.43 750.9 1159.61 38.5 2500 28NTTQLMAYLK 2 y5 monocharged 19.34 591.81 625.34 29.5 2500 29 NTTQLMAYLK2 y6 monocharged 19.34 591.81 738.42 29.5 2500 30 NTTQLMAYLK 2 y8monocharged 19.36 591.81 967.53 29.5 2500 31 NYIYNYGLAAK 2 y7monocharged 16.98 645.33 736.4 32.5 2500 32 NYIYNYGLAAK 2 y8 monocharged16.98 645.33 899.46 32.5 2500 33 NYIYNYGLAAK 2 y9 monocharged 16.98645.33 1012.55 32.5 2500 34 NYSIDQR 2 y3 monocharged 10.93 448.22 418.221.3 2500 35 NYSIDQR 2 y4 monocharged 10.91 448.22 531.29 21.3 2500 36NYSIDQR 2 y5 monocharged 10.91 448.22 618.32 21.3 2500 37QPQQPVTENTLFEVGSLSK 3 y5 monocharged 20.77 701.36 491.28 28.8 2500 38QPQQPVTENTLFEVGSLSK 3 y7 monocharged 20.77 701.36 719.39 28.8 2500 39QPQQPVTENTLFEVGSLSK 3 y8 monocharged 20.79 701.36 866.46 28.8 2500 40SLGVSYEDAIEK 2 y6 monocharged 16.42 655.83 704.35 33.1 2500 41SLGVSYEDAIEK 2 y8 monocharged 16.42 655.83 954.44 33.1 2500 42SLGVSYEDAIEK 2 y10 monocharged 16.42 655.83 1110.53 33.1 2500 43SVATPIVPPLPPQENVWINK 3 y10 dicharged 22.31 733.74 612.82 29.8 2500 44SVATPIVPPLPPQENVWINK 3 y13 dicharged 22.29 733.74 766.42 29.8 2500 45SVATPIVPPLPPQENVWINK 3 y10 monocharged 22.35 733.74 1224.64 29.8 2500 46TFAATLASYAQVSGK 3 y6 monocharged 19.93 505.6 589.33 22.8 2500 47TFAATLASYAQVSGK 2 y8 monocharged 19.93 757.9 839.43 38.9 2500 48TFAATLASYAQVSGK 2 y9 monocharged 19.93 757.9 910.46 38.9 2500 49TGSTNGFGAYIAFVPAK 3 y3 monocharged 21.68 567.63 315.2 24.7 2500 50TGSTNGFGAYIAFVPAK 3 y6 monocharged 21.68 567.63 632.38 24.7 2500 51TGSTNGFGAYIAFVPAK 2 y3 monocharged 21.68 850.94 315.2 44.2 2500 52TLLPQLGMHHSYLK 3 y11 dicharged 17.99 546.63 655.84 24 2500 53TLLPQLGMHHSYLK 3 y12 dicharged 17.95 546.63 712.38 24 2500 54TLLPQLGMHHSYLK 2 y11 dicharged 17.97 819.45 655.84 42.4 2500 55 TTSSDLLR2 y4 monocharged 13 446.74 516.31 21.2 2500 56 TTSSDLLR 2 y5 monocharged13 446.74 603.35 21.2 2500 57 TTSSDLLR 2 y6 monocharged 13 446.74 690.3821.2 2500 58 VPADQMENYAWGYNK 3 y4 monocharged 17.53 595.94 481.24 25.62500 59 VPADQMENYAWGYNK 3 y5 monocharged 17.53 595.94 667.32 25.6 250060 VPADQMENYAWGYNK 3 y6 monocharged 17.53 595.94 738.36 25.6 2500 61VYSNIGTGLLGMIAAK 3 y6 monocharged 24.59 536.63 590.33 23.7 2500 62VYSNIGTGLLGMIAAK 3 y7 monocharged 24.59 536.63 703.42 23.7 2500 63VYSNIGTGLLGMIAAK 2 y11 monocharged 24.59 804.45 1031.59 41.6 2500 64YVQANMGQLK 2 y4 monocharged 13.88 576.3 445.28 28.6 2500 65 YVQANMGQLK 2y7 monocharged 13.88 576.3 761.4 28.6 2500 66 YVQANMGQLK 2 y8monocharged 13.88 576.3 889.46 28.6 2500

The other machine parameters used are as follows:

Scan type: MRM MRM planned: no Polarity: Positive Ionising source: TurboV ™  (Applied BioSystems) Q1 setting: Filtering with unit resolution Q3setting: Filtering with unit resolution Inter-scan pause: 5.00 msecScanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage: 5500.00 VSource temperature: 500.00° C. Nebulising gas: 50.00 psi Heating gas:50.00 psi Collision gas which 9.00 psi induces dissociation: Dynamicfilling: activated Declustering potential 100.00 V (DP): Entry potentialbefore 6.00 V Q0 (EP): Collision cell exit 15 V potential (CXP): Totalcycle time: 1.32 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE32, the detection of the transition is considered to be positive and islabelled “1” in TABLE 33. When a transition has an area less than thepositivity threshold described in TABLE 32, the transition is considerednon-detected and is labelled “0” in TABLE 33.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 33 Transition number Sam96 Sam97 Sam98 Sam99 Sam100 Sam101 1 0 1 11 1 0 2 0 1 1 1 1 0 3 0 1 1 1 1 0 4 1 1 1 1 1 1 5 1 1 1 1 1 1 6 1 1 1 11 1 7 1 1 1 1 1 0 8 1 1 1 1 1 0 9 1 1 1 1 1 0 10 1 1 1 1 1 0 11 1 1 1 11 0 12 1 1 1 1 1 0 13 1 1 1 1 1 0 14 1 1 1 1 1 0 15 1 1 1 1 1 0 16 1 1 11 1 1 17 1 1 1 1 1 1 18 1 1 1 1 1 1 19 1 1 1 1 1 0 20 1 1 1 1 1 0 21 1 11 1 1 0 22 1 1 1 1 1 1 23 1 1 1 1 1 1 24 1 1 1 1 1 1 25 1 1 1 1 1 1 26 11 1 1 1 1 27 1 1 1 1 1 1 28 1 1 1 1 1 0 29 1 1 1 1 1 0 30 1 1 1 1 1 0 311 1 1 1 1 0 32 1 1 1 1 1 0 33 1 1 1 1 1 0 34 1 1 1 1 1 0 35 1 1 1 1 1 036 1 1 1 1 1 0 37 1 1 1 1 1 0 38 1 1 1 1 1 0 39 1 1 1 1 1 0 40 1 1 1 1 11 41 1 1 1 1 1 1 42 1 1 1 1 1 1 43 1 1 1 1 1 1 44 1 1 1 1 1 1 45 1 1 1 11 1 46 1 1 1 1 1 0 47 1 1 1 1 1 0 48 1 1 1 1 1 0 49 1 1 1 1 1 1 50 1 1 11 1 1 51 1 1 1 1 1 1 52 1 1 1 1 1 0 53 1 1 1 1 1 0 54 1 1 1 1 1 0 55 1 11 1 1 1 56 1 1 1 1 1 1 57 1 1 1 1 1 1 58 1 0 0 0 1 0 59 1 0 0 0 1 0 60 10 0 0 1 0 61 1 1 1 1 1 1 62 1 1 1 1 1 1 63 1 1 1 1 1 1 64 1 1 1 1 1 1 651 1 1 1 1 1 66 1 1 1 1 1 1

Samples Sam96 to Sam101 comprise at least one peptide which ischaracteristic of the ACC proteins. The bacteria present in samplesSam96 to Sam101 therefore express a beta-lactamase which confers on thema resistance to penicillins and to cephalosporins, with the exception offourth-generation cephalosporins.

EXAMPLE 26 Identification of a Resistance to CMY Beta-Lactams

Samples Sam102 to Sam108 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 34.

TABLE 34 Names Species Sam102 P. mirabilis Sam103 S. senftenberg Sam104P. mirabilis Sam105 K. oxytoca Sam106 E. coli Sam107 S. enterica sspenterica Sam108 P. mirabilis

Samples Sam102 to Sam108 correspond to a species able to comprise a CMYresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 35 instead of the peptides from TABLE 3.

TABLE 35 Retention (m/z) (m/z) Collision Transition time filtered infiltered in energy Positivity number Peptide (minutes) Q1 Q3 (eV)threshold 1 AALLHFYQNWQPQWTPGAK 22.2 752.72 372.22 30.4 2500 2AALLHFYQNWQPQWTPGAK 22.1 752.72 442.74 30.4 2500 3 AALLHFYQNWQPQWTPGAK22.2 752.72 884.46 30.4 2500 4 ADIANNHPVTQQTLFELGSVSK 19.9 790.41 427.2731.6 2500 5 ADIANNHPVTQQTLFELGSVSK 19.9 790.41 719.39 31.6 2500 6ADIANNHPVTQQTLFELGSVSK 19.9 790.41 866.46 31.6 2500 7 ADSIINGSDSK 11.3553.77 493.23 27.3 2500 8 ADSIINGSDSK 11.3 553.77 607.27 27.3 2500 9ADSIINGSDSK 11.3 553.77 720.35 27.3 2500 10 ANIGGVDDK 10 444.73 533.2621.1 2500 11 ANIGGVDDK 10 444.73 590.28 21.1 2500 12 ANIGGVDDK 10.1444.73 703.36 21.1 2500 13 ASWVHK 9.3 364.2 383.24 16.5 2500 14 ASWVHK9.3 364.2 569.32 16.5 2500 15 ASWVHK 9.3 364.2 656.35 16.5 2500 16DYAWGYR 15.6 465.71 395.2 22.3 2500 17 DYAWGYR 15.6 465.71 581.28 22.32500 18 DYAWGYR 15.6 465.71 652.32 22.3 2500 19 ESGSQVLFNK 14.5 554.79408.22 27.4 2500 20 ESGSQVLFNK 14.5 554.79 521.31 27.4 2500 21ESGSQVLFNK 14.5 554.79 620.38 27.4 2500 22 GAMQLDDK 11.4 439.21 490.2520.8 2500 23 GAMQLDDK 11.4 439.21 618.31 20.8 2500 24 GAMQLDDK 11.4439.21 749.35 20.8 2500 25 GIGIVMLANR 19.9 522.31 604.32 25.5 2500 26GIGIVMLANR 19.9 522.31 703.39 25.5 2500 27 GIGIVMLANR 19.9 522.31 873.525.5 2500 28 IGDMYQGLGWEMLNWPLK 27.9 717.69 357.25 29.3 2500 29IGDMYQGLGWEMLNWPLK 27.9 717.69 657.37 29.3 2500 30 IGDMYQGLGWEMLNWPLK27.9 717.69 901.5 29.3 2500 31 IPGMAVAVLK 19.3 499.81 600.41 24.2 250032 IPGMAVAVLK 19.3 499.81 788.47 24.2 2500 33 IPGMAVAVLK 19.3 499.81885.52 24.2 2500 34 LAHTWITVPQNEQK 16.5 832.94 743.37 43.2 2500 35LAHTWITVPQNEQK 16.5 832.94 943.48 43.2 2500 36 LAHTWITVPQNEQK 16.5832.94 1242.65 43.2 2500 37 LLHLATYTAGGLPLQIPDDVR 22.8 755.09 526.7930.5 2500 38 LLHLATYTAGGLPLQIPDDVR 23 755.09 601.29 30.5 2500 39LLHLATYTAGGLPLQIPDDVR 23 755.09 1052.57 30.5 2500 40 LSDPVTK 11.1 380.22444.28 17.4 2500 41 LSDPVTK 11.1 380.22 559.31 17.4 2500 42 LSDPVTK 11.1380.22 646.34 17.4 2500 43 NLGIVMLANK 19.6 536.81 576.32 26.3 2500 44NLGIVMLANK 19.6 536.81 675.39 26.3 2500 45 NLGIVMLANK 19.6 536.81 845.4926.3 2500 46 QAMASYAYGYSK 14.1 670.3 454.23 33.9 2500 47 QAMASYAYGYSK14.2 670.3 617.29 33.9 2500 48 QAMASYAYGYSK 14.1 670.3 688.33 33.9 250049 QWAPVYSPGSHR 14.7 692.84 553.28 35.2 2500 50 QWAPVYSPGSHR 14.8 692.84640.32 35.2 2500 51 QWAPVYSPGSHR 14.8 692.84 999.5 35.2 2500 52 QWQGIR13.1 394.21 345.22 18.2 2500 53 QWQGIR 13.1 394.21 473.28 18.2 2500 54QWQGIR 13.1 394.21 659.36 18.2 2500 55 SSVIDMAR 14.3 439.72 492.22 20.82500 56 SSVIDMAR 14.3 439.72 605.31 20.8 2500 57 SSVIDMAR 14.3 439.72704.38 20.8 2500 58 SYPNPVR 11.6 416.72 371.24 19.5 2500 59 SYPNPVR 11.6416.72 485.28 19.5 2500 60 SYPNPVR 11.6 416.72 582.34 19.5 2500 61TEQQIADIVNR 15.8 643.84 616.34 32.4 2500 62 TEQQIADIVNR 15.8 643.84687.38 32.4 2500 63 TEQQIADIVNR 15.8 643.84 800.46 32.4 2500 64TFNGVLGGDAIAR 17.9 645.84 602.33 32.5 2500 65 TFNGVLGGDAIAR 17.9 645.84659.35 32.5 2500 66 TFNGVLGGDAIAR 17.9 645.84 772.43 32.5 2500 67TITPLMQEQAIPGMAVAVIYQGK 24.9 820.44 617.34 32.5 2500 68TITPLMQEQAIPGMAVAVIYQGK 25 820.44 778.45 32.5 2500 69TITPLMQEQAIPGMAVAVIYQGK 24.9 820.44 1233.67 32.5 2500 70 TLQQGIALAQSR15.5 643.37 574.33 32.4 2500 71 TLQQGIALAQSR 15.5 643.37 645.37 32.42500 72 TLQQGIALAQSR 15.5 643.37 815.47 32.4 2500 73 TLTATLGAYAVVK 19.7654.38 707.41 33 2500 74 TLTATLGAYAVVK 19.7 654.38 820.49 33 2500 75TLTATLGAYAVVK 19.7 654.38 921.54 33 2500 76 VALAALPAVEVNPPAPAVK 21.1609.7 644.87 26 2500 77 VALAALPAVEVNPPAPAVK 21 609.7 679.41 26 2500 78VALAALPAVEVNPPAPAVK 21 609.7 793.46 26 2500 79 VEAAWR 12 366.2 432.2416.6 2500 80 VEAAWR 12 366.2 503.27 16.6 2500 81 VEAAWR 12 366.2 632.3216.6 2500 82 VLQPLK 13.1 349.23 357.25 15.6 2500 83 VLQPLK 13.1 349.23485.31 15.6 2500 84 VLQPLK 13 349.23 598.39 15.6 2500 85 VNPGMLADEAYGIK18.8 739.37 632.82 37.9 2500 86 VNPGMLADEAYGIK 18.9 739.37 795.39 37.92500 87 VNPGMLADEAYGIK 18.9 739.37 866.43 37.9 2500 88 WVQANMDASHVQEK13.4 548.26 615.28 24.1 2500 89 WVQANMDASHVQEK 13.4 548.26 679.31 24.12500 90 WVQANMDASHVQEK 13.4 548.26 728.85 24.1 2500 91 YWPELTGK 17.8497.26 305.18 24.1 2500 92 YWPELTGK 17.8 497.26 418.27 24.1 2500 93YWPELTGK 17.8 497.26 644.36 24.1 2500

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™  (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 50.00 psiHeating gas: 50.00 psi Collision gas which 9.00 psi inducesdissociation: Dynamic filling: activated Declustering potential 100.00 V(DP): Entry potential before 6.00 V Q0 (EP): Collision cell exit 15 Vpotential (CXP): Total cycle time: 0.04 sec Detection window: 120 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE35, the detection of the transition is considered to be positive and islabelled “1” in TABLE 36. When a transition has an area less than thepositivity threshold described in TABLE 35, the transition is considerednon-detected and is labelled “0” in TABLE 36.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 36 Tran- sition num- ber Sam102 Sam103 Sam104 Sam105 Sam106 Sam107Sam108 1 0 0 0 1 0 0 1 2 0 0 0 1 0 0 1 3 0 0 0 1 0 0 1 4 0 0 0 0 1 0 0 50 0 0 0 1 0 0 6 0 0 0 0 1 0 0 7 1 1 1 1 1 1 1 8 1 1 1 1 1 1 1 9 1 1 1 11 1 1 10 0 0 0 0 0 0 0 11 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 13 1 1 1 1 1 11 14 1 1 1 1 1 1 1 15 1 1 1 1 1 1 1 16 0 1 0 1 1 1 0 17 0 1 0 1 1 1 0 180 1 0 1 1 1 0 19 0 0 0 1 0 0 0 20 0 0 0 1 0 0 0 21 0 0 0 1 0 0 0 22 0 00 0 0 0 1 23 0 0 0 0 0 0 1 24 0 0 0 0 0 0 1 25 0 0 0 0 0 0 0 26 0 0 0 00 0 0 27 0 0 0 0 0 0 0 28 0 0 0 1 0 0 0 29 0 0 0 1 0 0 0 30 0 0 0 1 0 00 31 0 0 0 0 0 0 0 32 0 0 0 0 0 0 0 33 0 0 0 0 0 0 0 34 1 1 1 1 1 1 1 351 1 1 1 1 1 1 36 1 1 1 1 1 1 1 37 0 0 0 0 0 0 0 38 0 0 0 0 0 0 0 39 0 00 0 0 0 0 40 1 1 1 1 0 1 1 41 1 1 1 1 0 1 1 42 1 1 1 1 0 1 1 43 1 1 1 11 1 1 44 1 1 1 1 1 1 1 45 1 1 1 1 1 1 1 46 0 0 0 0 0 0 0 47 0 0 0 0 0 00 48 0 0 0 0 0 0 0 49 0 0 0 0 0 0 0 50 0 0 0 0 0 0 0 51 0 0 0 0 0 0 0 521 1 1 1 1 1 1 53 1 1 1 1 1 1 1 54 1 1 1 1 1 1 1 55 1 1 1 1 1 1 1 56 1 11 1 1 1 1 57 1 1 1 1 1 1 1 58 0 1 1 1 1 0 1 59 0 1 1 1 1 0 1 60 0 1 1 11 0 1 61 1 1 1 1 1 1 1 62 1 1 1 1 1 1 1 63 1 1 1 1 1 1 1 64 1 1 1 1 1 11 65 1 1 1 1 1 1 1 66 1 1 1 1 1 1 1 67 1 0 0 0 0 1 0 68 1 0 0 0 0 1 0 691 0 0 0 0 1 0 70 1 1 1 1 1 1 1 71 1 1 1 1 1 1 1 72 1 1 1 1 1 1 1 73 0 00 0 0 0 0 74 0 0 0 0 0 0 0 75 0 0 0 0 0 0 0 76 1 1 1 1 1 1 1 77 1 1 1 11 1 1 78 1 1 1 1 1 1 1 79 1 1 1 1 1 1 1 80 1 1 1 1 1 1 1 81 1 1 1 1 1 11 82 1 1 1 1 1 1 1 83 1 1 1 1 1 1 1 84 1 1 1 1 1 1 1 85 0 0 1 0 1 1 1 860 0 1 0 1 1 1 87 0 0 1 0 1 1 1 88 1 1 1 1 1 1 1 89 1 1 1 1 1 1 1 90 1 11 1 1 1 1 91 1 1 1 1 0 1 1 92 1 1 1 1 0 1 1 93 1 1 1 1 0 1 1

Samples Sam102 to Sam108 comprise at least one peptide which ischaracteristic of the CMY proteins. The bacteria present in samplesSam102 to Sam108 therefore express a beta-lactamase which confers onthem a resistance to penicillins and to cephalosporins, with theexception of fourth-generation cephalosporins.

EXAMPLE 27 Identification of a Resistance to CTX-M Beta-Lactams

Samples Sam109 to Sam118 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 37.

TABLE 37 Names Species Sam109 E. aerogenes Sam110 E. coli Sam111 E. coliSam112 E. coli Sam113 E. coli Sam114 K. pneumoniae Sam115 K. pneumoniaeSam116 P. mirabilis Sam117 Salmonella spp Sam118 Salmonella spp

Samples Sam109 to Sam118 correspond to a species able to comprise aCTX-M resistance mechanism. Each sample is treated according to example5, then analysed according to example 6 by detecting the peptides fromTABLE 38 instead of the peptides from TABLE 3.

TABLE 38 Charge Charge (m/z) Tran- state state of Retention (m/z)filtered Collision sition of the the Fragment time filtered in energyPositivity number Peptide precursor fragment ion (minutes) in Q1 Q3 (eV)threshold 1 AGLPK 2 1 y4 8.4 243.16 414.27 9.6 3000 2 AGLPK 2 1 y3 8.4243.16 357.25 9.6 3000 3 AGLPK 2 2 y3 8.4 243.16 179.13 9.6 3000 4AGLPTSWTVGDK 2 1 y9 18 616.32 990.49 30.9 2000 5 AGLPTSWTVGDK 2 1 y7 18616.32 792.39 30.9 2000 6 AGLPTSWTVGDK 2 2 y9 17.9 616.32 495.75 30.92000 7 AIGDETFR 2 1 y6 13.5 454.73 724.33 21.7 2000 8 AIGDETFR 2 1 y513.5 454.73 667.31 21.7 2000 9 AIGDETFR 2 1 y4 13.5 454.73 552.28 21.72000 10 ALAETQR 2 1 y5 7.5 394.72 604.31 18.2 2000 11 ALAETQR 2 1 y4 7.5394.72 533.27 18.2 2000 12 ALAETQR 2 2 y6 7.5 394.72 359.2 18.2 2000 13ALGDSQR 2 1 y5 3.5 373.69 562.26 17 2000 14 ALGDSQR 2 1 y3 3.6 373.69390.21 17 2000 15 ALGDSQR 2 2 y6 3.5 373.69 338.18 17 2000 16 AMAQTLR 21 y5 10.7 395.72 588.35 18.3 2000 17 AMAQTLR 2 1 y4 10.7 395.72 517.3118.3 2000 18 AMAQTLR 2 1 y3 10.7 395.72 389.25 18.3 2000 19APLILVTYFTQPQPK 2 1 y10 24.6 858.49 1208.63 44.7 2000 20 APLILVTYFTQPQPK3 1 y6 24.6 572.66 698.38 24.8 2000 21 APLILVTYFTQPQPK 3 1 y4 24.6572.66 469.28 24.8 2000 22 APLVLVTYFTQPQQNAESR 3 1 y8 23.6 721.38 929.4429.4 2000 23 APLVLVTYFTQPQQNAESR 3 1 y6 23.6 721.38 704.33 29.4 2000 24APLVLVTYFTQPQQNAESR 3 2 y8 23.6 721.38 465.23 29.4 2000 25 AQLVTWLK 2 1y6 20 479.79 759.48 23.1 2000 26 AQLVTWLK 2 1 y5 20 479.79 646.39 23.12000 27 AQLVTWLK 2 1 y4 20 479.79 547.32 23.1 2000 28 AQLVTWMK 2 1 y618.5 488.77 777.43 23.6 2000 29 AQLVTWMK 2 1 y5 18.6 488.77 664.35 23.62000 30 AQLVTWMK 2 1 y4 18.5 488.77 565.28 23.6 2000 31 DILAAAAK 2 1 y614.1 386.73 544.35 17.8 2000 32 DILAAAAK 2 1 y5 14.1 386.73 431.26 17.82000 33 DILAAAAK 2 1 y4 14.1 386.73 360.22 17.8 2000 34 DTTSPR 2 1 y5 1338.67 561.3 15 2000 35 DTTSPR 2 1 y4 1 338.67 460.25 15 2000 36 DTTSPR2 1 y3 1 338.67 359.2 15 2000 37 DTTTPLAMAQTLK 2 1 y9 19.4 695.87 972.5635.4 2000 38 DTTTPLAMAQTLK 2 1 y7 19.4 695.87 762.42 35.4 2000 39DTTTPLAMAQTLK 2 2 y9 19.4 695.87 486.78 35.4 2000 40 DTTTPR 2 1 y5 1345.67 575.32 15.4 2000 41 DTTTPR 2 1 y4 1 345.67 474.27 15.4 2000 42DTTTPR 2 1 y3 1 345.67 373.22 15.4 2000 43 DVLAAAAK 2 1 y6 12.2 379.72544.35 17.4 2000 44 DVLAAAAK 2 1 y5 12.2 379.72 431.26 17.4 2000 45DVLAAAAK 2 1 y4 12.2 379.72 360.22 17.4 2000 46 DVLASAAK 2 1 y6 11.4387.72 560.34 17.8 2000 47 DVLASAAK 2 1 y5 11.4 387.72 447.26 17.8 200048 DVLASAAK 2 1 y4 11.4 387.72 376.22 17.8 2000 49 DVLASAAR 2 1 y6 11.9401.73 588.35 18.6 2000 50 DVLASAAR 2 1 y5 11.9 401.73 475.26 18.6 200051 DVLASAAR 2 1 y4 11.9 401.73 404.23 18.6 2000 52 FAMCSTSK 2 1 y7 11.6466.2 784.33 22.3 2000 53 FAMCSTSK 2 1 y6 11.6 466.2 713.3 22.3 2000 54FAMCSTSK 2 1 y5 11.6 466.2 582.26 22.3 2000 55 FPMCSTSK 2 1 y7 12.3479.21 810.35 23.1 2000 56 FPMCSTSK 2 1 y6 12.3 479.21 713.3 23.1 200057 FPMCSTSK 2 2 y7 12.3 479.21 405.68 23.1 2000 58GNTTGAASIQAGLPASWVVGDK 3 1 y9 21.1 700.7 958.5 29.1 2000 59GNTTGAASIQAGLPASWVVGDK 3 1 y7 21.1 700.7 790.41 29.1 2000 60GNTTGAASIQAGLPASWVVGDK 3 2 y9 21.2 700.7 479.75 29.1 2000 61GNTTGAASIQAGLPTSWVVGDK 3 1 y9 21.3 710.7 988.51 29.1 8500 62GNTTGAASIQAGLPTSWVVGDK 3 2 y9 21.3 710.7 494.76 29.1 8500 63GNTTGAASIQAGLPTSWVVGDK 3 1 y3 21.3 710.7 319.16 29.1 8500 64 GNTTGAASIR2 1 y7 9.3 474.25 675.38 22.8 2000 65 GNTTGAASIR 2 1 y6 9.3 474.25574.33 22.8 2000 66 GNTTGAASIR 2 1 y4 9.3 474.25 446.27 22.8 2000 67GNTTGSASIR 2 1 y8 8 482.25 792.42 23.2 2000 68 GNTTGSASIR 2 1 y7 8482.25 691.37 23.2 2000 69 GNTTGSASIR 2 1 y6 8 482.25 590.33 23.2 200070 HLLNQR 2 1 y5 8.1 390.73 643.39 18 2000 71 HLLNQR 2 1 y4 8.1 390.73530.31 18 2000 72 HLLNQR 2 1 y3 8.1 390.73 417.22 18 2000 73 LAALEK 2 1y5 11.3 322.7 531.31 14.1 2000 74 LAALEK 2 1 y4 11.3 322.7 460.28 14.12000 75 LAALEK 2 1 y3 11.3 322.7 389.24 14.1 2000 76 LAELER 2 1 y5 11.7365.71 617.33 16.6 2000 77 LAELER 2 1 y4 11.7 365.71 546.29 16.6 2000 78LAELER 2 1 y3 11.7 365.71 417.25 16.6 2000 79 LGVALIDTADNTQVLYR 3 1 y621.5 621.34 779.44 26.3 2000 80 LGVALIDTADNTQVLYR 3 1 y5 21.5 621.34678.39 26.3 2000 81 LGVALIDTADNTQVLYR 3 1 y4 21.5 621.34 550.34 26.32000 82 LGVALIDTADNTQVLYR 3 1 y3 21.4 621.34 451.27 26.3 2000 83LGVALINTADNSQILYR 3 1 y6 21.4 621.01 779.44 26.3 2000 84LGVALINTADNSQILYR 3 1 y5 21.4 621.01 692.41 26.3 2000 85LGVALINTADNSQILYR 3 1 y4 21.4 621.01 564.35 26.3 2000 86LGVALINTADNSQILYR 3 1 y3 21.4 621.01 451.27 26.3 2000 87 LIAHLGGPDK 3 1y6 13.2 340.87 586.32 17.6 2000 88 LIAHLGGPDK 3 2 y9 13.2 340.87 454.2517.6 2000 89 LIAHLGGPDK 3 2 y8 13.2 340.87 397.71 17.6 2000 90LIAHVGGPASVTAFAR 3 1 y5 17.7 522.96 565.31 23.3 2000 91 LIAHVGGPASVTAFAR3 1 y4 17.7 522.96 464.26 23.3 2000 92 LIAHVGGPASVTAFAR 3 1 y3 17.7522.96 393.22 23.3 2000 93 LIAQLGGPGGVTAFAR 2 1 y11 20.3 764.44 989.5239.3 2000 94 LIAQLGGPGGVTAFAR 2 1 y9 20.3 764.44 875.47 39.3 2000 95LIAQLGGPGGVTAFAR 3 1 y5 20.3 509.96 565.31 22.9 2000 96 NLTLGK 2 1 y512.3 323.2 531.35 14.2 2000 97 NLTLGK 2 1 y4 12.3 323.2 418.27 14.2 200098 NLTLGK 2 1 y3 12.3 323.2 317.22 14.2 2000 99 QLGDETFR 2 1 y6 13.6483.24 724.33 23.3 2000 100 QLGDETFR 2 1 y4 13.6 483.24 552.28 23.3 2000101 QLGDETFR 2 1 y3 13.6 483.24 423.24 23.3 2000 102 QLTLGHALGETQR 3 2y11 15.6 475.26 591.82 21.8 2000 103 QLTLGHALGETQR 3 1 y5 15.6 475.26590.29 21.8 2000 104 QLTLGHALGETQR 3 2 y10 15.6 475.26 541.29 21.8 2000105 QSESDK 2 1 y5 0.8 347.16 565.25 15.5 2000 106 QSESDK 2 1 y4 0.8347.16 478.21 15.5 2000 107 QSESDK 2 1 y3 0.8 347.16 349.17 15.5 2000108 QSETQK 2 1 y5 0.8 360.68 592.29 16.3 2000 109 QSETQK 2 1 y4 0.8360.68 505.26 16.3 2000 110 QSETQK 2 1 y3 0.8 360.68 376.22 16.3 2000111 QSGGR 2 1 y4 0.7 252.63 376.19 10.1 2000 112 QSGGR 2 1 y3 0.7 252.63289.16 10.1 2000 113 QSGGR 2 2 y4 0.7 252.63 188.6 10.1 2000 114SDLVNYNPIAEK 2 1 y8 17.3 681.85 948.48 34.6 2000 115 SDLVNYNPIAEK 2 1 y617.4 681.85 671.37 34.6 2000 116 SDLVNYNPIAEK 2 1 y5 17.4 681.85 557.3334.6 2000 117 SESEPNLLNQR 2 1 y7 14.6 643.82 854.48 32.4 2000 118SESEPNLLNQR 2 2 y7 14.6 643.82 427.75 32.4 2000 119 SESEPNLLNQR 3 1 y314.6 429.55 417.22 20.4 2000 120 SLGDETFR 2 1 y6 13.9 462.73 724.33 22.12000 121 SLGDETFR 2 1 y5 13.8 462.73 667.31 22.1 2000 122 SLGDETFR 2 1y4 13.9 462.73 552.28 22.1 2000 123 SSGGR 2 1 y4 0.7 232.12 376.19 92000 124 SSGGR 2 1 y3 0.7 232.12 289.16 9 2000 125 SSGGR 2 2 y4 0.7232.12 188.6 9 2000 126 SWVVGDK 2 1 y5 13.9 395.71 517.3 18.3 2000 127SWVVGDK 2 1 y4 13.9 395.71 418.23 18.3 2000 128 SWVVGDK 2 1 y3 13.9395.71 319.16 18.3 2000 129 TEPTLNTAIPGDPR 2 2 y12 16.3 741.38 626.34 382000 130 TEPTLNTAIPGDPR 2 1 y5 16.3 741.38 541.27 38 2000 131TEPTLNTAIPGDPR 3 1 y5 16.3 494.59 541.27 22.4 2000 132TGSGDYGTTNDIAVIWPK 2 1 y8 20.9 947.96 941.55 49.8 2000 133TGSGDYGTTNDIAVIWPK 3 2 y6 21 632.31 357.22 26.7 2000 134TGSGDYGTTNDIAVIWPK 3 2 y5 20.9 632.31 321.7 26.7 2000 135TGSGDYGTTNDIAVIWPQGR 3 1 y6 20.5 703.34 756.42 28.9 2000 136TGSGDYGTTNDIAVIWPQGR 3 1 y5 20.5 703.34 643.33 28.9 2000 137TGSGDYGTTNDIAVIWPQGR 3 1 y4 20.5 703.34 457.25 28.9 2000 138TGSGGYGTTNDIAVIWPK 2 1 y3 20.9 918.96 430.25 48.1 2000 139TGSGGYGTTNDIAVIWPK 3 1 y6 20.9 612.98 713.43 26.1 2000 140TGSGGYGTTNDIAVIWPK 3 1 y5 20.9 612.98 642.4 26.1 2000 141 VMAAAAVLK 2 1y8 15.7 437.27 774.45 20.7 2000 142 VMAAAAVLK 2 1 y7 15.7 437.27 643.4120.7 2000 143 VMAAAAVLK 2 1 y6 15.7 437.27 572.38 20.7 2000 144VMAVAAVLK 2 1 y7 18.2 451.28 671.45 21.5 2000 145 VMAVAAVLK 2 1 y6 18.2451.28 600.41 21.5 2000 146 VMAVAAVLK 2 1 y5 18.2 451.28 501.34 21.52000 147 VTAFAR 2 1 y5 11 332.69 565.31 14.7 2000 148 VTAFAR 2 1 y4 11332.69 464.26 14.7 2000 149 VTAFAR 2 1 y3 11 332.69 393.22 14.7 2000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™  (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 50.00 psiHeating gas: 50.00 psi Collision gas which 9.00 psi inducesdissociation: Dynamic filling: activated Declustering potential 100.00 V(DP): Entry potential before 6.00 V Q0 (EP): Collision cell exit 15 Vpotential (CXP): Total cycle time: 0.04 sec Detection window: 120 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE38, the detection of the transition is considered to be positive and islabelled “1” in TABLE 39. When a transition has an area less than thepositivity threshold described in TABLE 38, the transition is considerednon-detected and is labelled “0” in TABLE 39.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 39 Transition number Sam109 Sam110 Sam111 Sam112 Sam113 Sam114Sam115 Sam116 Sam117 Sam118 1 0 0 0 0 0 0 0 0 1 0 2 1 1 0 0 1 0 0 0 1 13 1 1 0 0 1 0 0 0 1 1 4 0 0 0 0 0 0 0 1 0 0 5 0 0 0 0 0 0 0 0 0 0 6 0 00 0 0 0 0 1 0 0 7 0 1 0 0 1 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 00 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 11 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 00 0 0 13 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 00 16 1 1 1 1 1 0 1 1 0 1 17 1 1 1 1 1 0 1 1 0 1 18 1 1 1 1 1 0 1 1 0 119 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 220 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 25 1 10 0 1 0 1 0 1 0 26 1 1 1 0 1 1 1 1 1 0 27 1 1 0 0 1 0 1 0 1 0 28 0 0 0 00 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 30 1 1 0 0 1 0 1 0 0 0 31 0 1 1 0 1 00 0 1 1 32 0 0 0 0 0 0 0 0 0 0 33 0 0 0 0 0 0 0 0 0 0 34 0 0 0 0 0 0 0 00 0 35 0 0 0 0 0 0 0 0 0 0 36 0 0 0 0 0 0 0 0 0 0 37 0 0 0 0 0 0 0 1 1 038 0 0 0 0 0 0 0 1 1 0 39 0 0 0 0 0 0 0 0 1 0 40 0 0 0 0 1 0 0 0 0 0 410 0 0 0 1 0 1 0 0 1 42 0 0 0 0 0 0 0 0 0 1 43 1 0 0 0 0 0 0 0 1 0 44 1 00 0 0 0 0 0 1 0 45 1 0 0 0 0 0 0 0 1 0 46 1 0 0 0 0 0 0 0 0 1 47 1 0 0 00 0 0 0 0 1 48 0 0 0 0 1 0 0 0 0 1 49 0 1 0 0 1 0 1 0 0 0 50 0 1 0 0 1 01 0 0 0 51 0 1 0 0 1 0 1 0 0 0 52 1 0 1 1 0 1 0 1 1 1 53 1 0 1 1 0 1 0 11 1 54 1 0 1 1 1 1 1 1 1 1 55 0 0 0 0 1 0 0 0 0 0 56 0 0 0 0 1 0 0 0 0 057 0 0 0 0 1 0 0 0 0 0 58 0 0 0 0 0 0 0 0 0 1 59 0 0 0 0 0 0 0 0 0 0 600 0 0 0 0 0 0 0 0 1 61 1 0 0 0 0 0 0 0 0 0 62 1 0 0 0 0 0 0 0 0 0 63 1 00 0 0 0 0 0 0 0 64 0 1 0 0 1 1 1 0 0 0 65 0 1 0 0 1 1 1 0 0 0 66 0 1 0 01 1 1 0 0 0 67 0 0 0 0 0 0 0 0 1 0 68 0 0 0 0 0 0 0 0 1 0 69 0 0 0 0 0 00 0 1 0 70 0 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0 1 0 0 1 0 72 0 0 0 0 0 0 0 01 0 73 1 1 0 0 1 1 0 0 0 1 74 1 1 0 1 1 1 1 0 0 0 75 1 1 0 0 1 1 1 0 0 176 0 0 1 1 0 0 0 1 0 1 77 0 0 1 1 0 0 0 1 0 1 78 0 0 1 1 0 0 0 1 0 1 790 0 0 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 0 0 81 0 0 0 0 0 0 0 0 0 0 82 0 00 0 0 0 0 0 0 0 83 0 0 0 0 0 0 0 0 0 0 84 0 0 0 0 0 0 0 0 0 0 85 0 0 0 00 0 0 0 0 0 86 0 0 0 0 0 0 0 0 0 0 87 1 0 0 0 0 1 0 0 1 0 88 1 0 0 0 0 10 0 1 0 89 1 0 0 0 0 1 1 0 1 0 90 0 0 0 0 0 1 0 0 0 0 91 0 0 0 0 0 1 1 00 0 92 0 0 0 0 0 1 1 0 0 0 93 0 0 0 0 0 0 0 0 0 0 94 0 0 0 0 0 0 0 1 0 095 0 0 0 0 0 0 0 0 0 0 96 0 0 0 0 0 0 0 0 0 0 97 0 0 0 0 0 0 0 0 0 0 980 0 0 0 0 0 0 0 0 0 99 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1 0 101 00 0 0 0 0 0 0 0 0 102 0 1 0 0 1 0 1 0 0 0 103 0 1 0 0 1 1 1 1 0 1 104 01 0 0 1 1 1 0 0 0 105 0 0 0 0 0 0 0 0 0 0 106 0 0 0 0 0 0 0 0 0 0 107 00 0 0 0 0 0 0 0 0 108 0 0 0 0 0 0 0 0 0 0 109 0 0 0 0 0 0 0 0 0 0 110 00 0 0 0 0 0 0 0 0 111 0 0 0 0 0 0 0 0 0 0 112 0 0 0 0 0 0 0 0 0 0 113 00 0 0 0 0 0 0 0 0 114 0 0 1 1 0 0 0 1 1 1 115 0 1 1 1 0 0 0 1 1 1 116 00 1 1 0 0 0 1 1 1 117 0 0 0 0 0 0 0 0 0 1 118 0 0 0 0 0 0 0 0 0 1 119 00 0 1 0 0 0 0 0 1 120 0 0 0 0 0 0 0 0 0 0 121 0 0 0 0 0 0 0 0 0 0 122 00 0 0 0 0 0 0 0 0 123 0 0 0 0 0 0 0 0 0 0 124 0 0 0 0 0 0 0 0 0 0 125 00 0 0 0 0 0 0 0 0 126 0 0 0 0 0 0 0 0 0 0 127 0 0 0 0 0 0 0 0 0 0 128 00 0 0 0 0 0 0 0 0 129 1 1 0 1 1 1 1 1 1 1 130 1 1 0 1 1 1 1 1 1 1 131 11 0 1 1 1 1 1 1 1 132 0 0 0 0 0 0 0 0 0 0 133 0 0 0 0 0 0 0 0 0 0 134 00 0 0 0 0 0 0 0 0 135 1 1 0 0 1 0 1 0 0 0 136 1 1 1 0 1 0 1 0 0 0 137 01 0 0 1 0 1 0 0 0 138 0 0 0 1 0 0 0 0 0 1 139 1 0 0 1 0 0 0 0 0 1 140 10 0 0 0 0 0 0 0 1 141 1 1 0 1 1 1 1 1 1 1 142 1 1 0 1 1 1 1 1 1 1 143 11 0 1 1 1 1 1 1 1 144 0 0 1 0 0 0 0 0 0 0 145 0 0 1 0 0 0 0 0 0 0 146 00 1 0 0 0 0 0 0 0 147 0 0 0 0 0 0 0 0 0 0 148 0 0 0 0 0 0 0 0 0 0 149 00 0 0 0 0 0 0 0 0

Samples Sam109 to Sam118 comprise at least one peptide which ischaracteristic of the CTX-M proteins. The bacteria present in samplesSam109 to Sam118 therefore express a beta-lactamase which confers onthem a resistance to penicillins, to cephalosporins and to monobactams.

EXAMPLE 28 Identification of a Resistance to DHA Beta-Lactams

Samples Sam119 to Sam124 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 40.

TABLE 40 Names Species Sam119 E. coli Sam120 K. oxytoca Sam121 K.pneumoniae Sam122 K. pneumoniae Sam123 K. pneumoniae Sam124 K.pneumoniae

Samples Sam119 to Sam124 correspond to a species able to comprise a DHAresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 41 instead of the peptides from TABLE 3.

TABLE 41 Charge state Retention (m/z) (m/z) Collision Transition of thetime filtered filtered energy Positivity number Peptide precursorFragment ion (minutes) in Q1 in Q3 (eV) threshold 1 AAQAILSALEMK 2 y8monocharged 21.45 623.35 904.52 31.3 2500 2 AAQAILSALEMK 2 y7monocharged 21.45 623.35 791.43 31.3 2500 3 AAQAILSALEMK 2 y6monocharged 21.45 623.35 678.35 31.3 2500 4 ADLLNFYQQWQPSR 2 y3monocharged 22.92 883.44 359.2 46.1 2500 5 ADLLNFYQQWQPSR 3 y5monocharged 22.92 589.29 673.34 25.4 2500 6 ADLLNFYQQWQPSR 3 y3monocharged 22.92 589.29 359.2 25.4 2500 7 AGNADLEMAMYLAQTR 3 y6monocharged 21.53 585.61 751.41 25.2 2500 8 AGNADLEMAMYLAQTR 3 y5monocharged 21.53 585.61 588.35 25.2 2500 9 AGNADLEMAMYLAQTR 3 y4monocharged 21.53 585.61 475.26 25.2 2500 10 EMALNDPAAK 2 y8 monocharged13.12 530.26 799.43 26 2500 11 EMALNDPAAK 2 y6 monocharged 13.12 530.26615.31 26 2500 12 EMALNDPAAK 2 y4 monocharged 13.12 530.26 386.24 262500 13 GKPYYFNYGFADIQAK 3 y8 monocharged 19.85 627.98 849.45 26.5 250014 GKPYYFNYGFADIQAK 3 y6 monocharged 19.85 627.98 645.36 26.5 2500 15GKPYYFNYGFADIQAK 3 y5 monocharged 19.85 627.98 574.32 26.5 2500 16NYPNTER 2 y5 monocharged 7.63 447.21 616.31 21.2 2500 17 NYPNTER 2 y3monocharged 7.63 447.21 405.21 21.2 2500 18 NYPNTER 2 y5 dicharged 7.63447.21 308.66 21.2 2500 19 QPVTENTLFELGSVSK 2 y8 monocharged 20.9 874.96866.46 45.6 2500 20 QPVTENTLFELGSVSK 3 y8 monocharged 20.9 583.64 866.4625.2 2500 21 QPVTENTLFELGSVSK 3 y5 monocharged 20.9 583.64 477.27 25.22500 22 QVAIVILANK 2 y8 monocharged 18.75 534.84 841.55 26.2 2500 23QVAIVILANK 2 y6 monocharged 18.75 534.84 657.43 26.2 2500 24 QVAIVILANK2 y5 monocharged 18.75 534.84 558.36 26.2 2500 25 TFTGVLGAVSVAK 2 y11monocharged 20.03 625.36 1001.6 31.4 2500 26 TFTGVLGAVSVAK 2 y8monocharged 20.03 625.36 744.46 31.4 2500 27 TFTGVLGAVSVAK 2 y7monocharged 20.03 625.36 631.38 31.4 2500 28 TGATTGFGAYVAFIPEK 2 y3monocharged 22.12 865.44 373.21 45.1 2500 29 TGATTGFGAYVAFIPEK 3 y6monocharged 22.12 577.3 704.4 25 2500 30 TGATTGFGAYVAFIPEK 3 y3monocharged 22.12 577.3 373.21 25 2500 31 VSPGQLDAESYGVK 2 y8monocharged 15.43 725.37 868.41 37.1 2500 32 VSPGQLDAESYGVK 2 y13dicharged 15.43 725.37 675.83 37.1 2500 33 VSPGQLDAESYGVK 2 y12dicharged 15.43 725.37 632.31 37.1 2500 34 WAEMNMEPSR 2 y8 monocharged15.78 625.77 993.41 31.4 2500 35 WAEMNMEPSR 2 y6 monocharged 15.78625.77 733.33 31.4 2500 36 WAEMNMEPSR 2 y3 monocharged 15.78 625.77359.2 31.4 2500 37 YQPELALPQWK 2 y4 monocharged 20.97 686.87 558.3 34.92500 38 YQPELALPQWK 2 y9 dicharged 20.97 686.87 541.31 34.9 2500 39YQPELALPQWK 3 y4 monocharged 20.97 458.25 558.3 21.3 2500

The other machine parameters used are as follows:

Scan type: MRM MRM planned: no Polarity: Positive Ionising source: TurboV ™  (Applied BioSystems) Q1 setting: Filtering with unit resolution Q3setting: Filtering with unit resolution Inter-scan pause: 5.00 msecScanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage: 5500.00 VSource temperature: 500.00° C. Nebulising gas: 50.00 psi Heating gas:50.00 psi Collision gas which 9.00 psi induces dissociation: Dynamicfilling: activated Declustering potential 100.00 V (DP): Entry potentialbefore 6.00 V Q0 (EP): Collision cell exit 15 V potential (CXP): Totalcycle time: 1.17 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE41, the detection of the transition is considered to be positive and islabelled “1” in TABLE 42. When a transition has an area less than thepositivity threshold described in TABLE 41, the transition is considerednon-detected and is labelled “0” in TABLE 42.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 42 Transition number Sam119 Sam120 Sam121 Sam122 Sam123 Sam124 1 10 1 1 0 0 2 0 0 0 0 0 0 3 0 0 0 0 0 0 4 0 0 1 0 1 0 5 0 1 1 0 0 0 6 0 11 0 0 0 7 0 0 0 1 0 0 8 0 0 0 1 0 0 9 0 0 0 1 0 0 10 1 1 1 1 1 1 11 1 11 1 1 1 12 1 1 1 0 1 1 13 1 1 1 0 1 0 14 1 1 1 0 1 0 15 1 0 1 0 0 0 16 00 1 1 0 1 17 0 0 1 1 0 1 18 0 0 1 1 1 1 19 1 1 1 1 1 1 20 1 0 1 1 1 1 211 1 1 1 1 1 22 0 1 1 1 1 1 23 0 0 1 1 1 1 24 1 1 1 1 1 1 25 1 1 1 1 1 126 1 1 1 1 1 1 27 1 1 1 1 1 1 28 0 0 1 1 0 0 29 0 0 1 1 1 0 30 0 0 1 1 00 31 1 1 1 1 1 1 32 0 1 1 1 1 1 33 0 1 1 1 1 1 34 1 1 1 1 1 1 35 0 1 1 11 1 36 1 0 1 1 1 1 37 1 0 1 1 0 1 38 1 1 1 1 1 1 39 1 1 1 1 1 1

Samples 119 to Sam124 comprise at least one peptide which ischaracteristic of the DHA proteins. The bacteria present in samplesSam119 to Sam124 therefore express a beta-lactamase which confers onthem a resistance to penicillins and to cephalosporins, with theexception of fourth-generation cephalosporins.

EXAMPLE 29 Identification of a Resistance to FOX Beta-Lactams

Samples Sam125 to Sam130 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 43.

TABLE 43 Names Species Sam125 E. coli Sam126 E. coli Sam127 K. oxytocaSam128 K. oxytoca Sam129 K. pneumoniae Sam13 K. pneumoniae

Samples Sam125 to Sam130 correspond to a species able to comprise a FOXresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 44 instead of the peptides from TABLE 3.

TABLE 44 Charge state Retention (m/z) (m/z) Collision Transition of thetime filtered filtered energy Positivity number Peptide precursorFragment ion (minutes) in Q1 in Q3 (eV) threshold 1 AHYFNYGVANR 3 y3monocharged 14.08 437.88 360.2 20.7 2500 2 AHYFNYGVANR 3 y4 monocharged14.08 437.88 459.27 20.7 2500 3 AHYFNYGVANR 3 y5 monocharged 14.08437.88 516.29 20.7 2500 4 AMGEQR 2 y5 dicharged 1.08 346.16 310.65 15.52500 5 AMGEQR 2 y4 monocharged 1.08 346.16 489.24 15.5 2500 6 AMGEQR 2y5 monocharged 1.08 346.16 620.28 15.5 2500 7 ESGQR 2 y3 dicharged 0.8288.64 180.6 12.2 2500 8 ESGQR 2 y3 monocharged 0.76 288.64 360.2 12.22500 9 ESGQR 2 y4 monocharged 0.82 288.64 447.23 12.2 2500 10 FAVPK 3 y4monocharged 12.95 187.79 414.27 12.9 2500 11 FAVPK 2 y3 monocharged12.95 281.17 343.23 11.8 2500 12 FAVPK 2 y4 monocharged 12.93 281.17414.27 11.8 2500 13 GGFELDDK 2 y6 dicharged 14.31 440.71 383.69 20.92500 14 GGFELDDK 2 y4 monocharged 14.34 440.71 490.25 20.9 2500 15GGFELDDK 2 y5 monocharged 14.31 440.71 619.29 20.9 2500 16 GIAIVMLANR 2y4 monocharged 20.15 529.31 473.28 25.9 2500 17 GIAIVMLANR 2 y5monocharged 20.13 529.31 604.32 25.9 2500 18 GIAIVMLANR 2 y6 monocharged20.13 529.31 703.39 25.9 2500 19 IPGMAVAVLK 2 y9 dicharged 19.17 499.81443.27 24.2 2500 20 IPGMAVAVLK 2 y8 monocharged 19.17 499.81 788.47 24.22500 21 IPGMAVAVLK 2 y9 monocharged 19.15 499.81 885.52 24.2 2500 22NYPIEAR 2 y3 monocharged 12.04 431.73 375.2 20.3 2500 23 NYPIEAR 2 y4monocharged 12.04 431.73 488.28 20.3 2500 24 NYPIEAR 2 y5 monocharged12.06 431.73 585.34 20.3 2500 25 SWSPVYPAGTHR 3 y9 dicharged 14.97453.23 499.26 21.1 2500 26 SWSPVYPAGTHR 3 y10 dicharged 14.97 453.23542.78 21.1 2500 27 SWSPVYPAGTHR 3 y6 monocharged 14.97 453.23 638.3421.1 2500 28 TGSADLLK 2 y5 monocharged 12.97 402.73 559.35 18.7 2500 29TGSADLLK 2 y6 monocharged 12.95 402.73 646.38 18.7 2500 30 TGSADLLK 2 y7monocharged 12.97 402.73 703.4 18.7 2500 31 TGSTGGFGAYVAFVPAR 3 y5monocharged 21.03 553.28 589.35 24.2 2500 32 TGSTGGFGAYVAFVPAR 3 y6monocharged 21.03 553.28 660.38 24.2 2500 33 TGSTGGFGAYVAFVPAR 2 y3monocharged 21.03 829.42 343.21 43 2500 34 TGSTGGFGAYVAFVPAR 2 y6monocharged 21.03 829.42 660.38 43 2500 35 TLTATLGAYAAVK 2 y7monocharged 18.68 640.37 679.38 32.2 2500 36 TLTATLGAYAAVK 2 y8monocharged 18.68 640.37 792.46 32.2 2500 37 TLTATLGAYAAVK 2 y9monocharged 18.66 640.37 893.51 32.2 2500 38 VSEQTLFEIGSVSK 2 y5monocharged 20.34 762.4 477.27 39.2 2500 39 VSEQTLFEIGSVSK 2 y7monocharged 20.34 762.4 719.39 39.2 2500 40 VSEQTLFEIGSVSK 2 y8monocharged 20.34 762.4 866.46 39.2 2500 41 VSQHAPWLK 3 y6 dicharged14.1 355.87 376.22 18.1 2500 42 VSQHAPWLK 3 y8 dicharged 14.1 355.87483.76 18.1 2500 43 VSQHAPWLK 3 y4 monocharged 14.1 355.87 543.33 18.12500 44 VTPGVLAAEAYGIK 2 y12 dicharged 19.37 694.89 594.84 35.3 2500 45VTPGVLAAEAYGIK 2 y7 monocharged 19.37 694.89 751.4 35.3 2500 46VTPGVLAAEAYGIK 2 y8 monocharged 19.37 694.89 822.44 35.3 2500

The other machine parameters used are as follows:

Scan type: MRM MRM planned: no Polarity: Positive Ionising source: TurboV ™  (Applied BioSystems) Q1 setting: Filtering with unit resolution Q3setting: Filtering with unit resolution Inter-scan pause: 5.00 msecScanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage: 5500.00 VSource temperature: 500.00° C. Nebulising gas: 50.00 psi Heating gas:50.00 psi Collision gas which 9.00 psi induces dissociation: Dynamicfilling: activated Declustering potential 100.00 V (DP): Entry potentialbefore 6.00 V Q0 (EP): Collision cell exit 15 V potential (CXP): Totalcycle time: 1.38 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE44, the detection of the transition is considered to be positive and islabelled “1” in TABLE 45. When a transition has an area less than thepositivity threshold described in TABLE 44, the transition is considerednon-detected and is labelled “0” in TABLE 45.

For a given peptide, when at least 2 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 45 transition number Sam125 Sam126 Sam127 Sam128 Sam129 Sam130 1 00 1 1 0 0 2 1 0 1 1 0 0 3 1 1 1 1 0 1 4 1 1 0 1 1 1 5 1 1 0 1 1 1 6 1 11 1 1 1 7 0 0 0 0 0 0 8 0 0 1 0 0 0 9 0 0 0 0 0 0 10 0 0 0 0 0 0 11 0 00 0 0 0 12 0 0 0 0 0 0 13 1 1 1 1 1 1 14 1 0 0 1 0 1 15 1 0 0 1 0 1 16 10 1 1 1 1 17 1 1 1 1 1 1 18 1 1 1 1 1 1 19 1 1 1 1 1 1 20 1 1 1 1 1 1 211 1 1 1 1 1 22 1 1 1 1 1 1 23 1 1 1 1 1 1 24 1 1 1 1 1 1 25 1 1 1 1 1 126 1 1 1 1 1 1 27 1 1 1 1 1 1 28 1 1 1 1 1 1 29 1 1 1 1 1 1 30 1 1 1 1 11 31 1 0 1 1 1 1 32 0 1 1 1 1 1 33 0 1 1 0 1 1 34 0 1 1 1 1 1 35 0 0 0 00 1 36 1 1 1 0 1 1 37 1 0 1 0 1 1 38 1 1 1 1 1 1 39 1 1 1 1 1 1 40 1 1 11 1 1 41 1 1 1 1 1 1 42 1 1 0 0 1 1 43 1 1 1 1 1 1 44 0 0 0 0 0 0 45 0 00 0 0 0 46 0 0 0 0 0 0

Samples Sam125 to Sam130 comprise at least one peptide which ischaracteristic of the FOX proteins. The bacteria present in samplesSam125 to Sam130 therefore express a beta-lactamase which confers onthem a resistance to penicillins and to cephalosporins, with theexception of fourth-generation cephalosporins.

EXAMPLE 30 Identification of a Resistance to SHV Beta-Lactams

Samples Sam131 to Sam144 are identified according to one of the methodsdescribed in examples 1, 3 or 4. The identification of the species isset out in TABLE 46.

TABLE 46 Names Species Sam131 E. aerogenes Sam132 E. coli Sam133 E. coliSam134 E. coli Sam135 E. coli Sam136 K. pneumoniae Sam137 K. pneumoniaeSam138 K. pneumoniae Sam139 K. pneumoniae Sam140 K. pneumoniae Sam141 K.pneumoniae Sam142 K. pneumoniae Sam143 K. pneumoniae Sam144 K.pneumoniae

Samples Sam131 to Sam144 correspond to a species able to comprise an SHVresistance mechanism. Each sample is treated according to example 5,then analysed according to example 6 by detecting the peptides fromTABLE 47 instead of the peptides from TABLE 3.

TABLE 47 Charge Colli- Tran- state Retention (m/z) (m/z) sion sition ofthe time filtered filtered energy Positivity number Peptide precursorFragment ion (minutes) in Q1 in Q3 (eV) threshold 1 AGAGER 2 y3monocharged 0.9 280.64 361.18 11.7 2000 2 AGAGER 2 y4 monocharged 0.9280.64 432.22 11.7 2000 3 AGAGER 2 y5 monocharged 0.9 280.64 489.24 11.72000 4 ATTTPASMAATLR 3 y5 monocharged 16.2 431.23 531.33 20.5 2000 5ATTTPASMAATLR 2 y9 dicharged 16.2 646.34 459.25 32.6 2000 6ATTTPASMAATLR 2 y9 monocharged 16.2 646.34 917.49 32.6 2000 7CIISLLATLPLAVHASPQPLEQIK 3 y18 dicharged 27.4 871.5 957.05 34.1 2000 8CIISLLATLPLAVHASPQPLEQIK 3 y21 dicharged 27.4 871.5 1113.65 34.1 2000 9CIISLLATLPLAVHASPQPLEQIK 3 y22 dicharged 27.3 871.5 1170.19 34.1 2000 10DMPASMAER 2 y7 dicharged 12.4 504.22 381.18 24.5 2000 11 DMPASMAER 2 y5monocharged 12.4 504.22 593.27 24.5 2000 12 DMPASMAER 2 y7 monocharged12.4 504.22 761.36 24.5 2000 13 DSPASMAER 2 y7 dicharged 10.5 482.21381.18 23.2 2000 14 DSPASMAER 2 y5 monocharged 10.5 482.21 593.27 23.22000 15 DSPASMAER 2 y6 monocharged 10.5 482.21 664.31 23.2 2000 16DTLASMAER 2 y5 monocharged 14 497.24 593.27 24.1 2000 17 DTLASMAER 2 y6monocharged 14 497.24 664.31 24.1 2000 18 DTLASMAER 2 y7 monocharged 14497.24 777.39 24.1 2000 19 DTPASMAER 2 y7 dicharged 10.5 489.22 381.1823.6 2000 20 DTPASMAER 2 y5 monocharged 10.5 489.22 593.27 23.6 2000 21DTPASMAER 2 y7 monocharged 10.5 489.22 761.36 23.6 2000 22 DTPASMAK 2 y6dicharged 9.1 410.7 302.66 19.1 2000 23 DTPASMAK 2 y5 monocharged 9.1410.7 507.26 19.1 2000 24 DTPASMAK 2 y6 monocharged 9.1 410.7 604.3119.1 2000 25 DTTTPASMAATLR 3 y5 monocharged 16.5 445.89 531.33 20.9 200026 DTTTPASMAATLR 2 y9 dicharged 16.5 668.33 459.25 33.8 2000 27DTTTPASMAATLR 2 y9 monocharged 16.5 668.33 917.49 33.8 2000 28DTTTPASMAGTLR 3 y4 monocharged 15.3 441.22 446.27 20.8 2000 29DTTTPASMAGTLR 2 y9 dicharged 15.3 661.32 452.24 33.4 2000 30DTTTPASMAGTLR 2 y9 monocharged 15.3 661.32 903.47 33.4 2000 31DTTTPASMTATLR 2 y9 dicharged 15.9 683.34 474.25 34.7 2000 32DTTTPASMTATLR 2 y7 monocharged 15.9 683.34 779.41 34.7 2000 33DTTTPASMTATLR 2 y9 monocharged 15.9 683.34 947.5 34.7 2000 34 FPMISTFK 2y7 dicharged 20.2 485.76 412.22 23.4 2000 35 FPMISTFK 2 y5 monocharged20.2 485.76 595.35 23.4 2000 36 FPMISTFK 2 y6 monocharged 20.2 485.76726.39 23.4 2000 37 FPMMSTFK 2 y7 dicharged 19.3 494.74 421.2 23.9 200038 FPMMSTFK 2 y5 monocharged 19.3 494.74 613.3 23.9 2000 39 FPMMSTFK 2y6 monocharged 19.3 494.74 744.34 23.9 2000 40 GIVALLGGNIK 2 y5monocharged 21.1 527.84 488.28 25.8 2000 41 GIVALLGGNIK 2 y6 monocharged21.1 527.84 601.37 25.8 2000 42 GIVALLGGNIK 2 y8 monocharged 21.1 527.84785.49 25.8 2000 43 GIVALLGPDNK 2 y5 monocharged 18.9 548.82 530.26 272000 44 GIVALLGPDNK 2 y6 monocharged 19 548.82 643.34 27 2000 45GIVALLGPDNK 2 y8 monocharged 18.9 548.82 827.46 27 2000 46 GIVALLGPNHK 3y9 dicharged 17.6 373.56 474.79 18.7 2000 47 GIVALLGPNHK 3 y5monocharged 17.6 373.56 552.29 18.7 2000 48 GIVALLGPNHK 3 y6 monocharged17.6 373.56 665.37 18.7 2000 49 GIVALLGPNNK 2 y5 monocharged 18.6 548.33529.27 27 2000 50 GIVALLGPNNK 2 y6 monocharged 18.6 548.33 642.36 272000 51 GIVALLGPNNK 2 y7 monocharged 18.6 548.33 755.44 27 2000 52GIVALLGPNNNAER 3 y8 dicharged 18.8 479.93 436.2 22 2000 53GIVALLGPNNNAER 2 y7 monocharged 18.8 719.39 814.38 36.7 2000 54GIVALLGPNNNAER 2 y8 monocharged 18.7 719.39 871.4 36.7 2000 55 GIVALR 2y4 dicharged 14.1 314.71 229.66 13.7 2000 56 GIVALR 2 y3 monocharged14.1 314.71 359.24 13.7 2000 57 GIVALR 2 y4 monocharged 14.1 314.71458.31 13.7 2000 58 GPNNK 2 y4 dicharged 0.8 265.14 236.63 10.8 2000 59GPNNK 2 y3 monocharged 0.8 265.14 375.2 10.8 2000 60 GPNNK 2 y4monocharged 0.8 265.14 472.25 10.8 2000 61 GTTTPASMAATLR 2 y9 dicharged16 639.33 459.25 32.2 2000 62 GTTTPASMAATLR 2 y7 monocharged 16 639.33749.4 32.2 2000 63 GTTTPASMAATLR 2 y9 monocharged 16 639.33 917.49 32.22000 64 HLADGMTVGELCAAAITMSDNSAAK 3 y6 monocharged 21.3 845.39 605.2933.3 2000 65 HLADGMTVGELCAAAITMSDNSAAK 3 y7 monocharged 21.3 845.39692.32 33.3 2000 66 HLADGMTVGELCAAAITMSDNSAAK 3 y9 monocharged 21.3845.39 924.41 33.3 2000 67 HLLQWMVDDR 3 y3 monocharged 19.6 438.22405.17 20.7 2000 68 HLLQWMVDDR 3 y4 monocharged 19.6 438.22 504.24 20.72000 69 HLLQWMVDDR 3 y5 monocharged 19.6 438.22 635.28 20.7 2000 70IHYLQQDLVDYSPVSEK 3 y6 monocharged 19 678.68 646.34 28.1 2000 71IHYLQQDLVDYSPVSEK 3 y7 monocharged 19 678.68 809.4 28.1 2000 72IHYLQQDLVDYSPVSEK 3 y8 monocharged 18.9 678.68 924.43 28.1 2000 73IVVIYLR 2 y3 monocharged 19.3 438.29 451.27 20.7 2000 74 IVVIYLR 2 y4monocharged 19.3 438.29 564.35 20.7 2000 75 IVVIYLR 2 y5 monocharged19.3 438.29 663.42 20.7 2000 76 LCIISLLAALPLAVHASPQPLEQIK 3 y17dicharged 30.7 899.19 906.52 35 2000 77 LCIISLLAALPLAVHASPQPLEQIK 3 y18dicharged 30.7 899.19 942.04 35 2000 78 LCIISLLAALPLAVHASPQPLEQIK 3 y22dicharged 30.7 899.19 1155.18 35 2000 79 LCIISLLATLPLAVHASPQPLDQIK 3 y19dicharged 30.2 904.52 1006.58 35.1 2000 80 LCIISLLATLPLAVHASPQPLDQIK 3y22 dicharged 30.2 904.52 1163.18 35.1 2000 81 LCIISLLATLPLAVHASPQPLDQIK3 y23 dicharged 30.3 904.52 1219.72 35.1 2000 82LCIISLLATLPLAVHASPQPLEQIK 3 y15 dicharged 30.2 909.19 814.46 35.3 200083 LCIISLLATLPLAVHASPQPLEQIK 3 y17 dicharged 30.2 909.19 921.53 35.32000 84 LCIISLLATLPLAVHASPQPLEQIK 3 y19 dicharged 30.2 909.19 1013.5935.3 2000 85 LCIISLLATLPLAVHSSPQPLEQIK 3 y15 dicharged 29.3 914.53822.46 35.4 2000 86 LCIISLLATLPLAVHSSPQPLEQIK 3 y18 dicharged 29.3914.53 965.04 35.4 2000 87 LCIISLLATLPLAVHSSPQPLEQIK 3 y21 dicharged29.3 914.53 1121.64 35.4 2000 88 LCIISLLATLPLAVHTSPQPLEQIK 3 y15dicharged 29.4 919.2 829.47 35.6 2000 89 LCIISLLATLPLAVHTSPQPLEQIK 3 y21dicharged 29.5 919.2 1128.65 35.6 2000 90 LCIISLLATLPLAVHTSPQPLEQIK 3y23 dicharged 29.4 919.2 1241.74 35.6 2000 91 LCIISLLATLPLTVHASPQPLEQIK3 y15 dicharged 29.8 919.2 829.47 35.6 2000 92 LCIISLLATLPLTVHASPQPLEQIK3 y17 dicharged 29.8 919.2 936.53 35.6 2000 93 LCIISLLATLPLTVHASPQPLEQIK3 y22 dicharged 29.8 919.2 1185.19 35.6 2000 94LCIISLLATLPLVVHASPQPLEQIK 3 y19 dicharged 31.3 918.54 1027.6 35.6 200095 LCIISLLATLPLVVHASPQPLEQIK 3 y21 dicharged 31.3 918.54 1127.66 35.62000 96 LCIISLLATLPLVVHASPQPLEQIK 3 y23 dicharged 31.3 918.54 1240.7535.6 2000 97 LCIISLLATLSLAVHASPQPLEQIK 3 y18 dicharged 31.2 905.85952.04 35.2 2000 98 LCIISLLATLSLAVHASPQPLEQIK 3 y22 dicharged 31.3905.85 1165.18 35.2 2000 99 LCIISLLATLSLAVHASPQPLEQIK 3 y23 dicharged31.2 905.85 1221.72 35.2 2000 100 LCIISLLATMPLAVHASPQPLEQIK 3 y18dicharged 28.9 915.18 966.03 35.5 2000 101 LCIISLLATMPLAVHASPQPLEQIK 3y19 dicharged 28.9 915.18 1022.57 35.5 2000 102LCIISLLATMPLAVHASPQPLEQIK 3 y23 dicharged 28.9 915.18 1235.71 35.5 2000103 LCIISLLAVLPLAVHASPQPLEQIK 3 y17 dicharged 31 908.54 920.54 35.2 2000104 LCIISLLAVLPLAVHASPQPLEQIK 3 y22 dicharged 31.1 908.54 1169.2 35.22000 105 LCIISLLAVLPLAVHASPQPLEQIK 3 y23 dicharged 31.1 908.54 1225.7435.2 2000 106 LLISQR 2 y3 monocharged 13.4 365.24 390.21 16.6 2000 107LLISQR 2 y4 monocharged 13.4 365.24 503.29 16.6 2000 108 LLISQR 2 y5monocharged 13.4 365.24 616.38 16.6 2000 109 LLLATVGGPAGLTAFLR 3 y4monocharged 26.9 557.34 506.31 24.4 2000 110 LLLATVGGPAGLTAFLR 3 y5monocharged 26.9 557.34 607.36 24.4 2000 111 LLLATVGGPAGLTAFLR 2 y11monocharged 26.9 835.5 1059.6 43.4 2000 112 LLNSQR 2 y3 monocharged 8.4365.71 390.21 16.6 2000 113 LLNSQR 2 y4 monocharged 8.4 365.71 504.2516.6 2000 114 LLNSQR 2 y5 monocharged 8.4 365.71 617.34 16.6 2000 115LLTNQR 2 y3 monocharged 9.3 372.72 417.22 17 2000 116 LLTNQR 2 y4monocharged 9.3 372.72 518.27 17 2000 117 LLTNQR 2 y5 monocharged 9.3372.72 631.35 17 2000 118 LLTSQR 2 y3 monocharged 9.5 359.22 390.21 16.22000 119 LLTSQR 2 y4 monocharged 9.5 359.22 491.26 16.2 2000 120 LLTSQR2 y5 monocharged 9.5 359.22 604.34 16.2 2000 121LNIISLLATLPLAVHASPQPLEQIK 3 y17 dicharged 30.8 893.87 921.53 34.8 2000122 LNIISLLATLPLAVHASPQPLEQIK 3 y18 dicharged 30.7 893.87 957.05 34.82000 123 LNIISLLATLPLAVHASPQPLEQIK 3 y21 dicharged 30.8 893.87 1113.6534.8 2000 124 LSASSQR 2 y4 monocharged 1.2 374.7 477.24 17.1 2000 125LSASSQR 2 y5 monocharged 1.2 374.7 548.28 17.1 2000 126 LSASSQR 2 y6monocharged 1.2 374.7 635.31 17.1 2000 127 LSESQLSGR 2 y8 dicharged 11.6488.76 432.22 23.6 2000 128 LSESQLSGR 2 y6 monocharged 11.6 488.76647.35 23.6 2000 129 LSESQLSGR 2 y7 monocharged 11.6 488.76 776.39 23.62000 130 LSESQLSGSVGMIEMDLASGR 3 y3 monocharged 23.7 723.02 319.17 29.52000 131 LSESQLSGSVGMIEMDLASGR 3 y4 monocharged 23.7 723.02 390.21 29.52000 132 LSESQLSGSVGMIEMDLASGR 3 y6 monocharged 23.7 723.02 618.32 29.53000 133 MVVIYLR 2 y3 monocharged 19.5 447.27 451.27 21.2 3000 134MVVIYLR 2 y4 monocharged 19.5 447.27 564.35 21.2 3000 135 MVVIYLR 2 y5monocharged 19.5 447.27 663.42 21.2 2000 136 NEALPGDAR 2 y5 monocharged10.9 471.74 515.26 22.6 2000 137 NEALPGDAR 2 y6 monocharged 10.9 471.74628.34 22.6 2000 138 NEALPGDAR 2 y7 monocharged 10.9 471.74 699.38 22.62000 139 NQHIAGIGAALIEHWQR 3 y13 dicharged 20.1 638.68 711.39 26.9 2000140 NQHIAGIGAALIEHWQR 3 y14 dicharged 20.1 638.68 767.93 26.9 2000 141NQHIAGIGAALIEHWQR 3 y15 dicharged 20.1 638.68 836.46 26.9 2000 142NQQIAGIGAALIEHWQR 3 y13 dicharged 22.3 635.67 711.39 26.8 2000 143NQQIAGIGAALIEHWQR 3 y14 dicharged 22.3 635.67 767.93 26.8 2000 144NQQIAGIGAALIEHWQR 3 y15 dicharged 22.3 635.67 831.96 26.8 2000 145NQQIAGLGAALIEHWQR 3 y13 dicharged 22.7 635.67 711.39 26.8 2000 146NQQIAGLGAALIEHWQR 3 y14 dicharged 22.7 635.67 767.93 26.8 2000 147NQQIAGLGAALIEHWQR 3 y15 dicharged 22.6 635.67 831.96 26.8 2000 148NTTTPASMAATLR 3 y4 monocharged 16 445.56 460.29 20.9 2000 149NTTTPASMAATLR 3 y5 monocharged 16 445.56 531.33 20.9 2000 150NTTTPASMAATLR 2 y9 monocharged 16 667.84 917.49 33.8 2000 151 NVLTSQR 2y3 monocharged 10.2 409.23 390.21 19.1 2000 152 NVLTSQR 2 y4 monocharged10.2 409.23 491.26 19.1 2000 153 NVLTSQR 2 y5 monocharged 10.2 409.23604.34 19.1 2000 154 QIDDNVTR 2 y4 monocharged 10 480.74 489.28 23.12000 155 QIDDNVTR 2 y5 monocharged 10 480.74 604.31 23.1 2000 156QIDDNVTR 2 y6 monocharged 10 480.74 719.33 23.1 2000 157 QIGDK 3 y4monocharged 1.1 187.44 432.25 12.9 2000 158 QIGDK 2 y3 monocharged 1.1280.66 319.16 11.7 2000 159 QIGDK 2 y4 monocharged 1.1 280.66 432.2511.7 2000 160 QIGDNVTR 2 y3 monocharged 10.2 451.74 375.24 21.5 2000 161QIGDNVTR 2 y4 monocharged 10.2 451.74 489.28 21.5 2000 162 QIGDNVTR 2 y6monocharged 10.2 451.74 661.33 21.5 2000 163 QIGENVTR 2 y3 monocharged10.3 458.75 375.24 21.9 2000 164 QIGENVTR 2 y4 monocharged 10.3 458.75489.28 21.9 2000 165 QIGENVTR 2 y6 monocharged 10.3 458.75 675.34 21.92000 166 QLLQWMVDAR 2 y5 monocharged 22.1 630.33 591.29 31.7 2000 167QLLQWMVDAR 2 y6 monocharged 22.1 630.33 777.37 31.7 2000 168 QLLQWMVDAR2 y7 monocharged 22.1 630.33 905.43 31.7 2000 169 QLLQWMVDDGVAGPLIR 3 y4monocharged 25.7 637.68 498.34 26.8 2000 170 QLLQWMVDDGVAGPLIR 3 y5monocharged 25.8 637.68 555.36 26.8 2000 171 QLLQWMVDDGVAGPLIR 3 y6monocharged 25.7 637.68 626.4 26.8 2000 172 QLLQWMVDDR 2 y4 monocharged21.7 652.33 504.24 32.9 2000 173 QLLQWMVDDR 2 y5 monocharged 21.7 652.33635.28 32.9 2000 174 QLLQWMVDDR 2 y6 monocharged 21.7 652.33 821.36 32.92000 175 QLLQWMVDGR 2 y4 monocharged 21.4 623.32 446.24 31.3 2000 176QLLQWMVDGR 2 y5 monocharged 21.4 623.32 577.28 31.3 2000 177 QLLQWMVDGR2 y6 monocharged 21.4 623.32 763.36 31.3 2000 178 QLLQWMVEDR 3 y4monocharged 21.7 439.89 518.26 20.7 2000 179 QLLQWMVEDR 2 y5 monocharged21.7 659.34 649.3 33.3 2000 180 QLLQWMVEDR 2 y6 monocharged 21.7 659.34835.38 33.3 2000 181 QQDLVDYSPVSEK 3 y5 monocharged 16 503.25 559.3122.7 2000 182 QQDLVDYSPVSEK 2 y5 monocharged 16 754.37 559.31 38.7 2000183 QQDLVDYSPVSEK 2 y8 monocharged 16 754.37 924.43 38.7 2000 184QQHLVDYSPVSEK 3 y6 dicharged 14.2 510.59 323.67 22.9 2000 185QQHLVDYSPVSEK 3 y5 monocharged 14.2 510.59 559.31 22.9 2000 186QQHLVDYSPVSEK 3 y6 monocharged 14.3 510.59 646.34 22.9 2000 187QSESQLSGR 2 y3 monocharged 7.2 496.24 319.17 24 2000 188 QSESQLSGR 2 y8dicharged 7.2 496.24 432.22 24 2000 189 QSESQLSGR 2 y4 monocharged 7.2496.24 432.26 24 2000 190 QSESQLSGSVGMIEMDLASGR 3 y3 monocharged 22.3728.01 319.17 29.7 2000 191 QSESQLSGSVGMIEMDLASGR 3 y6 monocharged 22.3728.01 618.32 29.7 2000 192 QSESQLSGSVGMIEMDLASGR 3 y8 monocharged 22.3728.01 878.4 29.7 2000 193 SQLQLLQWMVDDR 3 y4 monocharged 24.9 544.61504.24 24 2000 194 SQLQLLQWMVDDR 3 y5 monocharged 24.9 544.61 635.28 242000 195 SQLQLLQWMVDDR 3 y6 monocharged 24.9 544.61 821.36 24 2000 196SVLPAGWFIADK 2 y9 dicharged 23.1 652.36 502.76 32.9 2000 197SVLPAGWFIADK 2 y10 dicharged 23.1 652.36 559.31 32.9 2000 198SVLPAGWFIADK 2 y9 monocharged 23.1 652.36 1004.52 32.9 2000 199SVLPAGWFIADR 2 y9 dicharged 23.4 666.36 516.77 33.7 2000 200SVLPAGWFIADR 2 y10 dicharged 23.4 666.36 573.31 33.7 2000 201SVLPAGWFIADR 2 y9 monocharged 23.4 666.36 1032.53 33.7 2000 202SVLSAGWFIADK 2 y7 monocharged 22.3 647.35 836.43 32.6 2000 203SVLSAGWFIADK 2 y8 monocharged 22.3 647.35 907.47 32.6 2000 204SVLSAGWFIADK 2 y9 monocharged 22.3 647.35 994.5 32.6 2000 205 TGAAER 2y3 monocharged 1 302.66 375.2 13 2000 206 TGAAER 2 y4 monocharged 1302.66 446.24 13 2000 207 TGAAER 2 y5 monocharged 1 302.66 503.26 132000 208 TGAAK 2 y4 dicharged 0.8 224.13 173.61 8.5 2000 209 TGAAK 2 y3monocharged 0.8 224.13 289.19 8.5 2000 210 TGAAK 2 y4 monocharged 0.8224.13 346.21 8.5 2000 211 TGAGER 2 y3 monocharged 1 295.65 361.18 12.62000 212 TGAGER 2 y4 monocharged 1 295.65 432.22 12.6 2000 213 TGAGER 2y5 monocharged 1 295.65 489.24 12.6 2000 214 TGAGK 3 y4 monocharged 0.7145.09 332.19 11.6 2000 215 TGAGK 2 y3 monocharged 0.7 217.12 275.17 8.12000 216 TGAGK 2 y4 monocharged 0.7 217.12 332.19 8.1 2000 217 TGASER 2y3 monocharged 1 310.65 391.19 13.4 2000 218 TGASER 2 y4 monocharged 1310.65 462.23 13.4 2000 219 TGASER 2 y5 monocharged 1 310.65 519.25 13.42000 220 TGASK 2 y4 dicharged 0.8 232.13 181.61 9 2000 221 TGASK 2 y3monocharged 0.8 232.13 305.18 9 2000 222 TGASK 2 y4 monocharged 0.8232.13 362.2 9 2000 223 TGASR 3 y4 monocharged 0.8 164.42 390.21 12.22000 224 TGASR 2 y3 monocharged 0.8 246.13 333.19 9.8 2000 225 TGASR 2y4 monocharged 0.8 246.13 390.21 9.8 2000 226 TLTAWCADER 2 y5monocharged 15.5 611.78 650.26 30.6 5200 227 TLTAWCADER 2 y6 monocharged15.5 611.78 836.34 30.6 5200 228 TLTAWCADER 2 y8 monocharged 15.5 611.781008.42 30.6 5200 229 TLTAWHADER 3 y6 dicharged 13.1 400.53 407.19 19.52000 230 TLTAWHADER 3 y8 dicharged 13.1 400.53 493.23 19.5 2000 231TLTAWHADER 3 y5 monocharged 13.1 400.53 627.28 19.5 2000 232 TLTAWR 2 y3monocharged 14.6 374.21 432.24 17.1 2000 233 TLTAWR 2 y4 monocharged14.6 374.21 533.28 17.1 2000 234 TLTAWR 2 y5 monocharged 14.6 374.21646.37 17.1 2000 235 TVGGPAGLTAFLR 2 y5 monocharged 22 630.36 607.3631.7 2000 236 TVGGPAGLTAFLR 2 y7 monocharged 22 630.36 777.46 31.7 2000237 TVGGPAGLTAFLR 2 y11 monocharged 22 630.36 1059.6 31.7 2000 238TVVIYLR 2 y3 monocharged 17.5 432.27 451.27 20.4 2000 239 TVVIYLR 2 y4monocharged 17.5 432.27 564.35 20.4 2000 240 TVVIYLR 2 y5 monocharged17.4 432.27 663.42 20.4 2000 241 VAGPLIR 2 y4 monocharged 13.8 363.24498.34 16.4 2000 242 VAGPLIR 2 y5 monocharged 13.8 363.24 555.36 16.42000 243 VAGPLIR 2 y6 monocharged 13.8 363.24 626.4 16.4 2000 244VALCGAVLAR 2 y8 dicharged 16.4 515.3 430.25 25.1 2000 245 VALCGAVLAR 2y6 monocharged 16.4 515.3 586.37 25.1 2000 246 VALCGAVLAR 2 y7monocharged 16.4 515.3 746.4 25.1 2000 247 VDAGDEQLER 2 y5 monocharged11 566.27 674.35 28 2000 248 VDAGDEQLER 2 y7 monocharged 11 566.27 846.428 2000 249 VDAGDEQLER 2 y8 monocharged 11 566.27 917.43 28 2000 250VDAGDK 2 y3 monocharged 1 302.65 319.16 13 2000 251 VDAGDK 2 y4monocharged 1 302.65 390.2 13 2000 252 VDAGDK 2 y5 monocharged 1 302.65505.23 13 2000 253 VGMIEMDLASGR 2 y6 monocharged 19.3 639.81 618.32 32.22000 254 VGMIEMDLASGR 2 y7 monocharged 19.3 639.81 749.36 32.2 2000 255VGMIEMDLASGR 2 y8 monocharged 19.3 639.81 878.4 32.2 2000 256VGMIEMDLASR 2 y6 monocharged 19.2 611.3 692.34 30.6 2000 257 VGMIEMDLASR2 y7 monocharged 19.2 611.3 821.38 30.6 2000 258 VGMIEMDLASR 2 y8monocharged 19.2 611.3 934.47 30.6 2000 259 VGMIEMDLASSR 2 y6monocharged 18.8 654.82 648.33 33.1 2000 260 VGMIEMDLASSR 2 y7monocharged 18.8 654.82 779.37 33.1 2000 261 VGMIEMDLASSR 2 y8monocharged 18.8 654.82 908.41 33.1 2000 262 VLLCGAVLAR 2 y6 monocharged18.2 536.32 586.37 26.3 5400 263 VLLCGAVLAR 2 y7 monocharged 18.3 536.32746.4 26.3 5400 264 VLLCGAVLAR 2 y8 monocharged 18.3 536.32 859.48 26.35400 265 VVLCGAMLAR 2 y6 monocharged 17.7 545.3 618.34 26.8 2000 266VVLCGAMLAR 2 y7 monocharged 17.7 545.3 778.37 26.8 2000 267 VVLCGAMLAR 2y8 monocharged 17.7 545.3 891.45 26.8 2000 268 VVLCGAVLAR 2 y6monocharged 17.2 529.31 586.37 25.9 2000 269 VVLCGAVLAR 2 y7 monocharged17.2 529.31 746.4 25.9 2000 270 VVLCGAVLAR 2 y8 monocharged 17.2 529.31859.48 25.9 2000 271 VVLCGTVLAR 2 y6 monocharged 16.9 544.32 616.38 26.82000 272 VVLCGTVLAR 2 y7 monocharged 16.9 544.32 776.41 26.8 2000 273VVLCGTVLAR 2 y8 monocharged 16.9 544.32 889.49 26.8 2000 274 WETDR 3 y4monocharged 8.2 236.11 520.24 14.4 2000 275 WETDR 2 y3 monocharged 8.2353.66 391.19 15.9 2000 276 WETDR 2 y4 monocharged 8.2 353.66 520.2415.9 2000 277 WETELNEAFPGDAR 3 y5 monocharged 19.1 545.59 515.26 24 2000278 WETELNEAFPGDAR 3 y6 monocharged 19.1 545.59 662.33 24 2000 279WETELNEAFPGDAR 2 y5 monocharged 19.1 817.88 515.26 42.4 2000 280WETELNEALPADAR 3 y5 monocharged 18.5 538.93 529.27 23.8 2000 281WETELNEALPADAR 2 y5 monocharged 18.5 807.89 529.27 41.8 2000 282WETELNEALPADAR 2 y7 monocharged 18.5 807.89 713.39 41.8 2000 283WETELNEALPGDAR 3 y5 monocharged 18.2 534.26 515.26 23.6 2000 284WETELNEALPGDAR 2 y5 monocharged 18.2 800.88 515.26 41.4 2000 285WETELNEALPGDAR 2 y7 monocharged 18.2 800.88 699.38 41.4 2000 286WETELNEALSGDAR 3 y5 monocharged 18.9 530.92 505.24 23.5 2000 287WETELNEALSGDAR 3 y6 monocharged 18.9 530.92 618.32 23.5 2000 288WETELNEALSGDAR 2 y5 monocharged 18.9 795.87 505.24 41.1 2000 289WETELNEVLPGDAR 3 y5 monocharged 20.1 543.6 515.26 23.9 2000 290WETELNEVLPGDAR 2 y5 monocharged 20.1 814.9 515.26 42.2 2000 291WETELNEVLPGDAR 2 y6 monocharged 20.1 814.9 628.34 42.2 2000 292 WETER 3y4 monocharged 9 240.78 534.25 14.5 2000 293 WETER 2 y3 monocharged 8.9360.67 405.21 16.3 2000 294 WETER 2 y4 monocharged 8.9 360.67 534.2516.3 2000

The other machine parameters used are as follows:

Scan type: MRM MRM planned: yes Polarity: Positive Ionising source:Turbo V ™  (Applied BioSystems) Q1 setting: Filtering with unitresolution Q3 setting: Filtering with unit resolution Inter-scan pause:5.00 msec Scanning speed: 10 Da/s Curtain gas: 50.00 psi Cone voltage:5500.00 V Source temperature: 500.00° C. Nebulising gas: 50.00 psiHeating gas: 50.00 psi Collision gas which 9.00 psi inducesdissociation: Dynamic filling: activated Declustering potential 100.00 V(DP): Entry potential before 6.00 V Q0 (EP): Collision cell exit 15 Vpotential (CXP): Total cycle time: 1 sec Detection window: 120 sec

The areas obtained for each of the transitions and for each of themicroorganisms studied were measured. When the areas of the transitionsare greater than or equal to the positivity threshold described in TABLE47, the detection of the transition is considered to be positive and islabelled “1” in TABLE 48. When a transition has an area less than thepositivity threshold described in TABLE 47, the transition is considerednon-detected and is labelled “0” in TABLE 48.

For a given peptide, when at least 3 transitions are labelled “1”, thepeptide is considered as being detected.

TABLE 48 transition number Sam131 Sam132 Sam133 Sam134 Sam135 Sam136Sam137 Sam138 Sam139 Sam140 Sam141 Sam142 Sam143 Sam144 1 0 0 0 0 0 0 00 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 1 0 0 0 1 0 3 0 0 0 0 0 0 0 0 0 0 0 0 10 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 00 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 00 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 110 0 0 0 1 0 0 0 0 0 0 0 0 0 12 0 0 0 0 1 0 0 0 0 0 0 0 0 0 13 0 0 0 0 00 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 0 1 0 0 0 0 1 0 15 0 0 0 0 0 0 0 0 0 00 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 1 0 0 0 0 1 1 1 1 1 1 1 1 1 180 0 0 0 0 0 0 0 0 0 0 0 0 0 19 1 0 0 0 1 1 1 1 1 0 0 1 1 1 20 1 0 0 0 11 1 0 1 0 0 1 1 1 21 1 0 1 0 1 1 1 0 1 0 0 1 1 0 22 0 0 0 0 0 0 0 0 0 00 0 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 251 1 1 0 1 1 1 0 1 0 1 1 1 0 26 1 1 1 0 1 1 1 0 1 1 1 1 1 0 27 0 1 1 0 11 1 0 1 0 1 1 1 0 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 00 0 0 0 30 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 0 0 0 0 0 1 0 0 0 0 0 0 0 0 320 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 0 0 0 0 00 0 0 0 0 0 0 0 0 35 0 0 0 0 0 0 0 0 0 0 0 0 0 0 36 0 0 0 0 0 0 0 0 0 00 0 0 0 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 38 0 0 0 0 1 0 0 1 0 0 0 0 1 0 390 0 0 0 0 0 0 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 0 0 0 0 0 0 0 41 0 0 0 0 00 0 0 0 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 0 1 1 1 0 1 00 1 1 0 44 0 0 0 0 1 1 1 0 1 0 0 1 1 0 45 0 0 1 1 1 1 1 0 0 0 0 1 1 0 460 0 0 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 0 0 0 0 00 0 0 0 0 0 0 0 0 49 1 1 1 1 1 1 1 1 1 1 1 1 1 1 50 1 1 1 1 1 1 1 1 1 11 1 1 1 51 1 1 1 1 1 1 1 1 1 1 1 1 1 1 52 1 0 0 0 0 0 0 0 0 0 0 0 0 0 530 0 0 0 0 0 0 0 0 0 0 0 0 0 54 1 0 0 0 0 0 0 0 0 0 0 0 0 0 55 1 1 1 1 11 1 1 1 1 1 1 1 1 56 1 1 1 1 1 1 1 1 1 1 1 1 1 1 57 1 1 1 1 1 1 1 1 1 11 1 1 1 58 0 0 0 0 0 0 0 0 0 0 0 0 0 0 59 0 0 0 0 0 0 0 0 0 0 0 0 0 0 600 0 0 0 0 0 0 0 0 0 0 0 0 0 61 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 0 0 0 0 00 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 64 0 0 0 0 0 0 0 0 0 00 0 0 0 65 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66 0 0 0 0 0 0 0 0 0 0 0 0 0 0 670 0 0 0 0 0 0 0 0 0 0 0 0 0 68 0 0 0 0 1 0 0 0 0 0 0 0 0 0 69 0 0 0 0 00 0 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0 0 0 1 0 00 0 0 0 72 0 0 0 0 0 0 0 0 0 0 0 0 0 0 73 0 0 0 0 0 0 0 1 0 0 0 0 0 0 740 0 0 0 0 0 0 0 0 0 0 0 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 0 0 76 0 0 0 0 00 0 0 0 0 0 0 0 0 77 0 0 0 0 0 0 0 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 0 00 0 0 0 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 810 0 0 0 0 0 0 0 0 0 0 0 0 0 82 0 0 0 0 0 0 0 0 0 0 0 0 0 0 83 0 0 0 0 00 0 0 0 0 0 0 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 0 0 85 0 0 0 0 0 0 0 0 0 00 0 0 0 86 0 0 0 0 0 0 0 0 0 0 0 0 0 0 87 0 0 0 0 0 0 0 0 0 0 0 0 0 0 880 0 0 0 0 0 0 0 0 0 0 0 0 0 89 0 0 0 0 0 0 0 0 0 0 0 0 0 0 90 0 0 0 0 00 0 0 0 0 0 0 0 0 91 0 0 0 0 0 0 0 0 0 0 0 0 0 0 92 0 0 0 0 0 0 0 0 0 00 0 0 0 93 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 0 0 0 0 0 0 0 0 0 0 0 0 0 0 950 0 0 0 0 0 0 0 0 0 0 0 0 0 96 0 0 0 0 0 0 0 0 0 0 0 0 0 0 97 0 0 0 0 00 0 0 0 0 0 0 0 0 98 0 0 0 0 0 0 0 0 0 0 0 0 0 0 99 0 0 0 0 0 0 0 0 0 00 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 101 0 0 0 0 0 0 0 0 0 0 0 0 0 0102 0 0 0 0 0 0 0 0 0 0 0 0 0 0 103 0 0 0 0 0 0 0 0 0 0 0 0 0 0 104 0 00 0 0 0 0 0 0 0 0 0 0 0 105 0 0 0 0 0 0 0 0 0 0 0 0 0 0 106 0 0 0 0 0 00 0 0 0 1 0 0 0 107 0 0 0 0 0 0 0 0 0 0 0 0 0 0 108 0 0 0 0 0 0 0 0 0 00 0 0 0 109 0 0 0 0 0 0 0 0 0 0 0 0 0 0 110 0 0 0 0 0 0 0 0 0 0 0 0 0 0111 0 0 0 0 0 0 0 0 0 0 0 0 0 0 112 0 0 0 0 0 0 0 0 0 0 1 1 1 0 113 0 00 0 0 0 0 0 0 0 0 1 0 0 114 0 0 0 0 0 0 0 0 0 0 0 0 0 0 115 0 0 0 0 0 00 0 0 0 0 0 0 0 116 0 0 0 0 0 0 0 0 0 0 0 0 0 0 117 1 0 0 0 0 0 0 0 0 00 0 0 0 118 0 1 1 1 0 0 0 0 0 0 0 1 0 0 119 0 0 0 0 0 0 0 0 0 0 0 1 0 0120 0 0 0 0 0 0 0 0 0 0 0 1 0 0 121 0 0 0 0 0 0 0 0 0 0 0 0 0 0 122 0 00 0 0 0 0 0 0 0 0 0 0 0 123 0 0 0 0 0 0 0 0 0 0 0 0 0 0 124 0 0 0 0 0 00 1 0 0 0 0 0 0 125 0 0 0 0 0 0 0 1 0 0 0 0 1 0 126 0 0 0 0 0 0 0 1 0 00 0 0 0 127 1 0 0 0 1 0 0 0 0 0 0 1 1 0 128 1 0 0 0 1 0 0 0 0 0 0 1 1 0129 1 0 0 0 1 0 0 0 0 0 0 1 1 0 130 0 0 0 0 0 0 0 0 0 0 0 0 0 0 131 0 00 0 0 0 0 0 0 0 0 0 0 0 132 0 0 1 0 0 0 0 0 0 0 0 0 0 0 133 0 0 0 1 0 01 0 0 0 0 0 0 0 134 0 1 0 0 0 0 0 0 0 0 1 1 0 1 135 0 0 0 1 0 0 1 0 1 11 1 1 1 136 0 0 0 0 0 0 0 0 0 0 0 0 0 0 137 0 0 0 0 0 0 0 0 0 0 0 0 0 0138 1 0 0 0 1 1 1 0 1 1 1 1 1 1 139 0 0 0 0 0 1 0 0 0 0 0 0 0 0 140 0 00 0 0 1 1 1 1 1 1 1 0 1 141 0 0 0 0 0 0 0 0 0 0 0 0 0 0 142 0 1 1 1 1 11 0 1 1 1 1 1 0 143 0 1 1 1 1 1 1 0 1 1 1 1 1 0 144 0 1 1 1 1 1 1 0 1 11 1 1 0 145 0 1 1 1 1 1 1 1 1 1 1 1 1 1 146 0 1 1 1 1 1 1 1 1 1 1 1 1 1147 0 1 1 1 1 1 1 1 1 1 1 1 1 1 148 0 0 0 0 0 0 0 0 0 0 0 1 0 0 149 1 11 1 1 1 1 1 1 1 1 1 0 1 150 0 0 0 0 0 0 0 0 0 0 0 1 0 0 151 0 0 0 0 0 00 0 0 0 0 0 0 1 152 0 0 0 0 0 1 0 0 0 0 0 0 0 1 153 0 0 0 0 0 0 0 0 0 00 0 0 1 154 0 0 0 0 0 0 0 0 0 0 0 0 0 0 155 0 0 0 0 0 0 0 0 0 0 0 0 0 0156 0 0 0 0 0 0 0 0 0 0 0 0 0 0 157 0 0 0 0 0 0 0 0 0 0 0 0 0 0 158 0 00 0 0 0 0 0 1 0 0 0 1 0 159 0 0 0 0 0 0 0 0 1 0 0 0 1 0 160 1 0 0 0 1 11 0 1 0 0 1 1 0 161 1 1 1 0 1 1 1 1 1 0 0 1 1 0 162 0 0 0 0 1 1 1 0 0 00 1 1 0 163 0 0 0 0 1 0 0 0 0 0 0 0 0 0 164 0 0 0 0 0 0 0 0 0 0 0 0 0 0165 1 0 0 0 0 0 0 0 0 0 0 0 0 0 166 0 0 0 0 0 0 0 0 0 0 0 0 0 0 167 0 00 0 0 0 0 0 0 0 0 0 0 0 168 0 0 0 0 0 0 0 0 0 0 0 0 0 0 169 0 0 0 0 0 00 0 0 0 0 0 0 0 170 0 0 0 0 0 0 0 0 0 0 0 0 0 0 171 0 0 0 0 0 0 0 0 0 00 0 0 0 172 0 0 0 0 0 0 0 1 0 0 0 0 0 0 173 0 0 0 0 0 0 0 0 1 0 0 0 0 0174 0 0 0 0 0 1 0 0 1 0 1 0 0 1 175 0 0 0 0 0 0 0 0 0 0 0 0 0 0 176 0 01 0 0 0 0 0 0 0 0 0 0 0 177 0 0 0 0 0 0 0 0 0 0 0 0 0 0 178 0 0 0 0 0 00 0 0 0 0 0 0 0 179 0 0 0 0 0 0 0 0 0 0 0 0 0 0 180 0 0 0 0 0 0 0 0 0 00 0 0 0 181 0 0 0 0 0 0 1 0 0 0 0 1 1 0 182 1 0 0 0 1 1 1 0 1 0 0 1 1 0183 0 0 0 0 1 1 1 0 0 0 0 1 1 0 184 0 0 0 0 0 0 0 0 0 0 0 0 0 0 185 0 00 0 0 0 0 0 0 0 0 0 0 0 186 0 0 0 0 0 0 0 0 0 0 0 0 0 0 187 0 0 0 0 0 00 0 0 0 0 0 0 0 188 0 0 0 0 0 0 0 0 0 0 0 0 0 0 189 0 0 0 0 0 0 0 0 0 00 0 0 0 190 0 0 0 0 0 0 0 0 0 0 0 0 0 0 191 0 0 0 0 0 0 0 0 0 0 0 0 0 0192 0 0 0 0 0 0 0 0 0 0 0 0 0 0 193 0 0 0 0 0 0 0 0 0 0 0 0 0 0 194 0 00 0 0 0 0 0 0 0 0 0 0 0 195 0 0 0 0 0 0 0 0 0 0 0 0 0 0 196 0 0 0 0 0 00 0 0 0 0 0 0 0 197 0 0 0 0 0 0 0 0 0 0 0 0 0 0 198 0 0 0 0 0 0 0 0 0 00 0 0 0 199 0 0 0 0 0 0 0 0 0 0 0 0 0 0 200 0 0 0 0 0 0 0 0 0 0 0 0 0 0201 0 0 0 0 0 0 0 0 0 0 0 0 0 0 202 0 0 0 0 0 0 0 0 0 0 0 0 0 0 203 0 00 0 0 0 0 0 0 0 0 0 0 0 204 0 0 0 0 0 0 0 0 0 0 0 0 0 0 205 1 1 1 1 1 01 1 0 0 0 0 0 0 206 1 1 1 1 1 0 1 1 0 1 1 1 0 0 207 1 1 1 1 1 1 0 1 0 11 1 0 1 208 0 0 0 0 0 0 0 0 0 0 0 0 0 0 209 0 0 0 0 0 0 0 0 0 0 0 0 0 0210 0 0 0 0 0 0 0 0 0 0 0 0 0 0 211 0 0 0 0 0 0 0 0 0 0 0 0 0 0 212 0 00 0 0 0 0 0 0 0 0 0 1 0 213 0 0 0 0 0 0 0 0 1 0 0 0 1 0 214 0 0 0 0 0 00 0 0 0 0 0 0 0 215 0 0 0 0 0 0 0 0 0 0 0 0 0 0 216 0 0 0 0 0 0 0 0 0 00 0 0 0 217 0 0 0 0 0 0 0 0 0 0 0 0 1 0 218 0 1 0 0 0 1 0 0 0 0 1 1 0 0219 0 0 1 1 0 0 0 0 0 0 0 0 0 0 220 0 0 0 0 0 0 0 0 0 0 0 0 0 0 221 0 00 0 0 0 0 0 0 0 0 0 0 0 222 0 0 0 0 0 0 0 0 0 0 0 0 0 0 223 0 0 0 0 0 00 0 0 0 0 0 0 0 224 0 0 0 0 0 0 0 0 0 0 0 0 0 0 225 0 0 0 0 0 0 0 0 0 00 0 0 0 226 1 0 0 0 0 0 1 1 0 0 0 0 0 0 227 0 0 0 0 0 0 0 0 0 0 0 0 0 0228 1 0 0 0 0 0 1 0 0 1 0 0 0 0 229 0 0 0 0 0 0 0 0 0 0 0 0 0 0 230 0 00 0 0 0 0 0 0 0 0 0 0 0 231 0 0 0 0 0 0 0 0 0 0 0 0 0 0 232 0 0 1 0 1 11 0 0 0 0 1 1 0 233 0 0 1 0 1 1 1 0 0 0 0 1 1 0 234 0 0 0 0 1 1 1 0 0 00 1 1 0 235 0 0 0 0 0 0 0 0 0 0 0 0 0 0 236 0 0 0 0 0 0 0 0 0 0 0 0 0 0237 0 0 0 0 0 0 0 0 0 0 0 0 0 0 238 0 0 0 0 0 0 0 0 0 0 0 0 0 0 239 0 00 0 0 0 0 0 0 0 0 0 0 0 240 0 0 0 0 0 0 0 0 0 0 0 0 0 0 241 1 1 1 1 1 11 1 1 1 1 1 1 1 242 1 1 1 1 1 1 1 0 1 0 1 1 1 1 243 1 1 1 1 1 1 1 0 1 01 1 1 1 244 0 0 0 0 0 0 0 0 1 0 0 0 0 0 245 0 0 0 0 1 0 0 0 0 0 0 0 0 0246 0 0 0 0 0 0 0 0 0 0 0 0 0 0 247 1 0 1 0 1 1 1 0 1 0 1 1 1 0 248 1 11 1 1 1 1 1 1 1 1 1 1 1 249 1 1 1 1 1 1 1 0 1 1 1 1 1 1 250 0 0 0 0 0 00 0 0 0 0 0 0 0 251 0 1 1 1 0 0 0 0 0 0 0 0 0 0 252 0 0 0 0 0 0 0 0 0 00 0 0 0 253 0 0 0 0 1 0 1 0 1 0 0 1 1 0 254 0 0 0 0 1 0 1 0 1 0 0 1 1 0255 0 0 0 0 1 0 1 0 1 0 0 1 1 0 256 0 0 0 0 0 0 0 0 0 0 0 0 0 0 257 0 00 0 0 0 0 0 0 0 0 0 0 0 258 0 0 0 0 0 0 0 0 0 0 0 0 0 0 259 0 0 0 0 0 00 0 0 0 0 0 0 0 260 0 0 0 0 0 0 0 0 0 0 0 0 0 0 261 0 0 0 0 0 0 0 0 0 00 0 0 0 262 0 0 0 0 0 0 0 0 0 0 0 1 1 0 263 0 0 0 0 0 0 0 0 0 0 1 0 1 0264 0 0 0 0 0 0 0 0 0 0 0 1 0 265 0 0 0 0 0 0 0 0 0 0 0 0 0 0 266 0 0 00 0 0 0 0 0 0 0 0 0 0 267 0 0 0 0 0 1 0 0 0 0 0 0 0 0 268 0 0 0 0 0 0 00 0 0 0 0 0 0 269 0 0 0 0 0 0 0 0 0 0 0 0 0 0 270 0 0 0 0 0 0 0 0 0 0 00 0 0 271 0 0 0 0 0 0 0 0 0 0 0 0 0 0 272 0 0 0 0 0 0 0 0 0 1 0 0 0 0273 0 0 0 0 0 0 0 0 0 1 0 0 0 0 274 0 0 0 0 0 0 0 0 0 0 0 0 0 0 275 0 00 0 0 0 0 0 0 0 0 0 0 0 276 0 0 0 0 0 0 0 0 0 0 0 0 0 0 277 0 0 0 0 0 00 0 0 0 0 0 0 0 278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 279 0 0 0 0 0 0 0 0 0 00 0 0 0 280 0 0 0 0 1 0 0 0 0 0 0 0 0 0 281 0 0 0 0 0 0 0 0 0 0 0 0 0 0282 0 0 0 0 1 0 0 0 0 0 0 0 0 0 283 0 0 0 0 1 1 1 0 0 0 0 1 1 0 284 0 11 0 0 1 1 0 0 0 0 1 1 0 285 0 0 0 0 0 1 1 0 0 0 0 1 1 0 286 0 0 0 0 0 00 0 0 0 0 0 0 0 287 0 0 0 0 0 0 0 0 0 0 0 0 0 0 288 0 0 0 0 0 0 0 0 0 00 0 0 0 289 0 0 0 0 0 0 0 0 0 0 0 0 0 0 290 0 0 0 0 0 0 0 0 0 0 0 0 0 0291 0 0 0 0 0 0 0 0 0 0 0 0 0 0 292 0 0 0 0 0 0 0 0 0 0 0 0 0 0 293 0 00 0 0 0 0 0 0 0 0 0 0 0 294 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Samples Sam131 to Sam144 comprise at least one peptide which ischaracteristic of the SHV proteins. The bacteria present in samplesSam131 to Sam144 therefore express a beta-lactamase which confers onthem a resistance to penicillins.

Sample Sam142 comprises a peptide specific to phenotype 2be. Thereforesample Sam142 is resistant to penicillins, to cephalosporins and tomonobactams.

No peptide specific to phenotypes 2b and 2br is observed, no sampletested is identified as belonging only to these phenotypes.

The detection methods described in examples 6 to 30 are particularlyadvantageous because they make it possible to assay a large number ofpeptides and at the same time to detect the presence of one or moreresistance mechanisms induced by one or more beta-lactamases.

Furthermore, the detection is performed in a short time, less than onehour. In fact, only the part of the gradient between 3 and 34 minutes isuseful to the analysis. Furthermore, the retention times of the assayedpeptides are all below 34 minutes.

In addition, the detection methods described in examples 6 to 30 aremore advantageous than the molecular biology methods because they detectthe product of the expression of the genes, and not the genesthemselves. The detection of a resistance may not have any clinicalmeaning if this gene is not expressed, or it if is expressed too weaklyto lead to an effective resistance. The detection of a peptidecharacterising a protein characteristic of a resistance mechanism doesnot have this disadvantage.

Surprisingly, the above examples show that it is possible to attain bymass spectrometry the sensitivity necessary for the specific detectionof the existence of a mechanism of resistance to at least oneantimicrobial of a microorganism contained in a sample, withoutemploying an amplification method as is usually the case when molecularbiology methods are used.

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The invention claimed is:
 1. A method of detecting a TEM protein in asample, comprising: subjecting the sample to MS/MS spectrometry in MRMmode and detecting whether one or more TEM fragments selected from thegroup consisting of SEQ ID NOS: 166-230, 232-257, 259-261, 1923, 1927,and 1928 is present, wherein detection of any of the TEM fragments bythe MRM mass spectrometry indicates the presence of TEM protein in thesample.
 2. The detection method according to claim 1, furthercomprising, before performing MS/MS spectrometry in MRM mode, digestingproteins to produce peptides in the sample.
 3. The detection methodaccording to claim 2, wherein the digestion is performed by an enzyme.4. The detection method according to claim 3, wherein the enzyme istrypsin.
 5. The detection method according to claim 1, wherein the oneor more TEM fragments is selected from the group consisting of SEQ IDNOS: 166-174, 180, 181, 186-203, 212-217, 219, 220, 223-230, 241-243,250-255, 259-261, 1927, and 1928.